Perceived effectiveness and recommendations from a childbirth quality assurance and improvement programme in India’s private sector: a qualitative evaluation using the RE-AIM frame... by Katherine Semrau, Meghna Desai, Lauren Spigel, Somesh Kumar, Megan Marx Delaney, Lauren Bobanski, Suranjeen Pallipamula, Natalie Henrich, Tapas Sadasivan Nair, Hema Divakar, Rajat Chabba, Shweta Jindal, Gulnoza Usmanova, Sukanya Dutta, Aarushi Gupta, Sucheta Kinjawadekar, Priti Kumar, Priyanka Kumari, Prerna Mukharya, Hrishikesh Pai, Ameya Purandare, Pompy Sridhar

“…Participants felt that continuous training, mentorship and quality assurance would be necessary to maintain Manyata over time, and Manyata could and should be scaled across India and to other countries.Conclusion Strategies for engaging with the private sector should include building strategic partnerships and messaging a value proposition that emphasises training, standardised care processes and improved quality of care. …”
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Human soft tissue sarcomas harbor an intratumoral viral microbiome which is linked with natural killer cell infiltrate and prognosis by William J Murphy, Robert J Canter, Nikhil Joshi, Sean J Judge, Morgan A Darrow, Steve W Thorpe, Alicia A Gingrich, Lauren M Perry, Sylvia M Cruz, Kara T Kleber, Louis B Jones, Ugur N Basmaci, Matthew L Settles, Blythe P Durbin-Johnson, Arta Monir Monjazeb, Janai Carr-Ascher, Jonathan A Eisen

“…In the tumor microenvironment, we observed a strong positive correlation between viral relative abundance and natural killer (NK) infiltration, and higher NK infiltration was associated with superior metastasis-free and overall survival by immunohistochemical, flow cytometry, and multiplex immunofluorescence analyses.Conclusions We prospectively demonstrate the presence of a distinct and measurable intratumoral microbiome in patients with STS at multiple time points. Our data suggest that the STS tumor microbiome has prognostic significance with viral relative abundance associated with NK infiltration and oncologic outcome. …”
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Reactogenicity and Immunogenicity Against MPXV of the Intradermal Administration of Modified Vaccinia Ankara Compared to the Standard Subcutaneous Route by Valentina Mazzotta, Pierluca Piselli, Alessandro Cozzi Lepri, Giulia Matusali, Eleonora Cimini, Rozenn Esvan, Francesca Colavita, Roberta Gagliardini, Stefania Notari, Alessandra Oliva, Silvia Meschi, Rita Casetti, Giulia Micheli, Licia Bordi, Alessandro Giacinta, Germana Grassi, Saba Gebremeskel Tekle, Claudia Cimaglia, Jessica Paulicelli, Alessandro Caioli, Paola Gallì, Giulia Del Duca, Miriam Lichtner, Loredana Sarmati, Enrica Tamburrini, Claudio Mastroianni, Alessandra Latini, Paolo Faccendini, Carla Fontana, Emanuele Nicastri, Andrea Siddu, Alessandra Barca, Francesco Vaia, Enrico Girardi, Fabrizio Maggi, Andrea Antinori

“…Results: We found that the ID route elicited higher titers of MPXV-specific IgG (mean difference of 0.26 log₂, <i>p</i> = 0.05) and nAbs (0.24 log₂, <i>p</i> = 0.08) than the subcutaneous (SC) route one month after the complete vaccination cycle. At the same time, no evidence for a difference in cellular response was found. …”
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Purinergic Signaling Pathway in Human Olfactory Neuronal Precursor Cells by Héctor Solís-Chagoyán, Edgar Flores-Soto, Marcela Valdés-Tovar, Montserrat G. Cercós, Eduardo Calixto, Luis M. Montaño, Carlos Barajas-López, Bettina Sommer, Arnoldo Aquino-Gálvez, Citlali Trueta, Gloria A. Benítez-King

“…Results demonstrated for the first time that ex vivo-expressed functional P2 receptors in MpSC-like hONPC regulate exocytosis and Ca2+ signaling. …”
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Establishment of Fermentation Kinetic Model of Streptococcus thermophilus JM108 by Wen SUN, Baolei LI, Baochao HOU, Weilian HONG, Jian HE, Chao LIANG, Yu ZHANG, Chaoxin MAN, Yujun JIANG, Ling GUO

“…This study examined the growth and metabolism of Streptococcus thermophilus JM108 to establish a time-varying model that simulated the dynamics of bacterial growth, product synthesis, and substrate consumption. …”
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Activity-based chemical proteomics reveals caffeic acid ameliorates pentylenetetrazol-induced seizures by covalently targeting aconitate decarboxylase 1 by Guanjun Li, Ling Huang, Di Gu, Peili Wang, Letai Yi, Wenhua Kuang, Ying Zhang, Junzhe Zhang, Dandan Liu, Qiaoli Shi, Huan Tang, Jichao Sun, Guohua Zeng, Xin Peng, Jigang Wang

“…Conclusion In summary, this study elucidates, for the first time, the potential antiepileptic targets and mechanism of action of caffeic acid using the ABPP strategy. …”
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Germline BRCA testing in Denmark following invasive breast cancer: Progress since 2000 by Aleksandar M. Kostov, Maj-Britt Jensen, Bent Ejlertsen, Mads Thomassen, Caroline Maria Rossing, Inge S. Pedersen, Annabeth H. Petersen, Lise Lotte Christensen, Karin A.W. Wadt, Anne-Vibeke Lænkholm

“…Results: Test rates rose most significantly among patients aged under 40 years, increasing from 47% (2000–2005) to 88% (2012–2017), albeit with regional discrepancies. Test timing shifted in recent years, with most results within 6 months of BC diagnosis, primarily among the youngest patients. …”
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<i>Ex Vivo</i> Regional Gene Therapy Compared to Recombinant BMP-2 for the Treatment of Critical-Size Bone Defects: An In Vivo Single-Cell RNA-Sequencing Study by Arijita Sarkar, Matthew C. Gallo, Jennifer A. Bell, Cory K. Mayfield, Jacob R. Ball, Mina Ayad, Elizabeth Lechtholz-Zey, Stephanie W. Chang, Osamu Sugiyama, Denis Evseenko, Jay R. Lieberman

“…However, the cellular and transcriptional mechanisms regulating the response to these two strategies for BMP-2 mediated bone regeneration are largely unknown. Here, for the first time, we performed single-cell RNA sequencing (10x Genomics) of hematoma tissue in six rats with critical-sized femoral defects that were treated with either regional gene therapy or rhBMP-2. …”
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Association between beta‐blocker atenolol use and prostate cancer upgrading in active surveillance1 by Ali H. Zahalka, Ethan Fram, Evan Garden, Lauren Howard, Emily Wiggins, Mustufa Babar, Jay Annam, Allison Reagan, Benjamin Eilender, Amanda deHoedt, Stephen J. Freedland, Ash Tewari, Kara L. Watts

“…Cox proportional hazard regression models were used to determine the associations between atenolol use and risk of upgrading with time, on a per‐examination basis. Results A total of 467 men with initial GG ≤ 2 were included. …”
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Efficient Differentiation of Mouse Induced Pluripotent Stem Cells into Alveolar Epithelium Type II with a BRD4 Inhibitor by Toru Momozane, Eriko Fukui, Soichiro Funaki, Makoto Fujii, Yuhei Kinehara, Emiko Ito, Shigeru Miyagawa, Yuko Ohno, Yoshiki Sawa, Meinoshin Okumura, Yasushi Shintani

“…First, the murine iPSC line 20D-17 was induced to differentiate into ATII over a period of 26 days (days 0-26) using previously reported embryoid body seeding and stepwise differentiation methods. mRNA expressions of differentiation markers including surfactant protein C (Sftpc) were confirmed by real-time reverse transcription-polymerase chain reaction (RT-PCR) results, and 17% of the cells were shown positive for prosurfactant protein C (proSPC) in flow cytometry analysis. …”
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Insights Into Antimicrobial Resistance From Dental Students in the Asia–Pacific Region by Saba Ghafoor, Gabriela Salvadori, Shiho Kino, Vy Thi Nhat Nguyen, Tam Thi-Thanh Nguyen, Miho Ishimaru, Antônio Pedro Ricomini-Filho, Cassiano Kuchenbecker Rösing, Dileep De Silva, Jun Aida, Belinda Farias Nicolau, Ratilal Lalloo, Roger Junges

“…Final-year students presented a mean (SEM) level of confidence to prescribe antibiotics of 6.01 (0.14) on a scale from 1 to 10, whilst 59.7% and 56.8% indicated feeling pressured to prescribe by patients or when lacking time, respectively. Final-year students participating in research activities assigned a higher priority to AMR compared to their peers not involved in research (mean [SEM] 8.6 [0.19] vs 7.81 [0.16]; P = .01). …”
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Epidemiology of notifiable outbreaks in different hospital units in Saudi Arabia: A national descriptive study by Nawal M. Alanazi, Nasser H. Alshanbari, Hala M. Roushdy, Yahya I. Alnshbah, Eman Ali Barnawi, Nawaf M. Almatrafi, Rula Felemban, Zainah M. Al Shahrani, Nadeen Burhan, Aiman El-Saed, Khalid H. Alanazi

“…Methods: A retrospective analysis of national data collected through timely notifications to the MOH during 2023. Data included hospital and patient information. …”
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The proportion of clinically relevant alarms decreases as patient clinical severity decreases in intensive care units: a pilot study by Ryota Inokuchi, Kent Doi, Kazuaki Shinohara, Kensuke Nakamura, Takehiro Matsubara, Susumu Nakajima, Hajime Sato, Masataka Gunshin, Takahiro Hiruma, Takeshi Ishii, Yoichi Kitsuta, Naoki Yahagi, Yuko Nanjo, Masahiro Echigo, Aoi Tanaka, Mitsuo Umezu

“…Objectives To determine (1) the proportion and number of clinically relevant alarms based on the type of monitoring device; (2) whether patient clinical severity, based on the sequential organ failure assessment (SOFA) score, affects the proportion of clinically relevant alarms and to suggest; (3) methods for reducing clinically irrelevant alarms in an intensive care unit (ICU).Design A prospective, observational clinical study.Setting A medical ICU at the University of Tokyo Hospital in Tokyo, Japan.Participants All patients who were admitted directly to the ICU, aged ≥18 years, and not refused active treatment were registered between January and February 2012.Methods The alarms, alarm settings, alarm messages, waveforms and video recordings were acquired in real time and saved continuously. All alarms were annotated with respect to technical and clinical validity.Results 18 ICU patients were monitored. …”
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Multidisciplinary, multicenter consensus for the care of patients affected with Sturge–Weber syndrome by May El Hachem, Andrea Diociaiuti, Angela Galeotti, Francesca Grussu, Elena Gusson, Alessandro Ferretti, Carlo Efisio Marras, Davide Vecchio, Simona Cappelletti, Mariasavina Severino, Carlo Gandolfo, Simone Reali, Rosa Longo, Carmen D’Amore, Lodovica Gariazzo, Federica Marraffa, Marta Luisa Ciofi Degli Atti, Maria Margherita Mancardi, and the Sturge-Weber Syndrome Multidisciplinary Group

“…Results Through a Delphi consensus methodology, 28 recommendations have been developed concerning (i) dermatological SWS manifestations and related treatment timing and modalities, (ii) neurological referral, diagnosis, pharmacological treatment of neurological signs and symptoms, neurosurgical indications, neurocognitive evaluation and related treatment, psychosocial support and patient follow-up, (iii) diagnosis of ophthalmological manifestations, medical and surgical treatment, and follow-up, (iv) maxillofacial surgical treatment, (v) oral cavity assessment, care and follow-up, and (vi) primary care paediatrician/general practitioner involvement. …”
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Carbon footprint reduction practices in the Olympic Games: a policy mobility approach by Wesselia Isa Ngoenha

“…This research thesis examines this gap to understand the ineffectiveness of these policies and their evolution over time using the policy mobility methodology, which allows us to understand how policies are created, transferred and reapplied in a new context, thanks to tools and people who transport knowledge from one place to another. …”
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Investigating the effect of learning and motivational strategies on the self-efficacy of physical education and sports science students with the mediating role of academic progress... by Ahmad Sabihabdollah Alharishavi, Hasan ghalavandi, Mohammad hassani

“…It is worth mentioning that the students of these sports fields spend a significant amount of time motionless in the classroom studying and using the computer and the Internet during their daily studies, and it is expected that they will join sedentary occupations in the future as well (Limani et al, 2022). …”
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Factors affecting the design of the management dashboard framework with an emphasis on the components of human resources productivity by Hassan Barmaki, Farshad Faezy Razi, Ehtesham Rashidi

“…Theoretical frameworkDefinition of productivityIn an article on the three concepts of power, production and income published in the Journal of Political Economy, productivity is defined as the concept of the relationship between the amount of product obtained in a certain period of time and the amount of factors consumed during the production of that product (Otoo, 2019).The role and importance of manpower productivityMeasuring and evaluating productivity is a useful tool for analyzing changes in productivity over time and the causes of those changes. …”
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À propos des foyers protohistoriques à pierres chauffantes en Provence-Alpes-Côte d’Azur by Denis Dubesset

“…Archaeologically, hot stone hearths represent infrequent occurrences, which occur in one area and may recur over long periods of time. Consequently, these spaces took on their own symbolism. …”
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Designing and explaining the political behavior model of managers in government organizations by Mehdi Izadi, Amir Hoshang Nazarpuri, Reza Sepahvand, Hojat Vahdati, Mohammad Hakak

“…The results showed that the political behavior of managers is, respectively, receiving control of access to information at the highest level, followed by showing calmness, resistance to change, pleasing others, playing with time, forming groups, blaming and attacking others, dealing with the opposite, strengthening a favorable impact, creating a communication network, support and empathy, and presenting oneself through other powerful people in the next priorities. …”
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Efficacy and safety of neoadjuvant therapy with tislelizumab plus axitinib for nonmetastatic renal cell carcinoma with inferior vena cava tumor thrombus: a retrospective study by Zhongjie Zhao, Zhengsheng Liu, Kaiyan Zhang, Wei Li, Lijian Zhang, Bingliang Jiang, Bin Chen, Jinchun Xing, Xuegang Wang

“…All patients showed a decrease in IVC tumor thrombus. The mean time from the end of neoadjuvant therapy to radical nephrectomy and thrombectomy was 31.7(range, 22–45) days. …”
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