Efficacy and safety of avacopan in antineutrophil cytoplasmic autoantibody-associated vasculitis: a retrospective cohort study in Japan by Genri Tagami, Makoto Yamaguchi, Hirokazu Sugiyama, Hiroshi Kinashi, Kentaro Imai, Keisuke Kamiya, Takayuki Katsuno, Takahiro Imaizumi, Shogo Banno, Yasuhiko Ito, Takuji Ishimoto

“…Results Among the 21 patients, 20 (95.2%) achieved clinical remission at 6 months, and 19 (90.4%) sustained remission at 12 months. The median time from initiation of immunosuppressive therapy to the start of avacopan was 12 days (interquartile range, 5–26). …”
Get full text

HDNLS: Hybrid Deep-Learning and Non-Linear Least Squares-Based Method for Fast Multi-Component T1ρ Mapping in the Knee Joint by Dilbag Singh, Ravinder R. Regatte, Marcelo V. W. Zibetti

“…Among these, HDNLS emerges as the optimal trade-off between performance and fitting time. Extensive experiments on synthetic data demonstrate that HDNLS achieves comparable performance to NLS and regularized-NLS (RNLS) with a minimum of a 13-fold improvement in speed. …”
Get full text

Good Tolerance of Citrate Accumulation due to Plasma Exchange among Patients with Acute-on-Chronic Liver Failure: A Prospective, Observational Study by Yuanji Ma, Yan Xu, Fang Chen, Ying Wang, Lang Bai, Hong Tang

“…The mean Catot/Caion at the time before PE was 2.05 ± 0.14. Catot/Caion≥2.5 occurred in 100.0% (54/54) and 29.6% (16/54) of patients with mean Catot/Caion of 4.34 ± 1.52 and 2.36 ± 0.32 immediately after PE and 1 hour after PE, respectively, and these levels were much higher than those before PE (p<0.01). …”
Get full text

Comparison of the Psychological Symptoms and Disease-Specific Quality of Life between Early- and Typical-Onset Parkinson’s Disease Patients by Seyed-Mohammad Fereshtehnejad, Hasti Hadizadeh, Farzaneh Farhadi, Gholam Ali Shahidi, Ahmad Delbari, Johan Lökk

“…PD patients with the onset age of ≤50 yr were defined as “early-onset” (EOPD) group (n=45), while the ones with >50 yr at the time of diagnosis were categorized as the “typical-onset” (TOPD) patients (n=95). …”
Get full text

大鼠放射性口腔黏膜炎病损组织细胞因子检测及意义

“…【目的】 检测大鼠放射性口腔黏膜炎形成过程中病损局部组织内细胞因子,探讨其动态变化规律及意义65377;【方法】 获取接受单次30 Gy X线照射后5 d65380;8 d65380;14 d的大鼠口腔黏膜组织,采用抗体芯片技术检测19种细胞因子;荧光定量PCR检测8种炎性相关因子的mRNA水平;ELISA定量检测IL-1α65380;IFN-γ65380;TIMP-165377;【结果】 抗体芯片技术检测到,照射后Frac65380;IL-465380;IL-665380;IL-1065380;TNF-α 5种细胞因子水平下降;IL-1β65380;LIX65380;VEGF65380;β-NGF 4种细胞因子照射前后水平无明显差异;照射后水平上升幅度 < 2倍的有CINC-265380;GM-CGF65380;Leptin65380;MCP-1和MIP-3α 5种细胞因子,上升幅度≥2倍的有CINC-365380;INF-γ65380;IL-1α和TIMP-1 4种细胞因子65377;Real-time PCR检测到抗凋亡相关基因Bcl-2,以及IL-665380;TNF-α65380;VEGF及IL-1β的mRNA表达水平下降;而促凋亡相关基因Bax65380;中性粒细胞局部募集相关基因CINC和TLR-9表达上升65377; IL-1α65380;IFN-γ65380;TIMP-1的ELISA检测结果与前两种检测结果一致65377;【结论】 大鼠抗体芯片和荧光定量PCR65380;ELISA检测结果互相佐证了病损组织内的细胞因子在口腔黏膜炎发生65380;发展65380;演进中呈现分泌受阻和表达增加的动态变化并发挥调控作用65377;…”
Get full text

Completion of registration of risk factor variables during telephone vs on-site follow-up after myocardial infarction: a nationwide observational study in 101 199 patients from con... by Maria Bäck, Margret Leosdottir, Emil Hagström, Nermin Hadziosmanovic, Halldora Ögmundsdottir Michelsen, Mattias Ekström

“…Patient characteristics and time trends in the proportion of missing values were also analysed.Results Baseline characteristics for patients with on-site visits and telephone consultations were similar. …”
Get full text

Dry eye post-cataract surgery: a systematic review and meta-analysis by Hillary Ta, Paul McCann, Mengli Xiao, Tiffany Lien, Kaleb Abbott, Darren G. Gregory, Riaz Qureshi, Tianjing Li

“…We compared postoperative dry eye outcomes with baseline including Ocular Surface Disease Index (OSDI), tear break up time (TBUT), Schirmer’s I test (ST1), and corneal fluorescein staining (CFS) at short-term (< 1 week) and medium-term (≥ 1 week to 3 months) follow-up. …”
Get full text

A New Global Ionospheric Electron Density Model Based on Grid Modeling Method by Huijun Le, Tingwei Han, Qiaoling Li, Libo Liu, Yiding Chen, Hui Zhang

“…On each grid, the electron density is modeled as a function of solar activity, geomagnetic activity, local time, and season variation using 21 coefficients. …”
Get full text

Grouting Design of Rich Water Tunnels and the Calculation of Distance between Annular Blind Pipes by Helin Fu, Pengtao An, Kai Li, Guowen Cheng, Jie Li, Xiaohui Yu

“…Based on Darcy’s law and the law of conservation of mass, the formula for calculating the seepage discharge and the seepage pressure with the parameters of annular blind pipe spacing is derived. At the same time, the design parameters of the grouting circle are optimised, and then the formula of annular blind pipe spacing is derived according to the design value of the antiwater pressure of the secondary lining structure and the allowable seepage discharge of the tunnel. …”
Get full text

The Ediacaran-Cambrian Radiation of Animals within the Villuercas-Ibores-Jara UNESCO Global Geopark, Spain by Iván Cortijo, Teodoro Palacios, Sören Jensen, José María Barrera

“…Geosites, geological itineraries and interpretation centres in the geopark show the visitors these exceptional fossils, including the holotype of Cloudina carinata, which provide vivid evidence of time that marked the beginning of life on our planet as we know it today.…”
Get full text

Endoscopic sinus surgery outcomes in patients with chronic rhinosinusitis and immunoglobulin deficiencies by Shireen Samargandy, Elysia Grose, Jonathan Yip, John M. Lee

“…The revision surgery rates, time to revision surgery, and changes in sinonasal outcome tests (SNOT-22) were evaluated. …”
Get full text

Unraveling the Beneficial Role of Resveratrol in Fructose-Induced Non-Alcoholic Steatohepatitis with a Focus on the AMPK/Nrf2 Signaling Axis by Soha S. Zakaria, Safaa M. Hanafy

“…We performed histological evaluations and assessed blood lipids and liver enzymes to study resveratrol’s impact on NASH. Quantitative real-time PCR was used to assess the mRNA expression of nuclear factor E2-related factor 2 (Nrf2) in the liver samples. …”
Get full text

Comparative Evaluation of Bandage Contact Lenses and Eye Patching after Bilateral Cataract Surgery by Dalan Jing, Aihua Deng, Hongmei Wang, Yilin Chou, Xiaodan Jiang, Zhenxiang Chen, Xuemin Li, Tingyi Wen

“…There were no significant differences in the BCVA and VF-14 between the groups at any time point. Conclusions. BCLs could be safely and effectively used in patients after cataract surgery.…”
Get full text

Effectiveness of community-based first aid training on head injury outcomes by Akilbekov Dzhumatovich, Mohamad Sorani

“…These findings underscore the transformative role of timely interventions in resource-limited settings. …”
Get full text

Interdigital and Plantar Foot Infections: A Retrospective Analysis of Molecularly Diagnosed Specimens in the United States and a Literature Review by Aditya K. Gupta, Tong Wang, Sara A. Lincoln, Wayne L. Bakotic

“…In conclusion, PCR diagnosis serves as a valuable tool for the management of tinea pedis. An accurate and timely detection of fungal pathogens and concomitant bacterial colonization can better inform healthcare providers of appropriate treatment selection.…”
Get full text

The efficiency of interferon stimulated gene 15 expression in peripheral blood for early pregnancy prediction in Awassi ewes by Eman H. Lazim, Khawla A. Hussein, Dhafer M. Aziz

“…Blood samples were collected on 0, 6, 15, and 25 days of gestation to measure ISG15 expression levels using quantitative real-time PCR (qRT-PCR). The results of the relative expression values of ISG15 in pregnant and non-pregnant ewes on 0, 6, 15, and 25 days of pregnancy were 0.044&plusmn;0.012 vs. 0.049&plusmn;0.009, 0.203&plusmn;0.083 vs. 0.201&plusmn;0.093, 1.839&plusmn;0.594 vs. 0.292&plusmn;0.136, and 0.583&plusmn;0.067 vs 0.200&plusmn;0.051, respectively. …”
Get full text

<i>Solanum nigrum</i> L. is a potato spindle tuber viroid reservoir by N. V. Mironenko, A. V. Khiutti, E. I. Kyrova, N. M. Lashina, O. S. Afanasenko

“…After artificial infection of healthy S. nigrum plants in a greenhouse, the presence of PSTVd in infected plants was confirmed and it was proved that the viroid was transmitted by seeds to plants of the next generation.Conclusion. For the first time in externally healthy plants of S. nigrum, widely distributed in the potato fields of Russia (Nizhny Novgorod and Tula Province), the potato spindle tuber viroid, PSTVd, was detected. …”
Get full text

Glucocorticoid receptor gene (NR3C1) methylation, childhood maltreatment, multilevel reward responsiveness and depressive and anxiety symptoms: A neuroimaging epigenetic study by Yajing Xu, Shan Yang, Cong Cao

“…Reward positivity (RewP) and its time‒frequency components were elicited via a classic monetary reward task. …”
Get full text

Monodispersed AgNPs Synthesized from the Nanofactories of Theobroma cacao (Cocoa) Leaves and Pod Husk and Their Antimicrobial Activity by Johnson Kwame Efavi, Emmanuel Nyankson, Kwaku Kyeremeh, Gloria Pokuaa Manu, Kingsford Asare, Nathaniel Yeboah

“…With a shorter nucleation time, the intensity of the UV-Vis spectrum was always higher in the case of CL-AgNPs, indicating a larger population of bioactive molecules available for CL-AgNPs synthesis. …”
Get full text

INNOVATION IN BIOCOMPATIBLE MATERIALS FOR DENTAL IMPLANTS: CURRENT PERSPECTIVE AND SITUATIONS by Asaftei Victoria, Ciornei Mădălina, Țabără Eduard Lucian, Agop-Forna Doriana, Maxim Alexandra, Norina Forna

“…However, the main drawback in these approaches is the potential toxicity and accumulative effect of the metals over time. In view of biological issues and in attempt to prevent and/or treat peri‐implantitis, biomaterials as carriers of antimicrobial substances have attracted special attention for application as coatings on dental implant devices. …”
Get full text