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59821
“Inclisiran: Early LDL-C target achievement in a real-life population”
Published 2025-03-01“…Blood samples were collected before the inclisiran administration and at week and one month afterward with the aim toevaluate achievement of LDL-C targets at these time intervals (primary endpoint) and reduction in LDL-C levels (secondary endpoint). …”
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59822
A BERT-Based Classification Model: The Case of Russian Fairy Tales
Published 2024-12-01“…Traditional classification methods including stylometric and parametric algorithms, however, are not only labour-intensive and time-consuming, but they are also struggling with identifying corresponding classifying discriminants. …”
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59823
Twelve barriers to COPD diagnosis in France: a comparative qualitative study
Published 2025-01-01“…The article respects the consolidated criteria for reporting qualitative research guidelines.Results Three phases in the patients’ clinical pathway to diagnosis and 12 barriers were found: Phase 1 (symptoms before consultation; n=4), lack of COPD knowledge, symptom denial, fear of lung cancer, and delayed general practice consultations; Phase 2 (primary care; n=3), letting bronchitis become chronic, priority to diseases with similar symptoms and/or more serious diseases, lack of COPD screening devices, time and curative treatments; Phase 3 (specialised medicine; n=5), treatment before diagnosis, late referral to pulmonologists, difficulty in accessing specialists and examination results, patient’s reluctance to undergo further examinations, and need for additional tests to confirm a diagnosis.Conclusion People unaware of their COPD condition can encounter up to 12 barriers, which may combine before obtaining a formal diagnosis. …”
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59824
Multimodality Imaging Probe for Positron Emission Tomography and Fluorescence Imaging Studies
Published 2014-05-01“…., Woodbridge, CT) and imaged (Λ ex : 465 nm, Λ em : 535 nm, time: 8 seconds, Xenon Light Source, Kodak). The same mouse was then placed under an Inveon microPET scanner (Siemens Medical Solutions, Knoxville, TN) injected (intravenously) with 25 μCi of 18 F and after a half-hour (to allow sufficient bone uptake) was imaged for 30 minutes. …”
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59825
慢病毒介导靶向PRL-3 基因的siRNA 抑制肝癌细胞的侵袭性
Published 2010-01-01“…【目的】 探讨肝再生磷酸酶-3(PRL-3)的表达对肝癌细胞侵袭能力的影响65377;【方法】 设计65380;合成4对针对PRL-3 基因siRNA 的寡核苷酸序列,分别构建质粒,转染293T 细胞,据其对PRL-3 的抑制率,筛选最有效的PRL-3 基因RNAi 靶序列,设计并合成其siRNA 的双链DNA Oligo,与含绿色荧光蛋白(GFP)编码基因的pGCL-GFP 线性化载体连接产生重组慢病毒质粒LV-PRL3-SiRNA,并行PCR 和测序鉴定65377;将LV-PRL3-SiRNA,pHelper 1.0 和pHelper 2.0三种质粒DNA共转染293T细胞,包装产生慢病毒,以293T细胞GFP蛋白的表达水平经孔稀释法测定病毒滴度65377;重组慢病毒感染肝癌SMCC7721 细胞,行real time-PCR和western-blot验证PRL-3基因的沉默效果65377;用Transwell侵袭试验检测SMCC7721细胞体外侵袭力的改变65377;【结果】 成功构建PRL-3 基因RNA干扰慢病毒载体并获得相应的慢病毒,浓缩病毒悬液的滴度为6 × 108 Tu/mL65377;和对照组相比,RNA 干扰组SMMC7721 细胞PRL-3 基因的mRNA 水平和蛋白水平的抑制率分别为75%和63%;其穿过人工基底膜的平均数(14.2 ± 0.8)明显少于空白对照组(33.0 ± 1.6)及非特异性siRNA感染组(31.2 ± 0.8),侵袭抑制率为58% (P < 0.01)65377;【结论】 降低PRL-3 的表达可抑制肝癌细胞的侵袭能力65377;…”
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59826
Removal of the Tumor Thrombus from the Right Atrium without Extracorporeal Circulation: Emphasis on the Displacement of the Tumor Apex
Published 2020-01-01“…Specific complications associated with the access to the right atrium from the abdominal cavity (paresis of the right phrenic nerve, pneumothorax, and mediastinitis) were not detected in any case. The average clamping time of the supradiaphragmatic inferior vena cava (IVC) was 6.3 ± 4.6 min. …”
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59827
Siphon-type hydroelectric plants: application for power generation in a low head dam in southern Brazil
Published 2024-01-01“…Continuing to leverage the hydroelectric sector is even more challenging today, because there is a growing world demand for energy, at the same time that the most attractive places from an economic point of view have already been benefited. …”
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59828
Evaluation of the long-term effects of COVID-19 on pulmonary functions in recovered patients
Published 2024-12-01“…Conclusions: Patients with COVID-19 pneumonia, which required oxygen, especially severe disease at the time of hospitalization, had a higher rate of abnormal spirometry than patients with mild symptoms. …”
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59829
Participant Contributions to Person-Generated Health Data Research Using Mobile Devices: Scoping Review
Published 2025-01-01“…Reporting completeness for data ownership and participants’ access to data after contribution worsened over time. ConclusionsOur work depicts the reporting practices in publications about research involving PGHD from mobile devices. …”
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59830
Machine Learning Based Modeling of Thermospheric Mass Density
Published 2024-05-01“…Further tests have been made by checking the MBiLE model prediction deviations in relation to magnetic local time, day of year, solar flux level, and magnetic activities. …”
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59831
Chemical Vapour Deposition of MWCNT on Silica Coated Fe3O4 and Use of Response Surface Methodology for Optimizing the Extraction of Organophosphorus Pesticides from Water
Published 2019-01-01“…The factors influencing the extraction efficiency such as pH, contact time, and adsorbent dosage were investigated and optimized by response surface methodology (RSM) and desirability function. …”
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59832
Effect of healthy lifestyle score trajectory on all-cause mortality in the late middle-aged and older population: Finding from 17-year retrospective cohort study
Published 2025-02-01“…However, as HLS may fluctuate over time, there is increasing focus on monitoring HLS trends. …”
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59833
Exploring the boundaries of anastomotic leak: experience in a high-volume center
Published 2025-01-01“…This facilitates the implementation of timely treatments, whether conservative, through the use of endoscopic or percutaneous strategies, or surgical procedures. …”
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59834
Salivary cardiac troponin does not correlate with serum levels
Published 2025-01-01“…However, prior investigations have not adequately addressed the critical aspect of collecting samples upon admission, which is essential for timely troponin level determination. This study aimed to evaluate the relationship between troponin levels in serum and saliva among patients admitted for chest pain evaluation.MethodsThis observational study was conducted at the Interventional Cardiology Department of the University Medical Center HCMC. …”
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59835
Efficacy and safety of upadacitinib in the treatment of moderate-to-severe atopic dermatitis: A systematic review.
Published 2024-01-01“…<h4>Methods</h4>PubMed, Medline, Embase, Web of Science, Clinical Trials Website, and Cochrane Library databases were searched from the time of establishment until January 6, 2024, to compile a list of all randomized controlled trials (RCTs) including upadacitinib in the treatment of moderate-to-severe AD. …”
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59836
Digital modeling of soil-borne fusarium’s nutritional: Investigating microbiological and microecological dynamics in Moroccan agroecosystems
Published 2024-01-01“…Any similar outbreak over time poses a serious threat to the long-term sustainability of these oases. …”
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59837
Constitutional identity and national values in the conditions of permanent threats to Ukraine’s stateship
Published 2025-01-01“…This objective stems directly from Ukraine’s legal tradition and contemporary state-building practices. At the same time, the formation of a modern political nation in Ukraine is impossible without fostering a sense of civic patriotism and national dignity. …”
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59838
Post-marketing safety surveillance for the recombinant zoster vaccine (Shingrix), vaccine adverse event reporting system, United States, October 2017–April 2024
Published 2025-02-01“…Descriptive analyses included sex, age, time-to-onset, seriousness, most commonly reported AEs, AE of special interest, and cause of death. …”
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59839
Water Risk and Mining Firms’ Stock Return
Published 2024-06-01“…ResultsThe significance of the water risk effect on stock returns of mining companies indicates the pricing and the confirmation power of this risk factor to explain the changes in stock returns over time, in a way that one unit increase in water risk will cause a decrease of about 3% in the excess return of the firm’s stock three quarters later. …”
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59840
Shaping a low-carbon future: Uncovering the spatial-temporal effect of population aging on carbon emissions in China.
Published 2025-01-01“…From the spatial dimension, there is a significant spatial spillover effect of the effect of aging on carbon emissions, and aging reduces local carbon emissions but increases carbon emissions in adjacent regions. From the time dimension, the effect of aging on carbon emissions shows a stage characteristic, initially it will reduce carbon emissions, but with the deepening of aging, its effect may tend to weaken. …”
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