The Impact of Antibiotics on the Development of Colorectal Cancer – A Review of Current Insights and Directions for Future Research by Karol Zagórski, Mateusz Kozik, Nina Skalska-Dziobek, Weronika Małagocka, Karolina Chybowska, Maria Naruszewicz, Przemysław Cetnarowski

“…State of knowledge: This review identified several key systematic reviews with meta-analyses of observational studies indicating that antibiotics have an impact on the onset, time of development, and localisation of CRC. The classes and spectrum of antibiotics were found to differ in the risk of occurrence of CRC.   …”
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Etiological Aspects of Infectious Endocarditis in a Tertiary Hospital in Northeastern Romania by Isabela Ioana Loghin, Amelia Elena Surdu, Șerban Alin Rusu, Ion Cecan, Victor Daniel Dorobăț, Amelia Andreea Mihăescu, Carmen Mihaela Dorobăţ

“…Despite advances in diagnosis and treatment, the high mortality rates highlight the importance of timely intervention. Future research should focus on improving preventive and therapeutic strategies for IE.…”
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Transcranial Magnetic Stimulation to Address Mild Cognitive Impairment in the Elderly: A Randomized Controlled Study by Hellen Livia Drumond Marra, Martin Luiz Myczkowski, Cláudia Maia Memória, Débora Arnaut, Philip Leite Ribeiro, Carlos Gustavo Sardinha Mansur, Rodrigo Lancelote Alberto, Bianca Boura Bellini, Adriano Alves Fernandes da Silva, Gabriel Tortella, Daniel Ciampi de Andrade, Manoel Jacobsen Teixeira, Orestes Vicente Forlenza, Marco Antonio Marcolin

“…ANOVA on the primary efficacy measure, the Rivermead Behavioural Memory Test, revealed a significant group-by-time interaction p=0.05, favoring the active group. …”
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Antileishmanial Effect of 5,3′-Hydroxy-7,4′-dimethoxyflavanone of Picramnia gracilis Tul. (Picramniaceae) Fruit: In Vitro and In Vivo Studies by Sara M. Robledo, Wilson Cardona, Karen Ligardo, Jéssica Henao, Natalia Arbeláez, Andrés Montoya, Fernando Alzate, Juan M. Pérez, Victor Arango, Iván D. Vélez, Jairo Sáez

“…The leishmanicidal activity attributed to this flavanone is also reported for the first time. Finally, the in vitro and in vivo leishmanicidal activity reported here for 5,3′-hydroxy-7,4′-dimethoxyflavanone offers a greater prospect towards antileishmanial drug discovery and development.…”
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Long-term impacts of agricultural greenhouse expansion on albedo, land surface temperature, and vegetation: Evidence from a typical province in China by Fangxin Chen, Cong Ou, Yue Chen, Xiaochuang Yao, Bowen Niu, Zhenbo Du

“…To fill this gap, we utilized multiple remote sensing data, time-series segmentation algorithm, and the Mann-Kendall test to analyze the spatiotemporal evolution patterns of AGs in Shandong Province, China from 2001 to 2018. …”
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Neuropilin 1 Mediates Keratinocyte Growth Factor Signaling in Adipose-Derived Stem Cells: Potential Involvement in Adipogenesis by Simona Ceccarelli, Cristina Nodale, Enrica Vescarelli, Paola Pontecorvi, Valeria Manganelli, Giovanni Casella, Maria Giuseppina Onesti, Maurizio Sorice, Ferdinando Romano, Antonio Angeloni, Cinzia Marchese

“…Here, we demonstrate for the first time that Neuropilin 1 (NRP1), a transmembrane glycoprotein expressed in ASCs acting as a coreceptor for some growth factors, is responsible for KGF-dependent pathway activation in these cells. …”
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IDBGL: A unique image dataset of black gram (Vigna mungo) leaves for disease detection and classificationMendeley Data by Md. Mehedi Hasan Shoib, Shahnewaz Saeem, Afia Benta Aziz Tonima, Mayen Uddin Mojumdar

“…We can apply deep learning models to recognize diseases in their early stages for timely interference. Diseases could be detected with the automation process, from which much enhancement in the management and yield of black gram crops is possible. …”
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A New Dual Steering System in a Compact Tractor by Giorgio Paolo Massarotti, German Filippini, Gustavo Raush Alviach, Pedro Javier Gamez-Montero, Esteban Codina Macia

“…For certain crops, a dual steering vehicle is used to meet the needs of professionals who require easy maneuverability in narrow spaces and/or reduced steering time. This study aims to explore the reasons behind the need for dual steering tractors, highlighting the advantages and disadvantages of these two different configurations and ultimately focusing on the combined benefits of both. …”
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Exploring Methacrylated Gellan Gum 3D Bioprinted Patches Loaded with Tannic Acid or L-Ascorbic Acid as Potential Platform for Wound Dressing Application by Federica Scalia, Alessandra Maria Vitale, Domiziana Picone, Noemi De Cesare, Maria Swiontek Brzezinska, Beata Kaczmarek-Szczepanska, Alfredo Ronca, Barbara Zavan, Fabio Bucchieri, Marta Anna Szychlinska, Ugo D’Amora

“…To improve stability and degradation time, gellan gum (GG) was chemically modified by grafting methacrylic moieties on the polysaccharide backbone. …”
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Synergistic defecation effects of Bifidobacterium animalis subsp. lactis BL-99 and fructooligosaccharide by modulating gut microbiota by Qi Zhang, Wen Zhao, Jie Luo, Shaoqi Shi, Xiaokang Niu, Jian He, Yicheng Wang, Zhaozhong Zeng, Qiuyue Jiang, Bing Fang, Juan Chen, Yixuan Li, Fuqing Wang, Jingjing He, Jie Guo, Ming Zhang, Liwei Zhang, Shaoyang Ge, Wei-Lian Hung, Ran Wang

“…The synergistic efficacy of Bifidobacterium animalis subsp. lactis BL-99 (BL-99) and fructooligosaccharide (FOS) on constipation have not been investigated.MethodsLoperamide-induced constipated mice model was established to explore the effect of BL-99, FOS, and BL-99+FOS on changes of defecation-related parameters, gut microbiota and metabolites.Results and discussionThe results showed that BL-99, FOS, and BL-99+FOS each alleviated constipation, with the synbiotic showing significant efficacy in the first black stool defecation time, fecal number, fecal weight, and the gastrointestinal transit rate (P < 0.05). …”
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Microbial Contamination in Chicken Meat in Traditional Markets in Banyuwangi by Prima Ayu Wibawati, Yunia Chrismonica, Racca Biana Susanti, Mario Putra Himawan, Afaf Heny Sintya Devy, Juwita Ayu Nirmalasari, Abzal Abdramanov

“…Chicken meat pH value decreased with the length of postmortem time; immediately after purchase (0 hours), the pH value was 5.78 ± 0.26, and after 24 hours of storage, it raised 6.02 ± 0.28. …”
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DeepAptamer: Advancing high-affinity aptamer discovery with a hybrid deep learning model by Xin Yang, Chi Ho Chan, Shanshan Yao, Hang Yin Chu, Minchuan Lyu, Ziqi Chen, Huan Xiao, Yuan Ma, Sifan Yu, Fangfei Li, Jin Liu, Luyao Wang, Zongkang Zhang, Bao-Ting Zhang, Lu Zhang, Aiping Lu, Yaofeng Wang, Ge Zhang, Yuanyuan Yu

“…Oligonucleotide aptamers are typically identified through a rigorous and time-consuming process known as systematic evolution of ligands by exponential enrichment (SELEX), which requires 20 to 30 iterative rounds to eliminate non/weak binding sequences and enrich tight binding sequences with high affinity. …”
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A Clinical Mentorship and Quality Improvement Program to Support Health Center Nurses Manage Type 2 Diabetes in Rural Rwanda by Aphrodis Ndayisaba, Emmanuel Harerimana, Ryan Borg, Ann C. Miller, Catherine M. Kirk, Katrina Hann, Lisa R. Hirschhorn, Anatole Manzi, Gedeon Ngoga, Symaque Dusabeyezu, Cadet Mutumbira, Tharcisse Mpunga, Patient Ngamije, Fulgence Nkikabahizi, Joel Mubiligi, Simon Pierre Niyonsenga, Charlotte Bavuma, Paul H. Park

“…Of 263 observed nurse mentee-patient encounters, mentor and mentee agreed on diagnosis 94.4% of the time. Similarly, agreement levels were high for medication, laboratory exam, and follow-up plans, at 86.3%, 87.1%, and 92.4%, respectively. …”
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Investigation of the Suitability of the DTV Method for the Online SoH Estimation of NMC Lithium-Ion Cells in Battery Management Systems by Jan Neunzling, Philipp Hainke, Hanno Winter, David Henriques, Matthias Fleckenstein, Torsten Markus

“…After a specified aging cycle was complete, a check-up measurement was performed. During this time, the cycler collected the electrical measuring values, while a negative temperature coefficient thermistor, which was located on the cell, was used to record the temperature fluctuations. …”
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The Effect of Goat Grazing on the Biodiversity of Pannonian Dry Grassland by Karoly Penksza, Ferenc Pajor, Andrea Kevi, Zsombor Wagenhoffer, Laszló Sipos, Eszter Salata-Falusi, Peter Penksza, Peter Poti, Jozsef Berke, Denes Salata, Marta Bajnok, Szilard Szentes

“…The overgrazed (N1) pasture had a low forage value because of the different timing of treatments. Even in the lightly grazed pasture (C1), the proportion of species indicative of degradation was significant. …”
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Satellite microglia: marker of traumatic brain injury and regulator of neuronal excitability by Alicia B. Feichtenbiner, Karinn Sytsma, Ryan P. O’Boyle, Rhonda Mittenzwei, Heather Maioli, Kathryn P. Scherpelz, Daniel D. Child, Ning Li, Jeanelle Ariza Torres, Lisa Keene, Amanda Kirkland, Kimberly Howard, Caitlin Latimer, C. Dirk Keene, Christopher Ransom, Amber L. Nolan

“…Taking our investigation into a mouse model, we identified that these satellite microglia suppress neuronal excitability in control conditions but lose this ability with chronic traumatic brain injury. At the same time, network hyperexcitability is present in both mouse and human orbitofrontal cortex. …”
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Geosciences and the Energy Transition by Nicholas J. Gardiner, Jennifer J. Roberts, Gareth Johnson, Daniel J. Smith, Clare E. Bond, Rob Knipe, Stuart Haszeldine, Sarah Gordon, Megan O’Donnell

“…Yet, emissions from fossil fuel energy generation—which dominate global greenhouse gas emissions—are at an all-time high. Progress and action for an energy transition to net zero carbon is critical, and one in which geoscience sectors and geoscientists will play multiple roles. …”
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Micronutrient status, food security, anaemia, Plasmodium infection, and physical activity as predictors of primary schoolchildren's body composition in Côte d'Ivoire by Kurt Z. Long, Kurt Z. Long, Sylvain G. Traoré, Sylvain G. Traoré, Kouadio B. Kouassi, Kouadio B. Kouassi, Jean T. Coulibaly, Jean T. Coulibaly, Bomey C. Gba, Bomey C. Gba, Daouda Dao, Daouda Dao, Johanna Beckmann, Christin Lang, Harald Seelig, Nicole Probst-Hensch, Nicole Probst-Hensch, Uwe Pühse, Markus Gerber, Jürg Utzinger, Jürg Utzinger, Bassirou Bonfoh, Bassirou Bonfoh, Bassirou Bonfoh

“…Associations of children's nutritional status, Plasmodium infection, physical activity and household characteristics with body composition were analyzed to identify what factors might be contributing to this dual burden of disease.MethodsLongitudinal growth curve models (LGCM) evaluated associations of micronutrient status, household food security, Plasmodium falciparum prevalence and physical activity assessed at three time points with fat free mass and fat mass.ResultsMore severe anaemia was inversely associated with FFM and TrFFM trajectories overall and among girls. …”
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Therapeutic effect of selective interleukin-2-inducible tyrosine kinase inhibitor in orbital fibroblasts from patients with Graves’ orbitopathy by Yeonjung Yoon, Hyun Young Park, Min Kyung Chae, Sun Young Jang, Jin Sook Yoon

“…ITK mRNA expression in orbital tissues from GO and normal controls was compared using real-time polymerase chain reaction (RT-PCR) and immunohistochemistry. …”
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In-situ observation of twinning and grain rotation assisted deformation in wire-arc direct energy deposited (WDED) single phase titanium by Blanca Palacios, Sohail M.A.K. Mohammed, Tanaji Paul, Brandon Aguiar, Sean Langan, Arvind Agarwal

“…Additive manufacturing of metals often results in microstructural inhomogeneities, leading to the simultaneous or sequential activation of multiple deformation mechanisms. Real-time monitoring of these mechanisms is essential for understanding material behavior. …”
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