The safety and efficacy of a protein-free diet with ketoacid analogues in chronic kidney disease-affected diabetic rats by Ahmed El-Sayed Nour El-Deen, Adel shallaby, Abdel Kader Ibrahim, Mohammed Abdel Aziz Mohammed, Ahmad Taha, Mohamed Zaeim Hafez Ahmed, Muhammad Abdelbaeth Elfiky, Ahmed A. Abd El-Rhman, Ahmed F. Abdel Ghany, Almoatazbellah Mahmoud Elsayed, Ahmed Noaman Ali, Ali Abdeslam

“…Conclusion: A protein-free diet containing KAA improves renal function, lowers blood glucose levels, maintains body weight, and does not worsen nutritional status in DN over time.…”
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Prediction of Cisplatin‐Induced Acute Kidney Injury Using an Interpretable Machine Learning Model and Electronic Medical Record Information by Kaori Ambe, Yuka Aoki, Miho Murashima, Chiharu Wachino, Yuto Deki, Masaya Ieda, Masahiro Kondo, Yoko Furukawa‐Hibi, Kazunori Kimura, Takayuki Hamano, Masahiro Tohkin

“…In total, 1253 patients were included, of whom 119 developed Cis‐AKI (9.5%). The median time of AKI onset was 7 days, and the interquartile range was 5–8 days. …”
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Long-term results of antiviral therapy in patients with chronic hepatitis C with sustained virologic response by T. M. Ignatova, T. N. Lopatkina, V. P. Chulanov, Ye. V. Gaydasheva, S. N. Batskikh, G. V. Mikhaylovskaya, D. T. Abdurakhmanov, S. Yu. Karpov, Ye. N. Nikulkina, O. A. Chernova

“…In 114 patients RNA HCV and DNA HBV in blood serum and peripheral mononuclear blood cells were studied by polymerase chain reaction (PCR) with fluorescent hybridization detection in «real time» mode (sensitivity of 10 IU/ml for HCV and 5 IU/ml for HBV).Results. …”
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Neutrophil-to-lymphocyte ratio and short-term mortality in patients having anti-MDA5-positive dermatomyositis with interstitial lung disease: a retrospective study by Hongxia Xin, Ping He, Bin Xi, Zhaojun Wang, Han Wang, Faxuan Wang, Zhanbing Ma, Jing Xue, Yuanyuan Jia, Hourong Cai, Bi Chen, Juan Chen

“…Furthermore, a generalized additive mixed model (GAMM) was applied to compare the NLR variations over time between 30-day survival group and non-survival group. …”
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Expression and Significances of Contactin-1 in Human Gastric Cancer by Ji-Wei Yu, Sheng-Hua Wu, Rui-qi Lu, Ju-gang Wu, Xiao-Chun Ni, Gou-cai Zhou, Hai-guang Jiang, Lin-Hai Zheng, Xiao-Qiang Li, Guang-Ye Du, Bo-Jian Jiang

“…Then we analyzed the relationships between VEGF-C, VEGFR-3, and CNTN-1, as well as their correlations with clinicopathologic features, LVD, and survival time. Results. The positivity rate of VEGF-C, VEGFR-3, and CNTN-1 in primary tumor was 56.19%, 64.76%, and 58.09%. …”
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Immunotherapy in metastatic renal cell carcinoma: Insights from a Dutch nationwide cohort by Hilin Yildirim, Anke Richters, Adriaan D. Bins, Arnoud W. Postema, Maureen J.B. Aarts, Martijn G.H. van Oijen, Patricia J. Zondervan, Katja K.H. Aben

“…Our results show trends over time for more favorable characteristics among patients receiving systemic treatment and improvements in survival.…”
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Accelerated aging as a mediator of the association between co-exposure to multiple air pollutants and risk of chronic kidney disease by Shuo Zhang, Yuxin Liu, Jike Qi, Yu Yan, Tongyu Gao, Xin Zhang, Dong Sun, Ting Wang, Ping Zeng

“…Results: During the median follow-up time of 12.9 years, 11,117 participants developed CKD. …”
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Design, Content and Ecological Validity and Reliability of the Physical Activity and Sport Habits Questionnaire for Children Aged 8–12 Years in the Province of Gipuzkoa (Spain) by Aduna Badiola-Lekue, Irantzu Ibañez, Maite Fuentes, Javier Yanci, Oidui Usabiaga, Aitor Iturricastillo

“…For reliability testing, 276 schoolchildren aged 8 to 12 completed the questionnaire twice, with a time interval of two weeks to two months. Statistical analyses included the Wilcoxon test to compare expert ratings, effect size and percentage change calculations for magnitude assessment, and McNemar, McN-Bowker or Wilcoxon tests to compare differences between initial and repeat responses. …”
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Burden of hospitalizations in newly diagnosed heart failure patients in Poland: real world population based study in years 2013–2019 by Przemysław Leszek, Daniel Waś, Kinga Bartolik, Kladiusz Witczak, Andrzej Kleinork, Bohdan Maruszewski, Katarzyna Brukało, Paulina Rolska‐Wójcik, Małgorzata Celińska‐Spodar, Tomasz Hryniewiecki, Marta Załęska‐Kocięcka

“…The median observation time was 946 days. As many as 49% experienced at least one acute heart failure hospitalization. …”
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Minor Antigen Disparities Impede Induction of Long Lasting Chimerism and Tolerance through Bone Marrow Transplantation with Costimulation Blockade by Sinda Bigenzahn, Ines Pree, Christoph Klaus, Nina Pilat, Benedikt Mahr, Elisabeth Schwaiger, Patrick Nierlich, Friedrich Wrba, Thomas Wekerle

“…Macrochimerism was followed over time by flow cytometry and tolerance was tested by skin grafting. 20 of 21 recipients of B10.D2 BMC but only 13 of 18 of Balb/c BMC and 13 of 20 of B10.A BMC developed stable long-term multilineage chimerism (p<0.05 for each donor strain versus B10.D2). …”
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Differential Signature of the Centrosomal MARK4 Isoforms in Glioma by Ivana Magnani, Chiara Novielli, Laura Fontana, Silvia Tabano, Davide Rovina, Ramona F. Moroni, Dario Bauer, Stefania Mazzoleni, Elisa A. Colombo, Gabriella Tedeschi, Laura Monti, Giovanni Porta, Silvano Bosari, Carolina Frassoni, Rossella Galli, Lorenzo Bello, Lidia Larizza

“…We then investigated the MARK4L and MARK4S expression profile in 21 glioma cell lines and 36 tissues of different malignancy grades, glioblastoma-derived cancer stem cells (GBM CSCs) and mouse neural stem cells (NSCs) by real-time PCR, immunoblotting and immunohistochemistry. …”
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Development of Attenuated Total Reflectance Mid-Infrared (ATR-MIR) and Near-Infrared (NIR) Spectroscopy for the Determination of Resistant Starch Content in Wheat Grains by Rong Wang, Xia Wei, Hongpan Wang, Linshu Zhao, Cengli Zeng, Bingrui Wang, Wenying Zhang, Luxiang Liu, Yanhao Xu

“…The chemical method for the determination of the resistant starch (RS) content in grains is time-consuming and labor intensive. Near-infrared (NIR) and attenuated total reflectance mid-infrared (ATR-MIR) spectroscopy are rapid and nondestructive analytical techniques for determining grain quality. …”
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The 0ν2β-decay CROSS experiment: preliminary results and prospects by The CROSS collaboration, I. C. Bandac, A. S. Barabash, L. Bergé, M. Brière, C. Bourgeois, P. Carniti, M. Chapellier, M. de Combarieu, I. Dafinei, F. A. Danevich, N. Dosme, D. Doullet, L. Dumoulin, F. Ferri, A. Giuliani, C. Gotti, P. Gras, E. Guerard, A. Ianni, H. Khalife, S. I. Konovalov, E. Legay, P. Loaiza, P. de Marcillac, S. Marnieros, C. A. Marrache-Kikuchi, C. Nones, V. Novati, E. Olivieri, C. Oriol, G. Pessina, D. V. Poda, T. Redon, V. I. Tretyak, V. I. Umatov, M. M. Zarytsky, A. S. Zolotarova

“…Its experimental investigation is the only viable method that can establish the Majorana nature of neutrinos, providing at the same time a sensitive inclusive test of lepton number violation. …”
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A Prospective Randomized Study for Comparison of Modified Proximal Femoral Plate with Dynamic Hip Screw System by Jitendra Wadhwani, Ramchander Siwach, Himanshu Bansal, Roop Singh, Pradeep Kamboj, Hemant More

“…Results: In the DHS group and PFLCP group, the mean time to union was 18.3 and 17.2 weeks, respectively. …”
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Asymmetries and Circumstellar Interaction in the Type II SN 2024bch by Jennifer E. Andrews, Manisha Shrestha, K. Azalee Bostroem, Yize Dong, Jeniveve Pearson, M. M. Fausnaugh, David J. Sand, S. Valenti, Aravind P. Ravi, Emily Hoang, Griffin Hosseinzadeh, Ilya Ilyin, Daryl Janzen, M. J. Lundquist, Nicolás Meza, Nathan Smith, Saurabh W. Jha, Moira Andrews, Joseph Farah, Estefania Padilla Gonzalez, D. Andrew Howell, Curtis McCully, Megan Newsome, Craig Pellegrino, Giacomo Terreran, Patrick Wiggins, Brian Hsu, Collin T. Christy, Noah Franz, Xiaofeng Wang, Jialian Liu, Liyang Chen

“…High-cadence photometry from the ground and Transiting Exoplanet Survey Satellite show that the SN brightened quickly and reached a peak M _V  ~ −17.8 mag within a week of explosion, and late-time photometry suggests a ^56 Ni mass of 0.050 M _⊙ . …”
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Gestational Diabetes Mellitus Does Not Change the Pharmacokinetics and Transplacental Distribution of Fluoxetine and Norfluoxetine Enantiomers by Daniela Miarelli Carvalho, Glauco Henrique Balthazar Nardotto, Gabriela Campos de Oliveira Filgueira, Geraldo Duarte, Ricardo Carvalho Cavalli, Vera Lucia Lanchote, Elaine Christine Dantas Moisés

“…<b>Results</b>: The area under the plasma over time curve (AUC_0–∞) were 197.93 and 109.62 ng∙h/mL for FLX and 600.39 and 960.83 ng∙h/mL for norFLX, respectively, for their R-(+)- and S-(-)- enantiomers. …”
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Advantages of using T1-mapping in cardiac magnetic resonance imaging in patients with acromegaly by Alina A. Almaskhanova, Konstantin V. Melkozerov, Elena G. Przhiyalkovskaya, Natalia V. Tarbaeva, Anastasya Y. Korneluk, Raisa S. Kosharnaia, Victor Y. Kalashnikov, Zhanna E. Belaya, Galina A. Mel'nichenko, Natalia G. Mokrysheva

“…All patients underwent standard medical examinations, including hormonal blood tests, electrocardiograms, echocardiography, Holter monitoring electrocardiograms and magnetic resonance imaging (MRI) of the heart with gadolinium contrast, additionally 48 patients underwent T1-mapping, which is an MRI method that allows the detection of diffuse changes by measuring the values of myocardial relaxation time – T1. Results. The study revealed a high incidence of MF – 53 (75.7%) cases (21 women, 32 men). …”
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Mind the blind spot: lessons from fungal community sequencing in a plant–soil feedback experiment by Mengshuai Liu, Jose G. Maciá-Vicente, Jasper van Ruijven, Wopke van der Werf, Zhenling Cui, Fusuo Zhang, Chunxu Song, Liesje Mommer

“…Here, we hypothesize that the strength of negative PSF experienced by a crop species is determined by the relative abundance of host-specific soil-borne pathogenic fungi, that is in turn driven by the crop’s relative abundance (in time). Methods We performed a PSF experiment, with different soils originating from three cropping systems in the North China Plain and three crop species (wheat, maize, soybean) in a full factorial design. …”
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Digital twin-based modeling of natural gas leakage and dispersion in urban utility tunnels [version 2; peer review: 2 approved] by Jiansong Wu, Jitao Cai, Ziqi Han, Yanzhu Hu, Ming Fu, Yuefei Li, Xin Wang, Xiaofu Zou

“…Based on this model, real-time integration of gas sensor data from utility tunnels is achieved through the DA algorithm. …”
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I-SPY COVID adaptive platform trial for COVID-19 acute respiratory failure: rationale, design and operations by Carolyn S Calfee, Michael A Matthay, Paul Henderson, Martin Eklund, Laura J Esserman, Chirag Patel, Angela Haczku, Michelle Jung, Tony Oliver, Alessio Crippa, Andrea Discacciati, Kathleen D Liu, Ellen L Burnham, Nuala J Meyer, Fady A Youssef, Derek W Russell, Julie Lang, Kevin W Gibbs, Daniel C Files, Sheetal Gandotra, Purnema Madahar, Nathan K Cobb, Timothy E Albertson, Rajiv Sonti, John P Reilly, Alejandra Jauregui, Iván García, Luis E Huerta, Daniel Clark Files, Neil R Aggarwal, Adam L Asare, Jeremy R Beitler, Paul A Berger, George Cimino, Melissa H Coleman, Paul T Henderson, Caroline A G Ittner, Kashif T Khan, Jonathan L Koff, Mary LaRose, Joe Levitt, Ruixiao Lu, Jeffrey D McKeehan, Karl W Thomas, Aaron M Mittel, Albert F Yen, Alexis E Suarez, Alexis L Serra, Alpesh N Amin, Amanda Rosen, Amy L Dzierba, Anna D Barker, Ariel R Weisman, Brian M Daniel, Brian M Morrissey, Caroline AG Ittner, Chayse Jones, Christina Creel-Bulos, Christina M Angelucci, Diana Ng, Fredy Chaparro-Rojas, Gavin H Harris, Harsh V Barot, Heny Su, Jacqueline B Sutter, Jamal Dodin, Jerry S Lee, John Kazianis, Joshua F Detelich, Julie E Lang, Justin Muir, Katarzyna Gosek, Katherine L Nugent, Kimberly Yee, Laura G Rodrigues, Laura R Macias, Lindsey A Orr, Lindsie L Boerger, Lissette Rosario-Remigio, Lucia Kufa, Maged Tanios, Maria B Reyes, Max W Adelman, Maya M Juarez, Michelle Meyers, Mitchell P Sternlieb, Neil Aggarwal, Nilam S Mangalmurti, Patrice Jones, Paul L Saban, Peter S Marshall, Philiip A Robinson, Philip Yang, Rahul Nair, Richard Anthony Lee, Richard G Wunderink, Romina Wahab, Roxana A Lupu, Santhi I Kumar, Sara C Auld, Scott Fields, Se Fum Wong, Skyler J Pearson, Spencer Whealon, Timothy F Obermiller, Anita Darmanian, John Schicchi, Esmeralda Martinez, Farjad Sarafian, Julie Nguyen, Bethany Weiler-Lisowski, Jaime Wyatt, Daniel Blevins, Marylee Melendrez, Brenda Lopez, Hiwet Tzehaie, Omowunmi Amosu, Austin Simonson, Erin Hardy, Brett Lindgren, Gregory Peterfreund, Leigha Landreth, Lisa Parks

“…Enrolled patients are randomised to receive one of up to four investigational agents or a control and are evaluated for a family of two primary outcomes—time to recovery and mortality. The statistical design uses a Bayesian model with ‘stopping’ and ‘graduation’ criteria designed to efficiently discard ineffective therapies and graduate promising agents for definitive efficacy trials. …”
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