Human_SNP_TATAdb: a database of SNPs that statistically significantly change the affinity of the TATA-binding protein to human gene promoters: genome-wide analysis and use cases by S. V. Filonov, N. L. Podkolodnyy, O. A. Podkolodnaya, N. N. Tverdokhleb, P. M. Ponomarenko, D. A. Rasskazov, A. G. Bogomolov, M. P. Ponomarenko

“…The method showed a high correlation of theoretical predictions with measured values during repeated experimental testing by independent groups of researchers. This model served as a base for other ICG web services, SNP_TATA_Z-tester and SNP_TATA_Comparator, which make a statistical assessment of the SNP-induced change in the affinity of TBP binding to the human gene promoter and help predict changes in expression that may be associated with a genetic predisposition to diseases or phenotypic features of the organism. …”
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Association between ethylene oxide exposure and osteoarthritis risk: an analysis of NHANES data (2013–2014 and 2017–2018) by Zhongshan Li, Zhongshan Li, Qi Qu, Qi Qu, Zhiyu Wang, Zhiyu Wang, Shuanglin Mou, Rui Jiang, Rui Jiang, Wensheng Zhu, Wensheng Zhu

“…Subgroup analysis and interaction test explored variations in the association across different characteristics.ResultsNo significant difference in EO concentrations was found between OA and non-OA groups. …”
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Evidence Gaps and Lessons in the Early Detection of Atrial Fibrillation: A Prospective Study in a Primary Care Setting (PREFATE Study) by Josep L. Clua-Espuny, Alba Hernández-Pinilla, Delicia Gentille-Lorente, Eulàlia Muria-Subirats, Teresa Forcadell-Arenas, Cinta de Diego-Cabanes, Domingo Ribas-Seguí, Anna Diaz-Vilarasau, Cristina Molins-Rojas, Meritxell Palleja-Millan, Eva M. Satué-Gracia, Francisco Martín-Luján

“…<b>Results:</b> A total of 18 cases (12.08%) were identified as positive for possible DDAF using FibriCheck^® and 13 new cases of AF were diagnosed during follow-up, with a 71.4-fold higher probability of confirming AF in FibriCheck^®-positive individuals than in FibriCheck^®-negative individuals, resulting in a post-test odds of 87.7%. Significant echocardiographic markers of AF included reduced left atrial strain (<26%) and left atrial ejection fraction (<50%). …”
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Frailty assessment tools for use by surgeons when evaluating older adults prior to surgery: a scoping review protocol by Duminda N Wijeysundera, Andrea C Tricco, Martine T E Puts, Shabbir M H Alibhai, Teruko Kishibe, Tyler R Chesney, Julian F Daza, Camilla Wong, Karim Shiraz Ladha, Samuel Dubé

“…We will exclude tools not assessed in clinical practice, or using laboratory or radiologic values alone. After pilot testing, two reviewers will independently assess information sources for eligibility first by titles and abstracts, then by full-text review. …”
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The effect of baseline versus early glucocorticoid use on immune checkpoint inhibitor efficacy in patients with advanced NSCLC by Yifan Wang, Yifan Wang, Jianying Zhou, Simin Peng, Simin Peng, Zhao Cui, Zhao Cui, Weiqi Wang, Weiqi Wang, Wenqin Zeng, Wenqin Zeng, Tingting Qiu, Zhentian Liu

“…Cox proportional hazards regression model and Logistic regression analysis were used to analyze the factors affecting ORR and PFS, and t test was used to analyze the changes of NEUT %/(CD4 +/CD8 +) during GC use.ResultsMultivariate Logistic analysis showed that GC use was associated with a higher ORR in 130 patients treated with ICIs [HR = 3.07,95% CI (1.31-7.21), P = 0.010]. …”
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Synthesis and Evaluation of N-[1-(((3,4-Diphenylthiazol-2(3H)-ylidene)amino)methyl)cyclopentyl]acetamide Derivatives for the Treatment of Diseases Belonging to MAOs by Gülhan Turan-Zitouni, Aouatef Tabbi, Weiam Hussein, Abdullah Burak Karaduman, Begüm Nurpelin Sağlık, Yusuf Özkay

“…In the wake of all these results, it was understood that compound 4b was found to be the most potent derivative in the series against both isoforms and selective as MAO-B inhibitor. The cytotoxicity test was performed for compounds 4a, 4b, and 4c, and it was found that these compounds were noncytotoxic at the concentration of their IC50 values. …”
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Impact of psychotropic pro re nata prescription-monitoring programme on prescriptions for inpatients with psychiatric disorders: a retrospective observational study by Yoshitaka Saito, Kyohei Sumida, Hiroyuki Muraoka, Satoru Oishi, Ryutaro Suzuki, Taiyo Nishikawa, Shin Miyake, Yukihiro Tanno, Yuki Tobita, Katsuya Otori, Ken Inada

“…The significance level of 5% was set at 1.67 × 10−3 using the Bonferroni correction for multiple testing. Results The psychotropic PRN prescription ratio at discharge in the monitoring group was 9.3%, which was significantly lower than the 28.1% in the non-monitoring group. …”
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Iodine Concentration in Drinking Water in the Same or Different Seasons of the Year in Brazilian Macroregions by Carina Aparecida Pinto, Dayane de Castro Morais, Sylvia do Carmo Castro Franceschini, Sarah Aparecida Vieira Ribeiro, Edimar Aparecida Filomeno Fontes, Nathália Marcolini Pelucio Pizato, Franciane Rocha de Faria, Renata Junqueira Pereira, Danielle Goés da Silva, Carolina Abreu de Carvalho, Fabiana de Cássia Carvalho Oliveira, Naiara Sperandio, Anderson Marliere Navarro, Sandra Patrícia Crispim, Silvia Eloiza Priore

“…To verify if there was a difference in the concentration of iodine in the water between the climatic seasons of the year in the same place and between the same seasons in different locations, the Mann–Whitney or Kruskal–Wallis test was used and a p<0.05 value was considered significant. …”
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Utility of High-Resolution Ultrasonography in the Evaluation of Posterior Segment Ocular Lesions Using Sensitivity and Specificity by Deb K. Boruah, Daisy Vishwakarma, Pallavi Gogoi, Navneet R Lal, Arup Deuri

“…Statistical analysis: Sensitivity, specificity, the positive predictive value, the negative predictive value, and the accuracy of B-scan USG were compared with the ophthalmological findings by using the Chi-square test. Results: Of 81 patients (n=48 males and n=33 females) with a mean age of 38.98 ± 16.48 [SD] years, posterior segment ocular lesions in association with cataracts were found in 27 (33.3%) patients, whereas 14 (51.9%) patients had posterior vitreous detachment (PVD), 10 (37%) patients had retinal detachment (RD), and 1 (3.7%) patient had choroidal detachment (CD). …”
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Porphyromonas gingivalis associates with the presence of anti-citrullinated protein antibodies, but not with the onset of arthritis: studies in an at-risk population by Helga Westerlind, Linda Mathsson-Alm, Alexandra Circiumaru, Aase Hensvold, Karin Lundberg, Jan Potempa, Yogan Kisten, Charlotte De Vries, Marina Dehara, Barbara Potempa

“…Here, we investigated whether antibodies against the Pg virulence factor arginine gingipain (Rgp) are associated with the RA-risk phase and development of arthritis.Methods At-risk individuals were included in a prospective study (Risk-RA) based on a positive anti-cyclic citrullinated peptide 2 (CCP2) antibody test, and having musculoskeletal complaints but no signs of arthritis. …”
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Ethical issues raised in the care of the elderly during the SARS-CoV-2 pandemic and possible solutions for the future: a systematic review of qualitative scientific literature by Mohamed Amine Bouchlaghem, Zoé Estey-Amyot, Erika Ethier, Miruna Anohim, Marie-Laurence Ouellet-Pelletier, Lyse Langlois, Félix Pageau

“…We highly recommend that future research be undertaken to test the efficacy of the proposed solutions in providing age-friendly, dilemma-free health care and environments.…”
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Increasing Quantity and Internal Quality of Japanese Quail (Coturnix coturnix japonica) Eggs by Shooting Laser Puncture at Reproductive Acupuncture Points by Sunaryo Hadi Warsito, Tatang Santanu Adikara, Septiana Megasari, Ilham Radifan Pratama, Mirni Lamid, Herry Agoes Hermadi

“…Then, the research results were analyzed using Analysis of Variance and followed by Duncan’s Multiple Range Test. Laser puncture shooting at the reproductive acupuncture point of Japanese quail (Coturnix coturnix japonica) can increase the quantity of eggs (p<0.05). …”
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Associations between neutrophil-percentage-to-albumin ratio level and all-cause mortality and cardiovascular disease-cause mortality in diabetes population by Geng Shen, Yuting Liu, Can Zhou, Wei Luo, Yun-xiao Yang, Shuai Guo, Jiayi Yi, Lin Wang, Wei Li, Zhao-gong Zhi, Xiu-huan Chen, Chen Li, Yanyan Jin, Hai Gao

“…The assessment of nonlinearity was conducted using the likelihood ratio test. Results After adjustment, the risk ratio for all-cause mortality in the highest NPAR group (≥ 15.40) compared to the lowest serum NPAR reference group (< 13.30) was 1.62 (95% CI, 1.36, 1.94) with P values < 0.001. …”
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Transition zone-based prostate-specific antigen density for differentiating clinically significant prostate cancer in PI-RADS score 3 lesions by Yongming Jin, Fei Chen, Gang Xu, Chaogang Wei, Congsong Dong

“…The best cutoff value was determined by the Youden index, and differences between diagnostic performances were compared with the Delong test. A total of 154 TZ lesions were included, of them 28 were diagnosed with csPCa. …”
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Leveraging machine learning for enhanced reservoir permeability estimation in geothermal hotspots: a case study of the Williston Basin by Abdul-Muaizz Koray, Emmanuel Gyimah, Mohamed Metwally, Hamid Rahnema, Olusegun Tomomewo

“…Overall, the SVM and GPR regression methods were observed to show consistent results with the training and testing datasets, with the SVM regression technique yielding higher R-squared values through regression across the different clustering techniques. …”
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Increasing the uptake of long-acting reversible contraception in general practice: the Australian Contraceptive ChOice pRoject (ACCORd) cluster randomised controlled trial protocol by Danielle Mazza, Angela Taft, Kevin McGeechan, Kirsten Black, Heather McKay, Marion Haas, Jayne Lucke, Jeffery F Peipert

“…This protocol paper describes the Australian Contraceptive ChOice pRojet (ACCORd), a cluster randomised control trial that aims to test whether an educational intervention targeting general practitioners (GPs) and establishing a rapid referral service are a cost-effective means of increasing LARC uptake.Methods and analysis The ACCORd intervention is adapted from the successful US Contraceptive CHOICE study and involves training GPs to provide ‘LARC First’ structured contraceptive counselling to women seeking contraception, and implementing rapid referral pathways for LARC insertion. …”
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Characteristics of Sluggish Cognitive Tempo among adults with ADHD: objective neurocognitive measures align with self-report of executive function by Beth Krone, Lenard A. Adler, Deepti Anbarasan, Terry Leon, Richard Gallagher, Pooja Patel, Stephen V. Faraone, Jeffrey H. Newcorn

“…Adults with (SCT+) and without (SCT-) SCT received a comprehensive clinical assessment battery, and neuropsychological testing. Clinical and neuropsychological variables were examined for their associations with SCT. …”
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Comparative analysis of clinical characteristics and outcomes between carbapenem-resistant and carbapenem-sensitive Klebsiella pneumoniae infections: insights from a tertiary hospi... by Bu Wang, Bu Wang, Wei Zhang, Hongxia Zhang, Maochen Li, Zhihua Zhang, Xiaocui Peng, Na Wang, Ning Song

“…Mortality rates between CRKP and CSKP groups were compared using chi-square tests, and survival curves were generated with the Kaplan–Meier method.ResultsThe study included 283 patients, with 104 (36.7%) infected by CRKP and 179 (63.3%) by CSKP. …”
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A Step Forward Towards Exploring Nutritional and Biological Potential of Mushrooms: A Case Study of Calocybe gambosa (Fr.) Donk Wild Growing in Serbia by Jovana Dragan Petrovic, Ângela Fernandes, Dejan Stojković, Marina Soković, Lillian Barros, Isabel C.F.R. Ferreira, Aditya Shekhar, Jasmina Glamočlija

“…Finally, enrichment of oatmeal cookies with C. gambosa flakes not only improved their nutritional value, but was praised among the participants in sensory evaluation test, indicating that along with results of chemical composition and biological activity, this mushroom has a potential to be regarded as functional food.…”
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Relating Sensory, Cognitive, and Neural Factors to Older Persons’ Perceptions about Happiness: An Exploratory Study by Alexandra J. Horne, Kimberly S. Chiew, Jie Zhuang, Linda K. George, R. Alison Adcock, Guy G. Potter, Eleonora M. Lad, Scott W. Cousins, Frank R. Lin, Sara K. Mamo, Nan-Kuei Chen, Abigail J. Maciejewski, Xuan Duong Fernandez, Heather E. Whitson

“…Sensory health and cognition were assessed by Snellen visual acuity, pure-tone audiometry, and in-person administration of the Brief Test of Adult Cognition by Telephone (BTACT) battery. …”
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