Mesenchymal Stem Cell-Derived Extracellular Vesicles for Regenerative Applications and Radiotherapy by Ning Wang, Feifei Ma, Huijuan Song, Ningning He, Huanteng Zhang, Jianguo Li, Qiang Liu, Chang Xu

“…Although many clinical treatments are currently available for tissue repair, they are expensive. The long recovery time and some unavoidable complications such as cell damage and the inflammatory reaction caused by radiotherapy have led to unsatisfactory results. …”
Get full text

Impact of Varying Amplitudes of Upward and Downward Motion on the Torque/Force Generation, Canal-Centering Ability, and Cyclic Fatigue Resistance of Nickel–Titanium Reciprocating I... by Keiko Hirano, Shunsuke Kimura, Keiichiro Maki, Satoshi Omori, Arata Ebihara, Takashi Okiji

“…Pecking at 3 mm led to a significantly longer time to fracture and shorter fragment lengths than 1 mm pecking (<i>p</i> < 0.05). …”
Get full text

Clonal hematopoiesis in patients with autoimmune thrombocytopenia: an international multicenter study by Bruno Fattizzo, Alfredo Marchetti, Alessandro Bosi, Carmelo Gurnari, Juri Alessandro Giannotta, Giacinto Luca Pedone, Elena Rossi, Valentina Carrai, Andrea Guido, Filippo Brioschi, Monica Carpenedo, Monica Crugnola, Domenica Caramazza, Livia Leuzzi, Monia Marchetti, Gabriele Merati, Simona Malato, Fabrizio Vianello, Andrea Patriarca, Hussein Awada, Marta Bortolotti, Marta Canzi, Niccolò Bolli, Marco Capecchi, Frederick Chen, Andrea Artoni, Jaroslaw P. Maciejewski, Wilma Barcellini

“…Mutated patients were more frequently older males and showed a shorter time from first to second-line therapy, particularly with thrombopoietin receptor agonist (TPO-RA). …”
Get full text

Unraveling the interplay between NDVI, soil moisture, and snowmelt: A comprehensive analysis of the Tibetan Plateau agroecosystem by Di Wei, Lin Yan, Ziqi Zhang, Jia Yu, Xue’er Luo, Yun Zhang, Bo Wang

“…NDVI and soil moisture exhibit mostly instantaneous responses, with a brief one-month time-lag effect, while NDVI demonstrates a more pronounced lagged response to snowmelt. …”
Get full text

Efficacy of soft palatal augmentation prosthesis for oral functional rehabilitation in patients with dysarthria and dysphagia: a protocol for a randomised controlled trial by Naoki Kodama, Tomonori Yokoyama, Takao Mukai, Kana Takao, Takashi Hiraoka, Nobuyuki Arai, Jitsuro Yano, Hiroaki Nagatsuka, Yousuke Manda, Kozo Hanayama, Shogo Minagi

“…Primary outcomes are the single-word intelligibility test score and pharyngeal transit time (PTT). Secondary outcomes are tongue function (evaluated based on maximum tongue pressure, repetitions of tongue pressure and endurance of tongue pressure), articulation function (evaluated based on speech intelligibility, oral diadochokinesis, Voice-Related Quality of Life (V-RQOL)) and swallowing function (evaluated using Eating Assessment Tool-10). …”
Get full text

MHD effect on peristaltic motion of Williamson fluid via porous channel with suction and injection by K. Chakradhar, K. Nandagopal, Vishnudasu Prashanthi, A. Parandhama, T. Somaiah, B.V. Sai Thrinath, Nainaru Tarakaramu, Ghulam Rasool, Dilsora Abduvalieva

“…The findings indicate that increasing the suction and injection parameters enhances volumetric flow rates, while the relationship between pressure rise and time-averaged volumetric flow rate is also explored. …”
Get full text

Prognostic Impact of miR-224 and RAS Mutations in Medullary Thyroid Carcinoma by Elisabetta Cavedon, Susi Barollo, Loris Bertazza, Gianmaria Pennelli, Francesca Galuppini, Sara Watutantrige-Fernando, Simona Censi, Maurizio Iacobone, Clara Benna, Federica Vianello, Stefania Zovato, Davide Nacamulli, Caterina Mian

“…In this group, REarranged during transfection (RET) and rat sarcoma (RAS) mutation status were assessed by direct sequencing in the tumor tissues. Quantitative real-time polymerase chain reaction was used to quantify mature hsa-miR-224 in tumor tissue. …”
Get full text

Improving dexamethasone drug loading and efficacy in treating rheumatoid arthritis via liposome: Focusing on inflammation and molecular mechanisms by Mohammad Yasin Zamanian, Hamidreza Zafari, Maria K. Osminina, Alla A. Skakodub, Raed Fanoukh Aboqader Al‐Aouadi, Maryam Golmohammadi, Nikta Nikbakht, Iman Fatemi

“…The liposomal formulation also shows better hemocompatibility, fewer adverse effects on body weight and immune organ index, and a longer circulation time with higher bioavailability. The anti‐inflammatory mechanism is associated with the downregulation of pro‐inflammatory cytokines like tumor necrosis factor‐α (TNF‐α) and B‐cell–activating factor (BAFF), which are key players in the pathogenesis of RA. …”
Get full text

Original Personalized Reconstruction Method for Certain Large Tumors of the Lower Lip (Not Including Oral Commissures) by Ovidiu Dan Grigorescu, Marius Irimie, Nadinne Roman, Roxana Steliana Miclaus, Maria-Cristina Cîmpeanu, Bogdan-Radu Necula, Christian-Gabriel Strempel, Simona Grigorescu, Marius Alexandru Moga, Dana Gabriela Festila

“…<i>Background/Objective</i>: Surgical treatment of extensive tumors of the lower lip generates important defects in its structure and functions. Over time, a multitude of reconstruction options for these defects have been imagined. …”
Get full text

A practical guide to FAIR data management in the age of multi-OMICS and AI by Douaa Mugahid, Jared Lyon, Charlie Demurjian, Nathan Eolin, Charlie Whittaker, Mark Godek, Douglas Lauffenburger, Sarah Fortune, Stuart Levine

“…However, these ambitious efforts are often limited by access to a variety of high-density intra-, extra- and multi-cellular measurements resolved in time and space and across a variety of perturbations. …”
Get full text

Oral nutritional supplements for gastric cancer – the review of current evidence by A. L. Potapov, V. E. Khoronenko, E. V. Gameeva, Zh. V. Khailova, A. D. Dorozhkin, V. Yu. Scoropad

“…After gastrectomy (GE) its administration reduces the time of recovery of bowel motor function and the duration of hospitalization. …”
Get full text

Empirical evidence for a process-based model of health-related quality of life using network analysis by Nicolette Stogios, Nicolette Stogios, Troy Francis, Troy Francis, Rachel G. Peiris, Aleksandra Stanimirovic, Aleksandra Stanimirovic, Valeria Rac, Valeria Rac, Robert P. Nolan, Robert P. Nolan

“…While contemporary assessments are structured to evaluate an individual's HRQL state, we propose a complementary process-based model, which is defined as an appraisal that evolves over time as it reflects and informs a self-regulatory process of adapting to dynamic changes in bio-psycho-social life domains. …”
Get full text

Prediction model, risk factor score and ventilator-associated pneumonia: A two-stage case-control study by Hua Meng, Yuxin Shi, Kaming Xue, Di Liu, Xiongjing Cao, Yanyan Wu, Yunzhou Fan, Fang Gao, Ming Zhu, Lijuan Xiong

“…Results: LASSO, RF and XGBoost consistently revealed significant associations of length of stay before MV, MV time, surgery, tracheotomy, multiple drug resistant organism infection, C-reactive protein, PaO2, and APACHE II score with VAP. …”
Get full text

Multimodal fusion model for diagnosing mild cognitive impairment in unilateral middle cerebral artery steno-occlusive disease by Ziyi Yuan, Zhaodi Huang, Chaojun Li, Shengrong Li, Qingguo Ren, Xiaona Xia, Qingjun Jiang, Daoqiang Zhang, Qi Zhu, Xiangshui Meng, Xiangshui Meng

“…Efficient automated diagnosis facilitates the early and accurate detection of MCI and timely intervention and treatment to delay or prevent disease progression.…”
Get full text

Ddx21 mutant peptide is an effective neoantigen in prophylactic lung cancer vaccines and activates long-term anti-tumor immunity by Zhe Zhang, Yimeng Xia, Yimeng Xia, Zhihong Wang, Yaxing Sun, Dan Pu, Yijia He, Ruixian Liu, Yanru Zhang, Yan Liu, Junzhi Yu, Shiyang Ning, Baisui Feng, Yaohe Wang, Na Wang

“…While the vaccine based on KPL 160424S, derived from advanced-stage murine lung cancer tissues, failed to extend survival time and demonstrated limited capacity to stimulate anti-tumor immunity. …”
Get full text

Modeling automatic horizontation system of steep-sloping mobile machine with hydraulic sensor roll by V. I. Grishchenko, A. A. Tumakov, M. S. Poleshkin, M. S. Kilina, D. D. Dymochkin

“…Using the developed mathematical and computer models will reduce the time and cost involved in designing mobile equipment leveling systems, developing prototypes and commissioning.…”
Get full text

Investigating the impact of acceptance and commitment therapy for mental healthcare professionals: the effect on patients´ self-stigmatization, a pilot study by Kim L. Helmus, Kim L. Helmus, Kim L. Helmus, Marilon van Doorn, Marilon van Doorn, Mariken B. de Koning, Mariken B. de Koning, Mariken B. de Koning, Inez Myin-Germeys, Frederike N. Schirmbeck, Frederike N. Schirmbeck, Therese A. M. J. van Amelsvoort, Dorien H. Nieman, Dorien H. Nieman, Monique W. M. Jaspers, Monique W. M. Jaspers, Arne Popma, Arne Popma, Lieuwe de Haan, Lieuwe de Haan

“…As the primary outcome, patients’ awareness, agreement, application and hurt-self, was measured using the Self Stigma of Mental Illness Scale - Short Form (SSMIS-SF), before and after the MHCPs’ ACT-based training.ResultsSignificant group x time interaction effects were found for ‘application’ (internalization of mental illness stereotypes) in patients after the ACT-based training of their MHCP: F (1,39) = 9.33, p &lt; 0.01, ηp2 = .85. …”
Get full text

Factors Associated With Missing Biological Samples in the Dog Aging Project by Sydney N. Holland, Amanda K. Tinkle, Jena N. Prescott, Brianna L. Blattman, Robyn L. McClelland, Yunbi Nam, Dog Aging Project Consortium, Kate E. Creevy, Virginia R. Fajt

“…No statistically significant difference in missingness was seen across regions, ease of blood collection, or cooperativeness of dog during sample collection. Higher time‐to‐receipt was associated with a higher missingness proportion. …”
Get full text

Mammalian mitochondrial inorganic polyphosphate (polyP) and cell signaling: Crosstalk between polyP and the activity of AMPK by Renata T. Da Costa, Anna Nichenko, Matheus M. Perez, Malgorzata Tokarska-Schlattner, Sheida Kavehmoghaddam, Vedangi Hambardikar, Ernest R. Scoma, Erin L. Seifert, Uwe Schlattner, Joshua C. Drake, Maria E. Solesio

“…Results: Our findings demonstrate for the first time the intimate crosstalk between the levels of polyP and the activation status of the AMPK signaling pathway, via a mechanism involving free phosphate homeostasis. …”
Get full text

Branched-chain fatty acids from goat milk alleviate ulcerative colitis via the TLR4/NF-κB/NLRP3 pathway by Jiaxin Zhang, Jinjing Zhong, Zhengying Cui, Yu Shen, Yaping Zheng, Yu Zhang, Chaoxin Man, Yanmei Hou, Qianyu Zhao, Yujun Jiang

“…These data also show that BCFAs can down-regulate the gene and protein expression of the toll-like receptor 4 (TLR4)/ nuclear factor κB p65 (NF-κB p65)/NOD-like receptor thermal protein domain associated protein 3 (NLRP3) signaling pathway, and at the same time significantly reduce the expression of pro-inflammatory factors tumor necrosis factor α (TNF-α), interleukin 1β (IL-1β), and IL-18 in colon tissue, and significantly increase the expression of the anti-inflammatory factor IL-10. …”
Get full text