Predictive role of ABC transporters in the efficacy of enfortumab vedotin for urothelial carcinoma by Toshiki Kijima, Atsuko Takada‐Owada, Hiroki Shimoda, Hidetoshi Kokubun, Toshitaka Uematsu, Kohei Takei, Hironori Betsunoh, Masahiro Yashi, Kazuyuki Ishida, Takao Kamai

“…Results Immunohistochemical analysis indicated that tumours with high ABC transporter expression exhibited shorter PFS time and poorer response to EV. Furthermore, a decrease in Nectin‐4 expression and an increase in ABC transporter expression were observed as the disease progressed from non‐muscle‐invasive to muscle‐invasive and metastatic. …”
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Stability Control of the Agricultural Tractor-Trailer System in Saline Alkali Land: A Collaborative Trajectory Planning Approach by Guannan Lei, Shilong Zhou, Penghui Zhang, Fei Xie, Zihang Gao, Li Shuang, Yanyun Xue, Enjie Fan, Zhenbo Xin

“…Based on the intrinsic property of the lateral deviation of the TTS, a collaborative trajectory prediction algorithm that satisfies the time domain and system constraints is proposed. Combining the dual-trajectory independent offset and lateral stability parameter of the TTS, an energy function optimization control parameter was constructed to balance the system trajectory tracking performance and lateral control stability. …”
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Comparison of HER2-Targeted Antibodies for Fluorescence-Guided Surgery in Breast Cancer by Solmaz AghaAmiri, Jo Simien, Alastair M. Thompson, Julie Voss, Sukhen C. Ghosh, Servando Hernandez Vargas, Sarah Kim, Ali Azhdarinia, Hop S. Tran Cao

“…We showed for the first time that fluorescent trastuzumab and pertuzumab immunoconjugates have similar NIRF imaging performance and demonstrated the possibility of performing HER2-targeted FGS with agents that possess distinct epitope specificity.…”
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Total Intravenous Anaesthesia with High-Dose Remifentanil Does Not Aggravate Postoperative Nausea and Vomiting and Pain, Compared with Low-Dose Remifentanil: A Double-Blind and Ran... by Seong-Hyop Kim, Chung-Sik Oh, Tae-Gyoon Yoon, Min Jeng Cho, Jung-Hyun Yang, Hye Ran Yi

“…The H group showed higher use of remifentanil and lower use of propofol, with similar recovery time. Mean systemic arterial blood pressure (MBP), heart rate, and BIS did not differ significantly before and after endotracheal intubation in the H group. …”
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The Validation of the sickle scan technique used to diagnose sickle cell disease by Magain Mihatano Barihuta, Guelord Inkalaba, Jocelyn Kakumba Mankulu, Olivier Nzingula, Maguy Luvandu Mbenza, Nicole M. Misengabu, M Ndeme, Michel Diyi, Mbembe Bitengeli, Tresor Bayebila Menanzambi, Nsimba Miezi, José Lami Nzunzu, Fridolin Kodondi Kule-koto

“…This test can also be applied to samples collected on blotting paper. The interpretation time should not exceed 2 minutes, contrary to the manufacturer's claims. …”
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Etodolac Single Dose Metabolic Profile Elucidation: Pharmacokinetics and Adverse Events in Healthy Volunteers by Karen Sánchez-Luquez, Anne Michelli Reis Silveira, Salvador Sánchez-Vinces, Alex Ap. Rosini Silva, Joyce Barreto, Rhubia Bethania Socorro Lemos de Brito, Caroline de Moura Garcia, Ana Lais Vieira, Marcia Ap. Antonio, Patrícia de Oliveira Carvalho

“…Pharmacokinetic profiles were determined using tandem mass spectrometry analysis, and the metabolomic profiling was conducted using baseline samples (pre-dose) and samples at maximum drug concentration (post-dose) via liquid chromatography coupled with a quadrupole time-of-flight mass spectrometer. Network analysis was employed to interpret the data. …”
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Fine-tuning a local LLaMA-3 large language model for automated privacy-preserving physician letter generation in radiation oncology by Yihao Hou, Yihao Hou, Christoph Bert, Christoph Bert, Christoph Bert, Ahmed Gomaa, Ahmed Gomaa, Ahmed Gomaa, Godehard Lahmer, Godehard Lahmer, Godehard Lahmer, Daniel Höfler, Daniel Höfler, Daniel Höfler, Thomas Weissmann, Thomas Weissmann, Thomas Weissmann, Raphaela Voigt, Raphaela Voigt, Raphaela Voigt, Philipp Schubert, Philipp Schubert, Philipp Schubert, Charlotte Schmitter, Charlotte Schmitter, Charlotte Schmitter, Alina Depardon, Alina Depardon, Alina Depardon, Sabine Semrau, Sabine Semrau, Sabine Semrau, Andreas Maier, Rainer Fietkau, Rainer Fietkau, Rainer Fietkau, Yixing Huang, Yixing Huang, Florian Putz, Florian Putz, Florian Putz

“…IntroductionGenerating physician letters is a time-consuming task in daily clinical practice.MethodsThis study investigates local fine-tuning of large language models (LLMs), specifically LLaMA models, for physician letter generation in a privacy-preserving manner within the field of radiation oncology.ResultsOur findings demonstrate that base LLaMA models, without fine-tuning, are inadequate for effectively generating physician letters. …”
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Oxidative stress promotes lipid-laden macrophage formation via CYP1B1 by Yin Zhu, Saugata Dutta, Yohan Han, Dooyoung Choi, Francesca Polverino, Caroline A. Owen, Payaningal R. Somanath, Xiaoyun Wang, Duo Zhang

“…CSE-induced LLM showed time-dependent alterations in inflammatory response and phagocytic ability. …”
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Portable Handheld Slit-Lamp Based on a Smartphone Camera for Cataract Screening by Shenming Hu, Hong Wu, Xinze Luan, Zhuoshi Wang, Mary Adu, Xiaoting Wang, Chunhong Yan, Bo Li, Kewang Li, Ying Zou, Xiaoya Yu, Xiangdong He, Wei He

“…Furthermore, the images collected by the smartphone are uploaded to the deep learning cataract screening system, which can achieve real-time and effective screening of cataract. Results. …”
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Children with autistic spectrum disorder can imagine actions— what can this reveal about the Broken Mirror Hypothesis? by Jessica Galli, Jessica Galli, Laura Dusi, Gioacchino Garofalo, Gioacchino Garofalo, Alessandra Brizzi, Michela Gritti, Federica Polo, Elisa Fazzi, Elisa Fazzi, Giovanni Buccino, Giovanni Buccino

“…Observed actions lasted 4 s and children were requested to follow the same time course during imagination. During this motor imagery (MI) task, children were interrupted at a specific timepoint (e.g., at 1.5 s) from the beginning of the task. …”
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Conversion therapy strategy: A novel GPC3-targeted multimodal organic phototheranostics platform for mid-late-stage hepatocellular carcinoma by Fan Wu, Xin Kuang, Sanlin Deng, Shuo Qi, Jian Xiong, Bibo Zhao, Chuanfu Li, Senyou Tan, Qiang Kang, Hao Xiao, Xiaofeng Tan, Gui-long Wu, Qinglai Yang, Guodong Chen

“…High-sensitivity FLI/MRI precisely delineates tumor boundaries, providing real-time surgical navigation and prognosis assessment. …”
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Fatal poisonings in Nordic countries in 2022 among people who use drugs by Pirkko Kriikku, Hilde Marie E. Edvardsen, Gunilla Thelander, Svava Thordardottir, Charlotte Uggerhøj Andersen, Ilkka Ojanperä, Anna K. Jönsson, Joachim Frost, Simon Kjær Hermansen, Gerd J.M. Delaveris, Kirsten Wiese Simonsen

“…The median age at the time of death among PWUD was 40–43 years in Denmark, Norway and Sweden, while it was about ten years younger in Finland and Iceland (median age 33 years). …”
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The impact of sports experience on manual dexterity performances in school-age children by Antonino Patti, Domenico Savio Salvatore Vicari, Valerio Giustino, Flavia Figlioli, Genny Margherita Seidita, Alessandra Calogera Montalto Monella, Aurora Oddo, Antonio Paoli, Patrik Drid, Ewan Thomas, Antonino Bianco

“…Results: The five trials (GPT1 to GPT5) showed a decrease in the time to complete the test by the participants. The between-group variance in the finger-tapping test (GPT-FTT) and the counting test (GPT-CT) showed significant differences between groups (<0.001). …”
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A deep learning model based on RGB and hyperspectral images for efficiently detecting tea green leafhopper damage symptoms by Yang Xu, Yilin Mao, He Li, Jiazhi Shen, Xiuxiu Xu, Shuangshuang Wang, Shah Zaman, Zhaotang Ding, Yu Wang

“…However, traditional methods of recognizing and classifying the damage symptoms of this pest rely on human visual observation, which is time-consuming, labor-intensive, and subjective. …”
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Numerical investigation and parametric analysis of PCM-based lightweight panels for wall's exterior cladding by Zeyad Amin Al-Absi, Muhammad Asif, Mohd Isa Mohd Hafizal

“…Finally, the year-round performance of the optimum PCMFC demonstrated substantial effectiveness in reducing annual discomfort time to 6 % in non-conditioned buildings, i.e., corresponding to CO₂ emissions reduction of 287.3 kg CO₂/year/m2, while lowering annual cooling energy by 22.1–50.3 % in conditioned buildings, i.e., CO₂ emissions reduction up to 63.5 kg CO₂/year/m2. …”
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Antimicrobial Susceptibility of <i>Glaesserella parasuis</i> to Macrolides and Characterization of <i>erm</i>(T)-Carrying Mobile Elements on Chromosome by Peng Zhang, Changmin Li, Shuna Shang, Ting Huang, Junqi Liu, Qianwen Ge, Xiaoping Liao, Liangxing Fang, Yang Yu

“…To the best of our knowledge, integrative and conjugative element (ICE)-borne <i>erm</i>(T) in <i>G. parasuis</i> is reported for the first time in this study. Taken together, these results provide insights into the susceptibility of <i>G. parasuis</i> to macrolides. …”
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An Environmentally Adaptive CRO-SL Algorithm Based on Dynamic Agents for the Channel Assignment Problem in Wireless Networks by Antonio J. Romero-Barrera, Luis Cruz-Piris, Marino Tejedor-Romero, Jose Manuel Gimenez-Guzman, Ivan Marsa-Maestre

“…The results show that incorporating the new environmental agents into the EnvAdapt-CRO-SL workflow significantly boosts throughput while reducing the computational time required to obtain optimal solutions.…”
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Potential Involvement of IL-17F in Asthma by Kyoko Ota, Mio Kawaguchi, Satoshi Matsukura, Masatsugu Kurokawa, Fumio Kokubu, Junichi Fujita, Yuko Morishima, Shau-Ku Huang, Yukio Ishii, Hiroaki Satoh, Nobuyuki Hizawa

“…We have recently identified, for the first time, that bronchial epithelial cells are its novel cell source in response to IL-33 via ST2-ERK1/2-MSK1 signaling pathway. …”
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Development of an analytical method for the simultaneous determination of 22 Polycyclic Aromatic Hydrocarbons (PAHs) in maternal and umbilical cord blood by Swiha, Stéphanie, Pichon, Valérie, Fournier, Thierry, Gil, Sophie, Delaunay, Nathalie

“…The aim of this project was to develop a method enabling, for the first time, the simultaneous determination of 22 listed PAHs from small volumes (100 ${\mu }$L) of maternal serum and umbilical cord blood, including a sample pre-treatment reducing as far as possible the quantity of solvents used. …”
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Exploring predisposing factors of hearing loss in prematurely born children: A nationwide case-control study by Pei-Chen Tsao, Hung-Chih Lin, Shang-Po Shen, Yu-Chia Chang

“…Methods: This study enrolled 21,576 children born at < 37 weeks of gestation; 3,596 with HL and 17,980 with normal hearing born between 2002 and 2015, matched for sex, age at diagnosis, and enrollment time. Data were abstracted from the concatenation of three nationwide databases for overall risk factors till the diagnosis of HL. …”
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