Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis by Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu

“…Abstract Background Colorectal cancer (CRC) exhibits a high incidence globally, with the liver being the most common site of distant metastasis. At the time of diagnosis, 20–30% of CRC patients already present with liver metastases. …”
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Critical technologies and geology-engineering integration practices for deep CBM production in the Yanchuannan CBM field by Zhenlong CHEN, Yunhai WANG, Xiao LIU, Bin CUI, Song YANG, Xin LI, Qilong FANG

“…Adhering to this work philosophy, the production capacity construction was performed through continuous assessment and adjustment of geological-engineering sweet spots and timely optimization of production schemes to effectively avoid the co-occurrence of a substantial number of inefficient wells. …”
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The contrasted impacts of grasshoppers on soil microbial activities in function of primary production and herbivore diet by Ibanez, Sébastien, Foulquier, Arnaud, Brun, Charles, Colace, Marie-Pascale, Piton, Gabin, Bernard, Lionel, Gallet, Christiane, Clément, Jean-Christophe

“…This highlights the multidimensional feature of the impacts of herbivory on ecosystem functioning, both in space and time. …”
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Effects of Bedaquiline on Antimicrobial Activity and Cytokine Secretion of Macrophages Infected with Multidrug-Resistant Mycobacterium tuberculosis Strains by Xia-Li Lyu, Ting-Ting Lin, Jing-Tao Gao, Hong-Yan Jia, Chuan-Zhi Zhu, Zi-Hui Li, Jing Dong, Qi Sun, Wei Shu, Sai-Sai Wang, Li-Ping Pan, Hai-Rong Huang, Zong-De Zhang, Qi Li

“…Bdq was strongly bactericidal against intracellular MDR-MTBs and H37Rv in a time-dependent, concentration-dependent manner. Bdq potentially exerted immunomodulatory effects by inducing high-level Th1 cytokine expression (IL-12/23 p40, TNF-α) and low-level Th2 cytokine expression (IL-10).…”
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Role of emotional disorders, personality features and disorders of intraceptive sensation in development of somatic symptoms at irritable bowel syndrome by Ye. A. Poluektova, A. A. Kurbatova, G. Ye. Rupchev, A. A. Sheptulin, V. T. Ivashkin

“…Number of days of feeling sick for the last year, number of medical encounters for the same time, intensity of abdominal pain according to VAS, frequency of bowel movements per day (number of defecations per day at IBS-D and number of defecations per week at IBS-C) were taken into account in correlation to disease severity and severity of anxiety and depression according to respective scales, to personality features of patients, and also to pattern and volume of individual dictionary for description of internal somatic sensations. …”
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The hidden crisis: double burden of malnutrition among refugee children in South Asia – a systematic review and meta-analysis from observational studies by Pooja Panchal, Mohd Usman, Tajung Longkumer, Reshma Susan Babu, Mahalaqua Nazil Khatib, Shariza Abdul Razak, Kavitha Menon

“…The prevalence of stunting ranged from 3.9–75.4% in the included studies [pooled prevalence: 31.8% (95% CI: 18.6–46.6%)]; wasting between 0.3–24.3% [pooled prevalence:10.1% (95% CI: 4.6–17.3)]; underweight between 4.4–65% [pooled prevalence: 19.1% (95% CI: 10.8–29.2%)]; and overweight between 3 and 24% [pooled prevalence: 6.5% (95% CI: 2.6–12.1%)]. Time trend analysis of the prevalence of malnutrition showed a decreasing trend in underweight, an increasing trend for stunting and wasting, and overweight including a rising prevalence of dual burden of under-and overnutrition.DiscussionThe study indicates a high prevalence of undernutrition and a rising prevalence of overnutrition -the Asian paradox of the double burden of malnutrition in refugee children living in South Asia. …”
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Phase II trial of nab-paclitaxel plus ramucirumab in combination with nivolumab for unresectable advanced or recurrent gastric cancer after progression on first-line treatment incl... by Hidekazu Hirano, Naoki Takahashi, Yusuke Amanuma, Nobumi Suzuki, Daisuke Takahari, Takeshi Kawakami, Chie Kudo-Saito, Kengo Nagashima, Narikazu Boku, Ken Kato, Hirokazu Shoji

“…Secondary endpoints include objective response rate, disease control rate, PFS, overall survival, duration of response, time to response, and safety. Biomarker analyses of serial blood and tumor samples are planned to clarify predictive markers and molecular mechanisms underlying treatment resistance by multifaceted analytical methods (e.g., flow cytometry, DNA sequencing [DNAseq]/RNA sequencing [RNAseq]). …”
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Development and optimization of a new competitive ELISA using recombinant (rPSA D15 and rCag11) antigens for the detection of Helicobacter pylori infection. by Biniam Moges Eskeziyaw, Naomi Maina, Rebecca Waihenya, Matthew Mutinda Munyao, Tonny Teya Nyandwaro, Shingo Inoue, Samson Muuo Nzou

“…In the current study, the optimal conditions including the dilution of anti-rPSA D15 and anti-rCag11 antibodies at 1:1000, coating antigens (rPSA D15 and rCag11) at a concentration of 1 μg/well, the dilution of HRP-labelled antibody at 1:5000 and H. pylori stool antigen dilution at 1:1000 with a 1hour incubation and color development time of 30 minutes for cELISA were determined using an ELISA checkerboard titration assay. …”
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Coarse-scale vertical distribution of pelagic amphipods in two contrasting seasons of the southern Gulf of Mexico by Marco Violante-Huerta, Laura Sanvicente-Añorve, Miguel Alatorre-Mendieta, Edlin Guerra-Castro

“…Comparisons of day/night sampling time in the average amphipod abundance indicated that only the members of the infraorder Physosomata showed significant differences during the summer (ANOSIM test, p < 0.05), which could be indicative of a migratory process. …”
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Analisis Perbandingan Pengalaman Pengguna pada Aplikasi Investasi dengan Menggunakan UX Curve (Studi pada Bibit dan Ajaib) by Griscipta Yosefanita, Buce Trias Hanggara, Retno Indah Rokhmawati

“…Based on the general UX curve at the beginning of use, Ajaib has a fairly positive perception of Bibit. Then, over time, Ajaib is described as continuing to increase while Bibit tends to be stable. …”
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Rehabilitation using virtual gaming for Hospital and hOMe-Based training for the Upper limb in acute and subacute Stroke (RHOMBUS II): results of a feasibility randomised controlle... by Cherry Kilbride, Tom Butcher, Meriel Norris, Nana Anokye, Alyson Warland, Karen Baker, Dimitrios A Athanasiou, Guillem Singla-Buxarrais, Jennifer Ryan, Francesca Gowing, Elmar Kal, Carole Pound, Victoria Stewart, Basaam Aweid, Arul Samiyappan

“…No significant group differences in fatigue, spasticity, pain scores or total number of AEs. The median (IQR) time to train participants was 98 (64) min over 1–3 sessions. …”
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Designing a Model for Demand Side Management in Electricity Sector Based on Collaborative Governance by Gholamreza kazemian, Mohammadreza Raecy, Reza Vaezi, Vajollah Ghorbanizadeh

“…Objective Demand Side Management (DSM) in electricity energy is a pivotal strategy for governments aiming to effectively control the timing and amount of energy consumption during critical periods of peak load. …”
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Diagnostic Accuracy of Non-Invasive Diagnostic Tests for Nonalcoholic Fatty Liver Disease: A Systematic Review and Network Meta-Analysis by Sun Y, Hu D, Yu M, Liang SB, Zheng Y, Wang X, Tong G

“…For high-risk NASH, Real-Time Elastography showing the highest performance (DOR 18.1, 95% CI 0.7– 96.33). …”
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Comparison of efficacy and safety between palonosetron and ondansetron to prevent postoperative nausea and vomiting in patients undergoing non-laparoscopic surgery: A systematic re... by Babu Lal, Ragavi Alagarsamy, Jitendra Kumar, Anshul J. Rai, Vineeta Yadav, Rajnish Joshi, Md. Yunus

“…Methods: A PRISMA-guided systematic review and meta-analysis was conducted in PubMed, Google Scholar, Semantic Scholar, and Cochrane Library to identify comparative studies that reported the efficacy (nausea and vomiting) at postoperative time points, namely T1 (0–2 hours), T2 (0–6 hours), T3 (12–24 hours), T4 (24–48 hours), and T5 (24–72 hours), as well as safety (number of incidence of adverse effects). …”
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Experimental Study of Steady Blowing from the Trailing Edge of an Open Cavity Flow by Naser Al Haddabi, Konstantinos Kontis, Hossein Zare-Behtash

“…The aim of this study was to investigate the impact of the steady jet on the time-averaged flow field and the cavity separated shear layer oscillations for an open cavity with a length-to-depth ratio of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>L</mi><mo>/</mo><mi>D</mi><mo>=</mo><mn>4</mn></mrow></semantics></math></inline-formula> at <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mi>R</mi><msub><mi>e</mi><mi>θ</mi></msub><mo>=</mo><mn>1.28</mn><mo>×</mo><msup><mn>10</mn><mn>3</mn></msup></mrow></semantics></math></inline-formula>. …”
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Semen quality and fertility effectiveness of cloned buffalo (Bubalus bubalis) bulls by Manoj Kumar Singh, Smiriti Gupta, Kanika Gandhi, S.S. Lathwal, Naresh L. Selokar

“…Animal cloning has proved beneficial in making identical genetic copies in the shortest possible time to meet the target of providing elite breeding bulls. …”
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Exploring the Diversity of Some Microorganisms from Lake Al-Asfar, KSA: The Good, the Bad, and the Pathogenic by Fatimah Al Tammar, Nermin El Semary, Munirah F. Aldayel, Duaa Althumairy, Gowhara Alfayad

“…<b>Conclusions:</b> Vitek technology is an emerging less time- and effort-consuming fast technology for identifying bacteria. …”
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Trends in certifications of overall vision impairment and that due to diabetic retinopathy/maculopathy in England and Wales, 2009/2010 to 2019/2020: a retrospective database analys... by Catey Bunce, Gwyn Samuel Williams, David Owens, Wen Xing, Rhianon Reynolds, Antra Zekite, Declan Flanagan, RL Thomas, Rebecca John

“…Poisson regression was employed to analyse changes in trends over time for certifications of vision impairment.Results In England, from 2010 to 2020, there was a small but significant reduction (p&lt;0.001) in the overall rate of certifications for SI and SSI due to any cause, from 43.4 certifications per 100 000 people to 41.7 per 100 000 people. …”
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Estimation of Suspended Sediment Concentration from Remote Sensing and In Situ Measurement over Lake Tana, Ethiopia by Zelalem R. Womber, Fasikaw A. Zimale, Mebrahtom G. Kebedew, Bekalu W. Asers, Nikole M. DeLuca, Christian D. Guzman, Seifu A. Tilahun, Benjamin F. Zaitchik

“…Applying the developed regression model, a 10-year time series of SSC from 2008–2017 for May-August was estimated and the trend was tested using the Mann–Kendall trend test. …”
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Effect of visceral fat area on prognosis of patients undergoing radical gastrectomy and construction of nomogram by Zhicheng Huang, Baohua Zheng, Zhiwei Wang, Xiaobin Chen, Yu Wang

“…We followed up with all patients for 0.5–48.5 months, with a median follow-up time of 30 months. We used the Kaplan-Meier method to draw the survival curve. …”
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