Understanding stakeholder views of the use of digital therapeutic interventions within children and young people’s mental health services by Brioney Gee, Brioney Gee, Tim Clarke, Tim Clarke, Jess Garner, Bonnie Teague, Bonnie Teague, Georgianna Coote, Aoife Dunne, Rachel McGuire, Andrew Laphan, Manjul Rathee, Jon Wilson, Jon Wilson

“…BackgroundProviding the growing number of children and young people seeking mental health support with timely access to care poses a significant challenge. …”
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Taxonomic composition and biodiversity of the gut microbiome from patients with irritable bowel syndrome, ulcerative colitis, and asthma by A. Y. Tikunov, A. N. Shvalov, V. V. Morozov, I. V. Babkin, G. V. Seledtsova, I. O. Voloshina, I. P. Ivanova, A. V. Bardasheva, V. V. Morozova, V. V. Vlasov, N. V. Tikunova

“…A signif icant increase in the proportion of Halomonas and Vibrio sequences in the gut microbiota in patients with BA has been described for the f irst time.…”
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Cultivatable Bacteriota of Chronic Wound of Patients with Diabetic Foot Syndrome with Critical Limb Ischemia Based on Wound Biopsy in Peri-Revascularization Period by Syedah Sarah Hussaini, Fran Dominic Grubesa, Mateusz Gajda, Martyna Schönborn, Katarzyna Bogucka, Mikołaj Maga, Paweł Maga, Jadwiga Wójkowska-Mach

“…The blood supply to the limb was assessed with laboratory tests and two time-point qualitative cultures using a wound biopsy. …”
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Guttiferone K Exerts the Anti-inflammatory Effect on Mycobacterium Tuberculosis- (H37Ra-) Infected Macrophages by Targeting the TLR/IRAK-1 Mediated Akt and NF-κB Pathway by Qingwen Zhang, Jinxia Sun, Yan Fu, Weigang He, Yinhong Li, Hongsheng Tan, Hongxi Xu, Xin Jiang

“…Under this circumstance, alternative host-directed therapy (HDT) emerges timely which can be exploited to improve the efficacy of TB treatment and disease prognosis by targeting the host. …”
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Response surface methodology for the design of malachite green dye removal by γ-Fe2O3 dispersed on reduced graphene oxide sheets by Liu Zhu, Anam Sana, Muhammad Tariq Qamar, Ali Bahadur, Guocong Liu, Mohammad Aslam, Ammar Zidan, İsmail Seçkin Çardaklı, Shahid Iqbal, Sajid Mahmood, Muhammad Saad, Khalid M. Alotaibi

“…The optimal adsorption parameters obtained from the within-range numerical optimization based on 0.923 Derringer’s desirability function were 200 mg/100 mL dose, 80 ppm dye solution, 7.99 pH and 112.68 min. contact time for ~ 90% MG dye removal and 40.64 mg/g adsorption capacity (qm) by rGO/γ-Fe2O3. …”
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Protocol on establishing a prospective enhanced surveillance of vaccine preventable diseases in residential aged care facilities in Central Queensland, Australia: an observational... by Mohammad Rashidul Hashan, Robert Booy, Michael Kirk, Gulam Khandaker, Gwenda Chapman, Jacina Walker, Sonya Jayne Davidson, Jill Auriac, Nicolas Smoll, Delwar Akbar

“…The increasing burden of emerging and existing VPDs (eg, COVID-19, influenza, pneumococcal, pertussis and varicella-zoster) necessitates the establishment of an active enhanced surveillance system to provide real-time evidence to devise strategies to reduce the burden of VPDs in RACFs.Method and analysis This study proposes a prospective active enhanced surveillance that will be implemented in RACFs across the Central Queensland (CQ) region. …”
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First detection and molecular characterization of Jingmen tick virus with a high occurrence in Rhipicephalus (Boophilus) microplus collected from livestock in Cameroon (2024) by Paloma Kiwan, Eva Lopez, Morena Gasparine, Geraldine Piorkowski, Agathe Colmant, Achille Paguem, Stephanie Mvodo, Laurence Thirion, Xavier de Lamballerie, Remi Charrel, Alessandra Falchi

“…Abstract Background Jingmen tick virus (JMTV) is a novel tick-borne virus detected for the first time in Rhipicephalus (Boophilus) microplus in China. …”
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Effects of entinostat, quisinostat, and tubastatin-A on alcohol consumption in male high ethanol consuming rats by Sheketha R. Hauser, Sheketha R. Hauser, Laura B. Ferguson, Laura B. Ferguson, Tiebing Liang, Erin E. Jarvis, R. Dayne Mayfield, Richard L. Bell, Richard L. Bell

“….), or tubastatin-A (selective HDAC6i, 0, 1.25, 2.5, 5 mg/kg, i. p.) over 4-5 consecutive days.ResultsIn HAD1 rats, entinostat reduced 2-, 4-, and 24-h ethanol intake across the 2nd – 5th test days; while, in P rats, entinostat’s effect was primarily seen at the 24-h time-point, at the highest dose and only across three test days. …”
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Development and external validation of a dynamic nomogram for predicting the risk of functional outcome after 90 days in patients with acute intracerebral hemorrhage by Shaojie Li, Hongjian Li, Jiani Chen, Baofang Wu, Jiayin Wang, Chaocan Hong, Changhu Yan, Weizhi Qiu, Yasong Li, Hongzhi Gao

“…The developed dynamic nomogram was easy to use and demonstrated strong predictive performance (training set AUC: 0.87; test set AUC: 0.839; external validation set AUC: 0.774), excellent calibration, and clinical applicability.ConclusionThe dynamic nomogram we developed using five independent risk factors serves as a practical tool for real-time risk assessment and can help facilitate early intervention and personalized patient management, thereby improving clinical outcomes in high-risk patients.…”
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Impacts of Sandstorms on Chemistries of Ambient PAHs in a Small City in North China by Zhiyong Li, Zhen Zhai, Jixiang Liu, Lan Chen, Zhuangzhuang Ren, Chen Liu, Ziyi Zhan, Ziyuan Yue, Wenjia Zhu, Jihong Wei, Huiying Gao, Songtao Guo

“…SSP exhibited a slightly high average PAH concentrations of 10.3 ng m−3 than 9.16 ng m−3 in the NSSP. At the same time, the average PM2.5 concentrations obviously increased from 60.7 µg m−3 to 75.2 µg m−3. …”
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Anti-phenolic glycolipid antibodies in Mycobacterium bovis infected cattle by Zijie Zhou, Anouk van Hooij, J. Hessel M. van Dijk, Nina Musch, Louise Pierneef, Hamza Khalid, Kees Franken, Thomas Holder, Neil Watt, Anita L. Michel, Jeroen D.C. Codée, Martin Vordermeier, Paul L.A.M. Corstjens, Elisabeth M.D.L. van der Heijden, Jayne C. Hope, Annemieke Geluk

“…This study shows for the first time that anti M. bovis PGL antibodies can be detected in infected cattle: anti-M. bovis PGL IgM is a highly specific, but moderately sensitive biomarker for M. bovis infection in cattle, showing potential for differentiate infected from vaccinated animals (DIVA). …”
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Radiomics for Predicting the Development of Brain Edema from Normal-Appearing Early Brain-CT After Cardiac Arrest and Return of Spontaneous Circulation by Michael Scheschenja, Eva-Marie Müller-Stüler, Simon Viniol, Joel Wessendorf, Moritz B. Bastian, Jarmila Jedelská, Alexander M. König, Andreas H. Mahnken

“…<b>Background:</b> Hypoxic-ischemic brain injury (HIBI) is a feared complication post-cardiac arrest (CA). The timing of brain imaging remains a topic of ongoing debate. …”
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Exosomes from LPS-Stimulated hDPSCs Activated the Angiogenic Potential of HUVECs In Vitro by Xiangyu Huang, Wei Qiu, Yuhua Pan, Jianjia Li, Zhao Chen, Kaiying Zhang, Yifei Luo, Buling Wu, Wenan Xu

“…This study revealed that exosomes derived from inflammatory hDPSCs possessed better proangiogenic potential in vitro. This is the first time to explore the role of exosomal microRNA from hDPSCs in inflammation-induced angiogenesis. …”
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Contribution of integrase inhibitor use, body mass index, physical activity and caloric intake to weight gain in people living with HIV by Giovanni Guaraldi, Jovana Milic, Elena Bacchi, Federica Carli, Marianna Menozzi, Iacopo Franconi, Alessandro Raimondi, Giacomo Ciusa, Valentina Masi, Michela Belli, Stefano Guaraldi, Emanuele Aprile, Maria Mancini, Cristina Mussini, Jordan E. Lake, Kristine M. Erlandson

“…Of 281 PLWH (74.3% males), mean follow-up was 4.2 years, age 50.3 years, median time since HIV diagnosis 17.8 years, CD4 cell count 630 cells/µL at baseline. …”
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Methicillin-Resistant <i>Staphylococcus aureus</i>: The Shifting Landscape in the United Arab Emirates by Syrine Boucherabine, Rania Nassar, Lobna Mohamed, Maya Habous, Anju Nabi, Riyaz Amirali Husain, Mubarak Alfaresi, Seema Oommen, Hamda Hassan Khansaheb, Mouza Al Sharhan, Handan Celiloglu, Mubarak Hussain Raja, Eman Abdelkarim, Nishi Ali, Salman Tausif, Victory Olowoyeye, Nelson Cruz Soares, Mahmood Hachim, Danesh Moradigaravand, Dean Everett, Elke Mueller, Stefan Monecke, Ralf Ehricht, Abiola Senok

“…Upward trends of CC1153 were observed along with rare CCs, such as CC121-MRSA and CC7-MRSA, with the latter being reported for the first time in the Arabian Gulf region. The presence of pandemic strains USA300 CC8-MRSA-[IVa + ACME1] and CC8-MRSA-IV strains were also observed, including variants lacking Panton–Valentine leukocidin (<i>pvl</i>) genes and missing <i>tst1</i> or enterotoxin genes. …”
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Transforaminal Endoscopic Lumbar Discectomy versus Coblation Nucleoplasty Combined with Collagenase Chemonucleolysis for Lumbar Disc Herniation with Grade I Degenerative Spondyloli... by Yuyu Guo, Liuhu Han, Tingting Li, Bingbing Xu, Penghui Ke, Jun Hu, Rongyi Zhang, Yan Guo, Long Zhao, Likui Wang

“…Results VAS (back and leg), ODI, and QoR-15 were significantly decreased at each time point after operation in all groups. There were significant differences in VAS (back and leg), ODI, and QoR-15 between the two groups at 3 days post-operation (P < 0.05), VAS (leg), ODI, and QoR-15 at 3 months post-operative (P < 0.05), and QoR-15 at 6 months post-operative (P < 0.05). …”
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The Global RAdical Cystectomy Evaluation and Management (GRACEM) pathway: single‐centre prospective observational cohort study protocol by Bruno Bernardini, Federico Piccioni, Manuele Pastore, Paolo Casale, NicolòMaria Buffi, Giovanni Lughezzani, Massimo Lazzeri, Alberto Saita, Maria Vittoria Fantacci, Stefano Mancon, Filipo Dagnino, Roberto Contieri, Pietro Brin, Stefano Mancin, Andrea Gobbo, Maria Rosaria Martucci, Giovanna Cerina, Sara Ghirmai, Ezio Lanza, Giulia Goretti, Giorgio Ferruccio Guazzoni, Rodolfoi Hurle

“…The purpose of the study is to determine whether a multifaceted prevention programme that tailors interventions to the syndromic components of frailty can improve postoperative morbidity and recovery time for patients. New insights will be gained into how to optimize the physical and mental status and quality of life of patients before and after surgery, up to 1 year later. …”
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Neutrophil elastase inhibitor (Sivelestat) in the treatment of acute respiratory distress syndrome induced by COVID-19: a multicenter retrospective cohort study by Yuting Li, Jianjun Zhao, Jiahui Wei, Yanhong Zhang, Haitao Zhang, Ying Li, Ting Liao, Yang Hu, Bo Yuan, Xinmei Zhang, Wanyan Liu, Changgang Liu, Qingsong Cui, Shunzi Wu, Hongmei Jiang, Wenge Liu, Weiheng Liu, Hongguang Xu, Gang Li, Yuyan Cai, Liting Chen, Bingwei Chen, Dong Zhang

“…In 158 patients matched on the propensity for treatment, receipt of sivelestat was associated with improved oxygenation, decreased Murray lung injury score, increased non-mechanical ventilation time within 28 days, increased alive and ICU-free days within 28 days (HR, 1.85; 95% CI 1.29 to 2.64; log-rank p < 0.001), shortened ICU stay and ultimately improved survival (HR, 2.78; 95% CI 1.32 to 5.88; log-rank p = 0.0074). …”
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The Fabrication and Evaluation of a Potential Biomaterial Produced with Stem Cell Sheet Technology for Future Regenerative Medicine by Shukui Zhou, Ying Wang, Kaile Zhang, Nailong Cao, Ranxing Yang, Jianwen Huang, Weixin Zhao, Mahbubur Rahman, Hong Liao, Qiang Fu

“…Then, acellular matrix was transplanted onto subcutaneous tissue for 1 week or 3 weeks; H&E staining and immunohistochemical analysis of CD68 expression and quantitative real-time PCR (qPCR) were performed to evaluate the immunogenicity and biocompatibility. …”
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Evolution paths of urban forms influenced by landforms: Asynchrony but convergence by Chao Yang, Qiyan Huang, Qiong Xian, Meng Yuan, Xiaoming Cong, Lisha Xun, Jianxiong Cheng, Hongyi Pan

“…The findings are as follows: (1) Urban forms in Sichuan are categorized into five types. Over time, nearly 81 % of clustered infill and compact adjoining cities are found in plains and hills, with the most compact forms in plains. …”
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