Development and validation of an explainable machine learning model for mortality prediction among patients with infected pancreatic necrosisResearch in context by Caihong Ning, Hui Ouyang, Jie Xiao, Di Wu, Zefang Sun, Baiqi Liu, Dingcheng Shen, Xiaoyue Hong, Chiayan Lin, Jiarong Li, Lu Chen, Shuai Zhu, Xinying Li, Fada Xia, Gengwen Huang

“…Ten ML models were developed to predict 90-day mortality in these patients. A benchmarking test, involving nested resampling, automatic hyperparameter tuning and random search techniques, was conducted to select the ML model. …”
Get full text

LGR4 is essential for maintaining β-cell homeostasis through suppression of RANK by Joanna Filipowska, Zelda Cisneros, Sneha S. Varghese, Nancy Leon-Rivera, Peng Wang, Randy Kang, Geming Lu, Yate-Ching Yuan, Hung-Ping Shih, Supriyo Bhattacharya, Sangeeta Dhawan, Adolfo Garcia-Ocaña, Nagesha Guthalu Kondegowda, Rupangi C. Vasavada

“…Using Lgr4fl/fl and Lgr4fl/fl/Rankfl/fl × Ins1-Cre mice we generated β-cell-specific conditional knockout (cko) mice to test the role of LGR4 and its interaction with RANK in vivo under basal and stress-induced conditions. …”
Get full text

Proteomic profiling of the local and systemic immune response to pediatric respiratory viral infections by Emily Lydon, Christina M. Osborne, Brandie D. Wagner, Lilliam Ambroggio, J. Kirk Harris, Ron Reeder, Todd C. Carpenter, Aline B. Maddux, Matthew K. Leroue, Nadir Yehya, Joseph L. DeRisi, Mark W. Hall, Athena F. Zuppa, Joseph Carcillo, Kathleen Meert, Anil Sapru, Murray M. Pollack, Patrick McQuillen, Daniel A. Notterman, Charles R. Langelier, Peter M. Mourani

“…To address this gap, gain insights into vLRTI pathophysiology, and test a novel diagnostic approach, we assayed 1,305 proteins in tracheal aspirate (TA) and plasma from 62 critically ill children using SomaScan. …”
Get full text

Impact of alcohol drinking and tobacco smoking on the drug-resistance of newly diagnosed tuberculosis: a retrospective cohort study in Shandong, China, during 2004–2020 by Yi-Fan Li, Yao Liu, Qi Fu, Wan-mei Song, Jin-yue Liu, Qian-yun Zhang, Ting-ting Xu, Shi-jin Li, Qi-qi An, Si-qi Liu, Huai-chen Li, Ning Ning Tao, Xue-han Zhu, Chun-bao Yu, Jihua Dong

“…Exclusive criteria: retreated cases; extrapulmonary tuberculosis; without information on drug susceptibility testing results, smoking or drinking habits; bacteriological identification as non-tuberculous mycobacteria.Primary and secondary outcome measures Patients were classified into four groups including smokers only (G1), drinker only (G2), smoker +drinker (G3), non-smoker +non-drinker group (G0). …”
Get full text

Associations between milk infrared-predicted plasma biomarkers of stress resilience and fertility in dairy cattle: Insights for enhancing breeding programs and herd management by Alessio Cecchinato, Hugo Toledo-Alvarado, Lucio Flavio Macedo Mota, Vittoria Bisutti, Erminio Trevisi, Riccardo Negrini, Sara Pegolo, Stefano Schiavon, Luigi Gallo, Giovanni Bittante, Diana Giannuzzi

“…The 2 databases were merged according to the milk test day (and thus, the MIR spectrum) closest to the date of insemination. …”
Get full text

Meta-synthesis of drivers of the circular business model by Atieh Khodaei, Mahdi Hosseinpour, Mohammad javad Jamshidi, Yoosof Mohamadifar

“…Using the coding method, the number of 27 codes, 8 concepts, and 3 components were identified and validated through Cohen's kappa test, and the model of the drivers of circular business model was presented and drawn. …”
Get full text

A simple staging system using biomarkers for wild‐type transthyretin amyloid cardiomyopathy in Japan by Naoya Nakashima, Seiji Takashio, Mami Morioka, Masato Nishi, Toshihiro Yamada, Kyoko Hirakawa, Masanobu Ishii, Noriaki Tabata, Kenshi Yamanaga, Koichiro Fujisue, Daisuke Sueta, Hisanori Kanazawa, Tadashi Hoshiyama, Shinsuke Hanatani, Satoshi Araki, Hiroki Usuku, Eiichiro Yamamoto, Mitsuharu Ueda, Kenichi Matsushita, Kenichi Tsujita

“…Kaplan–Meier analyses revealed significant differences in all‐cause death and rehospitalization for heart failure (log rank test; P < 0.001), and after adjusting for sex and age, the hazard ratio of all‐cause death was 6.96 (95% Cl 2.88–16.83, P < 0.001) and that for rehospitalization for heart failure was 4.27 (95% Cl 2.26–8.07, P < 0.001) in the high‐risk group, compared with those in the low‐risk group. …”
Get full text

Evaluation of hierarchical management of operating room nurses to in the promotion of high-quality nursing service (手术室护士分层管理在优质护理服务中的应用效果)... by LI Yanzhen (李棪臻), ZHANG Hui (张慧), HE Lili (何利利), ZHANG Jing (张静), LEI Dan (雷丹), WEI Qianqian (卫倩倩), XI Hongna (席红娜), LI Hao (李豪), LIU Ruzhong (刘儒忠), HUANG Xinkun (黄新坤), LIU Xiongtao (刘雄涛)

“…Results The implementation of hierarchical management had improved the test outcomes of nurses in surgical practice. There was an improved satisfaction with clinical teaching among nursing students and improved satisfaction with nursing among surgeons. …”
Get full text

Compositional Design, Microstructure, and Thermal Processing of Aluminum-Based Complex Concentrated Alloys by Spyridon Chaskis, Constantinos Tiktopoulos, Evangelos Gavalas, Marianthi Bouzouni, Fotis Tsiolis, Spyros Papaefthymiou

“…In order to investigate and evaluate the mechanical properties of the as-cast and heat-treated alloys, hardness testing along with electrical conductivity measurements were conducted at room temperature. …”
Get full text

Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps) by Dawit Asmamaw Ejigu, Abebaw Fekadu, Jeremy Whitty, Tsegahun Manyazewal, Pamela Nebeta, Almari Conradie, Brenda Okech, Alice Neequaye, Sinéad Whitty, Jennifer Lehrman, Renee Holt, Rahel Birhane, Mahnaz Vahedi, Helen Demarest, Eyasu Makonnen

“…We used Wilcoxon rank test to analyze pre- and post-survey scores and thematic analysis to analyze the qualitative data. …”
Get full text

Enzymic Activity, Metabolites, and Hematological Responses Changes of Clinical Healthy High-Risk Beef Calves During Their First 56-Days from Arrival by Octavio Carrillo-Muro, Pedro Hernández-Briano, Paola Isaira Correa-Aguado, Alejandro Rivera-Villegas, Oliver Yaotzin Sánchez-Barbosa, Rosalba Lazalde-Cruz, Alberto Barreras, Alejandro Plascencia, Daniel Rodríguez-Cordero

“…The following parameters were determined: total white blood cells (WBC): lymphocytes (LYM), lymphocytes % (LYM%), monocytes (MON), monocytes % (MON%), granulocytes (GRA), granulocytes % (GRA%), platelets (PLT), and mean platelet volume (MPV); red blood cells (RBC): red blood cell distribution width test % (RDW%), hematocrit (HCT), and mean corpuscular volume (MCV); hemoglobin (HGB): mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC). …”
Get full text

High risk of asthma among early teens is associated with quantitative differences in mite and cat allergen specific IgE and IgG4: a modified Th2 related antibody response revisited... by Thomas A. Platts-Mills, Behnam Keshavarz, Jeffrey M. Wilson, Sheryl L. Rifas-Shiman, Samuel M. Ailsworth, Joanne E. Sordillo, Lisa Workman, Martin Chapman, Jonas Lidholm, Emily Oken, Diane R. Gold

“…Indeed, values of specific IgE to Der p 1 >3.5 IU/mL were not significantly related to asthma (OR 1.5 CI 0.8–2.8, p = 0.3, Chi2 test). The prevalence and levels of specific IgG4 to these less abundant allergens are significantly lower for Der p 2 and almost absent for Der p 23. …”
Get full text

Evaluation of Southern African wild edible plants for potential herb-drug interactions through ex vivo p-glycoprotein and in vitro cytochrome P450 3A4 inhibitory effects by P.S. Kheoane, K.C. Mokhetho, S. Mokhele, K.C. Mbara, C.M. Leonard, T.H. Gadaga, C. Tarirai

“…Drug transport studies using propranolol, a P-glycoprotein substrate, across porcine intestinal tissue were conducted using intestinal sacs with test solutions in Krebs-Ringer bicarbonate buffer (pH 7.4) under a 95 % O2/5 % CO2 atmosphere. …”
Get full text

The role of smell in medical and psychological disorders: An interdisciplinary approach by Giuseppe Riva

“…Finally, central causes of smell alterations result from the damage of the olfactory processing pathways of the central nervous system, such as neurodegenerative diseases [1]. Olfactory testing includes subjective, psychophysical, and objective evaluations [4]. …”

Evaluation of a peer support group programme for vulnerable host population and refugees living with diabetes and/or hypertension in Lebanon: a before-after study by Leah Anku Sanga, Carla Njeim, Éimhín Ansbro, Rima Kighsro Naimi, Ali Ibrahim, Benjamin Schmid, Jasmin Lilian Diab, Jytte Roswall, Tim Clayton, Lars Bruun Larsen, Pablo Perel

“…We performed a before-after analysis of PROMs for all patients who completed the PSG sessions. T-tests were used to analyze the differences in PROMs from baseline. …”
Get full text

Health economic evaluation of different colorectal cancer screening strategies in Hubei province: a Markov simulation analysis based on local cancer registration and domestic study... by Jie JI, Yuying WANG, Duan ZHUO, Yuhan LIU, Jiaxi PENG, Ruijingfang JIANG, Hao WU, Song LIU, Lijian ZHAO, Jian WANG, Bing MAO, Shida ZHU, Hongbing TAO

“…ResultsThe cost-effectiveness analysis at the individual level showed that the screening strategy with the lowest cost was 50-74-1 (annual primary screening with immunochemical fecal occult blood testing [iFOBT] and then required colonoscopy from 50 to 74 years of age), which cost 483 100 Chinese yuan (CNY) in social costs, gained 17.82 life-years (LY) and 16.76 quality-adjusted life-years (QALY), with a cost-effectiveness ratio (CER) of 27 100 CNY/LY and 28 800 CNY/QALY, using LY and QALY as outcome measures, respectively. …”
Get full text

Application of probiotic microcapsules Bacillus cereus BR2 with different doses for the prevention of Aeromonas hydrophila NFC1 infection in catfish Clarias sp. by Nurul Faoziyatunnisa, Munti Yuhana, Dinamella Wahjuningrum, Sri Nuryati, Usamah Afiff

“…Fish rearing was continued after the challenge test with A. hydrophila NFC1 for 10 days. The results showed that the application of supplemented feed containing B. cereus BR2 probiotic microcapsules increased the survival rate, immune response, and digestive enzyme activities of catfish which was infected with A. hydrophila NFC1, 2% microcapsule supplementation demonstrated the best result.   …”
Get full text

Előszó by Ákos Forczek

“…Az újkori filozófia bűvkörében maradva, Szakács Evelyn fordításában ismerhető meg Lorenzo Vinciguerra átfogó tanulmánya a kép spinozai koncepciójáról, konkrétabban arról a komplex folyamatról, ahogyan a képek láncolata kibontja a kép jelentését a test affekcióinak emlékezet szerinti rendjében. Ezt követően Lehr János foglalja össze Hume tulajdonnal foglalkozó téziseit, illetve érvel amellett, hogy Hume elmélete nem egyszerűen Locke tételeinek cáfolata akart lenni, hanem az eredeti teória egy sajátos, modernizált változata is. …”
Get full text

A Prospective, Crossover, Randomized, Double-Blind Clinical Study Comparing the Effectiveness and Ocular Comfort of 0.1% Hyaluronic Acid and 0.3% Hyaluronic Acid in Patients With D... by Kim SJ, Yoo WS, Kwon LH, Kim RB, Yoon HJ, Yoon KC

“…Changes in the Schirmer test were greater in group 2, but this difference was also not statistically significant. …”
Get full text

Evaluation of corn steep liquor on the digestibility and growth performance of juvenile common carp strain Sinyonya by Dodi Hermawan, Lukman Anugrah Agung, Indah Juwita Sari, Haeru Wahyudin, Immanuel Tarigan

“…The reference diet used commercial feed with 30% protein, and the test diet used CSL at 0% (CSL0), 10% (CSL10), 20% (CSL20), and 30% (CSL30). …”
Get full text