Self-Assembly Iron Oxide Nanoclusters for Photothermal-Mediated Synergistic Chemo/Chemodynamic Therapy by Xiang Li, Zhen Wang, Mian Ma, Zhouqing Chen, Xiang-long Tang, Zhong Wang

“…The shell consisted of a human serum albumin- (HSA-) paclitaxel (PTX) layer, which extended the blood circulation time and ensured the effectiveness of the chemotherapy. …”
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The Ivermectin Related Compound Moxidectin Can Target Apicomplexan Importin α and Limit Growth of Malarial Parasites by Sujata B. Walunj, Geetanjali Mishra, Kylie M. Wagstaff, Swati Patankar, David A. Jans

“…Here we focus on the FDA-approved antiparasitic moxidectin, a structural analogue of ivermectin, for its IMPα-targeting and anti-apicomplexan properties for the first time. We use circular dichroism and intrinsic tryptophan fluorescence measurements to show that moxidectin can bind directly to apicomplexan IMPαs, thereby inhibiting their key binding functions at low μM concentrations, as well as possessing anti-parasitic activity against <i>P. falciparum</i> in culture. …”
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Colorectal Carcinoma with Extremely Low CA19-9 by Yutaka J. Kawamura, Aika Tokumitsu, Junichi Sasaki, Shingo Tsujinaka, Takafumi Maeda, Ken Mizogami, Fumio Konishi

“…Patients with CA19-9 level of less than 2 U/mL at the time of diagnosis were defined as Extremely Low CA19-9 (ELCA). …”
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Do pregnant women living in higher well-being populations in the USA experience lower risk of preterm delivery? A cross-sectional study by Jeph Herrin, Harlan M Krumholz, Carley Riley, Brita Roy, Erica Spatz, Mark T Silvestri, Anita Arora, Kenneth P Kell, Elizabeth Y Rula

“…In the model adjusted for maternal risk factors (age, race, Hispanic ethnicity, smoking status, timing of initiation of prenatal visits, multiparity, maternal insurance payer), the association was slightly attenuated with an absolute difference of 1.9% (95% CI 1.7% to 2.1%; p&lt;0.001).Conclusions Pregnant women who live in areas with higher population well-being have lower risk of preterm birth, even after accounting for individual risk factors.…”
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Design and simulation of a 5 KW solar-powered hybrid electric vehicle charging station with a ANN–Kalman filter MPPT and MPC-based inverter control for reduced THD by Youness Hakam, Hajar Ahessab, Ahmed Gaga, Mohamed Tabaa, Benachir El Hadadi

“…Unlike traditional MPPT methods, which face challenges with multiple peaks in the Power–Voltage (P–V) curve, the hybrid algorithm enhances tracking accuracy, reduces errors, and cuts tracking time by up to 99.93%. This ensures a reliable and sustainable power source for EV charging, reducing grid dependency during peak demand. …”
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Advancing <i>Glycyrrhiza glabra</i> L. Cultivation and Hairy Root Transformation and Elicitation for Future Metabolite Overexpression by Negin Afsharzadeh, Renate Paltram, Arne Jungwirth, Leila Tabrizi, Vahideh Nazeri, Hadi Kalantari, Heidi Halbwirth, Leila Samiei, Hester Sheehan, Majid Shokrpour

“…Hairy root cultures grown in blue light and in blue and red light combined had higher growth rates than those grown in red light only or in control conditions (dark). FRAP increased over time under all light treatments, including the control, and those cultures exposed to blue and red light combined had higher FRAP than the control. …”
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3D tomographic analysis of equatorial plasma bubble using GNSS-TEC data from Indonesian GNSS Network by Ihsan Naufal Muafiry, Prayitno Abadi, Teguh N. Pratama, Dyah R. Martiningrum, Sri Ekawati, Yuandhika G. Wismaya, Febrylian F. Chabibi, Gatot H. Pramono

“…Their 2D spatial distribution consistently captured the four EPB clusters over time. These tomography results were validated through a classical checkerboard test and comparisons with other ionospheric data sources, such as the Global Ionospheric Map (GIM) and International Reference Ionosphere (IRI) profile. …”
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MXene−Graphene Oxide Heterostructured Films for Enhanced Metasurface Plasmonic Biosensing in Continuous Glucose Monitoring by Rui Li, Hongli Fan, Youqian Chen, Shaoping Yin, Gang L. Liu, Yanan Li, Liping Huang

“…Abstract Non‐invasive biosensors have attracted attention for their potential to obtain continuous, real‐time physiological information through measurements of biochemical markers, such as one of the most important—glucose, in biological fluids. …”
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Inferring transcriptomic dynamics implicated in odor fatty acid accumulation in adipose tissue of Hulun Buir sheep from birth to market by Yechan Zhao, Zhangyan Li, Huimin Ou, Zhiliang Tan, Jinzhen Jiao

“…Overall, our findings provided novel insight into the critical time window and pivotal candidate genes of OFA synthesis in the adipose tissue, which will assist with the targeted development of nutritional strategies to inhibit OFA accumulation of lambs.…”
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RNA-Seq-Based Gene Expression Pattern and Morphological Alterations in Chick Thymus during Postnatal Development by Zhouyiyuan Xue, Abdur Rahman Ansari, Xing Zhao, Kun Zang, Yu Liang, Lei Cui, Yafang Hu, Ranran Cheng, Xiaolong Zhang, Juming Zhong, Huazhen Liu

“…The expression pattern revealed by RNA-seq was validated by quantitative real-time PCR (qPCR) analysis of four important genes, which are PCNA, CCNA2, CCNB2, and CDK1. …”
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Hot melt extrusion assisted additive manufacturing of mixed polymeric 3D printed metoprolol succinate extended-release tablets for controlled oral drug delivery by Shubham Ghatole, Jannu Dilip, Makka Krupali Ashokbhai, Himanshu Vishwakarma, Subham Banerjee, Santanu Kaity

“…The filaments were comprehensively characterized using tensile strength assessment, Fourier-transform infrared spectroscopy (FT-IR), and X-ray diffraction (XRD). At the same time, micro-computed tomography (µCT) provided detailed analysis of the 3D-printed tablets. …”
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A Picrorhiza kurroa Derivative, Picroliv, Attenuates the Development of Dextran-Sulfate-Sodium-Induced Colitis in Mice by De-Kui Zhang, Jian-Jie Yu, Yu-Min Li, Li-Na Wei, Yi Yu, Yan-Hu Feng, Xiang Wang

“…Myeloperoxidase (MPO) activity, and SOD, MDA concentrations were measured by enzyme-linked immunosorbent assay (ELISA) while the expression of cytokine mRNAs was studied by real-time-quantitative polymerase chain reaction and also ELISA. …”
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Influence of next-generation artificial intelligence on headache research, diagnosis and treatment: the junior editorial board members’ vision – part 2 by Igor Petrušić, Chia-Chun Chiang, David Garcia-Azorin, Woo-Seok Ha, Raffaele Ornello, Lanfranco Pellesi, Eloisa Rubio-Beltrán, Ruth Ruscheweyh, Marta Waliszewska-Prosół, William Wells-Gatnik

“…In addition, AI-driven wearable devices equipped with next-generation biosensors combined with multi-agent chatbots could enable real-time physiological and biochemical monitoring, diagnosing, facilitating early headache attack forecasting and prevention, disease tracking, and personalized interventions. …”
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Development of a pulsed magnetic field power supply for small size Betatron by Qi Liu, Jinhai Li, Haitao Wang, Yan Zhang, Haisheng Chen, Renbo Wang, Shumin Zhou

“…By adjusting the loss-compensation time, the problem of the pulsed current amplitude attenuation due to losses can be overcome, ensuring the stability of the pulsed magnetic field. …”
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CMIP6-based global estimates of future aridity index and potential evapotranspiration for 2021-2060 [version 2; peer review: 1 approved, 2 approved with reservations] by Jianchu Xu, Robert J. Zomer, Antonio Trabucco, Donatella Spano

“…The “Future_Global_AI_PET Database” provides high-resolution (30 arc-seconds) average annual and monthly global estimates of potential evapotranspiration (PET) and aridity index (AI) for 22 CMIP6 Earth System Models for two future (2021–2041; 2041–2060) and two historical (1960–1990; 1970–2000) time periods, for each of four shared socio-economic pathways (SSP). …”
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Negative Affect, Type D Personality, Quality of Life, and Dysfunctional Outcomes of Total Knee Arthroplasty by Matthias Vogel, Christian Riediger, Martin Krippl, Jörg Frommer, Christoph Lohmann, Sebastian Illiger

“…This study is the first to investigate the influence of TDP on TKA assuming (1) negative affect (NA) to be linked to fear avoidance and to increased dissatisfaction with TKA and (2) the expression of NA and social inhibition (SI) to not be stable over time. Method. We studied 79 participants using the brief symptom inventory-18, the pain-catastrophizing scale, the Tampa scale of kinesiophobia, the SF-36, and the WOMAC preoperatively and 12 months postoperatively. …”
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Levo-Tetrahydropalmatine Attenuates Bone Cancer Pain by Inhibiting Microglial Cells Activation by Mao-yin Zhang, Yue-peng Liu, Lian-yi Zhang, Dong-mei Yue, Dun-yi Qi, Gong-jian Liu, Su Liu

“…Thermal hyperalgesia and mechanical allodynia were measured at different time points before and after operation. L-THP (20, 40, and 60 mg/kg) were administrated intragastrically at early phase of postoperation (before pain appearance) and later phase of postoperation (after pain appearance), respectively. …”
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Extraction and Bioactivity Analysis of Major Flavones Compounds from Scutellaria baicalensis Using In Vitro Assay and Online Screening HPLC-ABTS System by Kwang Jin Lee, Pil Mun Jung, You-Chang Oh, Na-Young Song, Taesoo Kim, Jin Yeul Ma

“…In this case, the best yield of 37.01 mg/g in BG, WG, B, and W compounds was obtained by a dipping method with an extraction time of 4 h. In addition, the yield (43.05%) and IC50 (34.04 μg/mL) determined through ABTS assay of the 60% aqueous ethanol extract were the most satisfactory of all solvent solutions tested. …”
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The Bipolar Depression Electrical Treatment Trial (BETTER): Design, Rationale, and Objectives of a Randomized, Sham-Controlled Trial and Data from the Pilot Study Phase by Bernardo de Sampaio Pereira Junior, Gabriel Tortella, Beny Lafer, Paula Nunes, Isabela Martins Benseñor, Paulo Andrade Lotufo, Rodrigo Machado-Vieira, André R. Brunoni

“…The primary outcome is change (over time and across groups) in the scores of the Hamilton Depression Rating Scale (17 items). …”
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Clinical impact of direct rotational atherectomy in patients with complex coronary artery lesions by Kyusup Lee, Ji-hoon Jung, Woojin Kwon, Dae-Won Kim, Mahn-Won Park, Ik Jun Choi, Jae-Hwan Lee, Yong Hoon Yoon, Jang Hoon Lee, Sang Rok Lee, Pil Hyung Lee, Seung-Whan Lee, Ki Dong Yoo, Kyeong Ho Yun, Hyun-Jong Lee, Sung-Ho Her

“…Abstract Owing to limited data on the optimal timing of rotational atherectomy (RA), we sought to evaluate the clinical impact of the early application of the RA strategy. …”
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