An Interdisciplinary Analysis of the Late Islamic Cemeteries Within the Cathedral (15th–18th Century CE) and the Ruins of Adulis (Mid-19th–Early 20th Century CE), Massawa, Eritrea:... by Omar Larentis, Nelly Cattaneo, Paolo Lampugnani, Susanna Bortolotto, Emanuele Zappa, Andrea Gregorini, Yotam Gezae, Tsegai Medin, Ilaria Gorini, Serena Massa

“…These discoveries have enabled, for the first time in Eritrea, a detailed scientific study of the biological characteristics of the human remains, the funerary architecture, and the burial rites of Muslim communities from the 15th to the early 20th century. …”
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Valorization of mixed blackwater/agricultural wastes for bioelectricity and biohydrogen production: A microbial treatment pathway by G. Plason Z. Plakar, Abdulsalami S. Kovo, Kanayo L. Oguzie, Emeka E. Oguzie

“…The highest open circuit voltage achieved was 1090 mV at a hydraulic retention time (HRT) of 6 days. Maximum removal efficiencies for Chemical Oxygen Demand (COD) and Biochemical Oxygen Demand (BOD) were 90.87 % and 76.67 %, respectively, with a Columbic efficiency of 40.17 %. …”
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Melatonin Alleviates LPS-Induced Pyroptotic Cell Death in Human Stem Cell-Derived Cardiomyocytes by Activating Autophagy by Ya Qiu, Yan Ma, Min Jiang, Sulei Li, Jibin Zhang, Haixu Chen, Mengqi Xu, Shan Gao, Lei Tian, Bo Tao, Yabin Wang, Dong Han, Feng Cao

“…This study explored, for the first time, the protective effect of Mel on the pyroptosis of human stem cell-derived cardiomyocytes (hiPSC-CMs) exposed to lipopolysaccharide (LPS). …”
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Noise-induced ribbon synapse loss in the mouse basal cochlear region does not reduce inner hair cell exocytosis by David Oestreicher, David Oestreicher, Alfonso Mauro Malpede, Alfonso Mauro Malpede, Annalena Reitmeier, Annalena Reitmeier, Carolin Paula Bräuer, Carolin Paula Bräuer, Laura Schoch, Laura Schoch, Nicola Strenzke, Nicola Strenzke, Tina Pangrsic, Tina Pangrsic, Tina Pangrsic

“…Additionally, we report for the first time that acute application of isoflurane reduces IHC calcium currents, which may have implications for noise-induced IHC synaptic loss.…”
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Microbiota, parasitic infections and their relationship with nutritional status and neurocognitive functioning in children from Ecuador—Proyecto Guagua: research protocol for a cro... by Sandra Victoria Abril-Ulloa, Tannia Valeria Carpio-Arias, Renata Alejandra Alvarado-Barba, Cristina Gabriela Ríos-Romero, Pamela Vinueza-Veloz, Sueny Paloma Lima-dos-Santos, Sueny Paloma Lima-dos-Santos, Igor Eduardo Astudillo-Skliarova, Igor Eduardo Astudillo-Skliarova, Ruth Irene Arias-Gutiérrez, Manuel Pérez-Quintana, Henk-Jan Boele, Henk-Jan Boele, Henk-Jan Boele, María Fernanda Vinueza-Veloz

“…Parents and children were informed of their right to withdraw from the study at any time. The findings of “Proyecto Guagua” will be disseminated through open-access, peer-reviewed publications and presented at local and international scientific events.…”
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Improving community-based first response to out of hospital cardiac arrest (FirstCPR): protocol for a cluster randomised controlled trial by Sandra Ware, Blake Angell, Julie Redfern, Clara Chow, Cate Ferry, Lee Taylor, Christopher Semsarian, Adrian Bauman, Janet E Bray, Simone Marschner, Michael Nelson, Saurabh Kumar, Matthew Vukasovic, Kevin Lai, Paul M Middleton, Pramesh Kovoor, Garry Jennings, Sonali Munot, Andrew Coggins, Alan Robert Denniss, Sarah Khanlari, Ian Opperman

“…The study employs a novel approach to reaching community members via social and cultural groups, and the intervention aims to address commonly cited barriers to training including lack of availability, time and costs.Methods and analysis FirstCPR is a cluster randomised trial that will be conducted across 200 community groups in urban and regional Australia. …”
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Factors associated with cancer treatment delay: a protocol for a systematic review and meta-analysis by Timothy P Hanna, Elizabeth T Jacobs, Kristin E Morrill, Rogelio Robles-Morales, Melissa Lopez-Pentecost, Raigam J Martínez Portilla, Ahlam A Saleh, Meghan B Skiba, Taylor S Riall, Jessica D Austin, Rachel Hirschey, Lena Spotleson

“…The primary outcome of the meta-analysis will be the pooled adjusted and unadjusted odds of treatment delay for patient, disease, provider and system-level factors defined according to specified time intervals. The secondary outcomes will be mean or median treatment delay for each cancer site according to first treatment and the influence of factors on the pooled mean treatment delay for each cancer site (via meta-regression analyses). …”
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A national study of choanal atresia in tertiary care centers in Canada – part I: clinical presentation by Josee Paradis, Agnieszka Dzioba, Hamdy El-Hakim, Paul Hong, Frederick K. Kozak, Lily H. P. Nguyen, Demitri Perera, Evan Jon Propst, Jennifer M. Siu, Monika Wojtera, Murad Husein, National Choanal Atresia Study Working Group

“…The mean age of patients at time of CA presentation was 0.4 months (range 0.1 to 7.2 months) for bilateral CA and 37.8 months (range 0.1 to 164.1 months) for unilateral cases. …”
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Development of a core measurement set for research in degenerative cervical myelopathy: a study protocol (AO Spine RECODE-DCM CMS) by Robert Chen, Angus G K McNair, Vafa Rahimi-Movaghar, Julio C Furlan, Benjamin M Davies, Oliver D Mowforth, Iwan Sadler, Bizhan Aarabi, Brian K Kwon, Michael G Fehlings, James S Harrop, Armin Curt, Ellen Sarewitz, Carl Moritz Zipser, Timothy F Boerger, Mark R N Kotter, James Milligan, Lindsay Tetreault, Danyal Khan, Keng Siang Lee, Alvaro Yanez Touzet, Ricardo Rodrigues-Pinto, James D Guest, Sukhvinder Kalsi-Ryan, Shirley Widdop

“…Evidence on measurement properties, as well as on timing of assessments, are currently being aggregated. …”
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Relapse-free survival is progressively shortened in a subset of Black patients with immune-mediated TTP treated in the rituximab era by Ayotola Fatola, Michael D. Evans, Jenna Brown, Elizabeth Davis, Andrew Johnson, Ana G. Antun, Andrew M. Farland, Ryan Woods, Ara Metjian, Yara A. Park, Gustaaf de Ridder, Briana Gibson, Raj S. Kasthuri, Darla K. Liles, Susan Eubanks, Frank Akwaa, Todd Clover, Lisa Baumann Kreuziger, J. Evan Sadler, Meera Sridharan, Ronald S. Go, Keith R. McCrae, Harsh Vardhan Upreti, Ming Y. Lim, Nicole K. Kocher, Radhika Gangaraju, X. Long Zheng, Jay S. Raval, Camila Masias, Spero R. Cataland, Marshall Mazepa, Shruti Chaturvedi

“…Separately, we evaluated overall RFS (composite of time to clinical relapse, ADAMTS13 relapse, or preemptive rituximab) in a prospective iTTP cohort from the Johns Hopkins University and the University of Minnesota. …”
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Bisphenol Analogs Downregulate the Self-Renewal Potential of Spermatogonial Stem Cells by Seo-Hee Kim, Seung Hee Shin, Seok-Man Kim, Sang-Eun Jung, Beom-Jin Shin, Jin Seop Ahn, Kyoung Taek Lim, Dong-Hwan Kim, Kichoon Lee, Buom-Yong Ryu

“…We utilized flow cytometry, immunocytochemistry, real-time quantitative reverse transcription-PCR, and western blot analysis. …”

Innovative CO2-NBs-assisted ultrasonication for the phytochemical extraction of peanut (Arachis hypoga) shells: Synthesis and characterization of CO2-nanobubbles by Nayyar Iqbal, Miral Javed, Ramy M. Khoder, Areej Areej, Renyu Zheng, Shanbai Xiong, Ibrahim Khalifa, Hassan Barakat, Youming Liu

“…Response surface methodology (RSM) provided optimization parameters, including ultrasonic power of 358.76 W, surfactant concentration of 4.54 %, and extraction time of 41.41 min. HPLC analysis identified distinct peaks corresponding to polyphenolic compounds such as gallo-catechin, catechin gallate, resveratrol, and luteolin, confirming their presence and concentrations in the peanut shell extract (PSE). …”
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A physically-based formulation for texture evolution during dynamic recrystallization. A case study of ice by Chauve, Thomas, Montagnat, Maurine, Dansereau, Véronique, Saramito, Pierre, Fourteau, Kévin, Tommasi, Andréa

“…Although the present formulation is too time-consuming for direct implementation in large-scale ice flow models, R$^{3}$iCe can be used to adjust the parameterization used to implement texture-induced anisotropy in these models. …”
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Effectiveness of screening for colorectal cancer with a faecal occult-blood test, in Finland by J Pitkäniemi, K Seppä, M Hakama, O Malminiemi, T Palva, M-S Vuoristo, H Järvinen, H Paimela, P Pikkarainen, A Anttila, L Elovainio, T Hakulinen, S Karjalainen, L Pylkkänen, M Rautalahti, T Sarkeala, H Vertio, N Malila

“…In 2012, the programme covered 43% of the target age population in Finland.Results The median follow-up time was 4.5 years (maximum 8.3 years), with a total of 1.6 million person-years. …”
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GsMTx-4 venom toxin antagonizes biophysical modulation of metastatic traits in human osteosarcoma cells by Arianna Buglione, Giulia Alloisio, Chiara Ciaccio, David Becerril Rodriguez, Simone Dogali, Marco Luce, Stefano Marini, Antonio Cricenti, Magda Gioia

“…To elucidate the molecular mechanisms that translate biomechanical alterations into biochemical responses, we employed Western blotting, real-time quantitative RT-PCR, reactive oxygen species ROS assay, and the mechanosensitive channel blocker Grammostola MechanoToxin4 (GsMTx-4). …”
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Impact of landscape patterns on river water quality: Spatial-scale effects across an agricultural-urban interface by Kun Mei, Haonan Shi, Yupeng Wu, Randy A. Dahlgren, Xiaoliang Ji, Minmin Yang, Yueru Guan

“…In this study, we onducted an in-depth and meticulous exploration of the relationship between the landscape patterns and water quality in the Wen-Rui Tang River watershed at four distinct spatial scales (single subwatershed, dynamic subwatershed, riparian buffer, and reach buffer) and two time scales (dry season and rainy season). Regression models were used to investigate the quantitative impact of landscape patterns on water quality, redundancy analysis was employed to assess the overall explanatory power, and non-parametric point-of-change analysis was applied to evaluate variations in water quality along landscape gradients and identify critical landscape threshold ranges. …”
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The Protective Effects of Maresin 1 in the OVA-Induced Asthma Mouse Model by Guochun Ou, Qin Liu, Chengxiu Yu, Xiaoju Chen, Wenbo Zhang, Yong Chen, Tao Wang, Yongqiang Luo, Guolu Jiang, Mingmei Zhu, Hongmei Li, Mei Zeng

“…Western blotting was used to measure the protein level of IκBα, the activation of the NF-κB signaling pathway, and the expression of NF-κB downstream inflammatory cytokines. Quantitative real-time polymerase chain reactions (qRT-PCRs) were used to evaluate the expression levels of COX-2 and ICAM-1 in lung tissues. …”
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Association of tumour mutation burden with prognosis and its clinical significance in stage III gastric cancer by Ya-Lin Han, Li Chen, Xu-Ning Wang, Mao-Lin Xu, Rui Qin, Fang-Ming Gong, Peng Sun, Hong-Yi Liu, Zhi-Peng Teng, Zhao-Xia Li, Guang-Hai Dai

“…Western blot and quantitative real-time polymerase chain reaction were used to detect the expression levels of both proteins and genes. …”
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Upregulation of Tumor Necrosis Factor-α-Induced Protein 8-Like 2 mRNA Is Negatively Correlated with Serum Concentrations of Tumor Necrosis Factor-α and Interleukin 6 in Type 2 Diab... by Yongliang Liu, Xinmei Wang, Yan Zhao, Peiqing Zhao, Lianqing Wang, Qiaoli Zhai, Xiaowei Zhang, Wenxiu Tian, Xinxin Xiang, Tao Li

“…TIPE2 expression was measured by Western blotting and real-time polymerase chain reaction (RT-PCR) in peripheral blood mononuclear cells (PBMCs) isolated from T2DM patients and healthy controls, and tumor necrosis factor-α (TNF-α), high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL-6), and other related biometabolic parameters were detected using a nephelometer or by ELISA. …”
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Development and validation of a nomogram for predicting perioperative transfusion in children undergoing cardiac surgery with CPB by Wenting Wang, He Wang, Jia Liu, Yu Jin, Bingyang Ji, Jinping Liu

“…Abstract Background Timely recognition of perioperative red blood cell transfusion (PRT) risk is crucial for developing personalized blood management strategies in pediatric patients. …”
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