STAT3 Genotypic Variant rs744166 and Increased Tyrosine Phosphorylation of STAT3 in IL-23 Responsive Innate Lymphoid Cells during Pathogenesis of Crohn’s Disease by Ying Tang, Sanda A. Tan, Atif Iqbal, Jian Li, Sarah C. Glover

“…The accumulation of IFN-γ-producing ILC1s and increased level of proinflammatory cytokines produced by ILCs has been observed in the inflamed terminal ileum of CD patients. To date, the precise mechanisms of ILC plasticity and gene regulatory pathways in ILCs remain unclear. …”
Get full text

Rehabilitation needs screening to identify potential beneficiaries: a scoping review by Carla Sabariego, Wouter De Groote, Melissa Corso, Kent Murnaghan, Antony Duttine

“…When mapping screening items with the WHO International Classification of Functioning, Disability and Health (ICF), almost all ICF chapters for body functions and activities and participation have been included across screening tools, with the following most frequently included ICF categories: emotional functions (b152), acquiring, keeping and terminating a job (d845), sensation of pain (b280) and carrying out daily routine (d230).Conclusions Rehabilitation need screening tools commonly include the screening for current functioning limitations among people with selected health conditions. …”
Get full text

Transformation and fate of Fe(III) in petroleum-hydrocarbon-contaminated soil and groundwater by Essouassi Elikem, David Bulmer, Kris Bradshaw, Ardalan Hayatifar, Matthew B. J. Lindsay, Steven D. Siciliano, Derek Peak

“…The presence of major Fe(II) phases in the subsoils strongly indicate that secondary Fe(III) phases (especially Fe(III)-OM complex/coprecipitate) served as terminal electron acceptors during the microbial degradation of PHCs in the contaminated subsurface.…”
Get full text

Emotional impact on healthcare providers involved in medical assistance in dying (MAiD): a systematic review and qualitative meta-synthesis by Alexander Simpson, Alireza Bagheri, Saumil Yogendra Dholakia

“…Legislation allowing MAiD for terminal illness only influences the emotional impact: MAiD practitioners under this essential criterion experience more polarised emotions, whereas those practising in jurisdictions with greater emphasis on allaying intolerable suffering experience more reflective emotions. …”
Get full text

А method of surgical correction of genital prolapse in combination with elongation and cicatricial deformation of the cervix in patients of reproductive age. A retrospective study by Albina Kh. Karanasheva, Yulia E. Dobrokhotova

“…Pregnancy occurred in 8 people: in 3 (7.0%), it ended in timely delivery by cesarean section according to the sum of relative indications; in 2 (4.6%), medical terminations of pregnancy were performed; in 1 (2.3%) – surgical abortion. …”
Get full text

Resetting the Hsc70-mediated lysosomal degradation of PD-L1 via a supramolecular meso peptide for the restoration of acquired anti-tumor T cell immunity by Yujia Zhao, Dan Liu, Wenguang Yang, Wangxiao He, Jin Yan, Leiqing Yao

“…In order to enable internalization into tumor cells, supramolecular engineering techniques were employed through terminal modification involving sulfydryl and monovalent gold ion (Au(I)), both facilitating self-assembly of modified PEPPDL1 into supramolecular nanospheres termed CTAC-PDL1 driven by aurophilic interaction. …”
Get full text

HISTOLOGICAL ANALYSIS OF LYMPHOID MASSES OF THE STOMACH AND SMALL INTESTINE IN THE CLINICAL AND PATHOGENETIC PROFILE OF BABESIOSIS by I. I. Torianyk

“…A focal version of the nosological prototype was observed in individual specimens occasionally, presented as single cells (most often in the terminal parts of the organ). Histological changes of lymphoid masses of the stomach and small intestine in animals with babesiosis consisted in the development of expressive diffuse nodular hyperplasia with disorganization of the structure of lymphoid follicles, destruction of zonality of the latter, making it impossible to detect germinative centres.…”
Get full text

Analyzing frequency spectrum and Total Harmonic Distortion for high switching frequency operation of GaN-based filter-less multilevel cascaded H-bridge inverter by Ramkrishna Mishan, Xingang Fu, Chanakya Hingu, Poria Fajri

“…This paper analyzes the Fast Fourier Transform (FFT) and THD of the CHB inverter output from the PLECS simulation model and the actual hardware inverter terminal-end voltage outputs. This comparison identifies the optimum switching frequency operation range for specific levels in the PLECS simulation and the actual CHB inverter.…”
Get full text

Protection of personal data of the employee by S. M. Gusarov, K. Yu. Melnyk

“…The protection of personal data of an employee is the use of opportunities (tools) provided by law for the prevention of offenses in the field of collection, storage, use, destruction, dissemination of information related to a specific natural person working on the basis of an employment contract, termination of the specified offenses and renewal of violated rights in this area. …”
Get full text

Maternal and Perinatal Outcome of Triplet Pregnancies in a Tertiary Care Hospital in North India: A Prospective Observational Study by Sabreen Wani, Fiza Amin, Shagufta Yasmeen Rather

“…The majority of pregnancies, 85.3% (n=29), were terminated by lower segment caesarean section (LSCS), 8.8% (n=3) were delivered vaginally, and the mean duration of maternal hospital stay was 4.6 days ±3.45 (SD 2-14) days. …”
Get full text

Archival and Newly Isolated Historical <i>Bacillus anthracis</i> Strains Populate the Deeper Phylogeny of the A.Br.075(Sterne) Clade by Markus Antwerpen, Peter Braun, Wolfgang Beyer, Dirk Aldenkortt, Michael Seidel, Gregor Grass

“…Finally, some of the terminal clusters of the clade named A.Br.Eu-Sterne appear to be replete with (near) identical isolates, possibly a result of widespread use of the Sterne vaccine and of its re-isolation from vaccination-related animal anthrax outbreaks. …”
Get full text

Pain in pancreatitis: issue and ways out by A. V. Okhlobystin

“…Sensitization affect not only nerve terminals, but neurones of spinal cord and brain as well. …”
Get full text

Monthly Intramuscular Neridronate for the Treatment of Postmenopausal Osteoporosis: Results of a 6-Year Prospective Italian Study by L. Guiducci, C. Vassalle, P. Parchi, S. Maffei

“…At BL, month 3, and every 12 months after BL, total and ionized calcium, vitamin D, parathyroid hormone 1-84, bone alkaline phosphatase (BALP), osteocalcin, and N- and C-terminal telopeptides were assayed. Results. Overall, 60 women (mean age: 62.3±7.5 years) received monthly IM NE for 6 years, with vitamin D and calcium supplementation in 81.3% of cases. …”
Get full text

Efficacy of high-dose steroids versus low-dose steroids in the treatment of immune checkpoint inhibitor-associated myocarditis: a case series and systematic review by Xiuyue Man, Hong Wang, Chen Chen, Xiaofeng Cong, Lemeng Sun, Xueru Sun, Chen Chen, Jing Zhang, Lei Yang

“…The primary aim was to compare clinical outcomes and therapeutic responses between patients treated with high-dose versus low-dose methylprednisolone.ResultsPatients receiving an initial high-dose intravenous methylprednisolone (1 g/day) exhibited a more rapid reduction in myocardial injury markers, including troponin I/T (cTnI/T), creatine kinase (CK), and N-terminal pro b-type natriuretic peptide (NT-proBNP), compared to those receiving lower doses. …”
Get full text

Significance of immune factors in Crohn's disease development by D. S. Stavtsev, T. A. Astrelina, O. V. Knyazev, T. V. Pukhlikova

“…Associations with clinical forms of disease was found, in particular in Italy presence of DRB1*0304, DRB1*0305, DRB1*0307, DRB1*0309 is linked to total involvement of the large intestine, in Spain presence of HLA-DRB1*07 — with terminal ileitis at CD, HLA-DRB1*0103 — with colitis. …”
Get full text

Quantifying LAGA mutated mouse IgG2a monoclonal antibody with a rapid pepsin digestion enabled immunoaffinity LC/MS/MS assay by Linlin Dong, Susan Chen, Konstantin Piatkov, Dong Wei, Mark G. Qian

“…In brief, robust and reproducible C-terminal cleavage of both leucine and phenylalanine near the double mutation site of the mutated mIgG2a was accomplished at pH ≤2 and 37°C. …”
Get full text

Three Years of High Time-resolution Air Pollution Monitoring in the Complex Multi-source Harbor of New York and New Jersey by Gayle Hagler, Dan Birkett, Ronald C. Henry, Richard E. Peltier

“…The study area includes an international airport, interstate highway, port terminals and shipping lanes, and industrial sources, as well as typical urban emissions of a megacity. …”
Get full text

Gambaran Pengetahuan dan Keterampilan Dokter tentang Pengisian Penyebab Kematian Medis (Medical Cause of Death) Berdasarkan Standar ICD-10 di RS Tersier di Bandung by Noverika Windasari, Nur Adibah, Chevi Sayusman

“…Sebanyak 75,4% mengisi penyebab kematian yang salah, terutama karena menuliskan kondisi akhir sebelum kematian (terminal events). Masih separuh dokter (58,1%) mengetahui cara penulisan penyebab kematian medis yang benar sesuai standar WHO ICD-10. …”
Get full text

Autonomous Behavior Intelligence Control of Self-Evolution Mobile Robot for High-Voltage Transmission Line in Complex Smart Grid by Wei Jiang, Gan Zuo, De Hua Zou, Hongjun Li, Jiu Jiang Yan, Gao Cheng Ye

“…In view of the increasingly prominent contradiction between the robot single operation function and the diversification of power grid maintenance operations, additional with the robot weak autonomous operation and intelligent behavior ability, this paper proposes a new configuration of a reconfigurable power robot with terminal functions and its autonomous operation behavior control method for the three typical tasks which are the high-voltage transmission line insulators, drainage plates, and dampers maintenance. …”
Get full text

A multicenter, randomized, double-blind trial comparing LY01011, a biosimilar, with denosumab (Xgeva®) in patients with bone metastasis from solid tumors by Mingchuan Zhao, Xichun Hu, Pengpeng Zhuang, Aiping Zeng, Yan Yu, Zhendong Chen, Hongmei Sun, Weihua Yang, Lili Sheng, Peijian Peng, Jingfen Wang, Tienan Yi, Minghong Bi, Huaqiu Shi, Mingli Ni, Xiumei Dai, Changlu Hu, Hongjie Xu, Dongqing Lv, Qingshan Li, Kaijian Lei, Xia Yuan, Ou Jiang, Xicheng Wang, Baihui Hu, Zhe Hou, Zhaoping Su, Song Zheng, Ming Zhou, Changlin Dou

“…The primary endpoint was the natural logarithm of change of the urinary N-terminal crosslinked telopeptide of type I collagen level normalized to the urine creatinine level (uNTX/uCr) at week 13 from baseline. …”
Get full text