The Prognostic Value and Overexpression of Cyclin A Is Correlated with Gene Amplification of both Cyclin A and Cyclin E in Breast Cancer Patient by A. Husdal, G. Bukholm, I. R. K. Bukholm

“…The impact of TP53 gene mutations on gene amplification of cyclins was also evaluated. Methods: Real-Time Quantitative PCR was used to detect gene amplification of cyclins in tumour tissue from 86 patients operated for invasive breast carcinomas, while immunohistochemistry was applied to detect protein expression of the same cyclins. …”
Get full text

Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System by Li L, He Z, Yu C, Zhang C, Yu Y, Li Y, Xu X

“…In addition, immunohistochemical analyses and real-time polymerase chain reaction analyses were conducted to detect MMP-3 and MMP-9 expression.Results: After 1 week, both dermal thickness and collagen fiber density were significantly increased in the BMSC and combination treatment groups as compared to the control group (P< 0.05), while both of these parameters were significantly increased in all treatment groups after 4 weeks relative to the control group (P< 0.05), with the most pronounced effect in the combination therapy group (P< 0.05). …”
Get full text

A STUDY OF THE INFLUENCE OF EXTRACELLULAR VESICLES ON THE MORPHOFUNCTIONAL STATE OF THE ENDOMETRIUM IN VITRO by Оксана Александровна Мелкозерова, Ирина Викторовна Крутинь, Александра Юрьевна Храмцова, Мария Валерьевна Улитко, Алсу Фармутовна Мустафина

“…When adding vesicles, no critical changes in the structure of the cell cytoplasm were detected, it remains homogeneous. At the same time, the nuclear-cytoplasmic ratio in the endometrial cells increases dose-dependently, which indicates a change in the functional state of the cells in the culture. …”
Get full text

Sibling Species Composition and Susceptibility Status of Anopheles gambiae s.l. to Insecticides Used for Indoor Residual Spraying in Eastern Uganda by Julius Iga, Stephen Ochaya, Richard Echodu, Elizabeth A. Opiyo, Alex K. Musiime, Angella Nakamaanya, Geoffrey M. Malinga

“…The median knock-down time, KDT50, ranged from 6.6 to 81.4 minutes, while the KDT95 ranged from 21.6 to 118.9 minutes for 0.25% pirimiphos-methyl. …”
Get full text

Construction and validation of a prognostic model for NK/T-cell lymphoma based on random survival forest algorithm by HUANG Zhen, HUANG Zhen, WU Yazhou

“…In the validation cohort, the area under the ROC curve (AUC) for the nomogram model at 1, 3, and 5 years was 0.745, 0.771, and 0.748, respectively, while the AUC for the RSF model was 0.764, 0.792, and 0.761 at the same time points. ROC curve analysis indicated that both models demonstrated good accuracy and discrimination in predicting OS. …”
Get full text

Application of Patient-Generated Health Data Among Older Adults With Cancer: Scoping Review by Yesol Kim, Geonah Kim, Hyeonmi Cho, Yeonju Kim, Mona Choi

“…By enhancing symptom monitoring, enabling timely interventions, and promoting patient involvement, PGHD have the potential to improve the well-being of older adults with cancer, contributing to better health management and quality of life. …”
Get full text

Body mass index impacts the lipid-lowing effects of statins in patients with type 2 diabetes by Lulu Sun, Zhuo Wang, Bai Wang, Yuxiang Jia, Qidi Zhao, Jingjun Zhao, Xingtao Huang

“…Lipid levels were assessed at two time points, and multivariate logistic regression analysis was used to identify factors influencing the reduction of low-density lipoprotein-cholesterol (LDL-C) levels and lipid control achievement.ResultsThis study included 289 patients, with 82 in normal weigh, 143 in overweight, and 64 in obese. …”
Get full text

Humanities education reform exploration and practice under outcomes-based education (OBE) by P. Yang

“…The OBE operates within the framework of the following core issues: the things students learn and the extent of student success, not the manner of learning; the place, the time of learning and the duration of training.OBE process implies ultimate involvement of students’ individual cognitive abilities to master competencies, which help adapt to future life. …”
Get full text

The effects of magnitude of calcium decline at the onset of lactation on serotonin dynamics and the serotonin-calcium axis by M.K. Connelly, R.M. Rodney, J. Kuehnl, J.P.N. Andrade, F. Sonnewend Andrade, S. Henschel, E. Block, I.J. Lean, L.L. Hernandez

“…Cows fed a −DCAD diet prepartum had greater circulating serotonin concentrations pre- and postpartum. Time series analyses demonstrated that the pooled mean effect size (ES) of the relationship between ionized Ca and serotonin 36 h before parturition was significantly positive (ES = 0.164) prepartum. …”
Get full text

The search for a blood-based biomarker for Myalgic Encephalomyelitis/ Chronic Fatigue Syndrome (ME/CFS): from biochemistry to electrophysiology by Krista S. P. Clarke, Caroline C. Kingdon, Michael Pycraft Hughes, Eliana Mattos Lacerda, Rebecca Lewis, Emily J. Kruchek, Robert A. Dorey, Fatima H. Labeed

“…One in four individuals are bed-bound for long periods of time, others have difficulties maintaining a job/attending school, incurring individual income losses of thousands, while few participate in social activities. …”
Get full text

Exhaustion of CD8pos central memory regulatory T cell differentiation is involved in renal allograft rejection by Florian Kälble, Jonas Leonhard, Jonas Leonhard, Martin Zeier, Oliver Zivanovic, Matthias Schaier, Andrea Steinborn

“…In KTR with biopsy-confirmed rejection at the time of enrolment, an increased differentiation of RTE Tregs into CCR7negCD45RAposCD31neg terminally differentiated effector memory (CD31neg TEMRA Tregs) and CD31pos memory Tregs was observed. …”
Get full text

Assessment of in vitro skin permeation and accumulation of phenolic acids from honey and honey-based pharmaceutical formulations by Anna Nowak, Anna Muzykiewicz-Szymańska, Magdalena Perużyńska, Edyta Kucharska, Łukasz Kucharski, Karolina Jakubczyk, Paulina Niedźwiedzka-Rystwej, Justyna Stefanowicz-Hajduk, Marek Droździk, Juraj Majtan

“…This study aimed to identify and quantify phenolic acids in four Polish honey samples of different botanical origins (heather, buckwheat, linden and rapeseed) and to assess for the first time the permeation of the identified phenolic acids through the skin and their accumulation after the application of pure honey samples, as well as honey-based hydrogel and emulsion formulations. …”
Get full text

Regenerative fibroblasts derived from autologous skin tissue for the treatment of Sjögren’s syndrome: a case report by Zhao-Xia Ma, Xing-Fei Wu, Li Cao, Cheng-Yan Jiao, Dai-Ping Ma, Yun-Hui Zhao, Zhi-Xing Yang, Min Hu, Min Hu

“…From May 2021 to November 2022, she received allogeneic Umbilical cord mesenchymal stem cells (UCMSC) therapy (5.0 × 107 UCMSCs per time, totaling 10 infusions), but her condition did not improve. …”
Get full text

A Path to High-Value Gastric Cancer Surgery Care Delivery by Swee H. Teh, MD, Sharon Shiraga, MD, Aaron M. Kellem, BS (Math), Robert A. Li, MD, David M. Le, MD, Said P. Arsalane, MSHA, Fawzi S. Khayat, MD, Yan Li, MD, I-Yeh Gong, MD, Jessica M. Lee, MD

“…In addition, more patients received postoperative adjuvant chemotherapy (31.4% to 63.5%, P < 0.0001), and the time between gastrectomy and starting adjuvant chemotherapy was also less (49–41 days; P = 0.002). …”
Get full text

Pharmacokinetics of Hydrogen During Hydrogen-Saturated Saline Infusion in Pigs by Masaki Shibuya, Masafumi Fujinaka, Mako Yonezawa, Natsumi Nishimura, Hitoshi Uchinoumi, Hiroshi Sunahara, Kenji Tani, Eiji Kobayashi, Motoaki Sano

“…Hydrogen-saturated saline was administered intravenously (125 mL/h) through the left internal jugular vein of pigs, and the blood hydrogen concentration was measured over time. <b>Results</b>: It was confirmed that hydrogen can be safely mixed under pressure into intravenous solutions (pharmaceutical products) without the contamination of foreign substances by using a needle-less vial access cannula. …”
Get full text

PERAN STAKEHOLDER DALAM MENINGKATKAN PARTISIPASI PEMILIH PEMULA PADA PEMILIHAN UMUM 2024 DI KABUPATEN BOJONEGORO by Kidung Bukit Darmawan, Esa Septian, Ida Suwasanti

“…This investigation is descriptive research with a qualitative approach by identifying five informants as research objects, namely KPU Bojoneegoro, BAWASLU Bojonegoro, Academicians, Media Time, and community figures of the subject in determination with purposive sampling techniques in joining several focuses, namely initial conditions, institutional design, facilitative leadership and process of collaboration data obtained through the process of legislative rules interview – invitations and sponsorship data related to research. …”
Get full text

Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021 by Fangqun Cheng, Peiyu Cheng, Shudong Xie, Hailing Wang, Ying Tang, Ying Liu, Zhuo Xiao, Guixiang Zhang, Guangxiong Yuan, Ke Wang, Can Feng, Ying Zhou, Hong Xia, Yan Wang, Yuhang Wu

“…This study aims to evaluate the epidemiological trends and variations in the burden of ischemic stroke across BRICS-plus nations in a timely manner. Methods Data on the number, all-age rate, age-standardized rate, and relative change in ischemic stroke disability-adjusted life years (DALYs) from 1992 to 2021 within BRICS-plus were obtained from the Global Burden of Disease Study (GBD) 2021. …”
Get full text

Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy by Xia Liu, Emily Shaw, Fusheng Si, Guangyong Peng, Yan Tao, Feiya Ma, David Bagley, Yuanqin Zhang

“…Furthermore, T cell senescence induced by mouse tumor and regulatory T (Treg) cells in vitro was determined with multiple markers and assays, including real-time PCR, flow cytometry, and histochemistry staining. …”
Get full text

Predictive value of MMP-2, MMP-9, TIMP-1 in surgical treatment of localized renal cell cancer by A. I. Tarasenko, A. N. Rossolovskiy, O. L. Berezinets, D. A. Durnov, E. B. Popyhova, V. M. Popkov

“…The highest sensitivity and specificity for detecting tumor progression was demonstrated by matrix metalloproteinases: MMP‑2 – sensitivity 96 %, specificity 67 % (cut-off point 357.5 pg/ml) and MMP‑9 – sensitivity 87.5 % and specificity 62 % (cut-off point 958 ng/ml). At the same time, TIMP‑1 showed less significant indicators – sensitivity and specificity (74 % and 60 %, respectively) with a cut-off point of 0.49 ng/ml.Conclusion. …”
Get full text

Sentiment Analysis Twitter Bahasa Indonesia Berbasis WORD2VEC Menggunakan Deep Convolutional Neural Network by Hans Juwiantho, Esther Irawati Setiawan, Joan Santoso, Mauridhi Hery Purnomo

“…The use of Word2Vec also reduce the training time and improve the accuracy of the Deep Convolutional Neural Network algorithm. …”
Get full text