Prevalence and Determinants of Peripheral Microvascular Endothelial Dysfunction in Rheumatoid Arthritis Patients: A Multicenter Cross-Sectional Study by Gian Luca Erre, Matteo Piga, Anna Laura Fedele, Silvia Mura, Alessandra Piras, Maria Luisa Cadoni, Ignazio Cangemi, Martina Dessi, Gabriele Di Sante, Barbara Tolusso, Elisa Gremese, Alberto Cauli, Arduino Aleksander Mangoni, Pier Sergio Saba, Ciriaco Carru, Gianfranco Ferraccioli, Alessandro Mathieu, Giuseppe Passiu

“…This study demonstrates for the first time a high prevalence of peripheral microvascular ED in patients with RA free of previous cardiovascular events that appear to be only partially driven by traditional cardiovascular risk factors. …”
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Portable UV-C device to treat high flow of infectious aerosols generated during clinical respiratory care by Richard Vincent, David Rapoport, Priti Balchandani, Joseph Borrello, Michael Schotsaert, Robert Karlicek, Gabriel Laghlali, Prajakta Warang, Seokchan Park, Gagandeep Singh, Isabella Morgan, James Paredes, Raveen Rathnasinghe, Jacob Wolf, Adolfo García-Sastre

“…Our device consisted of a central quartz tube surrounded 6 high-output UV-C254 lamps, within a larger cylinder allowing recirculation past the UV-C254 lamps a second time before exiting the device. Testing was with nebulized A/PR/8/34 (H1N1) influenza virus. …”
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The Prognosis of Traumatic Small Bowel Injury Accompanied by Liver Injury by Yu Seong Noh, Sung Won Jung, Tae Gil Heo, Pyong Wha Choi, Jae Il Kim, Heung Man Jun, Yong Chan Shin, Sung Min Jung, Eun Hae Um

“…Purpose The aim of this study was to elucidate the prognosis, and other clinical features, such as time to surgery and the amount of transfusion, of small bowel injury (SBI) accompanied by liver injury (LI). …”
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Preoperative White Blood Cell Count and Risk of 30-Day Readmission after Cardiac Surgery by Jeremiah R. Brown, R. Clive Landis, Kristine Chaisson, Cathy S. Ross, Lawrence J. Dacey, Richard A. Boss, Robert E. Helm, Susan R. Horton, Patricia Hofmaster, Cheryl Jones, Helen Desaulniers, Benjamin M. Westbrook, Dennis Duquette, Kelly LeBlond, Reed D. Quinn, Patrick C. Magnus, David J. Malenka, Anthony W. DiScipio

“…There were 259 patients readmitted within 30 days, with a median time of readmission of 9 days (IQR 4–16). Patients with elevated WBC count at baseline (10,000–12,000 and >12,000 mm3) had higher 30-day readmission than those with lower levels of WBC count prior to surgery (15% and 18% compared to 10%–12%, P=0.037). …”
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Bimetallic selenium/zinc oxide nanoparticles: biological activity and plant biostimulant properties by Samy Selim, Amna A. Saddiq, Ruba Abdulrahman Ashy, Afra Mohammed Baghdadi, Ashwag Jaman Alzahrani, Ehab M. Mostafa, Soad K. Al Jaouni, Mohammed Yagoub Mohammed Elamir, Mohamed A. Amin, Ahmed M. Salah, Nashwa Hagagy

“…Abstract Extracts of medicinal seeds can be used to synthesize nanoparticles (NPs) in more environmentally friendly ways than physical or chemical ways. For the first time, aqueous extract from unexploited grape seeds was used in this study to create Se/ZnO NPS utilizing a green technique, and their antimicrobial activity, cytotoxicity, antioxidant activities, and plant bio stimulant properties of the economic Vicia faba L. plant were evaluated. …”
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Chromatin environment-dependent effects of DOT1L on gene expression in male germ cells by Manon Coulée, Alberto de la Iglesia, Mélina Blanco, Clara Gobé, Clémentine Lapoujade, Côme Ialy-Radio, Lucia Alvarez-Gonzalez, Guillaume Meurice, Aurora Ruiz-Herrera, Pierre Fouchet, Julie Cocquet, Laïla El Khattabi

“…Interestingly, while DOT1L appears to directly regulate the (re)activation of X genes following meiotic sex chromosome inactivation, it also controls the timely expression of (autosomal) differentiation genes during spermatogenesis.…”
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Memory B cells and their transcriptomic profiles associated with belimumab resistance in systemic lupus erythematosus in the maintenance phase by Takeshi Iwasaki, Takeshi Iwasaki, Hajime Yoshifuji, Koji Kitagori, Shuji Sumitomo, Shuji Akizuki, Ran Nakashima, Hideaki Tsuji, Ryosuke Hiwa, Mirei Shirakashi, Kosaku Murakami, Akira Onishi, Hideo Onizawa, Masao Tanaka, Fumihiko Matsuda, Akio Morinobu, Koichiro Ohmura, Koichiro Ohmura

“…Belimumab did not affect memory B cell proportion during the treatment time course, in contrast to naïve B cells. Higher memory B cell proportion was associated with higher type-I interferon (IFN) scores and lower white blood cell and complement C4 levels. …”
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The Analysis of Estrogen-Degrading and Functional Metabolism Genes in Rhodococcus equi DSSKP-R-001 by Kejian Tian, Fanxing Meng, Qi Meng, Yan Gao, Lili Zhang, Le Wang, Yuqing Wang, Xue Li, Hongliang Huo

“…In this study, the metabolic mechanisms by which Rhodococcus equi R-001 degrades various estrogens were analyzed for the first time. A new pollutant metabolism system is outlined, providing a starting point for the construction of engineered estrogen-degrading bacteria.…”
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Three local plants adapt to ecological restoration of abandoned lead-zinc mines through assembly of rhizosphere bacterial communities by Wei Gao, Shuyi Chen, Xin Yu, Sumin Chen, Caijing Wan, Ying Wang, Peng Wu, Qiang Li

“…In addition, different plants have been found to have different functions in the lead-zinc ecological restoration process, including iron complex transport system-permitting proteins and ATP binding cassettes.DiscussionThis study confirms for the first time that plants adapt to the remediation process of abandoned lead-zinc mines by non-randomly assembling rhizosphere bacterial communities and functions, providing a reference for screening microbial remediation bacterial resources and plant microbe joint bioremediation strategies for lead-zinc mines.…”
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Flexible reproductive seasonality in Africa-dwelling papionins is associated with low environmental productivity and high climatic unpredictability by Dezeure, Jules, Dagorrette, Julie, Burtschell, Lugdiwine, Chowdhury, Shahrina, Lukas, Dieter, Swedell, Larissa, Huchard, Elise

“…At a time when seasonal cycles are increasingly disrupted, the ecology and evolution of reproductive seasonality in tropical vertebrates remains poorly understood. …”
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Comparison of analytical sensitivity of automated microbiological blood culture systems by Lyamin A.V., Ismatullin D.D., Kozlov A.V., Alekseev D.V., Kayumov K.A., Bochkareva P.V., Antipov V.A.

“…In the case of obtaining a stable CFU value in the range 2–10 per 100 µl of bacterial cell suspension, 100 µl of suspension was inoculated into vials with nutrient media for each analyzer, followed by an analysis of the cultivation time, the presence or absence of a growth signal, and average CFU values. …”
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Providing medically tailored groceries and food resource coaching through the charitable food system to patients of a safety-net clinic in Dallas, Texas: a randomised controlled tr... by Michael Bowen, Sandi L Pruitt, Jaclyn Albin, Tammy Leonard, Willis Wong, Milette Siler, Carolyn Haskins, Jessica Turcios, Carla Pezzia, Alisha Ford, Bianca Schinzer, Kelseanna Hollis-Hansen

“…Analyses will include multiple regression models to analyse changes from baseline to follow-up as well as changes between groups over time. Deductive thematic analysis of qualitative data will be conducted.Ethics and dissemination This study was approved by the UT Southwestern Medical Center Institutional Review Board (STU-2023-1166) and the Parkland Health Office of Research Administration. …”
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Myocarditis in malaria—current evidence and future directions: a literature review by Gbolahan Olatunji, Emmanuel Kokori, Ikponmwosa Jude Ogieuhi, Olumide Akinmoju, Oluwatobi Omoworare, Doyin Olatunji, David Timilehin Isarinade, God-dowell O. Odukudu, Israel Charles Abraham, Samuel Owolabi, Jamil Nasrallah, Emmanuel Egbunu, Babafemi Oluwadarasimi Jaiyeoba, Ismaila Ajayi Yusuf, Olawale Olanisa, Nicholas Aderinto

“…Treatment outcomes underscore the efficacy of timely antimalarial therapy, advocating for integrated approaches to patient care. …”
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AIEgen-self-assembled nanoparticles with anti-PD-L1 antibody functionalization realize enhanced synergistic photodynamic therapy and immunotherapy against malignant melanoma by Lu Li, Qing Xu, Xiuzhen Zhang, Yuan Jiang, La Zhang, Jiao Guo, Haichuan Liu, Bin Jiang, Shenglong Li, Qiling Peng, Ning Jiang, Jianwei Wang

“…The TBP@aPD-L1-mediated PDT induces more powerful effects of direct tumor cell-killing and further elicits effective immunogenic cell death (ICD), which exerts anti-tumor immunity by activating T cells for ICI treatment and reshapes the tumor immune microenvironment (TIME), thereby enhancing the efficacy of PD-L1 blockade of anti-PD-L1. …”
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Investigation of newborn blood metabolomics in varying intrauterine growth conditions by Shengwen Wang, Xiaofei Lin, Yu Zhou, Xin Yang, Mingming Ou, Linxin Zhang, Yumei Wang, Jing Gao

“…Conclusion: Continuous monitoring of the short-term and long-term growth and metabolic status of full-term SGA and LGA newborns is warranted with individualized dietary and nutritional adjustments to promote healthy growth in a timely manner. The findings of this research contribute to the broader understanding of SGA/LGA and shall inform future research on metabolomics, interventions, and long-term outcomes.…”
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Comparative drug release kinetics of Terminalia arjuna mediated SeNPs NanoGel and ZnONPs NanoGel – An in-vitro study by R. Vijayalakshmi, N. Ambalavanan, S. Rajeshkumar, Jaideep Mahendra, Uma Sudhakar, Devi Parameswari

“…Result: The investigation revealed that SeNPs gel exhibited higher drug release percentages compared to ZnONPs gel across various concentrations and time points. The sustained release profiles of both formulations suggest effective control over drug release, maintaining therapeutic drug levels over an extended period. …”
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Early-Phase Recovery of Cardiorespiratory Measurements after Maximal Cardiopulmonary Exercise Testing in Patients with Chronic Obstructive Pulmonary Disease by Marie Bellefleur, David Debeaumont, Alain Boutry, Marie Netchitailo, Antoine Cuvelier, Jean-François Muir, Catherine Tardif, Jérémy Coquart

“…The first 3 min of recovery kinetics was investigated for oxygen uptake (V˙O2), minute ventilation (V˙E), respiratory equivalence, and HR. The time for V˙O2 to reach 25% (T1/4V˙O2) of peak value was also determined and compared. …”
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Sustainability assessment of pectin extraction from Citrus paradisi peel to support the encapsulation of lactic acid bacteria by Natalia A. Di Clemente, Enzo La Cava, Sonia Sgroppo, Andrea Gomez-Zavaglia, Esteban Gerbino

“…Green extractions have been developed to reduce conventional methods' extraction time and environmental impact. However, little is known about their actual impact. …”
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Resiquimod induces a mixed Th1 and Th2 response via STAT1 and STAT3 signalling in chickens by Deepthi Kappala, Saravanan Ramakrishnan, Patel Nikunjkumar Prakashbhai, Abinaya Kaliappan, Prasad Thomas, Jörg Linde, Mithilesh Singh, Sohini Dey, Madhan Mohan Chellappa

“…Eight key genes associated with signal transduction (MAPK14, MAP3K8, PIK3CD, STAT1, STAT3, MAPK11, LRRK2, and GATA3) were validated via real-time PCR in chicken peripheral blood mononuclear cells (PBMCs) from six biological replicates. …”
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Microwave-Assisted Extraction of Different Groups of Phenolic Compounds from Grape Skin Pomaces: Modeling and Optimization by Natka Ćurko, Karla Kelšin, Verica Dragović-Uzelac, Davor Valinger, Marina Tomašević, Karin Kovačević Ganić

“…Moreover, a significant effect of time and temperature was also noticed, except in the case of total hydroxycinnamic acids. …”
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