Multi-tissue network analysis reveals the effect of JNK inhibition on dietary sucrose-induced metabolic dysfunction in rats by Hong Yang, Cheng Zhang, Woonghee Kim, Mengnan Shi, Metin Kiliclioglu, Cemil Bayram, Ismail Bolar, Özlem Özdemir Tozlu, Cem Baba, Nursena Yuksel, Serkan Yildirim, Shazia Iqbal, Jihad Sebhaoui, Ahmet Hacımuftuoglu, Matthias Uhlen, Jan Boren, Hasan Turkez, Adil Mardinoglu

“…Excessive consumption of sucrose, in the form of sugar-sweetened beverages, has been implicated in the pathogenesis of metabolic dysfunction‐associated fatty liver disease (MAFLD) and other related metabolic syndromes. The c-Jun N-terminal kinase (JNK) pathway plays a crucial role in response to dietary stressors, and it was demonstrated that the inhibition of the JNK pathway could potentially be used in the treatment of MAFLD. …”
Get full text

Host protein PRPS2 interact with the non-structural protein p17 of Avian Reovirus and promote viral replication by Hu Xiaomiao, Zhao Ruihong, Li Wei, Pan Xiaocheng, Dai Yin, Wu Huimin, Wu Yantao, Zhang Chengcheng

“…Moreover, our findings demonstrate that the C-terminal region of PRPS2 is responsible for its binding to the p17 protein. …”
Get full text

Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Eff... by Anastasia Latanova, Stefan Petkov, Yulia Kuzmenko, Athina Kilpeläinen, Alexander Ivanov, Olga Smirnova, Olga Krotova, Sergey Korolev, Jorma Hinkula, Vadim Karpov, Maria Isaguliants, Elizaveta Starodubova

“…Inactivated multidrug-resistant RT (RT1.14opt-in) was N-terminally fused to the signal providing secretion of NS1 protein of TBEV (Ld) generating optimized inactivated Ld-carrying enzyme RT1.14oil. …”
Get full text

Unveiling risk factors: a prognostic model of frequent peritonitis in peritoneal dialysis patients by Qi-jiang Xu, Qi-jiang Xu, Zhi-yun Zang, Xue-li Zhou, Xue-li Zhou, Ni-ya Ma, Li Pu, Li Pu, Zi Li

“…In the training set, we found several independent risk factors significantly associated with frequent episodes in PDAP patients, including diabetes mellitus (DM), hemoglobin (HB), serum albumin (ALB), lactatic dehydrogenase (LDH), serum potassium (K), N-terminal pro-brain natriuretic peptide (NT-proBNP) and peritoneal dialysate white cell counts on day 1. …”
Get full text

Lactoferrin: a secret weapon in the war against pathogenic bacteria by Lucero Ruiz-Mazón, Gerardo Ramírez-Rico, Mireya de la Garza

“…Moreover, cleavage of the Lf molecule could promote the production of lactoferricins (Lfcins) and lactoferrampin (Lfampin) from the N-terminal end, which are known to often have stronger antimicrobial effects than the native molecule, as well as analogous peptides, such as HLopt2, which have also shown enhanced antimicrobial activity. …”
Get full text

Single-cell sequencing uncovers the mechanistic role of DAPK1 in glioma and its diagnostic and prognostic implications by Tian-Hang Yu, Yan-Yu Ding, Yan-Yu Ding, Si-Guo Zhao, Jie-Hui Zhao, Yu Gu, Dong-Hui Chen, Fang Zhang, Wen-Ming Hong, Wen-Ming Hong

“…DAPK1, serving as a marker gene for the terminal subpopulation, exhibited an association with poor prognosis.ConclusionsDAPK1-based prognostic models show promise for accurately predicting outcomes in glioblastoma and glioma. …”
Get full text

The Anti-Inflammatory Effects of Shinbaro3 Is Mediated by Downregulation of the TLR4 Signalling Pathway in LPS-Stimulated RAW 264.7 Macrophages by Hwa-Jin Chung, Wonil Koh, Won Kyung Kim, Joon-Shik Shin, Jinho Lee, Sang Kook Lee, In-Hyuk Ha

“…Three mechanisms explaining the effects of Shinbaro3 in RAW 264.7 cells were identified as follows: (1) inhibition of the extracellular signal-regulated kinase 1 and 2 (ERK1/2), stress-activated protein kinase (SAPK)/c-Jun N-terminal protein kinase (JNK), and p38 mitogen-activated protein kinase (MAPK) pathways; (2) suppression of IκB kinase-α/β (IKK-α/β) phosphorylation and nuclear factor-kappa B (NF-κB) subunits in the NF-κB pathway, which are involved in MyD88-dependent signalling; and (3) downregulation of IFN-β mRNA expression via inhibition of interferon regulatory factor 3 (IRF3) and Janus-activated kinase 1 (JAK1)/signal transducer and activator of transcription 1 (STAT1) phosphorylation, which is involved in TRIF-dependent signalling. …”
Get full text

Modern modes of chronic hepatitis B treatment in daily clinical practice by M. V. Mayevskaya, M. A. Morozova, S. A. Ondos, V. T. Ivashkin

“…This article reviews in brief up-to-date modes of CHB treatment, clinical case demonstrating the basic AVT stages is presented: decision-making on its onset, monitoring of the patient during treatment, rules of choice and substitution of antiviral agents, criteria of treatment response assessment and indications for its termination.Conclusion. The adequate choice of drug at definition of antiviral treatment approach allows to suppress virus replication effectively, reduces risk of resistance development and rate of side effects while violation of international standards can result in fatal outcome. …”
Get full text

Modeling of Measuring Transducers for Relay Protection Systems of Electrical Installations by Iliya Iliev, Andrey Kryukov, Konstantin Suslov, Nikolay Kodolov, Aleksandr Kryukov, Ivan Beloev, Yulia Valeeva

“…Based on the results of calculating the complexes of currents and voltages at the MT terminals, parametric identification of the power transmission line was performed. …”
Get full text

Enhanced breast cancer cell targeting: RGD integrin ligand potentiates RWQWRWQWR’s cytotoxicity and inhibits migration by Andrea Barragán-Cárdenas, Daniel Castellar-Almonacid, Yerly Vargas-Casanova, Claudia Parra-Giraldo, Adriana Umaña-Pérez, Joel López-Meza, Zuly Rivera-Monroy, Javier García-Castañeda

“…On the other hand, addition of the RGD sequence to the palindromic peptide in the N-terminal end resulted in a greater cytotoxic effect against cell lines derived from the three mainly diagnosed breast cancer molecular subtypes. …”
Get full text

Effect of icatibant on sweating-induced dermal pain by Shunsuke Takahagi, Shunsuke Takahagi, Daiki Matsubara, Emi Murakami, Yumi Aoyama, Shinya Imamura, Atsushi Fukunaga, Atsushi Fukunaga, Yoshiko Oda, Hiroyuki Murota, Michihiro Hide, Michihiro Hide

“…Before and after drug administration, dermal pain induced by an artificial thermal loading was assessed using the visual analog scale (VAS).ResultsFour patients were enrolled, three of whom completed the full procedure with the termination in the other. Among the three patients, the pain-VAS score decreased more with icatibant than with saline in one patient, whereas it decreased more with saline than with icatibant in the other two patients. …”
Get full text

64Cu-chelated InP/ZnSe/ZnS QDs as PET/fluorescence dual-modal probe for tumor imaging by Ziyu Zhao, Ayaka Otsuka, Noriko Nakamura, Toshifumi Tatsumi, Kazuhiro Nakatsui, Taiki Tsuzukiishi, Tomo Sakanoue, Kenji Shimazoe, Seiichi Ohta

“…The surface of the InP/ZnSe/ZnS QDs was functionalized with polyethylene glycol terminated with either a methoxy group or a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator group. …”
Get full text

Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…These proteins come together to form a functional enzyme complex, where the C-terminal helix of each HslU subunit is inserted into the binding pocket of each HslV dimer. …”
Get full text

Epidural Analgesia for Severe Chest Trauma: An Analysis of Current Practice on the Efficacy and Safety by Jesse Peek, Reinier B. Beks, B. Feike Kingma, Marije Marsman, Jelle P. Ruurda, Roderick M. Houwert, Loek P. H. Leenen, Falco Hietbrink, Mirjam B. de Jong

“…In 14 patients (18%), epidural analgesia was terminated early without intervention due to insufficient sensory blockade (n=4), medication-related side effects (n=4), and catheter-related complications (n=6). …”
Get full text

Polymerized-Type I Collagen Downregulates Inflammation and Improves Clinical Outcomes in Patients with Symptomatic Knee Osteoarthritis Following Arthroscopic Lavage: A Randomized,... by Janette Furuzawa-Carballeda, Guadalupe Lima, Luis Llorente, Carlos Nuñez-Álvarez, Blanca H. Ruiz-Ordaz, Santiago Echevarría-Zuno, Virgilio Hernández-Cuevas

“…Urinary levels of C-terminal crosslinking telopeptide of collagen type II (CTXII) and erythrocyte sedimentation rate (ESR) were determined. …”
Get full text

Phenylalanine-derived β-lactam TRPM8 antagonists: revisiting configuration and new benzoyl derivatives by Cristina Martín-Escura, Maria Angeles Bonache, Alicia Medina-Peris, Thomas Voets, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz

“…Results: For OtBu derivatives, a 3S,4S-configuration was preferred, while compounds with 2'R chiral centers show higher selectivity for TRPM8 versus transient receptor potential vanilloid, subtype 1 (TRPV1) than their 2'S-counterparts. N-terminal benzoyl derivatives, which increased TPSA values, resulted in equipotent compounds as previous prototypes, but also showed activity in other pain-related targets [TRPV1 and cannabinoid receptor, subtype 2 (CB2R)]. …”
Get full text

Multi-Temporal Analysis and Techno-Economic Evaluation of Offshore Wind Energy Integration to the Western Interconnection by Li He, Shahnawaz Siddiqui, Sameer Nekkalapu, Sohom Datta, Travis Douville, Konstantinos Oikonomou, Manisha Maharjan

“…Three generation and transmission scenarios across two future representations of the Western Interconnection (WI) are modeled, and detailed production cost modeling (PCM) and power flow (PF) models of each topology were constructed. A novel multi-terminal high voltage direct current (MTDC) model was developed and utilized, and its performance is compared with conventional high voltage direct current (HVDC) radial topology. …”
Get full text

Automated external defibrillator: Rhythm analysis and defibrillation on paediatric out-of-hospital cardiac arrest by Emma Menant, Delphine Lavignasse, Sarah Ménétré, Jean-Philippe Didon, Xavier Jouven

“…Conclusion: This study shows that AED detect shockable rhythm with a good sensitivity and specificity and that shocks are associated with a very high rates of termination of shockable rhythms in pOHCA.…”
Get full text

Bp-13 PLA2: Purification and Neuromuscular Activity of a New Asp49 Toxin Isolated from Bothrops pauloensis Snake Venom by Georgina Sucasaca-Monzón, Priscila Randazzo-Moura, Thalita Rocha, Frank Denis Torres-Huaco, Augusto Vilca-Quispe, Luis Alberto Ponce-Soto, Sérgio Marangoni, Maria Alice da Cruz-Höfling, Léa Rodrigues-Simioni

“…Amino acid analysis showed a high content of hydrophobic and basic amino acids and 14 half-cysteine residues. The N-terminal sequence showed a high degree of homology with basic Asp49 PLA2 myotoxins from other Bothrops venoms. …”
Get full text

(-)-Epigallocatechin Gallate Reduces Platelet-Derived Growth Factor-BB-Stimulated Interleukin-6 Synthesis in Osteoblasts: Suppression of SAPK/JNK by Shinji Takai, Rie Matsushima-Nishiwaki, Seiji Adachi, Hideo Natsume, Chiho Minamitani, Jun Mizutani, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa

“…We previously showed that the mitogen-activated protein (MAP) kinase superfamily, p44/p42 MAP kinase, p38 MAP kinase, and stress-activated protein kinase (SAPK)/c-Jun N-terminal (JNK), positively plays a part in the platelet-derived growth factor-BB- (PDGF-BB-) stimulated synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in osteoblast-like MC3T3-E1 cells while Akt and p70 S6 kinase negatively regulates the synthesis. …”
Get full text