MỘT SỐ PHƯƠNG PHÁP PHÂN TỬ TRONG CHẨN ĐOÁN PASTEURELLA MULTOCIDA VÀ MANNHEIMIA HAEMOLYTICA Ở ĐỘNG VẬT by Cong Tuan Le, Thi Xuan Tuy Ho, Thi Dieu The Nguyen, Thi Thu Thao Nguyen, Thi Ngoc Han Hoang, Thi Diem Nguyen, Van Phu Nguyen, Huu Tho Nguyen, Thi Oanh Nguyen, Thi Kim Cuc Nguyen, Xuan Huy Nguyen

“…Báo cáo này dựa trên những kết quả của nhóm nghiên cứu, các công bố liên quan tới chẩn đoán, định tuýp và nghiên cứu đa hình tụ huyết trùng bằng kỹ thuật PCR, multiplex PCR, real-time PCR và LAMP và phân tích những điểm mạnh, điểm yếu của từng phương pháp nhằm đánh giá toàn diện hơn về ứng dụng chỉ thị phân tử trong chẩn đoán tụ huyết trùng. …”
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Safety and efficacy of intraoperative radiation therapy using a low-energy X-ray source for resectable pancreatic cancer: an interim evaluation of an ongoing prospective phase II s... by Xingyun Chen, Shuo Li, Chuntao Gao, Wei Wang, Haorui Li, Yuxiao Liu, Rui Liu, Jihui Hao

“…The primary endpoint was time to treatment failure (TTF) survival, whereas the secondary endpoints were safety and overall survival (OS). …”
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Changing trends from inguinal radical orchiectomy to testis-sparing surgery in pediatric testicular tumors by Özlem Balcı, Aslı Nur Abay, Şule Yeşil, İbrahim Karaman, İsmet Faruk Özgüner, Burçak Kurucu, Derya Erdoğan, Gürses Şahin, Ayşe Karaman

“…The patients were evaluated as prepubertal, postpubertal, and in 10-year periods according to the operation time. Results A total of 47 children were identified. …”
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Haemodynamic changes of interatrial shunting devices for heart failure: a systematic review and meta‐analysis by Tieci Yi, Min Li, Fangfang Fan, Lin Qiu, Zhi Wang, Haoyu Weng, Xiaoke Shang, Changdong Zhang, Wei Ma, Yan Zhang, Yong Huo

“…Studies with larger sample size and longer follow‐up time are needed for further verification.…”
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Biocontrol Potential of Rhizospheric Bacillus Strains Against <i>Sclerotinia minor</i> Jagger Causing Lettuce Drop by Lihui Xu, Qinghua Shang, Mogens Nicolaisen, Rong Zeng, Shigang Gao, Ping Gao, Zhiwei Song, Fuming Dai, Jingze Zhang

“…Lipopeptide compounds produced by each strain were identified using matrix-assisted laser desorption ionization–time of flight mass spectrometry (MALDI–TOF MS) analysis. …”
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Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques by Nico A Flierman, Sue Ann Koay, Willem S van Hoogstraten, Tom JH Ruigrok, Pieter Roelfsema, Aleksandra Badura, Chris I De Zeeuw

“…We found that single-unit DN neurons modulated spiking activity over the entire time course of the task, and that their activity often bridged temporally separated intra-trial events, yet in a heterogeneous manner. …”
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The Secondary Component of the Extremely Low Mass Ratio Massive Binary HD 165246 Revealed by GHOST by C. N. Rodriguez, T. Ansin, G. A. Ferrero, O. G. Benvenuto, R. Gamen, N. I. Morrell, J. I. Arias, R. E. Higa, C. Putkuri, C. Johnston, K. Chiboucas, E. Deibert, C. R. Hayes, J.-E. Heo, M. Jeong, V. Kalari, E. Martioli, V. M. Placco, K. A. Venn, S. Xu, R. Diaz, M. Gomez-Jimenez, R. Ruiz-Carmona, C. Simpson, A. W. McConnachie, J. Pazder, G. Burley, T. A. M. Berg, J. G. Robertson, K. Labrie, J. Thomas-Osip

“…Thanks to the high-resolution capabilities of the new echelle spectrograph Gemini/GHOST, we could directly detect spectral features of the secondary component for the first time. A very low mass ratio for the system is confirmed ( q  ~ 0.16), making this binary one of the few extremely low mass ratio systems known. …”
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BAFF and APRIL immunotherapy following Bacille Calmette-Guérin vaccination enhances protection against pulmonary tuberculosis in mice by Min Xie, Chen-Yu Tsai, Joshua Woo, Frank Nuritdinov, Melissa Cristaldo, Narineh M. Odjourian, Rosleine Antilus-Sainte, Maureen Dougher, Martin Gengenbacher, Martin Gengenbacher

“…Administered at birth, BCG induces broad immune responses against a large number of antigens shared with Mycobacterium tuberculosis (Mtb), but protection wanes over time. We have previously shown that unconventional B cell subsets play a role in tuberculosis control.MethodsHigh-dimensional flow cytometry and multiplex cytokine analysis were employed to investigate the effects of immunotherapy on BCG-vaccinated mice in an Mtb challenge model.ResultsIn this study, we investigate the potential of recombinant cytokines targeting B cells – B-cell activating factor (BAFF) and A proliferation-inducing ligand (APRIL) – to modulate BCG immunity and improve protection in mice. …”
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Long-term maintenance of patient-specific characteristics in tumoroids from six cancer indications by Colin D. Paul, Chris Yankaskas, Pradip Shahi Thakuri, Brittany Balhouse, Shyanne Salen, Amber Bullock, Sylvia Beam, Anthony Chatman, Sybelle Djikeng, Xiaoyu Jenny Yang, Garrett Wong, Isha Dey, Spencer Holmes, Abigail Dockey, Lindsay Bailey-Steinitz, Lina Zheng, Weizhong Li, Vivek Chandra, Jakhan Nguyen, Jason Sharp, Erik Willems, Mark Kennedy, Matthew R. Dallas, David Kuninger

“…An example application of these models for assessing the cytotoxicity of a natural killer cell line and primary natural killer cells over time and at various doses demonstrated the compatibility of these models with assays used in compound and cell therapy development. …”
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H-NS controls the susceptibility of Escherichia coli to aminoglycosides by interfering its uptake and efflux by Qiuru Chen, Yulei Liang, Yanbin Dong, Junling Cui, Kun He, Xiaoyuan Ma, Jinfeng Zhao, Jinfeng Zhao, Yajun Zhai, Yajun Zhai, Li Yuan, Li Yuan, Li Yuan, Li Yuan

“…The hns-deleted mutant EΔhns, the hns-complemented strain EΔhns/phns and the hns-overexpressed strain E/phns were derivatives of Escherichia coli ATCC 25922, the susceptibility of which were assessed by the broth microdilution method and time-kill curves assays. We found that the MICs for strain EΔhns against gentamicin and amikacin were significantly decreased by 8–16 folds in contrast to E. coli ATCC 25922. …”
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Archival Research, Underwater Optical Surveys, and 3D Modelling: Three Stages for Shaping the Wreck of the Steamship <i>Bengala</i> (Isola di Capo Rizzuto, Crotone, Italy) by Salvatore Medaglia, Fabio Bruno, Ana Castelli, Matteo Collina, Barbara Davidde Petriaggi, Luca De Rosa, Julieta Frere, Fabrizio Fuoco, Guillermo Gutiérrez, Antonio Lagudi, Francesco Megna, Raffaele Peluso

“…<i>Bengala</i>, a steamer that sank in 1889 near Capo Rizzuto, Italy, was a relatively new vessel for its time, with an unusually short 18-year service life, given that steamers of the period typically operated for 30 to 40 years. …”
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A meta-core outcome set for stillbirth prevention and bereavement care following stillbirth in LMIC by Jamie J Kirkham, Declan Devane, Carol Bedwell, Tina Lavender, Tracey A Mills, Sabina Wakasiaka, Rose Laisser, Bellington Vwalika, Nasim Chaudhry, Angela Chimwaza, Elizabeth Ombeva Ayebare, Sudhindrashayana Fattepur, Tayyeba Kiran, Kushupika Dube, Farai Marenga, Idesi Chilinda, Unice Goshomi, Allen Nabisere, Zaib Un Nisa

“…To address this gap, the objective of this study was to establish consensus on the most important outcomes for stillbirth prevention and bereavement care following stillbirth in sub-Saharan Africa and South Asia.Methods Previous stillbirth outcomes were reviewed for inclusion into the COS by senior research leaders and community engagement and involvement members from six sub-Saharan African and two South Asian countries. An online real-time Delphi survey was then conducted with healthcare professionals, parents who have experienced a stillbirth and researchers in the field to score the agreed list. …”
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Genomic deletions on 16p11.2 associated with severe obesity in Brazil by Izadora Sthephanie da Silva Assis, Izadora Sthephanie da Silva Assis, Kaio Cezar Rodrigues Salum, Kaio Cezar Rodrigues Salum, Kaio Cezar Rodrigues Salum, Rafaela de Freitas Martins Felício, Lohanna Palhinha, Gabriella de Medeiros Abreu, Gabriella de Medeiros Abreu, Tamara Silva, Fernanda Cristina Carvalho Mattos, Eliane Lopes Rosado, Verônica Marques Zembrzuski, Mario Campos Junior, Clarissa Menezes Maya-Monteiro, Pedro Hernán Cabello, João Regis Ivar Carneiro, Patrícia Torres Bozza, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca, Ana Carolina Proença da Fonseca

“…We investigated the CNV using Multiplex Ligation-dependent Probe Amplification [MLPA] and real-time PCR. Chromosomal microarray analysis was used to assess the extent of genomic alterations.ResultsOne patient showed a ~206 kb deletion in the distal of the 16p11.2 region, encompassing twelve genes. …”
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Toxicological effects of the environmental pollutant perfluoronanoic acid on the ground-dwelling arthropod Solenopsis invicta by Wenxuan Wang, Mingrong Liang, Yangting Ou, Xiangrui Wang, Yunbo Song, Huimei Chen, Jingxin Hong, Yuling Liang, Yongyue Lu

“…Lethal concentrations (LC50) decreased over time, falling to 53.089 mg/L by day 7. Moreover, PFNA exhibited sublethal effects by curtailing feeding and raising mortality rates; in 100 mg/L and 500 mg/L treatments, cumulative mortality reached 30.70 % and 53.60 %, respectively, by day 15. …”
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Early health technology assessment of tongue swab for non-sputum based pulmonary tuberculosis diagnosis in ThailandResearch in context by Langming Mou, Teerawat Wiwatpanit, Apiwat Piriyapol, Puwadol Chawengkul, Janjira Thaipadungpanit, Puttarin Kulchaitanaroaj, Yot Teerawattananon, Yi Wang

“…An early health economic model evaluated the cost-effectiveness of two innovative strategies: tongue swab with Loop-Mediated Isothermal Amplification (LAMP) and tongue swab with real-time polymerase chain reaction (RTPCR). The TPP outlines three target levels to guide innovators in designing effective clinical studies. …”
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Construction and application of optimized model for mine water inflow prediction based on neural network and ARIMA model by Xiaoyu Gong, Bo Li, Yu Yang, MengHua Li, Tao Li, Beibei Zhang, Lulin Zheng, Hongfei Duan, Pu Liu, Xin Hu, Xin Xiang, Xinju Zhou

“…In order to better predict the amount of water surging in mines and to provide an important basis for mine water damage prevention work, based on the time series data of mine water influx from January 2020 to February 2023 in Northern Guizhou Province Longfeng Coal Mine, the BP-ARIMA prediction model was established by combining the BP neural network model and ARIMA autoregressive sliding average model, It also predicted the mine influx for a total of 6 months from July 2022 to February 2023, and compared the prediction results with four models, namely, BP neural network model, ARIMA autoregressive sliding average model, traditional method of Large well method, and GM(1,1) grey model, and used the absolute relative error as the calculation of model accuracy. …”
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Development of robust machine learning models for predicting flexural strengths of fiber-reinforced polymeric composites by Abdulhammed K. Hamzat, Umar T. Salman, Md Shafinur Murad, Ozkan Altay, Ersin Bahceci, Eylem Asmatulu, Mete Bakir, Ramazan Asmatulu

“…However, evaluating their flexural properties using conventional experimental techniques is time-consuming, costly, and limited by material and fabrication variations. …”
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Insights on the Permian tuff beds from the Saint-Affrique Basin (Massif Central, France): an integrated geochemical and geochronological study by Poujol, Marc, Mercuzot, Mathilde, Lopez, Michel, Bourquin, Sylvie, Bruguier, Olivier, Hallot, Erwan, Beccaletto, Laurent

“…This is particularly true for Permian basins from the southern part of the French Massif Central, making it difficult to determine correlations between basins and therefore robust timings and constraints on the environmental and climate events described in these basins, and to compare them with the larger-scale settings. …”
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Ecological problem identification based on spatial and temporal dynamics of ecosystem quality: A case study by Rui Zhang, Huamin Liu, Zhichao Xu, Xinchuan Zhao, Lu Wen, Yi Zhuo, Lixin Wang

“…The study found that: (1) Resource utilization efficiency varies among ecosystems in Bayannur, with human activities significantly impacting local ecosystems; (2) Ecological quality shows substantial variation over time and across regions. While ecological conditions have improved in some areas over recent decades, severe degradation persists in the northwest. …”
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Laboratory capacity-building during COVID-19 in Somalia: improving access to essential diagnostics for national health security in a fragile setting by Salvador Figuereo, Sahra Isse Mohamed, Desalegn Takele, Abdulrahman M. Sheikh, Solomon Chane Abera, Ayni Muhiadin Mohamed, Mutaawe Lubogo, Hassan Mukhtar Abukar, Mary Joan Karanja, Sulaiman Bangura, Antoine Abou Fayad, Ali Haji Adam, Abdinasir Yusuf Osman, Sk Md Mamunur Rahman Malik

“…Results The country was able to rapidly scale up testing for SARS-CoV-2 using reverse-transcriptase polymerase chain reaction assays. At the same time, other innovative solutions were used for testing, such as repurposing tuberculosis GeneXpert diagnostic platforms to increase access to testing at points-of-care and introducing antigen rapid diagnostic tests for hard-to-reach communities. …”
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