Pharmacological Evaluation of Secondary Metabolites and Their Simultaneous Determination in the Arabian Medicinal Plant Plicosepalus curviflorus Using HPTLC Validated Method by Raha Orfali, Shagufta Perveen, Nasir Ali Siddiqui, Perwez Alam, Tawfeq Abdullah Alhowiriny, Areej Mohammad Al-Taweel, Sami Al-Yahya, Fuad Ameen, Najwa Majrashi, Khulud Alluhayb, Bandar Alghanem, Hayat Shaibah, Shabana Iqrar Khan

“…Results proved for the first time the dual PPAR activation effect of the PCME and catechin (P2), in addition to the promising anti-inflammatory activity of the flavonoid quercetin (P1). …”
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Functional activity of blood eosinophils in patients with <i>Opisthorchis felineus</i> invasion by V. V. Tsukanov, N. E. Veselova, A. A. Savchenko, O. A. Kolenchukova, I. I. Gvozdev, A. V. Vasyutin, J. L. Tonkikh, E. V. Kasparov, A. G. Borisov, E. G. Gorchilova, M. Yu. Olkhovskaia, N. O. Prokopieva

“…An increase in the content of eosinophils in the blood in patients with opisthorchiasis was associated with an increase in the frequency of complaints of pain in the right hypochondrium, pruritus, skin rashes, an increase in the proportion of leukopenia and neutropenia, an increase in the level of gamma-glutamyl transpeptidase in the blood, and an increase in the frequency of ultrasound signs of cholecystitis. At the same time, a pronounced increase in the functional activity of blood eosinophils, determined by the chemiluminescent method, was observed in patients with O. felineus invasion.Conclusions. …”
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Systematic review: e-cigarettes vs. conventional cigarettes by Mateusz Janik, Barbara Ufnalska, Joanna Rychlewska-Duda, Justyna Lisiecka, Artur Fabijański, Anna Konarska, Anna Machowiak, Michał Nowak, Wojciech Firlej, Adrianna Dukacz

“…Their popularity is increasing and many aspects about their influence on health are still unclear. At the same time, better social acceptance than tobacco cigarettes brings out questions if they are a step to smoking cessation or if they encourage more people to start using nicotine. …”
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Radiopharmaceuticals and their applications in medicine by Siqi Zhang, Xingkai Wang, Xin Gao, Xueyao Chen, Linger Li, Guoqing Li, Can Liu, Yuan Miao, Rui Wang, Kuan Hu

“…These include high tumor uptake, prolonged retention time, and favorable pharmacokinetic properties that align with clinical standards. …”
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Temporal Trends in the Utilization and Survival Outcomes of Lobar, Segmental, and Wedge Resection for Early-Stage NSCLC, 2004 to 2020 by Eden Z. Deng, BS, Xiaofei Wang, PhD, Jianrong Zhang, MD, MPH, Thomas E. Stinchcombe, MD, Chi-Fu (Jeffrey) Yang, MD, Nasser Altorki, MD

“…Methods: To examine the trends over time in the utilization, quality, and overall survival (OS) differences of lobectomy, segmentectomy, and wedge resection, we performed an observational, population-level study of 76,466 patients with T1 or T2 N0M0 NSCLC tumors 2 cm or less in size in the National Cancer Database, from 2004 to 2020. …”
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Knowledge translation strategies for policy and action focused on sexual, reproductive, maternal, newborn, child and adolescent health and well-being: a rapid scoping review by Etienne V Langlois, Leah Boulos, Lori Wozney, Janet A Curran, Helen Wong, Zulfiqar Bhutta, Robin Urquhart, Hwayeon Danielle Shin, Allyson J Gallant, Julia Kontak

“…Reported barriers to KT strategies included limited resources and time constraints, while enablers included stakeholder involvement throughout the KT process.Conclusion We identified a number of gaps among KT strategies for SRMNCAH policy and action, including limited focus on adolescent, sexual and reproductive health and rights and SRMNCAH financing strategies. …”
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In-vivo high-resolution χ-separation at 7T by Jiye Kim, Minjun Kim, Sooyeon Ji, Kyeongseon Min, Hwihun Jeong, Hyeong-Geol Shin, Chungseok Oh, Robert J. Fox, Ken E. Sakaie, Mark J. Lowe, Se-Hong Oh, Sina Straub, Seong-Gi Kim, Jongho Lee

“…However, applying χ-separation at 7T presents difficulties due to the requirement of an R2 map, coupled with issues such as high specific absorption rate (SAR), large B1 transmit field inhomogeneities, and prolonged scan time. To address these challenges, we developed a novel deep neural network, R2PRIMEnet7T, designed to convert a 7T R2* map into a 3T R2′ map. …”
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High-z Stellar Masses Can Be Recovered Robustly with JWST Photometry by R. K. Cochrane, H. Katz, R. Begley, C. C. Hayward, P. N. Best

“…Robust inference of galaxy stellar masses from photometry is crucial for constraints on galaxy assembly across cosmic time. Here, we test a commonly used spectral energy distribution (SED) fitting code using simulated galaxies from the S phinx ^20 cosmological radiation hydrodynamics simulation with JWST NIRCam photometry forward-modeled with radiative transfer. …”
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Evaluating the Performance of Low-cost PM Sensors over Multiple COALESCE Network Sites by Vishal R. Dharaiya, Vasudev Malyan, Vikas Kumar, Manoranjan Sahu, Chandra Venkatraman, Pratim Biswas, Kajal Yadav, Diksha Haswani, Ramya Sunder Raman, Ruqia Bhat, Tanveer Ahmad Najar, Arshid Jehangir, Rohit P. Patil, G. Pandithurai, Sandeep Singh Duhan, Jitendra Singh Laura

“…Recent advances in low-cost sensors allow their deployment in large number to measure spatio-temporal and real-time air quality data. Low-cost sensors need careful evaluation with both regulatory approved methods and other data sets to understand their efficacy. …”
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CCD Standard Curve Fitting for Microarray Detection Base on Multi-Layer Perceptron by Zhenhua Gan, Dongyu He, Peishu Wu, Baoping Xiong, Nianyin Zeng, Fumin Zou, Feng Guo, Qin Bao, Fengyan Zhao

“…The gray-level of the fluorescent probe in detection image was obtained as the data set acquired by the microarray scanner at different exposure time. And the relative error and the standard deviation of the relative errors were used as evaluation indicators. …”
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Efficacy of a new treatment algorithm for capsulitis of the fingers in rock climbers by Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Volker Rainer Schöffl, Christoph Lutter, Christoph Lutter, Hans-Christoph Lang, Mario Perl, Othmar Moser, Michael Simon

“…The majority were able to maintain their level of performance after injury and the difference in climbing level before and after injury was not statistically significant (p = 0.22). The total time spent climbing was significantly less after the injury than before the injury (p &lt; 0.001). …”
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Clinical findings, treatment, and outcomes in cats with naturally occurring hypoadrenocorticism: 41 cases by Emma Roberts, Ian K. Ramsey, Ruth Gostelow, Anna Latysheva, Luca Battaglia, Paolo Silvestrini, Ghita Benchekroun, Karen Brenner, Bérénice Conversy, Riccardo Ferriani, Andre Kortum, Lisa Stammeleer, Nele Van den Steen, Flavia Tavares, Julia Lieser, Angie Hibbert, Antoine Duclos, Troy Bunn, Alisdair M Boag, Carolina Arenas, Kirsty Roe, Florian K. Zeugswetter, Yi Cui, Imogen Schofield, Federico Fracassi

“…In 2 cats, hypoadrenocorticism occurred secondary to lymphoma. Median survival time (MST) for all‐cause mortality was 2035 days (95% confidence interval [CI], 294‐4380 days); MST for disease‐specific mortality was not reached. …”
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Screening potential antileukemia ingredients from sweet potato: integration of metabolomics analysis, network pharmacology, and experimental validation by Lianling Xu, Lianling Xu, Kaixuan Zeng, Kaixuan Zeng, Zuoyue Duan, Zuoyue Duan, Jing Liu, Yan Zeng, Miao Zhang, You Yang, Qulian Guo, Yanling Jin, Wenjun Liu, Ling Guo

“…Subsequently, based on the results of metabolomics analysis and network pharmacology, cynaroside, nepitrin, and yuanhuanin were identified as potential antileukemia agents present in sweet potato for the first time; while CASP3, KDR, EGFR, and SRC were recognized as pivotal targets of these three monomers against AML. …”
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Extracellular vesicles-derived miR-21 as a biomarker for early diagnosis and tumor activity in breast cancer subtypes by Claudia Omarini, Virginia Catani, Ilenia Mastrolia, Angela Toss, Federico Banchelli, Chrystel Isca, Daniele Medici, Ornella Ponzoni, Marco Brucale, Francesco Valle, Maria Cristina Baschieri, Roberto D’Amico, Valentina Masciale, Chiara Chiavelli, Federica Caggia, Carlo Augusto Bortolotti, Federico Piacentini, Massimo Dominici

“…The levels of miR-21 in EVs was evaluated using real time PCR and compared between groups (EBC, MBC and FU vs. …”
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Functional Analysis of DNMT1 SNPs (rs2228611 and rs2114724) Associated with Schizophrenia by Sonal Saxena, Pranay Amruth Maroju, Sumana Choudhury, Vidhya Chitta Voina, Poonam Naik, Kavitha Gowdhaman, Poornima Kkani, Kiranmai Chennoju, S. Ganesh Kumar, C. Ramasubramanian, G. Prasad Rao, Trinath Jamma, Kumar Pranav Narayan, K. Naga Mohan

“…To gain insights into the functional effects of the two SNPs on the levels of DNMT1 transcripts, quantitative real-time PCR experiments were performed using peripheral blood monocytes from 10 individuals each with T/T–T/T (homozygous minor allele), C/T–C/T (heterozygous), and C/C–C/C (homozygous major allele) haplotypes. …”
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Peripheral Expression of IL-6, TNF-&#945; and TGF-&#946;1 in Alzheimer's Disease Patients by Gamze Güven, Pınar Köseoğlu, Ebba Lohmann, Bedia Samancı, Erdi Şahin, Başar Bilgiç, Haşmet Ayhan Hanağası, Hakan Gürvit, Nihan Erginel-Ünaltuna

“…In addition, we evaluated the mRNA expressions of IL-6 and TNF-&#945; in peripheral blood mononuclear cells from 31 AD patients and their respective controls (n=30) via quantitative real-time polymerase chain reaction. Results: AD patients tended to have higher serum IL-6 and TGF-&#946;1 levels compared to the controls, but the difference was not statistically significant. …”
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Neoadjuvant Immunotherapy and De-escalation of Surgery in Locally Advanced Breast Implant-associated Anaplastic Large Cell Lymphoma by Marzia Salgarello, Jaroslaw Krupa, Rebecca Allchin, Simon Pilgrim, Fiona Miall, Arianna Di Napoli, Maurizio Martelli, Giulio Tarantino

“…Although surgery is an essential part of treatment, the timing and type of intervention should be carefully planned, especially when primary, radical resection is uncertain.…”
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Role of microvascular pericyte dysfunction in antibody-mediated rejection following kidney transplantation by Jie Xu, Junyan Pu, Hao Chen, Li Sun, Shuang Fei, Zhijian Han, Jun Tao, Xiaobing Ju, Zijie Wang, Ruoyun Tan, Min Gu

“…KEGG pathway analysis from the GEO database identified gene expression changes in pericytes, which were further analyzed using electron microscopy and Western blot techniques.Results There were statistically significant differences in creatinine, urea nitrogen, urine protein, and eGFR among the groups over time, with ABMR displaying the poorest outcomes. …”
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Exploring the impact of insufficient thermal ablation on hepatocellular carcinoma: NDST2 overexpression mechanism and its role in facilitating growth and invasion of residual cance... by Weijun Wan, Danxia Guo, Tong Kang, Jinshu Pang, Yunjing Pan, Jiamin Chen, Wei Liao, Yuji Chen, Peng Lin, Lipeng Li, Hong Yang, Yun He

“…This study aims to investigate the expression changes of NDST2 following ITA of HCC and its impact on residual cancer cells.Methods An in vitro model of heat stress-induced liver cancer was constructed to measure the expression of NDST2 using Quantitative Real-Time PCR and Western blotting experiments. The sequencing data from nude mice were used for validation. …”
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The role of immunotherapy in the treatment of lip squamous cell carcinoma: A series of six cases and a review of the current literature by Ido Amir, Nir Tsur, Itamar Averbuch, Gideon Bachar, Noga Kurman

“…Another had a PET-avid supraclavicular node negative for malignancy. The median follow-up time since treatment initiation was 11.49 months (IQR 7.77 - 29.03). …”
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