Mitochondrial trifunctional protein deficiency caused by a deep intronic deletion leading to aberrant splicing by Thomas Cassini, Sarah Silverstein, Molly Behan, Cynthia J. Tifft, May Christine Malicdan, David R. Adams, Undiagnosed Diseases Network, Sun‐Young Ahn, Debra S. Regier

“…A review of the literature at that time revealed several case reports of the uncommon clinical findings of FSGS, bone marrow failure, and pulmonary involvement in patients with TFP, confirming this clinical diagnosis as the complete explanation for these siblings.…”
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Potential of Inducible Nitric Oxide Synthase as a Therapeutic Target for Allergen-Induced Airway Hyperresponsiveness: A Critical Connection to Nitric Oxide Levels and PARP Activity by Salome’ V. Ibba, Mohamed A. Ghonim, Kusma Pyakurel, Matthew R. Lammi, Anil Mishra, A. Hamid Boulares

“…We show, for the first time, that iNOS is highly expressed in peripheral blood mononuclear cells (PBMCs) of asthmatics with uncontrolled disease, which did not correspond to protein nitration. …”
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Accelerating maturation of Chinese rice wine by using a 20 L scale multi-sweeping-frequency mode ultrasonic reactor and its mechanism exploration by Zhuofan He, Furong Hou, Yansheng Du, Chunhua Dai, Ronghai He, Haile Ma

“…After sonication and stored for six months, 286.78 % increase of the volatile esters was found, compared to rice wine without ultrasoinc treatment and stored at same condition for same time. And the total volatile alcohol substances and total volatile aldehydes in rice wine decreased by 12.95 % and 67.46 %, while the total volatile acids increased by 17.11 %, respectively. …”
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Guava Leaf Extract Exhibits Antimicrobial Activity in Extensively Drug-Resistant (XDR) <i>Acinetobacter baumannii</i> by Daniela Gutierrez-Montiel, Alma L. Guerrero-Barrera, Flor Y. Ramírez-Castillo, Fabiola Galindo-Guerrero, Ingrid G. Ornelas-García, Norma A. Chávez-Vela, Matheus de O. Costa, Francisco J. Avelar-Gonzalez, Adriana C. Moreno-Flores, Erick Vazquez-Pedroza, José M. Arreola-Guerra, Mario González-Gámez

“…As a result, phytochemicals have emerged as a potential alternative to combat resistant strains, since they can exert antimicrobial activity through various mechanisms and, at the same time, represent a more natural and safe option. This study analyzes the antimicrobial effects of guava leaf extract in ten clinical isolates of extensively drug-resistant (XDR) <i>A. baumannii</i>, using the agar diffusion technique and the microdilution method to determine the minimum inhibitory concentrations (MICs). …”
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High Intensity Focused Ultrasound versus Brachytherapy for the Treatment of Localized Prostate Cancer: A Matched-Pair Analysis by Fouad Aoun, Ksenija Limani, Alexandre Peltier, Quentin Marcelis, Marc Zanaty, Alexandre Chamoun, Marc Vanden Bossche, Thierry Roumeguère, Roland van Velthoven

“…Median oncologic follow-up was 83 months (13–123 months) in the HIFU cohort and 44 months (13–89 months) in the brachytherapy cohort. Median time to achieve PSA nadir was statistically shorter in the HIFU. …”
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Formononetin Administration Ameliorates Dextran Sulfate Sodium-Induced Acute Colitis by Inhibiting NLRP3 Inflammasome Signaling Pathway by Dacheng Wu, Keyan Wu, Qingtian Zhu, Weiming Xiao, Qing Shan, Zhigang Yan, Jian Wu, Bin Deng, Yan Xue, Weijuan Gong, Guotao Lu, Yanbing Ding

“…Collectively, our study for the first time confirmed the protective effects of formononetin on DSS-induced acute colitis via inhibiting the NLRP3 inflammasome pathway activation.…”
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Impact of Chatbots on User Experience and Data Quality on Citizen Science Platforms by Akasha-Leonie Kessel, Soror Sahri, Sven Groppe, Jinghua Groppe, Hanieh Khorashadizadeh, Marc Pignal, Eva Perez Pimparé, Régine Vignes-Lebbe

“…Recent advancements in Large Language Models (LLMs) present a promising solution by providing automated, real-time assistance to users, reducing the need for extensive human intervention, and offering instant support. …”
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Baicalein Protects against Type 2 Diabetes via Promoting Islet β-Cell Function in Obese Diabetic Mice by Yu Fu, Jing Luo, Zhenquan Jia, Wei Zhen, Kequan Zhou, Elizabeth Gilbert, Dongmin Liu

“…In both type 1 (T1D) and type 2 diabetes (T2D), the deterioration of glycemic control over time is primarily caused by an inadequate mass and progressive dysfunction of β-cell, leading to the impaired insulin secretion. …”
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Three-dimensional phase field simulation for rafting of multiparticle precipitate in elastic inhomogeneous alloy under external stress by Mao H., Kong Y., Shuai X., Tang S., Du Y.

“…The results show that the average particle size is linearly related to the evolution time and satisfies the Lifshitz-Slyozov-Wagner (LSW) classical coarsening theory when the external stress is not applied. …”
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A multicenter, randomized, open label, two formulation, crossover bioequivalence trial of doxorubicin hydrochloride liposomal injection in Chinese patients with metastatic breast c... by Jingshu Wang, Xiuping Lai, Herui Yao, Hui Yang, Xiaolong Cao, Xiaochen Wang, Ying Wang, Weiqi Nian, Xiaodong Zheng, Qingxiu Mai, Anding Liu, Xiaozhi Lv, Xiaoying Bi, Junyi Chen, Junyan Wu, Suiwen Ye

“…Results The results indicated that the maximum concentration (Cmax), AUC from time zero to the last measurable concentration (AUC0-t), and AUC extrapolated to infinity (AUC0-∞) of in vivo non-encapsulated doxorubicin after administration of both formulations fell within the 80.00%–125.00% range at a 90% confidence interval. …”
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Modifications in aroma characteristics of ‘Merlot’ dry red wines aged in American, French and Slovakian oak barrels with different toasting degrees by Haocheng Lu, Binhao Cheng, Yibin Lan, Changqing Duan, Fei He

“…In the present study, the aroma compounds were analyzed from the ‘Merlot’ dry red wines, which were fermented in two types of fermenters (stainless steel tank and rotated oak barrel) and aged in six types of oak barrels (three geographic origins × two toasting degrees) for different time (0, 3, 6 and 9 months, respectively). Results showed that 30 volatiles were associated with barrels and increased during oak aging. …”
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Dual-modal super-resolution ultrasound and NIR-II fluorescence imaging of ischemic stroke with ICG-doped porous PLGA microspheres by Ziyue Li, Yu Qiang, Dongli Chen, Dehong Hu, Duyang Gao, Xiaohua Xu, Lei Sun, Yingjia Li, Weibao Qiu, Zonghai Sheng

“…The porous structure of ICG-pPLGA MPs enhances their stability, prolongs their circulation time, and improves ultrasound contrast compared to commercial lipid microbubbles. …”
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Classification of Melanoma and Nevus in Digital Images for Diagnosis of Skin Cancer by Muhammad Qasim Khan, Ayyaz Hussain, Saeed Ur Rehman, Umair Khan, Muazzam Maqsood, Kashif Mehmood, Muazzam A. Khan

“…The number of cases is growing among young people, but if it is diagnosed at an earlier stage, then the survival rates become very high. The cost and time required for the doctors to diagnose all patients for melanoma are very high. …”
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Simulation of Self-Occlusion Virtual Dataset Method for Robust Point Matching Algorithm, With Applications to Positioning of Guide Vanes by Fenglin Han, Hang Peng, Xian Wu, Haonan Ren, Yiwei Sun, Bin Su

“…Additionally, in real industrial scenarios, manually obtaining the real dataset is time-consuming, labor-intensive, and error-prone. …”
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Mathematical modeling of the parasitism and hyperparasitism increase on Halyomorpha halys eggs in a five-year survey in Northern Italy by Ezio Venturino, Francesco Cantaloni, Luciana Tavella, Silvia Moraglio, Francesco Tortorici

“…Focusing on the situation in Northern Italy, where also the hyperparasitoid Acroclisoides sinicus is present, a discrete-time model is developed for the simulation of the pest evolution. …”
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Role of MMP-2 (-1306 C/T) Polymorphism in Pituitary Adenoma by Brigita Glebauskiene, Rasa Liutkeviciene, Alvita Vilkeviciute, Loresa Kriauciuniene, Giedrimantas Bernotas, Arimantas Tamasauskas, Dalia Zaliuniene

“…The genotyping test of MMP-2 (-1306 C/T) was carried out using the real-time polymerase chain reaction method. Results. Analysis of MMP-2 (-1306 C/T) gene polymorphism has not revealed any differences in the genotype (C/C, C/T, and T/T) distribution between the PA patients and the reference group (as follows: 50%, 44%, and 6% versus 59.75%, 33.96%, and 6.29%). …”
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Common Bile Duct Dilatations in Asymptomatic Neonates: Incidence and Prognosis by Shun-Feng Lin, Hung-Chang Lee, Chun-Yan Yeung, Chuen-Bin Jiang, Wai-Tao Chan

“…Patients with initial CBD size ≥3 mm had significantly lower resolution rate and neonates whose mothers are older than 35 years took longer time to resolve. Conclusion. The incidence of CBD dilatation in asymptomatic neonates was 1.17%. …”
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Static voltage stability margin evaluation for a DC distribution network with DC electric springs by Xiaolong Xu, Qianggang Wang, Jianquan Liao, Yuan Chi, Tao Huang, Niancheng Zhou, Yiyao Zhou, Xuefei Zhang

“…The evaluation also accounts for the current limits of power supply converters. The time-domain simulation results show high consistency with the proposed method, especially in calculating the load power that drives the device outputs to their limits, thereby validating the effectiveness of the approach.…”
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Study on the Thermal State of a Transverse-Flux Motor by Andrii Yehorov, Oleksii Duniev, Andrii Masliennikov, Rupert Gouws, Oleksandr Dobzhanskyi, Mario Stamann

“…Graphs illustrating the temperature rise over time for each motor component were generated. The obtained results include corresponding graphs and dependencies, revealing that the average coil temperature reached 92&#x00B0;C, deviating by 3.3% from the experimental value. …”
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A Green Approach to the Production of Hybrid Diindolylmethane-Phenylboronic Acids via a 3MCR: Promising Antineoplasic Molecules by Mónica Zarco Juarez, Joel Omar Martínez, Olivia Noguez Cordova, María Inés Nicolás Vazquez, Teresa Ramírez-Apan, Javier Pérez Flores, René Miranda Ruvalcaba, Gabriel Arturo Arroyo Razo

“…The products were achieved with moderate yields (41–61%) within a short time frame (5 min) and appropriately characterized by elemental analysis and spectroscopic methods (NMR: 1H, 13C, 11B; MS: EI, CI, FAB+, HRMS). …”
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