Ginsenosides 20R-Rg3 and Rg5 enriched black ginseng inhibits colorectal cancer tumor growth by activating the Akt/Bax/caspase-3 pathway and modulating gut microbiota in mice by Peng Yu, Weiyin Xu, Yanqi Li, Zhaoyang Xie, Simeng Shao, Jianing Liu, Ying Wang, Long Wang, Hongmei Yang

“…Our results manifested for the first time that Rg3/Rg5-BG exerted its anti-cancer effects: through activation of the caspase-3/Bax/Bcl-2 pathway and by altering the gut microbiome composition, thus paving the way for new therapeutic strategies that incorporate natural products in cancer treatment.…”
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A randomized controlled interventional study for analgesic effects of intrathecal versus intravenous dexmedetomidine on subarachnoid anesthesia with hyperbaric bupivacaine by Manu Dadhwal, Anupama Gupta, Ajay Kurian

“…Materials and Methods: In this prospective, randomized controlled, double-blind study total of 90 patients with the American Society of Anesthesiologists grade I and II were randomly allocated into three groups: Group A (n=30) received IV 20 mL 0.9% NaCl over 10 min followed by intrathecal 2.4 mL 0.5% hyperbaric bupivacaine+0.2 mL normal saline, group B (n=30) received IV 20 mL 0.9% NaCl over 10 min followed by intrathecal 2.4 mL 0.5% hyperbaric bupivacaine+0.2 mL (5 mcg) dexmedetomidine, and group C (n=30) received IV dexmedetomidine 1 mcg/kg in 20 mL 0.9% NaCl over 10 min followed by intrathecal 2.4 mL 0.5% hyperbaric bupivacaine+0.2 mL normal saline. Results: The mean time for two-segment regression in group A was 100.57±4.24 min, in group B it was 193.3±7.07 min, and in group C was 170.23±3.53 min. …”
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The invisible enemy: A systematic review and meta-analysis of maternal smokeless tobacco use as a risk factor for low birth weight. by Akanksha Mahajan, Bhawna Gupta, Michael Tong

“…<h4>Methods</h4>Systematic literature search was performed in Medline (via PubMed), Embase, Scopus, and CINAHL with no restrictions on language or time until May 2024. All observational studies that examined the relationship between maternal smokeless tobacco use and low birth weight of infants were eligible for inclusion. …”
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Analysis of influenza epidemics during the COVID-19 pandemic using an improved surveillance system (from 2021 to 2024) by Ludmila S. Karpova, Maria Yu. Pelikh, Kirill A. Stolyarov, Ksenia M. Volik, Tatyana P. Stolyarova, Daria M. Danilenko

“…Assessing the effectiveness of new baselines and intensity thresholds of epidemics based on rates of incidence and hospitalization with a diagnosis of “influenza” to clarify the timing of epidemics and their spread throughout the Russian Federation against the backdrop of the COVID-19 pandemic (from 2021 to 2024). …”
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Financing of Preschool Education in Ukraine in 1919–1933: Historical and Legal, Historical and Economic Aspects by S. O. Tkachenko, О. V. Golovko

“…It has been proved that the system of legal regulation of financing of public preschool education in Ukrainian SSR at that time has passed three stages of development: – 1919–1922 – financing of preschool institutions was carried out in a centralized way by monthly allocations from the republican budget, as well as from the budget of central agencies; – 1923–1927 – financing of preschool institutions was transferred from the republican to local budgets; – 1928–1933 – attraction of state and local councils’ budgets, funds from trade unions, other institutions and enterprises, parental payment. …”
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Profiling gene alterations in striatonigral neurons associated with incubation of methamphetamine craving by cholera toxin subunit B-based fluorescence-activated cell sorting by Rachel D. Altshuler, Megan A. M. Burke, Kristine T. Garcia, Kenneth Class, Raffaello Cimbro, Xuan Li, Xuan Li

“…On abstinence day 28, we found increased mRNA expression for Grm3, Opcml, and Usp9x in all sorted DS neurons, but not DS homogenate.DiscussionTogether, these data demonstrated that incubation of Meth craving was associated with time-dependent, circuit-specific, and cell type-specific gene alterations in DS involved in glutamatergic, GABAergic, opioidergic, and protein degradation signaling.…”
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The prognostic importance of the pan-immune-inflammation value in patients with septic shock by Yasemin Bozkurt Turan

“…The univariate Cox proportional hazards (CPH) model showed that high PIV (HR = 2.13 (1.03—4.38)), low GCS (HR = 3.31 (1.34 – 8.15)), high SOFA (HR = 9.41 (2.86 – 30.95)), high APACHE II (HR = 3.08 (1.47 – 6.45)), high lactate (HR = 6.56 (2.73 – 15.75)), and high procalcitonin (PCT) (HR = 2.73 (1.11 – 6.69)) values were associated with a decreased survival time among ICU patients (p < 0.05). The multivariate CPH model showed the age-adjusted risk estimates for these six laboratory parameters. …”
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An updated regional model skill assessment for seasonal and interannual variability of bottom temperature across the eastern Bering Sea shelf by Kelly A. Kearney, Phyllis J. Stabeno, Albert J. Hermann, Albert J. Hermann, Calvin W. Mordy, Calvin W. Mordy

“…Here, we characterize bottom temperature on the southeastern Bering Sea shelf across time scales by combining data from our new pop-up floats with several existing temperature datasets. …”
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A network meta-analysis comparing treatment modalities of short and long implants in the posterior maxilla with insufficient bone height by Yixuan Zhang, Xiaoyue Tang, Yue Zhang, Can Cao

“…Abstract Objective Based on the critical role of implant length and placement timing in treatment success, this study aimed to compare clinical outcomes (implant failure, marginal bone loss, biological and mechanical complications) between short implants (4–8 mm) versus long implants (≥ 8 mm) with sinus floor elevation, and between delayed versus immediate placement of long implants in the posterior maxilla. …”
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Prevalence and Predictors of Overweight and Obesity Among School-Aged Children in the Country of Georgia: A Cross-Sectional Study, 2022 by Natia Kakutia, William Michael Caudle, Ziad N. Kazzi, Lela Sturua, Shalva (Davit) Zarnadze, Nana Mebonia

“…However, no significant differences were observed in the prevalence of various dietary behaviors or screen time between normal-weight and overweight/obese children. …”
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Tyrosine hydroxylase of the brain and it’s regulation by glucocorticoids by E. V. Sukhareva, T. S. Kalinina, V. V. Bulygina, N. N. Dygalo

“…Administration of hydrocortisone or dexamethasone to female rats on day 20 of pregnancy and to 3-day-old neonatal pups significantly increased TH mRNA levels (real-time PCR) and enzyme activity as well as protein levels determined by ICH in the locus coeruleus. …”
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Application of Internet Plus nursing services in the management of chronic diseases among the elderly (“互联网+护理服务”在老年慢性病患者管理中的应用) by LI Jiao (李娇), CAI Miaomiao (蔡苗苗)

“…With the increasingly significant aging trend of China's population, the number of patients with chronic diseases is constantly rising, and the characteristics of chronic diseases determine that most of the treatment and rehabilitation time is spent in the family and community, and traditional nursing services have been difficult to adapt to the changes in patients' needs. …”
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Unexpected placenta accreta spectrum in an unscarred uterus causing catastrophic post-partum hemorrhage: a case report and review of the literature by Priyanka Garg, Shweta Semwal, Romi Bansal

“…The management is often challenging, especially in low-middle-income countries like India with limited access to healthcare, where most cases are identified only at the time of delivery. Case presentation We narrate a case of a 25-year-old woman of North Indian ethnicity, para 2 live 2, who presented to our emergency in shock with retained placenta and severe postpartum haemorrhage. …”
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Development and Videographic Evaluation of a Vascular Access Simulation-Based Curriculum for Surgical and Medical Trainees by Alaska Pendleton, MD, MPH, Tiffany R. Bellomo, MD, Srihari K. Lella, MD, Kristen Jogerst, MD, Ada Stefanescu, MD, MSc, Douglas Drachman, MD, Nikolaos Zacharias, MD, Anahita Dua, MD, MBA, MSc

“…Procedural completion time decreased from 7.14 ± 4.26 to 3.81 ± 2.53 minutes (P < 0.001). …”
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Clinical performance of two commercially available rapid antigen tests for influenza, RSV, and SARS-CoV-2 diagnostics by Laura E. Savolainen, Joanna Peltola, Risto Hilla, Tapio Åman, Markku Broas, Ilkka S. Junttila

“…The clinical performance of two commercial combo-RATs for influenza A and B, respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) POC diagnostics, was assessed. RAT and real-time-PCR (RT-PCR) analysis were performed on 620 patients admitted to the emergency department due to respiratory symptoms. …”
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The French Actor on the London Stage: Charles Fechter by Catherine Quirk

“…Using published reviews, letters, and the plays in which he appeared—including Fechter’s own adaptations and his annotated Othello—I propose to examine how this often overlooked actor was both received as the London stage’s greatest lover and at the same time considered particularly French, and how this seeming contradiction reflects contemporary London theatre-goers’ divergent reactions to anything French on their stages.…”
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Treatment Patterns and Health Care Costs in Commercially Insured Patients with Follicular Lymphoma by Nathan H. Fowler, Guifang Chen, Stephen Lim, Stephanie Manson, Qiufei Ma, Frank Li

“…The average follow-up time was approximately 5.7 years. Of these patients, 50.2% (n=300) were female, with a mean age of 60.7 years (SD=13.1 years) when initiating their treatment with FL indicated regimens. …”
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Transcatheter Atrial Septal Defect Closure in Children with and without Fluoroscopy: A Comparison by S. Ackermann, D. Quandt, N. Hagenbuch, O. Niesse, M. Christmann, W. Knirsch, O. Kretschmar

“…There was no significant difference in number of defects or characteristics of ASD rims. Median procedure time was shorter in group 2 [60min (47-86) versus 34min (28-44)]. …”
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A Rare Case of Mosaic 3pter and 5pter Deletion-Duplication with Autism Spectrum Disorder and Dyskinesia by Luna Bajracharya, Meena Lall, Sunita Bijarnia-Mahay, Praveen Kumar, Imran Mushtaq, Pushpa Saviour, Preeti Paliwal, Anju Joshi, Shruti Agarwal, Praveen Suman

“…This case highlights a rare genetic finding and the need for timely genetic testing in a child with dysmorphism and autism with movement disorder to enable appropriate management and genetic counselling.…”
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Effect of cooling rate on metallurgical and mechanical properties in continuous wave laser welding of hot-dip galvanised steel-to-aluminium sheets in a zero part-to-part gap lap jo... by A. Baghbani Barenji, M.B. Russo, S. Jabar, H.R. Kotadia, D. Ceglarek, K.F. Ayarkwa, J.R. Smith, P. Franciosa

“…Results revealed that active cooling influences Zn vapours and IMCs differently; faster cooling reduced total IMCs and Fe2Al5 phase and increased joint strength; however, it exacerbated spattering and weld discontinuity due to insufficient time for outgassing the Zn vapours from the molten pool. …”
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