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57161
Analysis of early effects of human APOE isoforms on Alzheimer’s disease and type III hyperlipoproteinemia pathways using knock-in rat models with humanized APP and APOE
Published 2024-09-01“…Neuronal transmission and plasticity tests using field Input-Output (I/O) and long-term potentiation (LTP) recordings showed increased excitability in all APOE-carrying rats, with LTP deficits in APOE2 hAβ and APOE4 hAβ rats compared to Apoe hAβ and APOE3 hAβ rats. …”
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57162
Technology acceptance and use among nursing staff in Latin American hospitals: A mixed methods study
Published 2025-06-01“…Quantitative data were analyzed using descriptive statistics and hypothesis testing for mean differences, while qualitative data underwent content analysis. …”
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57163
Estudio genético en adultos con glomeruloesclerosis focal y segmentaria
Published 2025-02-01“…Genetic causes of FSGS present significant clinical variability, complicating their identification. Genetic testing is crucial to identify FSGS of genetic cause. …”
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57164
Ethnic and racial differences in children and young people with respiratory and neurological post-acute sequelae of SARS-CoV-2: an electronic health record-based cohort study from...
Published 2025-02-01“…Our cohort included those with a positive SARS-CoV-2 molecular, serology or antigen test, or with a COVID-19, multisystem inflammatory disease in children, or PASC diagnosis from February 29, 2020 to August 1, 2022. …”
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57165
Prospective Analysis of Confocal Laser Endomicroscopy for Assessment of the Resection Bed for Bladder Tumor
Published 2025-01-01“…Histopathology of an RB biopsy was the reference test. Results at first cystoscopy 3 mo after TURBT are reported. …”
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57166
Evaluation of CellerateRX Surgical Powder utility in reducing groin complications after femoral exposure
Published 2025-01-01“…A two-tailed Fisher's exact test demonstrated no statistically significant association between the presence of complications and the treatment group (P = .49, α = 0.05); however, patients in the experimental cohort were found to be a higher risk group, having significantly higher prevalence of diabetes and surgeries using a prosthetic. …”
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57167
Impact of zero-markup consumable policy and national procurement of coronary stents on hospitalization expenses: an interrupted time series analysis
Published 2025-01-01“…The median expenses for western drugs, diagnostic tests, treatment, surgery, medical consumables, and other categories also displayed varying patterns. …”
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57168
Impact of Bone-Modifying Agents on Post-Bone Metastasis Survival Across Cancer Types
Published 2025-01-01“…In non-small cell lung cancer (NSCLC), the log-rank test demonstrated that the epidermal growth factor receptor (EGFR) mutation was a significant factor for post-bone metastasis survival: EGFR mutation (−) <i>n</i> = 67, median post-bone metastasis survival 11.5 months (95% CI: 6.0–15.2); EGFR mutation (+) <i>n</i> = 39, median post-bone metastasis survival 28.8 months (95% CI: 18.1–35.7) (<i>p</i> < 0.05). …”
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57169
Radiomics signature for dynamic monitoring of tumor inflamed microenvironment and immunotherapy response prediction
Published 2025-01-01“…Cox models using aggregated CT-TIME scores from baseline images revealed a statistically significant reduction in the risk of PFS in the pan-cancer cohort (HR 0.62, 95% CI 0.44 to 0.88, p=0.007), and Kaplan-Meier analysis further confirmed substantial differences in PFS between patients with inflamed and uninflamed status (log-rank test p=0.009).Conclusions The signature holds promise for impacting clinical decision-making, pan-cancer patient stratification, and treatment outcomes in immune checkpoint therapies.…”
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57170
Identification and characteristics of distressed patients with coronary heart disease and insufficiently controlled medical risk factors: baseline findings and sex differences from...
Published 2025-01-01“…The multicenter randomized controlled TEACH study is the first trial testing a blended collaborative care (BCC) intervention vs. usual care in a cohort of only patients with CHD. …”
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57171
Immune-related adverse events with PD-1/PD-L1 inhibitors: insights from a real-world cohort of 2523 patients
Published 2025-01-01“…Patients were categorized into an irAEs group and a non-irAEs group, with the former further subdivided into a multiple irAEs group and a single irAE group. Chi-square tests were employed to evaluate differences in baseline characteristics and efficacy outcomes between the irAEs and non-irAEs groups, as well as between the multiple and single irAE groups. …”
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57172
Levels and related factors of occupational stress among nurses: hospital-based evidence from China, 2023
Published 2025-01-01“…For continuous variables, the mean, standard deviation (SD), median, and interquartile range were reported, while counts and percentages were used for categorical variables. The independent t-test and one-way analysis of variance were employed for univariate analysis. …”
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57173
Clinical and molecular outcomes from the 5-Year natural history study of SSADH Deficiency, a model metabolic neurodevelopmental disorder
Published 2024-04-01“…Methods SSADHD subjects underwent clinical evaluations, neuropsychological assessments, biochemical quantification of γ-aminobutyrate (GABA) and related metabolites, electroencephalography (standard and high density), magnetoencephalography, transcranial magnetic stimulation, magnetic resonance imaging and spectroscopy, and genetic tests. This was parallel to laboratory molecular investigations of in vitro GABAergic neurons derived from induced human pluripotent stem cells (hiPSCs) of SSADHD subjects and biochemical analyses performed on a versatile murine model that uses an inducible and reversible rescue strategy allowing on-demand and cell-specific gene therapy. …”
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57174
Association of systemic immune-inflammatory index with in-stent restenosis in patients with and without diabetes mellitus
Published 2025-01-01“…Additionally, the interaction test and subgroup analysis were performed to evaluate the robustness of our findings. …”
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57175
High-risk human papillomavirus: prevalence, association with clinical and morphological characteristics of invasive cervical cancer
Published 2023-12-01“…Ambiguous conclusions on the presence of an association between a number of molecular-genetic parameters of HPV infection with the main prognostic factor – stage of the disease (due to the heterogeneity of samples, the use of different test systems, and the insufficiently complete account of the main parameters of HPV infection, especially data on viral DNA integration), make it advisable to conduct further research on a representative group of patients with homogeneous diagnostic protocols to determine the most complete spectrum of parameters of high oncogenic risk HPV. …”
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57176
Productivity of water and heat resources and cotton yield response to cropping pattern and planting density in cotton fields in arid area
Published 2025-02-01“…This study hypothesized that optimizing cropping patterns and planting densities would enhance hydrothermal resource productivity and cotton yield in the region. To test this, a two-year field experiment (2022–2023) employed a split-plot design with two main planting patterns (four rows per film and six rows per film) and three planting densities (low, medium, and high) as subplots. …”
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57177
Comprehensive analysis of endoscopic ultrasound (EUS) in mediastinal lesions: patient characteristics, diagnostic outcomes, safety, and efficacy: a multi-country study
Published 2025-02-01“…The p-values were obtained using the Chi-square two-tailed exact test. The significance of the analysis was defined as p < 0.05. …”
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57178
Clinical And Molecular-Genetic Features Of Congenital Aniridia
Published 2018-07-01“…Contingency tables 2X2 were analyzed by the exact Fisher test.<br> <b>Results</b>: AN clinical picture associated with loss of function mutations (nonsense, frame shift and splicing) has more severe clinical course. …”
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57179
A community-based study to assess the prevalence and predictors of stunting among under-five children in Sheger City, Oromia, Ethiopia
Published 2025-01-01“…The goodness-of-fit for the model was assessed using the Hosmer-Lemeshow test.ResultsThe prevalence of stunting was 18.9% (95% CI: 16, 22%) among under-five children in our study setting. …”
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57180
Trends and Outcomes in Sarcomatoid Renal Cell Carcinoma: Analysis of the National Cancer Data Base
Published 2025-01-01“…Trend analyses were conducted using the Cochran-Armitage test. Multivariable analyses were used to assess factors associated with sRCC diagnosis and clinicopathologic characteristics associated with all-cause mortality (ACM). …”
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