Membrane-targeted push-pull azobenzenes for the optical modulation of membrane potential by Valentina Sesti, Arianna Magni, Matteo Moschetta, Chiara Florindi, Marlene E. Pfeffer, Mattia Lorenzo DiFrancesco, Michele Guizzardi, Giulia Folpini, Luca Sala, Alessandra Gilda Ritacca, Beatrice Campanelli, Paola Moretti, Giuseppe Maria Paternò, Luca Maragliano, Matteo Tommasini, Francesco Lodola, Elisabetta Colombo, Fabio Benfenati, Chiara Bertarelli, Guglielmo Lanzani

“…The most promising species, MTP2, was extensively studied. Time-resolved spectroscopy techniques provide insights into the excited state evolution and a complete understanding of its isomerization reaction. …”
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Evaluation of the intracellular lipid-lowering effect of polyphenols extract from highland barley in HepG2 cells by Yijun Yao, Zhifang Li, Bowen Qin, Xingrong Ju, Lifeng Wang

“…We also preliminary studied the lipid-lowering mechanism by Real-time fluorescent quantitative polymerase chain reaction (qPCR). …”
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Hearing loss prevalence and burden of disease in China: Findings from provincial-level analysis by Yu Wang, Yang Xie, Minghao Wang, Mengdan Zhao, Rui Gong, Ying Xin, Jia Ke, Ke Zhang, Shaoxing Zhang, Chen Du, Qingchuan Duan, Fang Wang, Tao Pan, Furong Ma, Xiangyang Hu, Jing Ni

“…Background:. Without timely and effective rehabilitation, hearing loss may profoundly affect human life quality. …”
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Intraparenchymal Neural Stem/Progenitor Cell Transplantation for Ischemic Stroke Animals: A Meta-Analysis and Systematic Review by Hailong Huang, Kun Qian, Xiaohua Han, Xin Li, Yifeng Zheng, Zhishui Chen, Xiaolin Huang, Hong Chen

“…With further analysis, it was found that the administration time poststroke, NSPC donor species, and transplantation immunogenicity had close correlations with the degree of infarct volume reduction. …”
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Microneedle technology for enhanced topical treatment of skin infections by Tingting Peng, Yangyan Chen, Xuanyu Luan, Wanshan Hu, Wentao Wu, Bing Guo, Chao Lu, Chuanbin Wu, Xin Pan

“…Also, integrating biosensing functionality to MNs offers point-of-care wearable medical devices for analyzing specific pathogens, disease status, and drug pharmacokinetics, thus providing personalized therapy for skin infections. Herein, we do a timely update on the development of MN technology in skin infection management, with a special focus on how to devise MNs for personalized antimicrobial therapy. …”
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Identification of MYC and STAT3 for early diagnosis based on the long noncoding RNA-mRNA network and bioinformatics in colorectal cancer by Kunhou Yao, Hao Fan, Tiancheng Yang, Can Yang, Guibin Wang, Xingwang Li, Xin-Ying Ji, Qun Wang, Shaojiang Lv, Shihao Guo

“…Differential expression between normal and CRC tissues was assessed, followed by Receiver Operating Characteristic (ROC) analysis to evaluate the diagnostic potential of these markers. Quantitative Real-Time PCR (qRT-PCR) was performed to validate MYC and STAT3 expression levels, and findings were further confirmed using the Human Protein Atlas (HPA) database.ResultsDatabase analysis revealed significant differential expression of MYC and STAT3 between normal and CRC tissues. …”
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Feruloyl-amides as natural antimicrobials for crop and food protection by Denise Dozio, Sharmila Ghosh, Daniele Alessandro Consolini, Josè Luis Ermini Starna, Loris Pinto, Federico Baruzzi, Martina Letizia Contente, Andrea Pinto, Paolo Cortesi, Salvatore Princiotto, Andrea Kunova, Sabrina Dallavalle

“…Monitoring of six growth parameters (taking into account growth rate, time and absorbance) measured during 24 h incubation showed that the synthesized molecules, assayed at four concentrations between 12.5 and 100 mg/L, produced a stronger average antimicrobial effect against Gram-positive pathogenic strains than against Gram-negative ones. …”
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Policy relevant crop diversity monitoring based on earth observation and farmers’ declarations by Marijn van der Velde, Martin Claverie, Raphaël d’Andrimont, Melissande Machefer, Simona Bosco, Rui Catarino, Frank Dentener, Vincenzo Angilieri

“…Furthermore, we track changes in crop diversity over time using the Dutch farmers’ declarations from 2009 to 2021, which suggest a positive response to the 2014 CAP greening policy. …”
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Effect of infill pattern on mechanical properties of 3D printed PLA-Zn composites for drone frame structures: A topology optimization integrated application study by P. Arunkumar, D. Balaji, N. Radhika, L. Rajeshkumar, Sanjay Mavinkere Rangappa, Suchart Siengchin

“…The drone frame was also tested in real time for its mechanical strength. The topologically optimized 3D-printed drone frame with a cubic infill pattern can be used as a low-cost replacement for the currently used conventional frame.…”
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ICOS Potenza (Italy) Atmospheric Station: A New Spot for the Observation of Greenhouse Gases in the Mediterranean Basin by Emilio Lapenna, Antonella Buono, Alessandro Mauceri, Isabella Zaccardo, Francesco Cardellicchio, Francesco D’Amico, Teresa Laurita, Davide Amodio, Canio Colangelo, Gianluca Di Fiore, Antonella Gorga, Ermann Ripepi, Francesco De Benedictis, Silvana Pirelli, Liborio Capozzo, Vincenzo Lapenna, Gelsomina Pappalardo, Serena Trippetta, Lucia Mona

“…Preliminary data collected during a short campaign are compared with STILT (Stochastic Time-Inverted Lagrangian Transport) model results as a first test of the measurements and to provide a first insight of the specific Potenza situation in terms of GHG concentrations.…”
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Secondary Circulating Prostate Cells Predict Biochemical Failure in Prostate Cancer Patients after Radical Prostatectomy and without Evidence of Disease by Nigel P. Murray, Eduardo Reyes, Nelson Orellana, Cynthia Fuentealba, Leonardo Bádinez, Ruben Olivares, José Porcell, Ricardo Dueñas

“…Results. 114 men participated, and secondary CPCs were detected more frequently in patients with positive margins, extracapsular extension, and vascular and lymphatic infiltration and were associated with biochemical failure independent of these clinicopathological variables, and with a shorter time to BF. Conclusions. Secondary CPCs are an independent risk factor associated with increased BF in men with a PSA <0.2 ng/mL after radical prostatectomy, but do not determine if the recurrence is due to local or systemic disease. …”
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An Evaluation of the Responsiveness and Discriminant Validity of Shoulder Questionnaires among Patients Receiving Surgical Correction of Shoulder Instability by Kyle A. R. Kemp, David M. Sheps, Lauren A. Beaupre, Fiona Styles-Tripp, Charlene Luciak-Corea, Robert Balyk

“…Health-related quality-of-life (HRQL) measures must detect clinically important changes over time and between different patient subgroups. Forty-three patients (32 M, 13 F; mean age  =  26.00  ±  8.19 years) undergoing arthroscopic Bankart repair completed three validated shoulder questionnaires (Western Ontario Shoulder Instability index (WOSI), American Shoulder and Elbow Surgeons Standardized Shoulder Assessment form (ASES), Constant score) preoperatively, and at 6, 12, and 24 months postoperatively. …”
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Poor efficacy of the combination of clarithromycin, amikacin, and cefoxitin against Mycobacterium abscessus in the hollow fiber infection model by Etienne Vignaud, Sylvain Goutelle, Charlotte Genestet, Jérôme Guitton, Sabine Cohen, Chloé Bourg, Aurore Durand, Laura Lebouteiller, Albin Bernard, Caroline Richet, Oana Dumitrescu, Elisabeth Hodille

“…Moreover, increasing clarithromycin concentrations stabilized the amikacin-tolerance level: amikacin minimal inhibitory concentration of amikacin-tolerant strains increased over time using blood concentrations while it remained stable using lung concentrations. …”
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Spatial analysis of teen births near the New Bedford Harbor Superfund site by Nicole V DeVille, Carolina Villanueva, Susan A Korrick, Verónica M Vieira

“…We examined associations between teen births (age < 20 years) from 1993–2009 and maternal residence at time of birth among mothers living in towns adjacent to the NBH Superfund site. …”
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Long-term Breast Shape Analysis After Short-scar Reduction Mammaplasty: A Critical View by Daniel Hilewitz, MD, Oren Ganor, MD, Neta Adler, MD, Asaf Olshinka, MD, Dafna Shilo Yaacobi, MD, Lior Har-Shai, MD, Tamir Shay, MD, Michael Icekson, MD, Dean Ad-El, MD, Sagit Meshulam-Derazon, MD

“…The mean sternal notch-to-nipple and upper breast-to-nipple distances decreased postoperatively by 22% and 43%, respectively, and remained stable over a mean time of 110.1 ± 65.58 weeks. The nipple-to-inframammary fold distance, which was intraoperatively shortened by an average of 63%, elongated back to 88% of its preoperative measurements. …”
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Cost-effectiveness of the addition of sintilimab as a first-line therapy for locally advanced or metastatic oesophageal squamous cell carcinoma: a Chinese healthcare system perspec... by Cuicui Yu, Yingqi Wu, Yadi Geng, Hui Yan, Pengli Zhu, Peng Ji, Fei Wu, Lijuan Ning, Yubin Feng, Aizong Shen

“…Conclusions In patients with locally advanced or metastatic OSCC, sintilimab chemotherapy could improve survival time and health benefits compared with traditional chemotherapy, but the present analysis suggests that sintilimab is not a cost-effective treatment option in China.…”
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LOW POWER BRACHYTHERAPY IN COMBINED TREATMENT IN PATIENTS WITH INTERMEDIATE RISK OF LOCALIZED PROST ATE CANCER by V. A. Biryukov, O. B. Karyakin, O. V. Morov, O. G. Lepilina, D. V. Neledov, D. B. Sanin, G. N. Grishin, M. S. Kalinina

“…PSA relapse-free survival in the group of brachytherapy and hormone treatment at the time of observation 5 years amounted to 97.1%. In the group of combined radiation therapy with brachytherapy, and hormonal treatment PSA relapse-free survival rate was 95.5%.In both groups, relapse-free survival was noted in 96,8% of cases. …”
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Unveiling cellular changes in leukaemia cell lines after cannabidiol treatment through lipidomics by David Chamoso-Sanchez, Martina Panini, Clarissa Caroli, Matilde Marani, Lorenzo Corsi, Francisco J Rupérez, Antonia Garcia, Federica Pellati

“…CBD treatment reduced cell viability and initiated apoptotic and necrotic processes in both cancer cell lines in a time and dose-dependent manner, showing acute myeloid leukaemia (HL-60) cells greater sensitivity than chronic myeloid leukaemia ones (K-562), without differences in the activation of caspases 3/7. …”
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Deep-learning based electromagnetic navigation system for transthoracic percutaneous puncture of small pulmonary nodules by Muyun Peng, Xinyi Fan, Qikang Hu, Xilong Mei, Bin Wang, Zeyu Wu, Huali Hu, Lei Tang, Xinhang Hu, Yanyi Yang, Chunxia Qin, Huajie Zhang, Qun Liu, Xiaofeng Chen, Fenglei Yu

“…In the animal study, DL-EMNS significantly improved technical success rate (100% vs. 84.0%, p = 0.015), reduced operation time (121.36 ± 38.87 s vs. 321.60 ± 129.12 s, p < 0.001), number of CT acquisitions (1.09 ± 0.29 vs. 2.96 ± 0.73, p < 0.001) and complication rate (0% vs. 20%, p = 0.002). …”
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Modeling of drying kinetics and chemical analysis for optimal preservation of pitahaya, aguaymanto and pineapple fruits using a parabolic solar dehydrator in the Amazon region - Pe... by Merbelita Yalta Chappa, Wildor Gosgot Angeles, Luz Quispe-Sanchez, Diana Carina Mori Servan, Homar Santillan Gomez, Manuel Oliva-Cruz, Miguel Ángel Barrena Gurbillón

“…In the chemical analysis evaluation, it was evident that as time went by, the pH increased and the titratable acidity decreased; the fruit with the highest pH when reaching its optimum dehydration point was the pitahaya (5.98); it also indicated the lowest titratable acidity (0.0010 %). …”
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