Protocol for a systematic review and individual participant data meta-analysis for risk factors for lung cancer in individuals with lung nodules identified by low-dose CT screening by Matthew Callister, Harry J de Koning, Robert C Rintoul, Carolyn Horst, Arjun Nair, John K Field, Christine D Berg, Samantha Quaife, Rhian Gabe, Stephen Duffy, Sam Janes, Philip AJ Crosbie, Mark M Hammer, Panos Alexandris, Michael PA Davies

“…Therefore, there is a need to identify individuals who need no interval CT between screening rounds.Methods and analysis The aim of this study is to identify risk factors predictive of LC, which are known at the time of the scan, in patients with LDCT screen-detected lung nodules. …”
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Cost-effectiveness of metacognitive therapy for cardiac rehabilitation participants with symptoms of anxiety and/or depression: analysis of a randomised controlled trial by David Reeves, Calvin Heal, Patrick Joseph Doherty, Gemma E Shields, Adrian Wells, Lora Capobianco, Anthony Heagerty, Deborah Buck, Linda M Davies, Elizabeth Camacho

“…The primary outcome of the cost-effectiveness analysis was quality-adjusted life-years (QALYs). The time horizon of the primary analysis was a 12-month follow-up. …”
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Making stereopsis related to the ability of ocular deviation: a new paradigm for assessment of intermittent exotropia by Jian-Bing Li, Wan-Ting Kong, Tao Shen, Yong-Guang Yuan, Chong-Lin Chen, Dan-Min Peng, Min-Tong Liang, Xuan He, Dan Luo, Jia-Yi Su, Wei Wang, Rui-Xin Wang, Xin-Ping Yu

“…Recording with a smartphone, we captured videos to analyze the accurate time of spontaneous exodeviation and subsequent realignment before and after breaking fusion. …”
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Active Moss Biomonitoring of Mercury in the Mine-Polluted Area of Abbadia San Salvatore (Mt. Amiata, Central Italy) by Federica Meloni, Sergio Calabrese, Orlando Vaselli, Francesco Capecchiacci, Francesco Ciani, Lorenzo Brusca, Sergio Bellomo, Walter D’Alessandro, Kyriaki Daskalopoulou, Stefania Venturi, Barbara Nisi, Daniele Rappuoli, Franco Tassi, Jacopo Cabassi

“…Active biomonitoring of mercury (Hg) using non-indigenous moss bags was performed for the first time within and around the former Hg mining area of Abbadia San Salvatore (Mt. …”
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The maternal and newborn health eCohort to track longitudinal care quality: study protocol and survey development by Catherine Arsenault, Katherine Wright, Tefera Taddele, Ashenif Tadele, Anagaw Derseh Mebratie, Firew Tiruneh Tiyare, Rose J. Kosgei, Jacinta Nzinga, Bethany Holt, Irene Mugenya, Emma Clarke-Deelder, Adiam Nega, Dorairaj Prabhakaran, Sailesh Mohan, Nompumelelo Gloria Mfeka-Nkabinde, Londiwe Mthethwa, Damen Haile Mariam, Gebeyaw Molla, Theodros Getachew, Prashant Jarhyan, Monica Chaudhry, Munir Kassa, Margaret E. Kruk

“…The final MNH eCohort instrument is centered around six key domains of high-quality health systems including competent care (content of ANC, delivery, and postnatal care for the mother and newborn), competent systems (prevention and detection, timely care, continuity, integration), user experience, health outcomes, confidence in the health system, and economic outcomes. …”
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Bilateral prophylactic mastectomy: should we preserve the pectoral fascia? Protocol of a Dutch double blinded, prospective, randomised controlled pilot study with a within-subject... by Cornelis Verhoef, Linetta B Koppert, Marloes E Clarijs, Laurentine S E van Egdom, Dalibor Vasilic, T. van Dalen, C. de Betue, J. Rothbarth, E.V.E. Madsen, L.M. Beelen, M.A.M. Mureau, E.M.L. Corten, A.J.M. Luijsterburg, M.J. Hop, H.M. Zuijdendorp, N.A.S. Posch, C.M.C.A. van Laarhoven, M. de Kraker

“…Secondary study outcomes include time to drain removal, number of needle aspirations, postoperative complications and length of hospital stay.Ethics and dissemination The study is approved by the Erasmus Medical Center Review Board (REC 2020–0431). …”
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Bleeding control of an injury to the infrarenal inferior vena cava and right external iliac vein by ipsilateral internal iliac artery and superficial femoral vein ligation after bl... by Hoonsung Park, Maru Kim, Dae-Sang Lee, Tae Hwa Hong, Doo-Hun Kim, Hangjoo Cho

“…A second-look operation was performed 2 days later, by which time most of the bleeding sites had ceased. Orthopedic surgeons then took over the operation, performing closed reduction and external fixation. …”
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Revealing intra- and inter-container fruit quality heterogeneity within overseas refrigerated container shipments using a physics-based digital twin by Celine Verreydt, Tarl Berry, Leo Lukasse, Deniz Turan, Paul Cronje, Thijs Defraeye

“…Overall, the digital twin serves as a first step towards real-time quality monitoring within fresh fruit supply chains.…”
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Integration of ground-based and remote sensing data with deep learning algorithms for mapping habitats in Natura 2000 protected oak forests by Lucia Čahojová, Ivan Jarolímek, Barbora Klímová, Michal Kollár, Michaela Michalková, Karol Mikula, Aneta A. Ožvat, Denisa Slabejová, Mária Šibíková

“…The study also seeks to evaluate the accuracy of this approach, specifically in oak-dominated forests, as well as identify the optimal time period within a year for effective habitat identification.Using the specialised software NaturaSat, automated segmentations were performed based on the coordinates of phytosociological relevés and forest strands defined in database. …”
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Exploring changes in metabolites and fecal microbiota of advanced gastric cancer based on plasma metabolomics and 16S rDNA sequencing by Xinyi Feng, Yu Zhang, Jun Feng, Zhongjun Li, Zhi Zhang, Lin Zhu, Ruoyu Zhou, Haibo Wang, Xiaojun Dai, Yanqing Liu

“…Conclusion: For the first time, we comprehensively used plasma metabolomics and 16S rDNA sequencing to reveal the changes and correlations between metabolites and intestinal microbiota in advanced gastric cancer. …”
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Age-Stage, Two-Sex Life Table of <i>Leptinotarsa decemlineata</i> (Coleoptera: Chrysomelidae) Experiencing Cadmium Stress by Bingyu He, Jiebo Zhang, Yang Hu, Yi Zhang, Jianan Wang, Chao Li

“…Key population parameters, including the innate rate of increase (r), finite rate of increase (λ), net reproductive rate (R₀), and gross reproduction rate (GRR), were evidently lower in cadmium-exposed <i>L. decemlineata</i>, while the average generation time did not show a significant difference. 3. Cadmium exposure also resulted in a remarkable reduction in survival and reproductive rates at specific life stages, along with an increase in the incidence of deformations in newly emerged adults. …”
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Rapid Screening for Cognitive Impairment in Parkinson’s Disease: A Pilot Study by YanHong Dong, Way Inn Koay, Leonard Leong Litt Yeo, Christopher Li-Hsian Chen, Jing Xu, Raymond Chee Seong Seet, Erle Chuen Hian Lim

“…The NINDS-CSN 5-minute protocol is time expeditious while remaining statistically equivalent to MoCA and superior to MMSE and therefore is suitable for rapid cognitive screening of CI in PD patients.…”
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Regulation of IL-33 by Oncostatin M in Mouse Lung Epithelial Cells by Carl D. Richards, Laura Izakelian, Anisha Dubey, Grace Zhang, Steven Wong, Karen Kwofie, Aatif Qureshi, Fernando Botelho

“…Oncostatin M stimulated IL-33 mRNA and IL-33 full length protein in C10 mouse type 2 alveolar epithelial cells in culture in time-dependent and dose-dependent fashion, whereas IL-6, LIF, IL-31, IL-4, or IL-13 did not, and TGFβ repressed IL-33. …”
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Inhibition of Corneal Neovascularization by Subconjunctival Injection of Fc-Endostatin, a Novel Inhibitor of Angiogenesis by Junko Yoshida, Robert T. Wicks, Andrea I. Zambrano, Betty M. Tyler, Kashi Javaherian, Rachel Grossman, Yassine J. Daoud, Peter Gehlbach, Henry Brem, Walter J. Stark

“…Corneas were digitally imaged at 5 time points. An angiogenesis index (AI) was calculated (vessel length (mm) × vessel number score) for each observation. …”
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Multi-channel spatio-temporal graph attention contrastive network for brain disease diagnosis by Chaojun Li, Kai Ma, Shengrong Li, Xiangshui Meng, Ran Wang, Daoqiang Zhang, Qi Zhu

“…Second, we develop a multi-channel spatial attention contrastive network to extract topological features from the brain network within each time window. This network incorporates an intra-window graph contrastive constraint to enhance the discriminative ability of the extracted features. …”
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Clinical Features and Dynamics of T Cells-Related Markers in Immunocompetent Patients with Cytomegalovirus Hepatitis by Takuya Komura, Takashi Kagaya, Hideo Takayama, Masahiro Yanagi, Takatoshi Yoshio, Saiho Sugimoto, Michiko Nishino, Noriaki Orita, Yoshiro Asahina, Masashi Nishikawa, Shuichi Kaneko, Masashi Unoura

“…All patients had a good clinical course without liver failure or transition to chronic liver injury. The time to recover from liver injury ranged from 12 to 142 days (mean, 43.4 ± 28.7 days). …”
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Targeting transforming growth factor-β1 by methylseleninic acid/seleno-L-methionine in clear cell renal cell carcinoma: Mechanisms and therapeutic potential by Aseel O. Rataan, Yan Xu, Sean M. Geary, Yousef Zakharia, Eman S. Kamel, Youcef M. Rustum, Aliasger K. Salem

“…MSA treatment significantly downregulated TGF-β1, PD-L1, and VEGF in a dose- and time-dependent manner in both non-sarcomatoid and sarcomatoid ccRCC cell lines. …”
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Adsorptive Removal of Copper by Using Surfactant Modified Laterite Soil by Tien Duc Pham, Hoang Hiep Nguyen, Ngoc Viet Nguyen, Thanh Tu Vu, Thi Ngoc Mai Pham, Thi Hai Yen Doan, Manh Ha Nguyen, Thi Mai Viet Ngo

“…The optimum conditions for removal of Cu2+ by adsorption using SML were systematically studied and found as pH 6, contact time 90 min, adsorbent dosage 5 mg/mL, and ionic strength 10 mM NaCl. …”
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Physically Meaningful Surrogate Data for COPD by Harry J. Davies, Ghena Hammour, Hongjian Xiao, Patrik Bachtiger, Alexander Larionov, Philip L. Molyneaux, Nicholas S. Peters, Danilo P. Mandic

“…Deep learning techniques are &#x201C;data hungry&#x201D; whilst patient-based data is invariably expensive and time consuming to record. To this end, we introduce a novel COPD-simulator, a physical apparatus with an easy to replicate design which enables rapid and effective generation of a wide range of COPD-like data from healthy subjects, for enhanced training of deep learning frameworks. …”
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miR-34a Regulates Multidrug Resistance via Positively Modulating OAZ2 Signaling in Colon Cancer Cells by Yong Li, Ping Gong, Ji-xue Hou, Wei Huang, Xiao-ping Ma, Yu-li Wang, Jing Li, Xiao-bin Cui, Na Li

“…Here, we report for the first time that miR-34a expression was significantly downregulated in clinical CCa samples from oxaliplatin-resistant patients and in experimentally established multidrug-resistant CCa cells. …”
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