Notch-Hes1 Signaling Regulates IL-17A+γδ+T Cell Expression and IL-17A Secretion of Mouse Psoriasis-Like Skin Inflammation by Yanqin Wang, Xinxin Li, Xiaoyun Xing, Haibo Xue, Ruiqun Qi, Hong Ji, Lei Ma

“…Flow cytometry detected IL-17A+γδ+T cell percentage. Quantitative real-time RT-PCR detected Hes1 mRNA expression. Enzyme-linked immunosorbent assay and western blot measured IL-17A serum concentration and protein expression. …”
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Development and validation of a novel tool to measure tear volume in volumetric unit (microlitre) per minute “the standard international unit (SI) tear strip” by R Balamurugan, Anusuya Bhattacharyya, Phulen Sarma

“…This new tear volume measuring tool (named SI tear strip) represents a valuable tool for the measurement of tear volume (in μl) per unit time. This tool may be very helpful for the quantitative evaluation of dry eye patients and functional assessment of lacrimal glands.…”
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Research investigating patient and carer psychoeducation needs regarding post-stroke cognition: a scoping review by Nele Demeyere, Georgina Hobden, Faye Tabone

“…Factors potentially impacting cognition-related psychoeducation needs were identified as time since stroke and family member relationship. …”
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Study on the drying characteristics of green pellets of ultrafine iron ore concentrate by Wen B.-L., Zhang X.-P., Liu D.-L., Li J.-X., Sun X.-D., Yang J.-L.

“…As the drying temperature and air speed increased, the drying time decreased. The coefficient of determination R2 for the fitted Weibull distribution function model ranged from 0.995 to 0.998, while the R2 value for the Dincer model ranged from 0.990 to 0.996. …”
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Adaptation of an additively manufactured reactor concept for catalytic methanation with in-situ tar co-reforming of biogenic syngas by Jakob Müller, Alexander Feldner, Simon Markthaler, Peter Treiber, Jürgen Karl

“…A temperature hot spot near the inlet provides the necessary conditions (high temperature, a suitable catalyst and sufficient residence time) for the reforming of tar species, that are present in the syngas. …”
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Novel Poly-Arginine Peptide R18D Reduces α-Synuclein Aggregation and Uptake of α-Synuclein Seeds in Cortical Neurons by Emma C. Robinson, Anastazja M. Gorecki, Samuel R. Pesce, Vaishali Bagda, Ryan S. Anderton, Bruno P. Meloni

“…Methods: To induce intracellular α-syn aggregation, rat primary cortical neurons were exposed to α-syn seed (0.14 μM) for 2 h to allow uptake of the protein, followed by R18D treatment (0.0625, 0.125, 0.25, 0.5 μM), and a subsequent measurement of α-syn aggregates 48 h later using a homogenous time-resolved fluorescence (HTRF) assay. To assess neuronal uptake, α-syn seeds were covalently labelled with an Alexa-Fluor 488 fluorescent tag, pre-incubated with R18D (0.125, 0.25, 0.5 μM), and then exposed to cortical neurons for 24 h and assessed via confocal microscopy. …”
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Ultrasonography, contrast-enhanced ultrasonography and contrast-enhanced computer tomography features of hepatic sarcomatoid carcinoma and hepatic sarcoma: a retrospective study of... by Xingyun Long, Haiyun Shen, Jie Wu, Han Liu, Danqing Huang, Wentao Kong

“…The degree of enhancement, the time of wash-out start, and the presence of necrotic areas may contribute to distinguish the different pathological types of HS.…”
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Perceptions in 3.6 Million Web-Based Posts of Online Communities on the Use of Cancer Immunotherapy: Data Mining Using BERTopic by Xingyue Wu, Chun Sing Lam, Ka Ho Hui, Herbert Ho-fung Loong, Keary Rui Zhou, Chun-Kit Ngan, Yin Ting Cheung

“…Six themes were identified, primarily covering (1) hopeful prospects offered by immunotherapy, (2) perceived effectiveness of immunotherapy, (3) complementary therapies or self-treatments, (4) financial and mental impact of undergoing immunotherapy, (5) impact on lifestyle and time schedules, and (6) side effects due to treatment. …”
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Clinical significance of establishing a red blood cell alloantibody detection database by XIAO Xiao, CHEN Long, ZHAO Zhenyu, HE Zhanghan, ZHOU Mengjun, TANG Jie

“…In the database, 48 patients experienced antibody decay, accounting for 15.24%(48/315), with an average time span of antibody decay ranging from 22 to 1 324 days. …”
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卒中：回眸2024 Highlights in Stroke in 2024 by 熊云云1，2，3，4，李光硕1，马宇洁1，李祉馨1，沈柯佳1，马瑛1，孙大鹏1，孙溢阳1，王拥军1，2，3，5，6，7（XIONG Yunyun1,2,3,4, LI Guangshuo1, MA Yujie1, LI Zhixin1, SHEN Kejia1, MA Ying1, SUN Dapeng1, SUN Yiyang1, WANG Yongjun1,2,3,5,6,7 ）

“…Exciting breakthroughs have been made in the field of hemorrhagic stroke, including the treatment of subdural hematoma and primary intracerebral hemorrhage. At the same time, as a research hotspot in recent years, ischemic stroke has seen a continuous emergence of high-quality research results in various aspects such as intravenous thrombolysis, arterial thrombectomy, and secondary prevention, providing more robust evidence for clinical diagnosis and treatment. …”
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Dopamine receptors and key elements of the neurotrophins (BDNF, CDNF) expression patterns during critical periods of ontogenesis in the brain structures of mice with autism-like be... by P. D. Pravikova, M. A. Arssan, E. A. Zalivina, E. M. Kondaurova, E. A. Kulikova, I. I. Belokopytova, V. S. Naumenko

“…The obtained results suggest that the decrease in the expression levels of CDNF, BDNF-TrkB and dopamine receptors in the frontal cortex in the postnatal period can lead to significant changes in both the morphology of neurons and dopamine neurotransmission in cortical brain structures. At the same time, the increase in p75NTR receptor gene expression observed on the 14th day of embryogenesis, crucial for hippocampus and frontal cortex development, may have direct relevance to the manifestation of early autism.…”
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Evolution of gender representation among Canadian OTL-HNS residents: a 27-year analysis by Sarah Chorfi, Joseph S. Schwartz, Neil Verma, Meredith Young, Lawrence Joseph, Lily H. P. Nguyen

“…The difference in annual growth rate of female representation versus male representation in OTL-HNS over this time period was 2.7%, which was similar to other large specialty programs and surgical subspecialties. …”
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Systemic nitric oxide metabolites and the chance of pre-diabetes regression to normoglycemia: A 9-year cohort study by Zahra Bahadoran, Parvin Mirmiran, Fereidoun Azizi, Asghar Ghasemi

“…Higher BW-adjusted NOx-to-Cr increased chance of returning to NG (OR=2.05, 95% CI= 0.98-4.32, P=0.058) and decreased levels of 2h-serum glucose over time (Ptime×group=0.025), as well as the decreased overall mean of fasting (106, 95% CI=103-109 vs. 110, 95% CI=108-112 mg/dL, P=0.008) and 2h-serum glucose (153, 95% CI=146-159 vs. 163, 95% CI=158-168 mg/dL, P=0.018). …”
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Psychosocial factors influencing dietary management in patients with type 2 diabetes and healthy adults: an ecological momentary assessment approach by Junichi Saito, Hiroaki Kumano, Hiroaki Kumano

“…Ecological momentary assessment (EMA) allows patients to consistently report their experiences in real-time over a certain period and across different contexts. …”
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Umbilical Cord Mesenchymal Stem Cell-Derived Small Extracellular Vesicles Deliver miR-21 to Promote Corneal Epithelial Wound Healing through PTEN/PI3K/Akt Pathway by Xiaolong Liu, Xuran Li, Guangyuan Wu, Pengfei Qi, Yanyan Zhang, Zhiyu Liu, Xinyue Li, Yu Yu, Xiangmei Ye, Yang Li, Dongguang Yang, Yueqiu Teng, Ce Shi, Xin Jin, Sen Qi, Yuting Liu, Shudan Wang, Ying Liu, Fenglin Cao, Qingran Kong, Zhenkun Wang, Hong Zhang

“…Full-length transcriptome sequencing was performed to identify the differentially expressed genes associated with HUMSC-sEVs treatment, followed by validation via real-time PCR and Western blot. Results. The sEVs derived from HUMSCs can significantly promote corneal epithelial cell proliferation, migration in vitro, and corneal epithelial wound healing in vivo. …”
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Doxycycline-integrated silk fibroin hydrogel: preparation, characterizations, and antimicrobial assessment for biomedical applications by Kranti Kiran Reddy Ealla, Chandra Sri Durga, Vikas Sahu, Neema Kumari, Jayachandran Venkatesan, Vishnu Priya Veeraraghavan, Pratibha Ramani, Kiran Kumar Bokara, Karthikeyan Ramalingam

“…This emphasizes the importance of a drug delivery system to gradually slow its release at the oral wound site and increase its bioavailability to make the treatment effective over time. Methods Silk fibroin (SF) - doxycycline hyclate (DH) hydrogel was developed and subsequently characterized for gelation kinetics, swelling, stress-strain analysis, morphology using scanning electron microscopy, interaction between SF and DH using Fourier transform infrared (FT-IR) spectroscopy, drug release profile, antibacterial efficacy, and biocompatibility studies. …”
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Worldwide Research Trends on Diabetic Foot Ulcers (2004–2020): Suggestions for Researchers by Pin Deng, Hongshuo Shi, Xuyue Pan, Huan Liang, Shulong Wang, Junde Wu, Wei Zhang, Fasen Huang, Xiaojie Sun, Hanjie Zhu, Zhaojun Chen

“…The University of Washington had the greatest number of publications within this time period (n=103), and it had the most cooperative units and was in the core position in all research institutions, followed by the University of Manchester (n=94) and the University of Miami (n=92). …”
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A remarkable and durable response to tislelizumab treatment of an anaplastic thyroid carcinoma without targetable genomic alterations: a case report by Jingjing Chai, Jiaqi Lv, Jian Xiong, Xiuwen Chen, Senyuan Luo, Zhiguo Luo, Zhiguo Luo, Ming Luo

“…Anaplastic thyroid carcinoma (ATC) is a rare and highly aggressive malignancy characterized by a poor prognosis, with a median survival time of approximately 3 to 4 months. In this report, we present a case involving a 59-year-old patient diagnosed with ATC, who experienced swift local recurrence and pulmonary metastasis following radical thyroidectomy. …”
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Pembrolizumab plus Pemetrexed and Platinum in Metastatic Non-Squamous Non-Small Cell Lung Cancer: A Real-Life Study at a Portuguese Centre by Maria João Santos, Filipa Ferro, Andrea Machado, Ana Sofia Vilariça, Direndra Hasmucrai, Paula Alves

“…Median overall and progression-free survival were 12.2 months and 6.7 months, respectively. At the time of the cut-off, 21.2% of patients were alive and progression-free. …”
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Total hip arthroplasty in hip tuberculosis: a systematic review by Shengyuan Zheng, Mufeng Li, Hong Chen, Yanguo Qin

“…In general, physicians are accustomed to deciding the appropriate timing of surgery based on inflammatory markers; 90% of the studies recommended preoperative and postoperative antituberculosis therapy (ATT), and 14 studies used antituberculosis drugs during surgery. …”
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