Adherence and efficacy outcomes in young Australians with suicidal ideation using a self-management app and digital engagement strategy compared with a sham app: a three-arm random... by Michelle Torok, Lauren McGillivray, Daniel Z.Q. Gan, Jin Han, Sarah Hetrick, Quincy J.J. Wong

“…There were no differences in the number of modules completed between the intervention conditions (OR 1.10, 1.03, respectively) and no significant differences in their ideation scores at any time (ds −0.15 to 0.08). Serious adverse events (hospital presenting non-suicidal self-harm and/or suicide attempts) were reported by 6% of participants during the trial (control condition: 9%; combined intervention condition: 4%). …”
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The efficacy and safety of induction chemotherapy combined with sintilimab followed by concurrent chemoradiotherapy plus sintilimab sequencing maintaining with sintilimab for patie... by Ruifeng Wang, Tianhui Guo, Qi Wang, Wen Gao, Yimiao Yu, Jun Zhang, Wenqian Fu, Haiji Wang, Biyuan Zhang

“…Results In total, 29 eligible patients were enrolled and analyzed. The median follow-up time was 20.5 months. The median PFS was not reached; the 6-, 12-, and 18-month PFS rates were 100.0%, 93.1%, and 82.8%, respectively. …”
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Hard and soft tissue alterations after the application of different soft tissue grafting materials during immediate dental implant placement: a systematic review and Bayesian netwo... by Ali Azadi, Fatemeh Rezaei, Atoosa Yazdani, Kimia Hejazi, Aryousha Moallem Savasari, Reza Amid, Mahdi Kadkhodazadeh

“…However, CTG in MIBL, KTW, STT, PH, and MGML, and uni-layer xenogenic collagen matrix in PES were the superior treatments, according to the treatment ranking based on surface under cumulative ranking (SUCRA). Conclusions At the time of immediate implantation, there is no significant difference between different soft tissue grafts regarding the clinical outcomes of implants. …”
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Kualitas Air Minum Yang Diproduksi Depot Air Minum Isi Ulang Di Kecamatan Bungus Padang Berdasarkan Persyaratan Mikrobiologi by Rido Wandrivel, Netty Suharti, Yuniar Lestari

“…Research executed in 2 phase that is intake of water sample with gallon at the same time do observation of the factor that influencing the quality of water and mikrobiological test with Most Probable Number Test ( MPN) to the sampel which consist of three test, that is presumtive test, konfirmative test, and complete test. …”
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The prognostic value of systemic inflammation response index in digestive system carcinomas: a systematic review and meta-analysis by Zuo-hu Niu, Li Lin, Hong-ye Peng, Xin-zhuo Zheng, Mi-yuan Wang, Feng-xia Sun, Chun-jun Xu

“…The primary outcome of interest was the overall survival (OS), while secondary outcomes included progression-free survival (PFS), disease-free survival (DFS), time to progression (TTP), and disease specific survival (DSS). …”
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Alpha EEG Spectral Characteristics in the Parieto-Occipital lobe of Elderly Patients with Chronic Insomnia and Mild Cognitive Impairment by GUO Zhenxing, BAI Linxin, ZHANG Lin, GAO Jiahui, RAO Ting, LIU Zhizhen

“…The total PSQI scores, sleep quality, sleep onset latency, total sleep time, sleep efficiency, and sleep disturbance scores were significantly higher in the CI group and the CI-MCI group, while the use of hypnotics score was significantly reduced, with statistically significant differences （P <0. 05）. （2）MoCA scores：Compared to the HC and CI groups, the CI-MCI group exhibited significantly lower total MoCA scores, as well as reductions in visuospatial execution, naming, attention, verbal fluency, delayed recall, and orientation, with statistically significant differences （P <0. 05）. （3）EEG spectral characteristics：Compared to the HC group, the CI-MCI group showed significantly increased alpha spectral power at sites P1, P6, POZ, PO4, and PO6 in the Parieto-Occipital lobe, with statistically significant differences （P <0. 05）. …”
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Systematic Review and Meta-Analysis of Risk Factors Associated with Postoperative Stress Hyperglycemia in Patients without Diabetes Following Cardiac Surgery by Mengli Zhang, Ziyi Zhang, Ningning Zhu, Lulu Wang, Hui Huang, Yike Wang, Fang Xue

“…The results of the meta-analysis indicated that statistically significant risk factors included age >65 years [odds ratios (OR) (95% CI ) = 3.47 (2.61–4.32)], female gender [OR (95%) = 1.54 (1.34–1.76)], combined heart valve and coronary artery bypass surgery [OR (95%) = 1.82 (1.23–2.70)], ejection fraction <40% [OR (95%) = 1.38 (1.17–1.63)], history of heart surgery [OR (95%) = 1.30 (1.06–1.59)], myocardial infarction [OR (95%) = 1.17 (1.05–1.31)], hyperlipidemia [OR (95%) = 0.76 (0.67–0.86)], hypertension [OR (95%) = 1.12 (1.03–1.22)], anticoagulant medication [OR (95%) = 0.77 (0.65–0.90)], cardiopulmonary bypass time >2 hours [OR (95%) = 20.26 (17.03–23.48)] and history of cardiopulmonary bypass [OR (95%) = 1.24 (1.09–1.41)]. …”
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Determination of distance away and depth of transmitters relative to a vertical acoustic telemetry array in the open ocean by Eric V. C. Schneider, Brendan S. Talwar, David M. Bailey, Shaun S. Killen, Dale M. Webber, Courtney E. MacSween, Travis E. Van Leeuwen, Frank I. Smith

“…Abstract Background Many ecologically and commercially important species occur in the epipelagic marine environment and have been observed to spend a considerable amount of time associating with surface structure. The bottom depth of this habitat often exceeds transmission (~ 500-1000 m) and receiver (500–750 m) range specifications for commonly used acoustic telemetry methods that rely on an array of receivers deployed on the seafloor with overlapping fields of detection to provide positioning of acoustically tagged individuals. …”
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Clinical Features and Contributing Factors of Excessive Daytime Sleepiness in Chinese Obstructive Sleep Apnea Patients: The Role of Comorbid Symptoms and Polysomnographic Variables by Chuan Shao, Huan Qi, Ruyi Lang, Biyun Yu, Yaodong Tang, Lina Zhang, Xun Wang, Ling Wang

“…Logistic regression analysis showed waist circumference, memory loss, work/commute disturbances, and sleep efficiency were independently associated with mild to moderate EDS, and the microarousal index, apnea-hypopnea index (AHI), and saturation impair time below 90% were independent contributing factors of mild to moderate EDS. …”
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A novel approach to regulate glucose uptake in an anaplastic thyroid cancer cell line by Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpour, Mehdi Hedayati

“…Moreover, herein, for the first time, we decided to investigate the anti-thyroid cancer effects of a bioactive phytochemical and establish a signaling link between curcumin and the glucose uptake metabolism of anaplastic thyroid cancer cells. …”
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Factors influencing the kinetics of MSU crystal depletion measured with dual-energy CT in patients with gout by Tristan Pascart, Victor Laurent, Charlotte Jauffret, Aurore Pacaud, Vincent Ducoulombier, Julie Legrand, Stéphane Verdun, Laurène Norberciak, Jean-François Budzik

“…In multivariable analysis, time (in days) with a multilevel coefficient of −0.06 (95% CI: −0.08 to −0.03, p&lt;0.001), hypertension (coefficient: 41.87, 95% CI: 16.38 to 67.18, p&lt;0.01) and SU level &lt;5.0 mg/dL (coefficient: −39.46, 95% CI: −70.93 to −8.34, p=0.02) were the only variables significantly associated with MSU crystal volume change.Conclusion In patients with DECT-measured MSU crystal deposition, reaching the &lt;5.0 mg/dL SU target provides more extensive and rapid crystal dissolution than reaching the &lt;6.0 mg/dL SU target.…”
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Inflammatory burden index as a prognostic marker in patients with advanced gastric cancer treated with neoadjuvant chemotherapy and immunotherapy by Jiao-Bao Huang, Zhi-Yong Zhou, Jun Lu, Ji-Yun Zhu, Bin Lai, Sheng-Xun Mao, Jia-Qing Cao

“…The median cycle of neoadjuvant therapy was 4(3-4). The median survival time was 85.1%(1 years), 65.6%(2 years), and 47.4%(3 years).Univariate analysis showed that IBI was an independent risk factor for non-TR(residual tumor cells&gt;50%) (HR=1.08,95%CI:1.00-1.45,p&lt;0.001)and OS(HR=1.04,95%CI:1.03-1.05,p&lt;0.001). …”
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One-Step Solid Extraction for Simultaneous Determination of Eleven Commonly Used Anticancer Drugs and One Active Metabolite in Human Plasma by HPLC-MS/MS by Shouhong Gao, Zhengbo Tao, Jingya Zhou, Zhipeng Wang, Yunlei Yun, Mingming Li, Feng Zhang, Wansheng Chen, Yejun Miao

“…Therapeutic drug monitoring for anticancer drugs could timely reflect in vivo drug exposure, and it was a powerful tool for adjusting and maintaining drug concentration into a reasonable range, so that an enhanced efficacy and declined adverse reactions could be achieved. …”
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Impact of pharmacist-led educational intervention on knowledge of self-management among asthmatic patients: a prospective cohort study by Ahmad Khan, Saima Mushtaq, Amjad Khan, Nafees Ahmad, Shahzadi Sidra Saleem, Rubina Aman, Shahzadi Sadia Saleem, Ayesha Bibi, Saifullah Mehsud, Ivan R Green, Sheikh Abdur Rashid, Kifayat Ullah Shah

“…This study aims to assess the impact of pharmacist-led educational intervention on knowledge of self-management among asthmatic patients.Design A pre–post cohort study.Setting Outpatient department of a tertiary care hospital affiliated with Quaid-i-Azam University, Pakistan.Participants Approximately 265 adult asthmatic patients selected through a spirometry process, aged ≥18 years, were approached. 240 patients gave consent to participate in the study and were divided into control and treatment groups.Interventions The educational intervention consisted of individual patient counselling using educational material with time varied according to each patient’s comprehension and previous knowledge.Primary and secondary outcome measures Assessment consisted of a 14-item Asthma Self-Management Knowledge Questionnaire (ASMQ) quantifying a patient’s self-management knowledge through an ASMQ score and its change following an educational intervention.Results Disease self-management knowledge was low with an average raw ASMQ score of 4.1 (max 14); which equates to a transformed score of 29.34 (max 100) and the proportion of patients who correctly answered more than 50% of questions were 16.7% preintervention. …”
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The effect of repetitive transcranial magnetic stimulation on sleep quality in patients with more than mild depressive mood: a systematic review and meta-analysis by Yu’ang Liu, Silang Huang, Xinxin Zhang, Huangying Liao, Weiguo Liu, Zhi Zhang, Xianhui Qu, Ziwen Wang

“…Subgroup analyses showed that the group using the 1-Hz stimulation frequency, the group with more than 4 weeks of treatment time, and the group with rTMS alone had better efficacy in treating the sleep quality of patients with more than mild depressive mood using rTMS, with the use of combination treatment or not being the main source of heterogeneity.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/, identifier CRD42023467971…”
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Influence of Extra-Articular Augmentation on Clinical Outcomes and Survival in Patients Undergoing Anterior Cruciate Ligament Reconstruction: A Pseudorandomized Study by Antonio Maestro, Nicolás Rodríguez, Iván Pipa, Carmen Toyos, Lucía Lanuza, Filipe Machado, César Castaño, Santiago Maestro

“…Nor were differences found in the limb symmetry index; the single hop test (<i>p</i> = 0.710); the triple hop test (<i>p</i> = 0.653); the crossover hop test (<i>p</i> = 0.682); the 6 meter timed hop test (<i>p</i> = 0.360); the normalized Y-balance test (YBT) (<i>p</i> = 0.459 anterior; <i>p</i> = 0.898 posterolateral; and <i>p</i> = 0.211 posteromedial directions); or the limb symmetry index of the composite YBT (<i>p</i> = 0.488). …”
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Spatial and Temporal Variations in 94-GHz Radar Backscatter From a Springtime Snowpack by William D. Harcourt, Duncan A. Robertson, David G. Macfarlane, Brice R. Rea, Mike R. James, Mark Diggins, Blair Fyffe

“…We measured an increase in <inline-formula><tex-math notation="LaTeX">$\sigma ^{0}$</tex-math></inline-formula> of <inline-formula><tex-math notation="LaTeX">$\sim$</tex-math></inline-formula>10 dB over 24 h during which time the daytime (09:00&#x2013;18:00) average air temperature reduced from 2.2 to 0.3 <inline-formula><tex-math notation="LaTeX">$^{\circ }$</tex-math></inline-formula>C. …”
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Progressively complex neurorehabilitation: from a severe coma to a vegetative state, minimal consciousness ... and the Phoenix bird survives and is reborn from its ashes by Andreea-Iulia Vlădulescu-Trandafir, Aurelian Anghelescu, Ana-Andreea Cristea, Gelu Onose

“…The patient had slight improvements in motor and cognitive abilities, resulting in simple voluntary gestures and affective response schemes. In time, he progressed to a minimally conscious state; he responded to verbal stimuli through blinking and reactive adequate affective mimic in the context of persistent expressive aphasia. …”
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Influence of High-Frequency Repetitive Transcranial Magnetic Stimulation on Neurobehavioral and Electrophysiology in Patients with Disorders of Consciousness by Jian-Min Chen, Qing-Fa Chen, Zhi-Yong Wang, Yang-Jia Chen, Nan-Nan Zhang, Jian-Wen Xu, Jun Ni

“…The outcome measures of performed pre- and postintervention included the latencies of the N20 and N20-P25 amplitudes of SEP, brainstem auditory-evoked potential (BAEP) grade, JFK Coma Recovery Scale-Revised (CRS-R) score, and Glasgow Coma Scale (GCS) score; any adverse events were recorded at any time during the intervention. Result. Following six weeks of treatment, a significant increase was observed in the total CRS-R and GCS scores, and the N20-P25 amplitudes of patients in the two groups were compared with that obtained from preintervention (all p values < 0.05). …”
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Search for and functional annotation of multi-domain PLA2 family proteins in flatworms by M. E. Bocharnikova, I. I. Turnaev, D. A. Afonnikov

“…Our results made it possible for the first time to systematically identify PLA2 sequences in flatworms, and demonstrated that their evolution is subject to gene loss processes characteristic of parasite genomes in general. …”
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