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  1. 56921

    Pilot clinical trial of neoadjuvant toll-like receptor 7 agonist (Imiquimod) immunotherapy in early-stage oral squamous cell carcinoma by Angela J. Yoon, Richard D. Carvajal, Evan M. Graboyes, John M. Kaczmar, William G. Albergotti, Alexandra E. Kejner, Scott H. Troob, Elizabeth Philipone, Jean-Sebastien Anoma, Kent E. Armeson, Elizabeth G. Hill, Mary S. Richardson, Tina R. Woods, Bhishamjit S. Chera, Farzad Nourollah-Zadeh, Byung J. Lee, Subramanya Pandruvada, Antonis Kourtidis, Christina Kingsley, Elizabeth C. O’Quinn, Stephanie Mills, Victoria C. Jordan, Mike Spencer, Danielle Fails, Trevor D. McKee, Mark Zaidi, Alan Brisendine, Shane Horn, Shikhar Mehrotra, Besim Ogretmen, Jason G. Newman

    Published 2025-01-01
    “…The treatment was well tolerated with the application site mucositis being the most common adverse event (grades 1-3), and no grade 4 life-threatening event. The median follow-up time was 17 months (95% CI = 16 months - not reached), and one-year recurrence-free survival was 93% of evaluable patients.ConclusionNeoadjuvant imiquimod immunotherapy could be safe and promising regimen for early-stage oral cancer.Trial registrationClinicalTrials.gov, Identifier NCT04883645.…”
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  2. 56922

    FTA-Net: Frequency-Temporal-Aware Network for Remote Sensing Change Detection by Taojun Zhu, Zikai Zhao, Min Xia, Junqing Huang, Liguo Weng, Kai Hu, Haifeng Lin, Wenyu Zhao

    Published 2025-01-01
    “…Therefore, a new frequency-temporal-aware network (FTA-Net) is proposed, it recognizes changes by means of a frequency-domain temporal fusion module and supervised attention to multilevel time-difference features, while reducing the model size. …”
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  3. 56923

    Reconstruction of U.S. Regional-Scale Soybean SIF Based on MODIS Data and BP Neural Network by YAO Jianen, LIU Haiqiu, YANG Man, FENG Jinying, CHEN Xiu, ZHANG Peipei

    Published 2024-09-01
    “…[Conclusions]The BPSIF proposed has significantly enhancing the regional and temporal continuity of OCO-2 SIF while preserving the time and spatial attributes contained in the original SIF dataset. …”
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  4. 56924

    Clinical and experimental rationale for using phenylephrine with hypromellose for the treatment of extra accommodation strain in patients with myopia by M.V. Makhova, E.V. Shikh, V.V. Strakhov, D.S. Blinov, G.K. Poluosmak, E.V. Semeleva, E.V. Blinova

    Published 2023-03-01
    “…</p> <p> <b>Results</b>: the drug therapy of extra accommodation strain comprising 2.5% phenylephrine hydrochloride solution with hypromellose as an excipient (Irifrin<sup>®</sup> BK) demonstrated a decrease in severity of extra accommodation strain after 30 days of treatment. At the same time, Preparation B did not demonstrate its efficacy. …”
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  5. 56925

    甲基转移酶3对人脑血管平滑肌细胞基因表达及增殖和迁移功能的影响 Effects of Methyltransferase 3 on Gene Expression, Proliferation, and Migration Functions of Human Brain Vascular Smooth Muscle Cells... by 孟晨曦1,孙洪英2,张佳2,毛戬2,杨阳3,策乐木格3 (MENG Chenxi1, SUN Hongying2, ZHANG Jia2, MAO Jian2, YANG Yang3, Celemuge3 )

    Published 2025-01-01
    “…The mRNA expression levels of cerebral small vessel disease-related genes including zinc finger protein 395 (ZNF395), zinc finger protein 548 (ZNF548), DIS3-like exosome 3’-5’ exonuclease (DIS3L), interleukin enhancer binding factor 3 (ILF3) and G protein-coupled receptor 107 (GPR107) were detected by real-time reverse transcriptional PCR (RT-qPCR). Methylated RNA immunoprecipitation (MeRIP) was used to detect the N6-methyladenosine (m6A) modification levels of the mRNA for the genes above. …”
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  6. 56926

    Authority and Moral Conflicts in the Films of Adébáyọ Fálétí: Àfọ̀njá, Gáà, Ṣawo Ṣẹ̀gbẹ̀rì and the Yorùbá Cosmopolis by Olayinka Agbetuyi

    Published 2021-12-01
    “…In addition to being staged in the theater, Gáà and Ṣawo Ṣẹgbẹ ̀ rì̀ were produced for tele[1]vision audiences as dramatic thrillers and became household favourites in the ‘70s and ‘80s at the time of his career as a radio/television broadcaster. …”
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  7. 56927

    Editorial by Ann-Kristin Kölln, Antony Mason, Jörg Tremmel, Markus Rutsche, Maria Lenk

    Published 2019-07-01
    “… In April 2019, Greta Thunberg made TIME Magazine’s 100 Most Influential People of 2019 list. …”
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  8. 56928

    Research Status and Prospects of Key Technologies for Rice Smart Unmanned Farms by YU Fenghua, XU Tongyu, GUO Zhonghui, BAI Juchi, XIANG Shuang, GUO Sien, JIN Zhongyu, LI Shilong, WANG Shikuan, LIU Meihan, HUI Yinxuan

    Published 2024-11-01
    “…The smart irrigation system is based on the water demand of the whole life cycle of rice to realize adaptive irrigation control, and the current smart irrigation technology can automatically adjust the irrigation strategy through real-time monitoring of soil, climate and crop growth conditions to further improve irrigation efficiency and agricultural production benefits. …”
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  9. 56929

    Le camp F de Lautagne à Valence (Drôme) : l’organisation interne et la vie quotidienne d’un camp militaire romain au milieu du ier s. av. J.-C. by Magalie Kielb Zaaraoui, Loïc Buffat, Michel Reddé, Yahya Zaaraoui

    Published 2022-12-01
    “…This indicates with certainty that the ditch remained open for a relatively short period of time, a few weeks or months at most. Two entrances to the camp were observed on the eastern and southern border. …”
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  10. 56930

    Hubungan Penurunan Kadar Natrium Terhadap Gangguan Pola Tidur Pasca TURP (Transurethral Resection of The Prostate) by Khomeini Khomeini, Dody E Dody E, Erkadius Erkadius

    Published 2013-01-01
    “…In this research, the operating time &lt;1 hr make a decrease sodium levels 3.783 + 2.235 mmol / L, while operating &gt; 1 hour decrease sodium 6.692 + 6.047 mmol/L with a statistically significant difference. …”
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  11. 56931

    Flavor Quality of Scomberomorus niphonius by Shanyu WANG, Chong JIAN, Yong XUE, Ling ZHAO, Huihui SUN, Rong CAO

    Published 2025-02-01
    “…Among various fish products, vacuum-packed ready-to-eat soft canned products are popular and widely used with high commercial value due to their short sterilization time, low nutritional loss, and easy portability. …”
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  12. 56932
  13. 56933

    Investigating and Completing Khanlari’s Theory on Metrical Units by Abbas Jahed Jah

    Published 2024-12-01
    “…Khanlari’s suggested method was never fully applied by him or others, thus leaving it shrouded in ambiguity, which necessitates a practical evaluation of its strengths and weaknesses.The research pursues two primary objectives: first, to precisely describe Khanlari’s metrical units and identify the advantages and weaknesses of this type of segmentation; second, to refine, complete, and apply this method in alignment with later advancements and findings in prosody since Khanlari’s time. Materials and Methods The scope of this research is Khanlari’s theory on metrical units as discussed in the book The Meter of Persian Poetry (Khanlari, 1994). …”
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  14. 56934

    Effect of Berberine on the Inflammatory Response of ANA-1 Cells Induced by Angiotensin Ⅱ Based on TLR4 Signaling Pathway by GAO Dexing, JIA Peizhi, PENG Jun, LIN Wei

    Published 2022-04-01
    “…Cell proliferation and toxicity test (CCK-8) was used to detect the effect of different concentrations of BBR on cell viability; the flow cytometry was used to detect the mean fluorescence intensity (MFI) of TLR4 on cell membrane ; ELISA method was used to detect the content of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α); the real-time quantitative PCR was used to detect the mRNA level of IL-1β, IL-6, TNF-α; Western blot was used to detect the phosphorylation of p-ERK/ERK, p-p38/p38, p-JNK/JNK, p-p65/p65 and p-IRF3/IRF3 and the expression of TLR4, MyD88 and AP-1; the biochemical assay was used to detect the content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD).Results① CCK-8 assay results: compared with the control group, there was no significant difference in cell activity of the low, medium and high- dose BBR group, the difference was not statistically significant (<italic>P</italic>&gt;0.05). ② Flow cytometry results: compared with the fluorescent antibody group, MFI of the model group was significantly decreased; compared with the model group, MFI of the model group + the high dose BBR group was significantly increased, the difference was statistically significant (<italic>P</italic>&lt;0.05). ③ ELISA results: compared with the control group, the content of IL-1β, IL-6, TNF- α of the model group was significantly increased; compared with the model group, the content of IL-1β, IL-6, TNF- α of the model group + the low, medium and high dose BBR group was significantly decreased, the difference was statistically significant (<italic>P</italic>&lt;0.05). ④ Real-time quantitative PCR results: compared with the control group, the mRNA level of IL-1β, IL-6, TNF-α of the model group was significantly increased; compared with the model group, the mRNA level of IL-1β, IL-6, TNF- α of the model group + the low, medium and high-dose BBR group was significantly decreased, the difference was statistically significant (<italic>P</italic>&lt;0.05). ⑤ Western blot results: compared with the control group, the phosphorylation expression of p65 and IRF-3 protein of the model group after intervention for 45 minutes was significantly increased, and the phosphorylation expression of p65, IRF-3 protein in the model group + the low, medium and high-dose BBR group was significantly decreased. …”
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  15. 56935

    Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

    Published 2025-01-01
    “…For an earlier version of the GRAIL test, the time to diagnostic resolution was shorter for those with a true positive result compared to false-positive results. …”
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  16. 56936

    Presenting a model for the establishment and maintenance of expert human resources in the government organizations of Sistan and Baluchestan province by Majid Reza Dahmardeh, Vahid pourshahabi, Amin Reza Kamalian, Habibollah Salaerzehi

    Published 2024-11-01
    “…The longer a person stays in the organization, the more skills he acquires; so ideally, employees should stay for a long time so that the organization achieves consistent success (Chawla. 2021). …”
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  17. 56937

    The intellectual paradigm and scientific mapping of brand image in International Researches by Maryam Najafi Yazdi, Seyed Hassan Hataminasab, Shahnaz Nayebzadeh

    Published 2025-02-01
    “…Customer loyalty is defined as bias towards a specific brand and behavioral response during a defined period of time, and it is decided as a psychological commitment (Behrozi, Sohrabi, 2022). …”
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  18. 56938

    Prose poetry in theory and practice /

    Published 2022
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  19. 56939

    Diagnostic Accuracy of Periapical Radiography in Detection and Measurement of the External Root Resorption in Primary Molars: A Single-Blind Prospective Clinical Study by Shirin Taravati, Zohreh Balak, Vahid Rakhshan

    Published 2022-01-01
    “…Thus, this study was undertaken for the first time. Methods. This was a single-blind prospective clinical diagnostic study performed on 501 observations (observed by 3 observers) pertaining to 167 roots of 45 maxillary/mandibular primary molars (in 6–8-year-old patients) which were indicated for extraction and did have succeeding permanent teeth. …”
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  20. 56940

    Protection and Security Method for Multiple Energy Power Plant-Based Microgrids Using Dual Filtering Algorithm by Danni Liu, Shengda Wang, Weijia Su, Xiaojuan Zhang, Shichun Hui

    Published 2025-01-01
    “…Furthermore, the scheme offers low computational burden, making it highly appropriate &#x0026; efficient for real-time applications in modern MEPPBM.…”
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