Effect of healthy lifestyle score trajectory on all-cause mortality in the late middle-aged and older population: Finding from 17-year retrospective cohort study by Jeong Min Yang, Jieun Hwang

“…Methods: After excluding missing values, data from 6249 participants were analyzed using the group-based trajectory model (GBTM) to classify HLST, based on the first to fourth waves of the Korean Longitudinal Study of Aging (KLoSA). The chi-square test and Cox proportional hazards model were employed to examine the association between HLST and all-cause mortality over a 10-year follow-up period (December 31, 2012, to December 31, 2022; 3650 days). …”
Get full text

Addressing unmet mental health needs of older adults in Turbo, Colombia: a multi-component psychosocial intervention feasibility study by Clarissa Giebel, Erika Montoya, Gabriel Saldarriaga, Thais Caprioli, Mark Gabbay, Danicza Martinez, Jessica Rua, Maria Isabel Zuluaga

“…Without adequate mental health resources in place, the aim of this study was to feasibility test a co-produced community-integrated intervention for older adults to improve their mental health and well-being in Turbo, Colombia. …”
Get full text

Baseline [18F]FDG PET/CT radiomics for predicting interim efficacy in follicular lymphoma treated with first-line R-CHOP by Zeying Wen, Xiaohe Gao, Qingxia Wu, Jianwei Yang, Jian Sun, Keliu Wu, Hongfei Zhao, Ruihua Wang, Yanmei Li

“…Model performance was assessed using the area under the receiver operating characteristic (ROC) curve, accuracy, and the Delong test to compare AUC differences. Result Among the 97 patients, 42 (43.30%) achieved complete response (CR) for interim efficacy, while 55 (56.70%) had non-complete response (non-CR). …”
Get full text

Exploring health related quality of life for women with breast cancer in Ireland and Québec, Canada throughout the COVID-19 pandemic by Charlotte Myers, Kathleen Bennett, Caitriona Cahir, Josée Savard, Sophie Lauzier

“…COVID-19 stressor impact was computed post-pandemic, and change in HR-QoL during and post-pandemic was compared between Ireland and Québec using independent t-tests. Multivariable analysis of covariance (ANCOVA) was used to evaluate the association between COVID-19 stressor impact and changes in HR-QoL, and compare it between Ireland and Québec. 405 participants were included from both settings (Ireland n = 267; Québec n = 138). …”
Get full text

Advancing global herbal medicine: Enhancing herb quality through innovative strategies explored in Hong Kong - An international hub by Hiu-Lam Ngai, Pang-Chui Shaw

“…Moreover, it was found that chemical inspection tests were generally avoided due to cost and time concerns. …”
Get full text

Macro-environment oscillation notably up risk of water quality degradation: A case study in Shanxi Reservoir, China by Wangwei Cai, Jihong Xia, Zewen Liu, Jiayi Zu, Shuyi Ji, Yue Wang, Qihua Wang

“…Shanxi Reservoir in Zhejiang, China, a large reservoir with a total storage capacity of 1.82 billion m3 was used as the study area to test this hypothesis. Monthly macro-environment data from 2014 to 2022 (sample size = 108), including 10 factors of meteorology, hydrology, and pollution, was used to create a Macro-Environment Index (MEI) by Principal Component Analysis. …”
Get full text

An adenoviral vector encoding an inflammation-inducible antagonist, HMGB1 Box A, as a novel therapeutic approach to inflammatory diseases by Kari Ann Shirey, John Joseph, Lynda Coughlan, Haye Nijhuis, Alan W. Varley, Jorge C. G. Blanco, Stefanie N. Vogel

“…The recombinant protein would be produced and released only in the presence of the inciting stimulus, avoiding immunosuppression or other unwanted side effects that may occur when treating infectious diseases with anti-inflammatory drugs. To test this hypothesis, we developed AdV.C3-Tat/HIV-Box A, an inflammation-inducible cassette that remains innocuous in the absence of inflammation but releases HMGB1 Box A, an antagonist of high mobility group box 1 (HMGB1), in response to inflammatory stimuli such as lipopolysaccharide (LPS) or influenza virus infection. …”
Get full text

Biochar effects on durum wheat (Triticum durum) under ambient and elevated atmospheric CO2 by Lorenzo Brilli, Franz-Werner Badeck, Lorenzo Genesio, Silvia Baronti, Fulvia Rizza, Clara Fares, Luigi Cattivelli, Franco Miglietta, Anita Maienza, Alessandro Zaldei, Federica Camin, Rosella Motzo, Piero Toscano

“…The use of biochar as amendment, thanks to its well-known ability to improve soil fertility and crop production and quality, could be a suitable solution to cope with the negative effect of e[CO2] on qualitative traits. To test this hypothesis, we present the results of an open field experiment investigating the combined effects of biochar application and e[CO2] on quantitative and qualitative performance of two commercial durum wheat (Triticum durum) cultivars (Aureo and Claudio). …”
Get full text

Recognition of HER2 expression in hepatocellular carcinoma and its significance in postoperative tumor recurrence by Ji‐Hua Shi, Wen‐Zhi Guo, Yang Jin, Hua-Peng Zhang, Chun Pang, Jie Li, Pål‐Dag Line, Shui‐Jun Zhang

“…Western Blotting and immunohistochemistry were employed to test expression of HER2, E‐cadherin, and Vimentin. …”
Get full text

Development of an imputation model to recalibrate birth weights measured in the early neonatal period to time at delivery and assessment of its impact on size-for-gestational age a... by Joanne Katz, James M Tielsch, Luke C Mullany, Diwakar Mohan, Subarna K Khatry, Seema Subedi, Scott L Zeger, Elizabeth A Hazel

“…We aimed to develop an imputation model that predicts the ‘true’ birth weight at time of delivery.Design We developed and applied a model that recalibrates weights measured in the early neonatal period to time=0 at delivery and uses those recalibrated birth weights to impute missing birth weights.Setting This is a secondary analysis of pregnancy cohort data from two studies in Sarlahi district, Nepal.Participants The participants are 457 babies with daily weights measured in the first 10 days of life from a subsample of a larger clinical trial on chlorhexidine (CHX) neonatal skin cleansing and 31 116 babies followed through the neonatal period to test the impact of neonatal massage oil type (Nepal Oil Massage Study (NOMS)).Outcome measures We developed an empirical Bayes model of early neonatal weight change using CHX trial longitudinal data and applied it to the NOMS dataset to recalibrate and then impute birth weight at delivery. …”
Get full text

Effect of remote ischemic preconditioning on perioperative neurocognitive disorder in elderly patients undergoing major surgery and associated genetic variant analysis: a randomize... by Feifei Xu, Tingting Liu, Huiqing Liu, Jiao Deng, Shan He, Zhihong Lu, Haopeng Zhang, Hailong Dong

“…A total of five cycles were repeated with ischemia for five minutes and reperfusion for five minutes. Six neurological tests were performed before and after the surgery to assess the incidence of PND. …”
Get full text

Effectiveness of flipped classrooms in Chinese students of clinical medicine major undergoing clinical practice: a meta-analysis by Xinrui Sun, Xin Yuan, Linyu Zhang, Yi Zhang, Xue Xiao, Hanmin Liu, Fang Ma

“…Weighted mean differences (WMD) and 95% confidence interval (CI) were used to compare the differences in theoretical and skill scores between the flipped classrooms and traditional lecture groups. The Cochran Q test and the I2 statistic were used for heterogeneity analysis. …”
Get full text

The Relationship between Simple Snoring and Metabolic Syndrome: A Cross-Sectional Study by Juanjuan Zou, Fan Song, Huajun Xu, Yiqun Fu, Yunyan Xia, Yingjun Qian, Jianyin Zou, Suru Liu, Fang Fang, Lili Meng, Hongliang Yi, Jian Guan, Huaming Zhu, Bin Chen, Shankai Yin

“…The polynomial linear trend test was used to assess the linear trend across snoring intensity for metabolic score, and logistic regression was used to evaluate the odds ratios (ORs) for MetS after controlling for age, sex, obesity, smoking status, and alcohol consumption. …”
Get full text

Antimicrobial photodynamic inactivation of Pseudomonas aeruginosa persister cells and biofilms by Mona Mahmoud, Peter Richter, Philipp Arnold, Michael Lebert, Andreas Burkovski

“…Antimicrobial susceptibility tests were performed using the broth microdilution checkerboard method. …”
Get full text

Plant response to the fire regime (1970–2023) in a fynbos World Heritage Site: Ecological indicators for fire management by Tineke Kraaij, Johan Baard, AnneLise Schutte-Vlok

“…In these ecosystems, particular plant species may be used as indicators to develop or test thresholds for sound management of fires. We analysed long-term datasets to assess the response of indicator plants (slow-maturing obligatory reseeding Proteaceae shrubs; ‘proteoids’) to the historical fire regime (1970–2023) in the Outeniqua World Heritage Site (OWHS), South Africa. …”
Get full text

Structural Properties, Cytotoxicity, and Anti-Inflammatory Activity of Silver(I) Complexes with tris(p-tolyl)Phosphine and 5-Chloro-2-Mercaptobenzothiazole by L. Kyros, N. Kourkoumelis, M. Kubicki, L. Male, M. B. Hursthouse, I. I. Verginadis, E. Gouma, S. Karkabounas, K. Charalabopoulos, S. K. Hadjikakou

“…All these complexes and {[(Et3NH)+]2⋅[Ag6(μ3-Hmna)4(μ3-mna)2]2−⋅(DMSO)2⋅(H2O)} (5) (Hmna = 2-mercaptonicotinic acid) were evaluated for cytotoxic and anti-inflammatory activity. The in vitro testing of cytotoxic activity of 1–5 against leiomyosarcoma cancer cells (LMS), were evaluated with Trypan Blue and Thiazolyl Blue Tetrazolium Bromide or 3-(4.5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assays. …”
Get full text

COVID-19 Pandemic Experiences in Pediatric Intensive Care Unit: An Iranian Referral Hospital-Based Study by Masoud Mohammadpour, Seyed Abbas Hassani, Meisam Sharifzadeh, Leila Tahernia, Setareh Mamishi, Bahareh Yaghmaie, Zeinab Najafi, Farzaneh Beirami, Mehrnoush Afsharipour, Maryam Minuyeefar, Mina Dolatzadeh, Neda Pak, Anahita Majmaa, Zahra Zamani, Shima Mahmoudi

“…Patients were evaluated in terms of demographic categories, primary symptoms and signs at presentation, underlying disease, SARS-CoV-2 RT-PCR test result, laboratory findings at PICU admission, chest X-ray (CXR) and lung CT findings, and treatment. …”
Get full text

Exposure to copper metal enhances the tolerance of An. gambiae s.s. over multiple generations while reducing both fertility and fecundity in this primary malaria vector. [version 2... by Adam Gbankoto, Rousseau Djouaka, Camille Dossou, Louckman Monra Seidou, Ghislain T. Tepa-Yotto, Danahé Adanzounon, Genevieve Tchigossou, Innocent Djègbè, Aldo Emmanuel C. Glokpon, Massioudou Koto Yérima Gounou Boukari, Eric Tossou, Donald Hessou-Djossou

“…The average number of eggs laid was lower in the test groups from generation 4 to generation 5 (C1 and C2, p = 0.00) and egg fertility was also negatively affected by exposure of the larval stage of An. gambiae s.s. to copper. …”
Get full text

Technologies of suspension cultivation in bioreactor of the Chlamydophila abortus strain on McCoy cell culture by Yerkin Krykbayev, Nurtas Tyrsynbayev, Nurlan Akhmetsadykov, Damir Khussainov, Zhanat Batanova

“…Samples from the organs of aborted foetuses and swabs with vaginal contents were taken to confirm this diagnosis. Complement fixation tests with chlamydia antigen were found to be positive in 7 (23%) of the 30 animals that were examined. …”
Get full text

Effectiveness of chain of survival for out-of-hospital-cardiac-arrest (OHCA) in resource limited countries: A systematic review by Mirza Noor Ali Baig, Zafar Fatmi, Nadeem Ullah Khan, Uzma Rahim Khan, Ahmed Raheem, Junaid Abdul Razzak

“…Descriptive analysis and narrative synthesis were conducted, with return of spontaneous circulation (ROSC) rates compared across income groups using t-tests. Results: Sixteen (16) eligible studies were included. …”
Get full text