Clinical profile and outcomes analysis of HIV infection by Ashwant Kumar, Yoganathan Chidambaram, Clement J. Dhas, Nekkanti Abilash, Murali Alagesan

“…Complete understanding of HIV paradigm would facilitate timely identification, intervention, and medical modulation to obtain maximum benefits with minimal side effects. …”
Get full text

SIRT5‐mediated HOXA5 desuccinylation inhibits ferroptosis to alleviate sepsis induced‐lung injury by Lei Wang, Heng Fan, Min Sun, Ji‐Hui Ye

“…HOXA5, ferroptosis suppressor protein 1 (FSP1), sirtuin 5 (SIRT5), and glutathione peroxidase 4 (GPX4) expressions were measured using western blotting and Real‐Time Quantitative Polymerase Chain Reaction (RT‐qPCR. …”
Get full text

The transcription factor dFOXO controls the expression of insulin pathway genes and lipids content under heat stress in <i>Drosophila melanogaster</i> by M. A. Eremina, P. N. Menshanov, O. D. Shishkina, N. E. Gruntenko

“…Thus, we may conclude that dFOXO takes part in regulating the IIS pathway response to heat stress as well as the changes in lipids content caused by heat stress, and this regulation is mediated by DILP6. At the same time, the feeding behaviour of imago might be controlled by dFOXO and DILP6 under normal conditions, but not under heat stress.…”
Get full text

Analysis of 42 Years of Cosmic Ray Measurements by the Neutron Monitor at Lomnický štít Observatory by Imre Kisvárdai, Filip Štempel, Lukáš Randuška, Šimon Mackovjak, Ronald Langer, Igor Strhárský, Ján Kubančák

“…Lastly, the computed prediction power score of 0.22 for neutron flux in the context of geomagnetic field strength presents exciting possibilities for developing real‐time geomagnetic storm prediction models based on cosmic ray measurements.…”
Get full text

Assessing the Direct Impact of Typhoons on Vegetation Canopy Structure and Photosynthesis by Yaoyao Zheng, Simin Zhan, Zaichun Zhu, Sen Cao, Jiana Chen, Pengjun Zhao, Weimin Wang, Ranga B. Myneni

“…We developed random forest models based on satellite-observed leaf area index (LAI) and environmental data during typhoon-free periods to simulate LAI under non-typhoon conditions. The simulated LAI time series was then compared with the satellite-observed typhoon-affected LAI to assess the typhoon-induced canopy loss and recovery, which was then used to estimate the typhoon-caused photosynthesis loss and recovery with 2 widely used light-use efficiency models. …”
Get full text

Automated skin lesion detection and prevalence estimation in Tamanend's bottlenose dolphins by Colin J. Murphy, Melissa A. Collier, Ann-Marie Jacoby, Eric M. Patterson, Megan M. Wallen, Janet Mann, Shweta Bansal

“…Anthropogenic global change is occurring at alarming rates, leading to increased urgency in the ability to monitor wildlife health in real time. Monitoring sentinel marine species, such as bottlenose dolphins, is particularly important due to extensive anthropogenic modifications to their habitats. …”
Get full text

Validated HPLC method for simultaneous determination of azelastine hydrochloride fluticasone propionate and oxymetazoline in nasal mucosa and nasopharyngeal swabs from real human s... by Neven N. Mikawy, Nancy Magdy, Marwa H. Mohamed, Amira M. El-Kosasy

“…A good separation of the three proposed analytes with a short run time of 10 min was noted. Our method was validated according to FDA guidelines for bioanalytical validation methods. …”
Get full text

shRNA-interfered of Nrf2 reveals a critical role for Keap1-Nrf2 signaling pathway during effects of zearalenone induced oxidative stress in IPEC-J2 cells by Qun Cheng, Shu Zhen Jiang, Li Bo Huang, Wei Ren Yang

“…Results The study results showed that, compared with the Sh-Nrf2 group, ZEA significantly increased the apoptosis rate of IPEC-J2 in a time- and dose-dependent manner. Compared with the Sh-Nrf2 group, the activities of total superoxide dismutase and glutathione peroxidase and relative expressions of Keap1 at mRNA and protein level in the Sh-Nrf2+ZEA20 and Sh-Nrf2+ZEA40 groups were significantly reduced, the malondialdehyde level, and the fluorescence intensity around and within the nucleus of reactive oxygen species and Nrf2, and the relative expressions of Nrf2, quinone oxidoreductase 1, and hemeoxygenase 1 at mRNA and protein level significantly increased. …”
Get full text

Analisis Sentimen Maskapai Penerbangan Menggunakan Metode Naive Bayes dan Seleksi Fitur Information Gain by Arif Bijaksana Putra Negara, Hafiz Muhardi, Indira Melinda Putri

“…The user reviews contained on the pegipegi.com website are currently very large so this makes it difficult and time consuming to read in its entirety. Therefore sentiment analysis is designed to help classify reviews into positive or negative categories so that they can provide airline recommendations based on the number of review categories. …”
Get full text

Association between combined healthy lifestyles and infertility: a cross-sectional study in US reproductive-aged women by Xiaofeng Ye, Xiaoxia Song, Sihang Zhou, Guoqing Chen, Liping Wang

“…A healthy lifestyle score was created based on healthy diet (top two-fifths of the Healthy Eating Index-2015 score), low-to-moderate alcohol drinking (1–14 g/day), optimal waist circumference (less than 80 cm), adequate physical activity (at least 150 min of moderate-to-vigorous leisure-time exercise per week), and current nonsmoking. …”
Get full text

Pharmacokinetic Analysis of Diosgenin in Rat Plasma by a UPLC-MS/MS Approach by Pei Liu, Lin Xu, Jing-han Guo, Jin-hua Chang, Xi-gang Liu, He-fei Xue, Ru-xing Wang, Zhong-si Li, Guang-xin Miao, Cui-zhe Liu, Jian-yu Zhou

“…The current diosgenin analysis methods have the disadvantages of long analysis time and low sensitivity. The aim of the present study was to establish an efficient, sensitive ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) approach for pharmacokinetic analysis of diosgenin amorphous solid dispersion (ASD) using tanshinone IIA as an internal standard (IS). …”
Get full text

Effects of coal mine dust on lung function in rats by LIU Yang, LI Meng, LU Liyuan, WANG Ru, YANG He, ZHANG Huifang

“…The relative mRNA expressions of peroxisome proliferators-activated receptor gamma coactivator 1-alpha (PGC-1α) and mitochondrial transcription factor A (TFAM) were detected using real-time fluorescent quantitative polymerase chain reaction assay. …”
Get full text

Study of the Optimal Control of the Central Air Conditioning Cooling Water System for a Deep Subway Station in Chongqing by Xingyu Shu, Yu Dong, Jun Liu, Xinhua Xu

“…The results also demonstrate that the cooling water pipes release heat to the air in the corridor most of the time, and the released heat is larger than the absorbed heat. …”
Get full text

Determination of Electrolytes in Critical Illness Patients at Different pH Ranges: Whom Shall We Believe, the Blood Gas Analysis or the Laboratory Autoanalyzer? by Christopher Hohmann, Roman Pfister, Kathrin Kuhr, Julia Merkle, Julian Hinzmann, Guido Michels

“…All patients suffered an infarct-related cardiogenic shock and were intubated and not under therapeutical hypothermia at the time of blood collection. We used scatter plots to compare different distributions of sodium and potassium values between the methods. …”
Get full text

Protective Effect of High-Intensity Interval Training (HIIT) and Moderate-Intensity Continuous Training (MICT) against Vascular Dysfunction in Hyperglycemic Rats by Nurul Paramita, Brilliant C. Puspasari, Randika Arrody, Neng T. Kartinah, Trinovita Andraini, Julfiana Mardatillah, Hardiyanti Rusli, Dewi I. S. Santoso

“…A colorimetric assay was used to measure superoxide dismutase (SOD) activity and malondialdehyde (MDA) levels. Quantitative real-time polymerase chain reaction (PCR) was used to measure the expression of the receptor for advanced glycation end-products (RAGE) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). …”
Get full text

Differential expressed genes (DEGs) and differential alternative splicing genes (DASs) revealed the common pathologic mechanism of three bacterial pathogens to American eels (Angui... by Zihao Chen, Guanghua Sun, Songlin Guo

“…Together, we report for the first time a comparative analysis of pathogenicity and RNA sequencing for E. anguillarum, V. harveyi and V. vulnificus in the American eel. …”
Get full text

Enhancing the Solubility of Co-Formulated Hydrophobic Drugs by Incorporating Functionalized Nano-Structured Poly Lactic-<i>co</i>-glycolic Acid (<i>nf</i>PLGA) During Co-Precipitat... by Mohammad Saiful Islam, Somenath Mitra

“…The incorporation of <i>nf</i>PLGA also reduced the amount of time taken to reach 50% (T₅₀) and 80% (T₈₀) dissolution. …”
Get full text

Effects of Soil Conservation Practice and Crop Rotation on Selected Soil Physicochemical Properties: The Case of Dembecha District, Northwestern Ethiopia by Melkamu Degu, Asmare Melese, Wondwosen Tena

“…A critical study on such type of issue should be carried out over a longer period of time in order to announce detailed understanding about response of soil property to crop rotations to the community.…”
Get full text

Efficacy and safety of immune checkpoint inhibitors in patients with advanced intrahepatic cholangiocarcinoma by Ziting Peng, Jianhui Dong, Shuyao Tang, Jiaxu Shi, Tongdong Shi

“…All patients returned to normal after symptomatic treatment.ConclusionsIn patients with advanced ICC, the timely initiation of ICIs as adjuvant therapy following first-line antitumor treatment can result in favorable efficacy and a good safety profile.…”
Get full text

Biomarkers predicting postoperative adverse outcomes in children with congenital heart disease: a systematic review and meta-analysis by Shifan Zhou, Shifan Zhou, Lu Liu, Xiaochuang Jin, Daniel Dorikun, Songfeng Ma

“…Lower postoperative N-terminal pro-B-type natriuretic peptide (NT-pro BNP) levels were associated with lower mortality (OR: 0.23, 95% CI: 0.08–0.68) and shorter mechanical ventilation time (OR: 0.40, 95% CI: 0.18–0.90). Higher serum albumin levels were associated with longer hospital stays (OR: 3.12, 95% CI: 1.66–5.84). …”
Get full text