Safety evaluation of medroxyprogesterone acetate: a pharmacovigilance analysis using FDA adverse event reporting system data by Luyang Su, Ren Xu, Yanan Ren, Shixia Zhao, Weilan Liu, Zeqing Du

“…Disproportionality analyses were conducted using several statistical methods, including reporting odds ratio (ROR), proportional reporting ratio (PRR), empirical Bayesian geometric mean (EBGM). Additionally, time-to-onset (TTO) analysis was employed to quantify the signals of the MPA-associated AEs.ResultsA comprehensive dataset comprising 21,035,995 AE reports was compiled. …”
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Design of an RCT on cost-effectiveness of group schema therapy versus individual schema therapy for patients with Cluster-C personality disorder: the QUEST-CLC study protocol by Iuno Z. Groot, Anne-Sophie S. M. Venhuizen, Nathan Bachrach, Simone Walhout, Bregje de Moor, Kasper Nikkels, Susanne Dalmeijer, Myrte Maarschalkerweerd, Joël R. van Aalderen, Hinde de Lange, Renske Wichers, Agatha Ph. Hollander, Silvia M. A. A. Evers, Raoul P. P. P. Grasman, Arnoud Arntz

“…Group ST (GST) might improve cost-effectiveness as larger numbers can be treated in (>50%) less time compared to IST. However, to date there is no RCT supporting its (cost-) effectiveness. …”
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Real-world short-term outcomes and treatment regimen comparisons in patients with metastatic renal cell carcinoma treated with first-line immune combinations by Masato Kikuta, Sei Naito, Takahiro Osawa, Kazuyuki Numakura, Takafumi Narisawa, Yuki Takai, Mayu Yagi, Yuya Sekine, Ojiro Tokairin, Nobuo Shinohara, Tomonori Habuchi, Norihiko Tsuchiya

“…Progression free survival (PFS), time to treatment failure 2 (TTF2), and overall survival (OS) were compared between IMDC risk categories. …”
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O-GlcNAcylation attenuates ischemia-reperfusion-induced pulmonary epithelial cell ferroptosis via the Nrf2/G6PDH pathway by Liuqing Yang, Hexiao Tang, Jin Wang, Dawei Xu, Rui Xuan, Songping Xie, Pengfei Xu, Xinyi Li

“…Results First, we identified O-GlcNAc transferase 1 (Ogt1) as a differentially expressed gene in lung epithelial cells of acute lung injury/acute respiratory distress syndrome (ALI/ARDS) patients, using single-cell sequencing, and Gene Ontology analysis (GO analysis) revealed the enrichment of the ferroptosis process. We found a time-dependent dynamic alteration in lung O-GlcNAcylation during I/R injury. …”
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The Genealogy of Šemetas' in 15th-16th century by Saulė Viskantaitė-Saviščevienė

“…They were interested in the accumulation of books in their private libraries and communicated with highbrows of that time. It is possible that they were associated with the well-known intellectual, historian, and annalist Maciej Stryjkowski. …”
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Analysis of the accuracy of disease prediction in pediatric ward patients based on the modified early warning score for children: A randomized controlled trialWhat is already known... by Kang Lin, Xiaojun Weng, Bing Du, Ting Tian, Xiaoxiang Quan

“…The modified PEWS is valuable for early identification of illness and assessing changes in patient conditions. It enables timely recognition of deterioration and the provision of personalized nursing interventions, thereby reducing the incidence of complications in critically ill patients, preventing further deterioration, shortening hospital stays, and lowering hospitalization costs, ultimately improving parental satisfaction. …”
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Plasma S100β is a predictor for pathology and cognitive decline in Alzheimer’s disease by Geetika Nehra, Bryan J. Maloney, Rebecca R. Smith, Wijitra Chumboatong, Erin L. Abner, Peter T. Nelson, Björn Bauer, Anika M. S. Hartz

“…The goal of this study was to assess markers for barrier dysfunction in postmortem tissue samples from research participants who were either cognitively normal individuals (CNI) or diagnosed with AD at the time of autopsy and determine to what extent these markers are associated with AD neuropathologic changes (ADNC) and cognitive impairment. …”
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Rate of Suture Material Absorption Does Not Impact Short Term Outcome of Tubularized Incised Plate Repair of Distal Penile Hypospadias in Children: A Randomized Controlled Study by Mohamed Abdelwahab, Mohamed Salah, Waseem Aboul Ela, Ahmed Salem, Amr Amin Ragab, Ahmed Mahmoud Shouman, Mohamed Abdelghany

“…Results: The mean ± SD age at the time of surgery for groups (A) and (B) was 46.95 ± 28.07 and 39.33± 21.63 months respectively (p = 0.353). …”
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Impacts of drought on respiratory mortality in the upper midwest United States: a population subgroup assessment by Yeongjin Gwon, Yuanyuan Ji, Jesse D Berman, Azar M Abadi, Ronald D Leeper, Jared Rennie, Jesse E Bell

“…We used the Evaporative Demand Drought Index categorized into three levels and analyzed it at two timescales: 6 months and 12 months. A Bayesian two-stage time-series modeling approach was applied to estimate the county-level and overall risk along with the 95% Credible Intervals (Cr). …”
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External beam radiation therapy versus radical prostatectomy for high-risk prostate cancer: protocol of the RECOVER study by Caroline M. van der Starre, Chris H. Bangma, Maarten J. Bijlsma, Alfons C.M. van den Bergh, Lambertus A.L.M. Kiemeney, Wietske Kievit, Kees Vos, Diederik M. Somford, Sally M. Wildeman, Katja K.H. Aben, Igle J. de Jong, Floris J. Pos, Berdine L. Heesterman

“…Descriptive statistics and mixed-effects models are used to assess differences in HRQoL and functional outcomes over time between the patients treated with radical prostatectomy versus EBRT (+ ADT). …”
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Dual-Stage AI Model for Enhanced CT Imaging: Precision Segmentation of Kidney and Tumors by Nalan Karunanayake, Lin Lu, Hao Yang, Pengfei Geng, Oguz Akin, Helena Furberg, Lawrence H. Schwartz, Binsheng Zhao

“…Objectives: Accurate kidney and tumor segmentation of computed tomography (CT) scans is vital for diagnosis and treatment, but manual methods are time-consuming and inconsistent, highlighting the value of AI automation. …”
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Comparison of Functioning, Quality of Life, and Cognition between Lithium and Sodium Valproate Combination Therapy and Sodium Valproate Monotherapy in Euthymic Bipolar Patients: A... by M Ashwini, R Jhamuna, V Jaikumar

“…Cognitive variables like FAB score, and time taken to complete TMT-A and TMT-B in seconds showed no significant differences (p-value>0.05). …”
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Association between cardiometabolic index and risk of testosterone deficiency in adult men: a cross-sectional study by Yangyang Mei, Bo Zhang, Xiaogang Wang, Renfang Xu, Wei Xia, Yiming Chen, Xingliang Feng

“…Using CMI for early detection and timely intervention could reduce the disease burden and promote reproductive health. …”
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Diagnostic and Predictive Values of Inflammatory Factors in Pathology and Survival of Patients Undergoing Total Cystectomy by Xingxing Tang, Yudong Cao, Jia Liu, Shuo Wang, Yong Yang, Peng Du

“…Only NLR (AUC=0.706, cut‐off value=3.12, sensitivity=75.00%, specificity=70.00%, P=0.014), dNLR (AUC=0.700, cut‐off value=2.49, sensitivity=66.67%, specificity=76.67%, P=0.015), and SII (AUC=0.704, cut‐off value=463.56, sensitivity=100.00%, specificity=40.00%, P=0.004) had a diagnostic value for lymph node metastasis. The median follow-up time was 31 months, and there was no significant difference in OS between the two groups for all IFs. …”
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Entre espaces domestiques et « espaces domestiqués » : « L’autonomisation intime » des étudiantes en Turquie by Tuğba Gökduman

“…These women, most of them being heterosexual and aged between 20-25, were mainly issued from middle-class families from different towns and villages in Turkey. At the time of my enquiry, they were students or recent graduates. …”
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Assessment of Air Pollution and Lagged Meteorological Effects in an Urban Residential Area of Kenitra City, Morocco by Mustapha Zghaid, Abdelfettah Benchrif, Mounia Tahri, Amine Arfaoui, Malika Elouardi, Mohamed Derdaki, Ali Quyou, Moulay Laarbi Ouahidi

“…Lag analyses revealed that PM_2.5 and BC levels responded to wind speed, temperature, and humidity over time, highlighting the temporal dynamics of dispersion and accumulation. …”
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THE APPLICATION OF IOT (INTERNET OF THINGS) FOR SMART HOUSING ENVIRONMENTS AND INTEGRATED ECOSYSTEMS by Andi Hildayanti, M Sya'Rani Machrizzandi

“…Abstract_ Technological development increases rapidly over time. Starting from smart cars that can walk alone to various destinations without a human driver, to smart home devices that can automatically remind the voice to do activities on schedule. …”
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The effect of prone positioning on maternal haemodynamics and fetal wellbeing in the third trimester-A primary cohort study with a scoping review. by Laura Ormesher, Jessica Catchpole, Linda Peacock, Heather Pitt, Anastasia Fabian-Hunt, Dexter Hayes, Claudia Popp, Jason M Carson, Raoul van Loon, Lynne Warrander, Karli Büchling, Alexander E P Heazell

“…Regression analyses (adjusted for time) compared variables between positions. The information derived from the primary study was used in an existing mathematical model of maternal circulation in pregnancy, to determine whether occlusion of the inferior vena cava could account for the observed effects. …”
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Design, synthesis, structural characterization, in vitro anticancer activity, and in silico studies of some new hydroxylated and fluorinated-substituted hydrazone derivatives by Reşit Çakmak, Eyüp Başaran, Ömer Erdoğan, Suraj N. Mali, Semiha Köprü, Haya Yasin, Shailesh S. Gurav, Giray Topal

“…In this study, novel hydroxylated and fluorinated-substituted hydrazone derivatives bearing an aromatic nitro moiety (2a-d and 3a-d) were designed as potential anticancer drug candidates, synthesized for the first time, and evaluated for their anticancer activity against chondrosarcoma (SW1353), a common primary malignant cartilage-forming tumor, neuroblastoma (SH-SY5Y), a type of brain cancer, and healthy (L929) cell lines using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) method for 24 h. …”
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The effect of supplementation with type I and type III collagen peptide and type II hydrolyzed collagen on pain, quality of life and physical function in patients with meniscopathy... by Ahmet Serhat Genç, Ali Kerim Yılmaz, Berna Anıl, Esra Korkmaz Salkılıç, Enes Akdemir, Berna Güzel, Ahmet Mor, Hacı Ahmet Yarar, Nizamettin Güzel, Lokman Kehribar

“…Patients completed the Visual Analog Scale (VAS), Western Ontario and McMaster Universities Osteoarthrtis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score Physical Function Short Form (KOOS-PS), Oxford Knee Score (OKS), Tampa Scale for Kinesiophobia (TSK), Short Form Health Survey (SF-12), Lower Extremity Functional Scale (LEFS), Foot Function Index (FFI), proprioceptive sensation, Timed Up and Go (TUG), 6-Minute Walking Test (6MWT), The Five Repetition Sit to Stand Test (5STS), Stair Climbing Test (SCT), Berg Balance Scale (BBS) and back and leg strength tests and scales were applied. …”
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