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56481
A Comparative Study of the In Vitro Intestinal Permeability of Pinnatoxins and Portimine
Published 2025-01-01“…Portimine was the only toxin displaying both a time- and concentration-dependent passage, likely involving a passive diffusion process. …”
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56482
Performance of wood bottom ash as a replacement for Portland cement in coating mortars
Published 2025-01-01“…However, the properties that showed improvement were the setting time and the dynamic elastic modulus. Moreover, it was noticed by the calorimetry analysis that the 5% WBA replacement mortar favored nucleation during hydration. …”
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56483
Fully automatic fossa ovalis segmentation from computed tomography images using deep neural network with atlas-based localization
Published 2025-01-01“…At present, this information is obtained manually from pre-procedural medical images, which is time consuming with limited reproducibility. In this paper, we propose a method to automatically segment the FO region from computed tomography (CT) images. …”
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56484
MicroRNA-33 regulates the synaptic plasticity-related gene ARC in temporal lobe epilepsy
Published 2025-01-01“…We observed that miR-33 levels were reduced at 1 hour and 60 days post-seizure, while ARC expression notably increased at these time points. In the hippocampal CA1 and CA3 regions of post-seizure rats, ARC expression significantly exceeded that of control groups. …”
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56485
How Antiretroviral Drug Concentrations Could Be Affected by Oxidative Stress, Physical Capacities and Genetics: A Focus on Dolutegravir Treated Male PLWH
Published 2025-01-01“…Drug concentrations and oxidative stress biomarkers levels were evaluated through liquid chromatography coupled with tandem mass spectrometry, while genetic variants through real-time PCR. No statistical differences were suggested for drug concentrations, with the exception of intracellular DTG (<i>p</i> = 0.047). …”
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56486
Simons Observatory: Predeployment Performance of a Large Aperture Telescope Optics Tube in the 90 and 150 GHz Spectral Bands
Published 2025-01-01“…These data will provide new insights into the genesis, content, and history of our Universe, the astrophysics of galaxies and galaxy clusters, objects in our solar system, and time-varying astrophysical phenomena. This ambitious new instrument suite, initially comprising three 0.5 m diameter small aperture telescopes and one 6 m diameter large aperture telescope, is designed using a common combination of new technologies and new implementations to realize an observatory significantly more sensitive than the previous generation. …”
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56487
Phenylethanoid glycosides from traditional Mongolian medicine Cymbaria daurica alleviate alloxan-induced INS-1 cells oxidative stress and apoptosis
Published 2023-09-01“…INS-1 cells were treated with C. daurica, cell viability assay, RNA-seq technology, superoxide dismutase activity and malonaldehyde content, quantitative real time-PCR and Western blot analysis were used to study the protective effects of C. daurica. …”
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56488
Agile cavity ringdown spectroscopy enabled by moderate optical feedback to a quantum cascade laser
Published 2024-11-01“…Cavity ringdown spectroscopy (CRDS), relying on measuring the decay time of photons inside a high-finesse optical cavity, offers an important analytical tool for chemistry, physics, environmental science, and biology. …”
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56489
From guideline to practice: three years of ICH S11 insights and recommendations
Published 2025-02-01“…Although in 12 of selected PIPs a JAS was already ongoing or completed at the time of submission, in all other cases (115/127), the PIP was submitted before the initiation of JAS. …”
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56490
Evaluating the Effect of Chloroform and Water Extract of Satureja khuzistanica on the Expression of Bcl-2 and Bax in Gastric Cancer Cell Line
Published 2024-04-01“…The expression of Bax and Bcl-2 was evaluated using real-time polymerase chain reaction. Finally, all data were analyzed using REST software. …”
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56491
Response surface method-driven design of experiments for the synthesis of fly ash-based geopolymers in the gallic acid optimized removal from wastewater
Published 2025-03-01“…Kinetic studies indicated that the pseudo-first-order model best described the adsorption process. At the same time, equilibrium data fitted well with both Langmuir and Freundlich isotherms, with GP_2.0_10_2.5 showing the best fit for the Langmuir model. …”
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56492
GATA2 mutated allele specific expression is associated with a hyporesponsive state of HSC in GATA2 deficiency syndrome
Published 2025-01-01“…This population showed hyporesponsiveness, accumulated over time, and exhibited allele-specific expression (ASE) favoring the mutated Gata2 allele, also observed in GATA2 mutated patients. …”
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56493
Detection of fusion events by RNA sequencing in FFPE versus freshly frozen colorectal cancer tissue samples
Published 2025-01-01“…However, tumor biosamples are usually formalin-fixed paraffin-embedded (FFPE) tissue blocks where RNA is heavily degraded, which in theory may result in decreased efficiency of fusion detection. Here, for the first time, we compared the efficacy of gene fusion detection by RNAseq for matched pairs of freshly frozen in RNA stabilizing solution (FF) and FFPE tumor tissue samples obtained from 29 human colorectal cancer patients. …”
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56494
Comprehensive Mass Spectrometric Analysis of Snake Fruit: Salak (Salacca zalacca)
Published 2021-01-01“…Among the detected compounds, 11 were reported and quantified for the first time in salak pulp. Chlorogenic acid was by far the most predominant phenolic compound. …”
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56495
Forest fire risk assessment model optimized by stochastic average gradient descent
Published 2025-01-01“…Therefore, it’s of great importance to research forest fire risk assessment and prediction to protect the ecological environment of forests, respond to disaster damage in time and mitigate the effect of disasters. Most of the current related research methods rely on a stable operating environment and high raw data accuracy, the number of influencing factors considered is always different from the actual in many ways, and there is no systematic validation, etc., which makes the feasibility insufficient. …”
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56496
Integrating multi-source monitoring data and deep convolutional autoencoder technology for slope failure pattern recognition
Published 2025-01-01“…The proposed model accurately identified the time and evolution of the landslide, demonstrating its capability to detect failure events effectively.DiscussionValidation results confirm that the model can effectively distinguish previously unseen abnormal modes, offering significant practical value for identifying similar structural anomalies. …”
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56497
The Physics Case for an Electron-Muon Collider
Published 2021-01-01“…With this in mind, one can imagine a lepton collider complex, starting from colliding order 10 GeV electron and muon beams for the first time in history and to probe charged lepton flavor violation, then to be upgraded to a collider with 50-100 GeV electron and 1-3 TeV muon beams to measure Higgs properties and search for new physics and finally to be transformed to a TeV-scale muon-muon collider. …”
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56498
Evolutionary origins of synchronization for integrating information in neurons
Published 2025-01-01“…Quantum synchronization is hypothesized to involve ion coherence during ion channel passage and the entanglement of photons within the myelin sheath. Unlike the finite-time synchronization seen in chemical and electromagnetic processes, quantum entanglement provides instantaneous non-local coherence states. …”
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56499
Whole exome sequencing identifies ABHD14A and MRNIP as novel candidate genes for developmental language disorder
Published 2025-01-01“…We performed whole-exome sequencing (WES) of a first-time-described Tunisian-family with DLD. Analyses of segregation patterns with stringent filtering of the exome data identified disease-causing compound heterozygous variants. …”
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56500
Species diversity of saprophagous flies (Diptera) in hospital grounds of Tehran, Iran
Published 2025-01-01“…Sarcophaga nigriventris Meigen, 1826 is reported for the first time for Iranian fauna.…”
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