Alpha-Linolenic Acid Attenuates Inflammatory Response in LPS-stimulated Macrophages by Regulating TLR4/MyD88/NF-κB Signaling Pathway by Ruixin CAI, Xiaodie CHEN, Haibin ZHU, Yushun QIAN, Jianhua XIE, Mingyue SHEN

“…The results showed that α-linolenic acid significantly inhibited the release of MCP-1 and increased the secretion level of anti-inflammatory cytokine IL-13. At the same time, α-linolenic acid also reduced ROS production and alleviated ROS-mediated inflammatory damage. …”
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SS316/CCA laminated metal composite fabricated by additive friction stir deposition: Microstructure and mechanical properties by Ravi Sankar Haridas, Anurag Gumaste, Eric Kusterer, Devin Davis, Supreeth Gaddam, Brandon McWilliams, Kyu C. Cho, Rajiv S. Mishra

“…Conventionally, adhesive bonding, roll bonding or deposition methods are used to engineer the LMC for property optimization. For the first time, the present study investigated the potential of the novel solid-state additive friction stir deposition (AFSD) technique to additively manufacture an LMC containing SS316 and Fe40Co20Mn20Cr15Si5 complex concentrated alloy (CS-CCA) exhibiting transformation induced plasticity (TRIP). …”
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Elucidating the metabolic mechanisms and active constituents of ZuoGui Wan in combatting postmenopausal osteoporosis: A metabolomics and network pharmacology approach by Yanchen Feng, KaiKai Shi, Dingming Li, Shunzhi Yang, Xue Dang, Jinyao Li, Yan Chen, Jianping Yao, Yunke Zhang, Lu Sun, Feixiang Liu

“…Conclusion: this study comprehensively revealed the metabolic mechanism and active ingredients of ZGW against PMOP for the first time, providing a new perspective on the study of the mechanism of ZGW against PMOP.…”
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Distinct relative abundances in pathogens detected in mechanically ventilated patients with suspected pneumonia in the intensive care unit at King Abdulaziz University Hospital by Haifa Algethamy, Diyaa H. Bokhary, Ibrahim Abushoshah, Abdulrahman A. Alalyani, Maan K. Baamer, Dalya M. Attallah, Ruba M. Alotaibi, Shehla N. Amin, Shaza A. Mass, Nisreen R. Tashkandy

“…Abstract In this study, we present for the first time the landscape of the lung microbiota in patients with ventilator-associated pneumonia in Intensive Care Units in Saudi Arabia. …”
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The Enigmatic Upper Ordovician of the Naturtejo UNESCO Global Geopark (Portugal) by Sofia Pereira, Jorge Colmenar, Cristiana Esteves, Ícaro Dias da Silva, Miguel Pires, Carlos Neto de Carvalho

“…Remobilized upper Katian fossiliferous clasts were found for the first time within the Hirnantian Casal Carvalhal from the Fajão-Muradal Syncline and a new fossil site is added to the Orvalho GeoTrail. …”
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Endoscopic ultrasound-guided hepaticogastrostomy and endoscopic retrograde cholangiopancreatography-guided biliary drainage for distal malignant biliary obstruction due to pancreat... by Naminatsu Takahara, Yousuke Nakai, Kensaku Noguchi, Tatsunori Suzuki, Tatsuya Sato, Ryunosuke Hakuta, Kazunaga Ishigaki, Tomotaka Saito, Tsuyoshi Hamada, Mitsuhiro Fujishiro

“…Technical and clinical success, early (<3 months) and overall RBO rates, time to RBO (TRBO), and adverse events were compared between the EUS-HGS and ERCP-BD groups. …”
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Delineation of the Genetic Architecture and Clinical Polymorphism of 3q29 Duplication Syndrome: A Review of the Literature and a Report of Two Novel Patients With Single‐Gene BDH1... by A. A. Kashevarova, M. E. Lopatkina, O. Yu. Vasilyeva, D. A. Fedotov, A. D. Lobanov, E. A. Fonova, I. Z. Zhalsanova, A. A. Zarubin, O. A. Salyukova, E. O. Belyaeva, V. V. Petrova, E. G. Ravzhaeva, A. A. Agafonova, A. D. Cheremnykh, N. B. Torkhova, S. L. Vovk, I. N. Lebedev

“…In two patients, duplications were found in the single BDH1 gene, a candidate gene for the 3q29 duplication phenotype. For the first time, we delineated and described the smallest minimal critical region, including the single BDH1 gene; in our patients, this region was associated with ASD, heart defects, biliary tract dysfunction, and obesity. …”
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River water quality monitoring using machine learning with multiple possible in-situ scenarios by Dani Irwan, Saerahany Legori Ibrahim, Sarmad Dashti Latif, Chris Aaron Winston, Ali Najah Ahmed, Mohsen Sherif, Amr H. El-Shafie, Ahmed El-Shafie

“…The study looks into the possibility of estimating WQI solely using dissolved oxygen (DO) and pH as predictors because the chemical parameters in the current Malaysian WQI calculation method takes some time to compute. This research provides insight into the accuracy, precision, and general performance of these models in predicting water quality by looking at the residuals of various scenarios and evaluating performance metrics across different machine learning models. …”
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Deep Learning in the Fast Lane: A Survey on Advanced Intrusion Detection Systems for Intelligent Vehicle Networks by Mohammed Almehdhar, Abdullatif Albaseer, Muhammad Asif Khan, Mohamed Abdallah, Hamid Menouar, Saif Al-Kuwari, Ala Al-Fuqaha

“…Based on our thorough analysis, we identify key limitations in current methodologies and propose potential paths for future research, focusing on integrating real-time data analysis, cross-layer security measures, and collaborative IDS frameworks.…”
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Effects of the tide on the temporal and spatial physicochemical structure of the Kienké river estuary (South Atlantic Coast of Cameroon, Kribi) and its phytoplankton by Mama Anselme Crépin, Ghepdeu Gisele Flodore Youbouni, Fossi Tankoua Olivia, Bonga Manfred Desire, Abouga Bodo Willy Karol, Mandeng Thérésa Irma, Owona Edoa François Désiré, Tangko Noel Chuye, Ngoupayou Ndam Jules Rémi

“…The nutrients variation (ammonium, nitrite, nitrate and orthophosphate) is very low in space and time, with a longitudinal distribution controlled by tidal flows, river flows and the biological pump. …”
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Visually Impaired People Learning Virtual Textures Through Multimodal Feedback Combining Vibrotactile and Voice by Dapeng Chen, Yi Ding, Hao Wu, Qi Jia, Hong Zeng, Lina Wei, Chengcheng Hua, Jia Liu, Aiguo Song

“…We first propose an Informer based haptic texture rendering model that can fuse texture images with real-time action information to generate vibration acceleration (VA) signals. …”
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Predatory bacteria can intensify lung-injury in a multidrug-resistant Acinetobacter baumannii pneumonia model in rat by Zeinab Mohsenipour, Farzaneh Kianian, Behnaz Jahanbin, Hamid Reza Abtahi, Tooba Ghazanfari, Maryam Edalatifard, Saeid Amanpour, Mikael Skurnik, Parya Arazi, Mohammad Mehdi Feizabadi, Mohammad Mehdi Feizabadi

“…Also, the colistin MIC value for B. bacteriovorus HD100 (8 μg/mL) was determined for the first time to our knowledge. Removal of excess endotoxin from the predator suspension was performed with the help of organic solvents before inoculation of rats.ResultsThe most successful treatment was observed in the group treated with colistin followed by combined treatment. …”
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Considerable decline in prostate cancer mortality in Nordic countries after 2000 by Rune Kvåle, Giske Ursin, Christian Ekanger, Bjørn Møller

“…By 2022 Norway had the second lowest mortality among the Nordic countries overall, and the lowest under 85 years. The life-time risk of dying from prostate cancer declined from 5.6–7.1% in 1995–99 to 3.1–4.2% in the last 5-year period. …”
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Research on Density Peak Clustering Color-Separation Algorithm Based on SOM Neural Network by Xin Ru, Yanhao Wang, Ran Chen, Zhifa Zeng, Laihu Peng, Wei Tang, Weimin Shi, Hui Wang

“…In addition, the traditional color-separation algorithm needs to rely on the manual setting of clustering parameters, which is very time-consuming and laborious. To solve these problems, In this paper, we propose a density peak clustering color-separation algorithm based on self-organizing mapping (SOM) neural network, which firstly uses enhanced super-resolution generative adversarial network (Real-ESRGAN) blind super-resolution reconstruction network to clarify the degraded image and obtain a high-resolution image with clear boundaries; secondly, we carry out the initial clustering through the SOM neural network to simplify the image information; and then we use an improved density peak clustering (DPC) algorithm to calculate clustering centers under the conditions of conforming to the perception of human eyes, and carry out secondary clustering on the image; finally, carry out image post-processing through the variegated spots merging algorithm based on the connected component analysis. …”
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Intrinsically anisotropic 1D NbTe4 for self-powered polarization-sensitive photodetection by Huahu Luo, Fafa Wu, Chaowei He, Wanfu Shen, Chunguang Hu, Weina Zhao, Peng Yu, Guowei Yang

“…Meanwhile, the device exhibits a pronounced photothermoelectric effect, conferring a broad spectral photoresponse ranging from visible to near-infrared wavelengths (532-1064 nm), with a rapid response time of 158 ms. This study demonstrates that NbTe4 inherently possesses in-plane anisotropy, making it a promising candidate for polarization-sensitive photodetection applications.…”
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PPARα Activation Protects against Anti-Thy1 Nephritis by Suppressing Glomerular NF-κB Signaling by Koji Hashimoto, Yuji Kamijo, Takero Nakajima, Makoto Harada, Makoto Higuchi, Takashi Ehara, Hidekazu Shigematsu, Toshifumi Aoyama

“…To investigate whether PPARα activation improves the disease activity of MsPGN, we examined the protective effects of a PPARα agonist, clofibrate, in a well-established model of human MsPGN, anti-Thy1 nephritis, for the first time. This study demonstrated that pretreatment with clofibrate (via a 0.02% or 0.1% clofibrate-containing diet) continuously activated the glomerular PPARα, which outweighed the PPARα deterioration associated with the nephritic process. …”
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MEK Inhibition Targets Cancer Stem Cells and Impedes Migration of Pancreatic Cancer Cells In Vitro and In Vivo by Karolin Walter, Kanishka Tiwary, Marija Trajkovic-Arsic, Ana Hidalgo-Sastre, Laura Dierichs, Sven T. Liffers, Jiangning Gu, Johann Gout, Lucas-Alexander Schulte, Jan Münch, Thomas Seufferlein, Bruno Sainz, Jens T. Siveke, Eva Rodriguez-Aznar, Patrick C. Hermann

“…Pancreatic ductal adenocarcinoma (PDAC) remains a devastating disease with a very poor prognosis. At the same time, its incidence is on the rise, and PDAC is expected to become the second leading cause of cancer-related death by 2030. …”
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Knockdown of YAP/TAZ Inhibits the Migration and Invasion of Fibroblast Synovial Cells in Rheumatoid Arthritis by Regulating Autophagy by Wei Zhou, Qin Shen, Hui Wang, Jie Yang, Chen Zhang, Zijing Deng, Keyan Wu, Yang Zhou, Jing Zeng, Yu Zhang, Weigan Shen

“…Reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR) and western blotting assays were performed to examine the expression of indicated genes. …”
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Branched polyethyleneimine functionalized tin(IV)-porphyrinic complex: Synthesis, characterization and application towards acid blue 25 adsorption from water by Raoudha Soury, Mahjoub Jabli, Mabrouka El Oudi, Ashanul Haque, Khalaf M. Alenezi, Ahmed Al Otaibi, Fahad Abdulaziz, Amor Bchetnia

“…Under optimized conditions (pH = 5, time = 60 min., and T = 295.15 K), the adsorption capacity of [Sn(TPP)(Cl2)]-PEI was 208 mg/g while it was 14 mg/g for [Sn(TPP)(Cl2)]. …”
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Convective Cold Pool Associated with Offshore Propagation of Convection System over the East Coast of Southern Sumatra, Indonesia by Erma Yulihastin, Ibnu Fathrio, Trismidianto, Fadli Nauval, Elfira Saufina, Wendi Harjupa, Didi Satiadi, Danang Eko Nuryanto

“…It is important to note that the intensity, duration, timing, and structure of heavy rainfall simulated were in good agreement with satellite-observed rainfall. …”
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