Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics by Krutika Patidar, Nikhil Pillai, Saroj Dhakal, Lindsay B. Avery, Panteleimon D. Mavroudis

“…By unraveling new design rules for antibody drug properties that are dependent on ML-based TO assessment, we deliver a first-in-class ML-based target pharmacology assessment framework toward better understanding of the biology-specific PK and ADME processes of antibody drug candidate proteins and reduce the overall time for drug development.…”
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Durable resistance or efficient disease control? Adult Plant Resistance (APR) at the heart of the dilemma by Rimbaud, Loup, Papaïx, Julien, Rey, Jean-François, Moury, Benoît, Barrett, Luke G., Thrall, Peter H.

“…Using the demogenetic, spatially explicit, temporal, stochastic model landsepi, this study is a first attempt to investigate how resistance efficiency, age at the time of resistance activation and target pathogenicity trait jointly impact resistance durability and disease control at the landscape scale. …”
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An explainable deep learning model for diabetic foot ulcer classification using swin transformer and efficient multi-scale attention-driven network by R. Karthik, Armaano Ajay, Anshika Jhalani, Kruthik Ballari, Suganthi K

“…To address this challenge, Deep Learning (DL) methods offer an efficient and automated approach to facilitate timely treatment and improve patient outcomes. This research proposes a novel feature fusion-based model that incorporates two parallel tracks for efficient feature extraction. …”
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Impact of Out-of-pocket Costs on Varenicline Utilization and Persistence by Aaron Galaznik, Katherine Cappell, Leslie Montejano, Geoffrey Makinson, Kelly H. Zou, Gregory Lenhart

“…Generalized linear models and time-to-event analyses were conducted. **Results:** There were 142,251, 458,966 and 222,241 individuals in the low, medium and high out-of-pocket cohorts, respectively. …”
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Effect of chikungunya, Mayaro and Una virus coinfection on vector competence of Aedes aegypti mosquitoes by Tessa M. Visser, Haidong D. Wang, Sandra R. Abbo, Chantal B.F. Vogels, Constantianus J.M. Koenraadt, Gorben P. Pijlman

“…Additionally, we show for the first time that Ae. aegypti is a competent vector for UNAV, and that dual infections do not influence vector competence. …”
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Microsimulation models on child and adolescent health: a scoping review protocol by Filipa Sampaio, Claire de Oliveira

“…We will search PubMed (until 23 September 2024), Embase (until 18 September 2024), CINAHL (until 9 September 2024), PsyclNFO (11 September 2024), EconLit (until 9 September 2024) and Scopus (until 10 September 2024), with an update closer to the time of manuscript submission. We will also undertake snowballing, Google searches and searches on specific journal (eg, International Journal of Microsimulation) and websites (eg, https://www.microsimulation.ac.uk/) to complement database searches. …”
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The effect of feeding methods and non-nutritive sucking habits on early childhood caries and development of occlusion (A cross-sectional study) by Huda R. Awsi, Bayan A. Hassan

“… Background and objectives: Early Childhood Caries (ECC ) is the most common chronic disease conditioning childhood and involves the presence of one or more decayed (noncavitated or cavitated lesions),missing(due to caries), or filled tooth surfaces in children under 72 months of age.Time and frequency of breast-feeding, artificial feeding and of non-nutritive sucking habits can influence orofacial development, and when negative can provoke instability of orofacial function. …”
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Identification of cuproptosis and ferroptosis-related subtypes and development of a prognostic signature in colon cancer. by Yinghao He, Fuqiang Liu, Qingshu Li, Zheng Jiang

“…Finally, we analyzed differential expression of model-related genes between tumor tissues and normal tissues, validated through real-time quantitative PCR and immunohistochemistry. In summary, our study provides a relatively accurate prognostic tool for colon cancer patients, offering guidance for treatment selection and indicating the potential of immunotherapy in colon cancer.…”
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Medial sural artery perforator free flap for small- to medium-sized defects in head and neck reconstruction: a suitable replacement for radial forearm free flap by Yulian Zhang, Keran Pan, Jian Wu, Xi Tang

“…The patient and flap characteristics (age, sex, flap size, harvest time, etc.) and outcomes (success rate, donor site complications including infection, hematoma, and fistula, donor site morbidity including abnormal sensation, weakness, range of motion, postoperative oral function) were recorded and compared. …”
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Smart building energy management with renewables and storage systems using a modified weighted mean of vectors algorithm by Mohamed Ebeed, Sabreen hassan, Salah Kamel, Loai Nasrat, Ali Wagdy Mohamed, Abdel-Raheem Youssef

“…Additionally, it incorporates time-of-use-based demand-side response (DSR) to manage shiftable loads, thereby reducing electricity costs and peak-to-average ratio (PAR) simultaneously and independently. …”
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Design and experiment of air-suction drum-type seedling seeder for irregular-shaped vegetable seeds by Yanjun Li, Yunqiang Liu, Yichao Ning, Hongxin Wu, Yaqian Zhao

“…The results show that: the factors affecting the seeding qualification rate in the order of suction air pressure, clearing air pressure and vibration frequency, the optimal parameter combination of suction air pressure 16.0 kPa, clearing air pressure 3.4 kPa, vibration frequency of 50 Hz, in the optimal parameter combination of the sowing test, to get the replanting rate, the rate of empty holes, the qualification rate of the time were 1.4%, 1.7% and 96.9%, respectively.It shows that the performance of this seeder is better adapted, accurate and efficient, and can meet the requirements of irregular-shaped vegetable seeding operation. …”
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Evaluation of Prevalence and Risk Factors for Postpartum Depression Using the Edinburgh Postpartum Depression Scale: A Cross-Sectional Analytic Study by Gaye Kahveci, Bekir Kahveci, Hamza Aslanhan, Pakize Gamze Erten Bucaktepe

“…EPDS) for early diagnosis and timely treatment of symptoms. …”
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Joint statement on evidence-based practices in mechanical ventilation: suggestions from two Brazilian medical societies by Juliana Carvalho Ferreira, Arthur Oswaldo de Abreu Vianna, Bruno Valle Pinheiro, Israel Silva Maia, Sérgio Vasconcellos Baldisserotto, Alexandre Marini Isola

“…Review articles, consensus statements and clinical practice guidelines have become important sources of guidance in mechanical ventilation, and although clinical practice guidelines offer rigorously developed recommendations, they take a long time to develop and can address only a limited number of clinical questions. …”
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Patient experiences of an ankle fracture and the most important factors in their recovery: a qualitative interview study by Rebecca Samantha Kearney, Rebecca McKeown, David R Ellard, Zi Heng Liew

“…Thematic content analysis was used to identify themes in the data.Setting Individuals were recruited from a sample of participants of a UK-based clinical trial of immobilisation methods for ankle fracture (ISRCTN15537280 at the pre-results stage at time of writing). Interviews were conducted at the participants’ own homes or on a university campus setting.Participants A purposive sample was used to account for key variables of age, gender and fracture management. …”
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Effect of Bio MTA plus & ProRoot MTA pulp capping materials on the regenerative properties of human dental pulp stem cells by Khaled Mohamed Ayoub, Mohamed Mokhtar Nagy, Riham Mohamed Aly, Ghada Nour El Deen, Karim El-Batouty

“…The effects of ProRoot MTA and Bio MTA + extraction media on the stemness properties of hDPSCs were assessed via real-time quantitative PCR, and the expression of odontogenic markers (RUNX2, DMP1 & DSSP) was analyzed via RT‒PCR Alizarin Red staining. …”
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INTERACTION IN AN EDUCATIONAL ENVIRONMENT WITH VIRTUAL AND AUGMENTED REALITY by Svitlana H. Lytvynova, Natalia V. Soroko

“…We concluded that the use of virtual and augmented reality technologies in the educational process provides a wealth of teaching and learning resources that can enhance the learning experience and free participants from limitations in time and space. However, the effective organization of interaction between participants in the educational process using VR and AR requires careful consideration of educational space and pedagogical and methodological recommendations. …”
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Memahami Perjalanan "Kampung Cyber" Melalui Lensa Actor Network Theory by Alfandya Alfandya, Fathul Wahid

“…The study also finds that the role of the leading actor (i.e. the head of neighborhood unit)) diminishes over time and the dominant role is taken over by the community.     …”
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Irritable Bowel Syndrome: What Are the Reasons for Dissatisfaction with the Treatment of Patients and Doctors? (Based on the Experience of Medical Institutions of the Northwestern... by A. Yu. Baranovsky, T. V. Reshetova, I. S. Sakeyan

“…The treatment complex for IBS patients can be considered optimal if, in addition to symptomatic medications, appropriate psychotropic medications are necessarily included in it basing on diagnostic assessment of the psychoemotional status of a particular patient, as well as the appointment of individually selected non-medicinal methods of psychological correction in accordance with psychosomatic symptoms. Full-time cycles on psychodiagnostics and psychotherapy should be included in the educational programs of advanced training of doctors working with IBS patients.…”
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Comparative analysis of alectinib and brigatinib in real-world treatment of advanced NSCLC with ALK rearrangements by Kyuhwan Kim, Kyu Yean Kim, Hye Seon Kang, Ah Young Shin, Sung Kyoung Kim, Chan Kwon Park, Sang Haak Lee, Seung Joon Kim, Jeong Uk Lim, Chang Dong Yeo

“…Patients diagnosed with ALK-positive advanced NSCLC and treated with alectinib or brigatinib were included. Key outcomes such as time to discontinuation (TTD), duration of response (DOR), overall survival (OS), and objective response rate (ORR) were analyzed. …”
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Revealing Halal Certification Oversight Gaps for MSEs through ArcGIS Dashboard Integration by Imam Arifa’illah Syaiful Huda, Maratun Saadah, Agus Sugiarto, Mohd Hairy Bin Ibrahim, Ravinesh Rohit Prasad, Alfyananda Kurnia Putra, Ahyat Budianto

“…Geographic Information System (GIS) technology can serve as a solution for data management in the halal industry, encompassing the management, monitoring and analysis of spatial-temporal and real-time data. This research is aimed at developing geospatial technology for industrial halal management within the scope of MSEs. …”
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