Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration by Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter

“…Tarperprumig incorporates a C-terminal variable domain of a heavy chain only antibody (VHH) that binds properdin (FP) connected via a flexible linker to an N-terminal VHH that binds human serum albumin (HSA). …”
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Towards a Vaccine Against Rheumatic Fever by L. Guilherme, K. C. Faé, F. Higa, L. Chaves, S. E. Oshiro, S. Freschi de Barros, C. Puschel, M. A. Juliano, A. C. Tanaka, G. Spina, J. Kalil

“…Although these epitopes were from different regions of the C-terminal portion of the M protein, they showed an identical core of 16 amino acid residues. …”
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Mitochondrial trifunctional protein deficiency caused by a deep intronic deletion leading to aberrant splicing by Thomas Cassini, Sarah Silverstein, Molly Behan, Cynthia J. Tifft, May Christine Malicdan, David R. Adams, Undiagnosed Diseases Network, Sun‐Young Ahn, Debra S. Regier

“…Subsequent evaluation by the Undiagnosed Diseases Network with genome and transcriptome sequencing revealed a rare maternally inherited 17 base pair deletion in HADHB, NM_000183.3:c.1390‐515_1390‐499del, located in the final intron and resulting in a pseudoexon that harbors a premature termination codon. Both sisters were compound heterozygous for this and the paternal premature termination codon. …”
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Lipid and Bile Acid Dysmetabolism in Crohn’s Disease by Koji Uchiyama, Hisashi Kishi, Wataru Komatsu, Masanori Nagao, Shuji Ohhira, Gen Kobashi

“…Similarly, the impairment of the terminal ileum also induces fatty acid malabsorption, which may influence the role of fatty acids in Crohn’s disease. …”
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The WRKY Transcription Factor Genes in Lotus japonicus by Hui Song, Pengfei Wang, Zhibiao Nan, Xingjun Wang

“…Researchers previously believed that group II and III WRKY domains were derived from the C-terminal WRKY domain of group I. Our results suggest that some WRKY genes in group II originated from the N-terminal domain of group I WRKY genes. …”
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Binding Orientations and Lipid Interactions of Human Amylin at Zwitterionic and Anionic Lipid Bilayers by Zhenyu Qian, Yan Jia, Guanghong Wei

“…We find that the adsorption of hIAPP to POPC bilayer is mainly initiated from the C-terminal region and the peptide adopts a helical structure with multiple binding orientations, while the adsorption to POPG bilayer is mostly initiated from the N-terminal region and hIAPP displays one preferential binding orientation, with its hydrophobic residues exposed to water. hIAPP monomer inserts into POPC lipid bilayers more readily than into POPG bilayers. …”
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Hydrogen Peroxide-Induced DNA Damage and Repair through the Differentiation of Human Adipose-Derived Mesenchymal Stem Cells by Mahara Valverde, Jonathan Lozano-Salgado, Paola Fortini, Maria Alexandra Rodriguez-Sastre, Emilio Rojas, Eugenia Dogliotti

“…In this study, we used the ROS-inducing agent hydrogen peroxide to explore the responses of (1) hADMSCs and (2) derived terminally differentiated adipocytes to oxidatively generated DNA damage. …”
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A State of Charge Estimation Method for Lithium-Ion Battery Using PID Compensator-Based Adaptive Extended Kalman Filter by Zheng Liu, Yuan Qiu, Chunshan Yang, Jianbo Ji, Zhenhua Zhao

“…The common single proportional feedback of Kalman filter (KF) is replaced by the innovation vector-based PID feedback, which means that the multiple prior terminal voltage innovation is used in the measurement correction step of KF. …”
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An Imaging Method for Marine Targets in Corner Reflector Jamming Scenario Based on Time–Frequency Analysis and Modified Clean Technique by Changhong Chen, Wenkang Liu, Yuexin Gao, Lei Cui, Quan Chen, Jixiang Fu, Mengdao Xing

“…Thirdly, in response to the poor universality of the traditional Clean iterative termination condition, the kurtosis of the residual signal spectrum amplitude is adopted as the new iterative termination condition. …”
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Interstellar Pickup Ion Observations to 60 au by D. J. McComas, B. L. Shrestha, G. Livadiotis, J. R. Szalay, E. J. Zirnstein, H. A. Elliott, P. C. Brandt, A. R. Poppe, K. N. Singer, A. Stern, A. Verbiscer, the New Horizons Heliophysics Team

“…Such large values further highlight the importance of PUIs as the dominant driver of the physics of the outer heliosphere, as well as at the termination shock.…”
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Simulation and Economic Benefit Analysis of Carburetor Combined Transport in Winter at a Liquefied Natural Gas Receiving Station by Song Cao, Tao Luan, Pengliang Zuo, Xiaolei Si, Pu Xie, Yingjun Guo

“…In the winter, a certain LNG receiving terminal operates exclusively with the submerged combustion vaporizer (SCV). …”
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Phase separation of a microtubule plus-end tracking protein into a fluid fractal network by Mateusz P. Czub, Federico Uliana, Tarik Grubić, Celestino Padeste, Kathryn A. Rosowski, Charlotta Lorenz, Eric R. Dufresne, Andreas Menzel, Ioannis Vakonakis, Urs Gasser, Michel O. Steinmetz

“…Its liquid condensation likely involves the formation of higher-order oligomers that phase separate in a manner dependent on the protein’s N-terminal CAP-Gly domain and C-terminal EEY/F-like motif. …”
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Anti-proteolytic regulation of KRAS by USP9X/NDRG3 in KRAS-driven cancer development by Han Koo, Kyung Chan Park, Hyun Ahm Sohn, Minho Kang, Dong Joon Kim, Zee-Yong Park, Sehoon Park, Sang Hyun Min, Seong-Hwan Park, Yeon-Mi You, Yohan Han, Bo-Kyung Kim, Chul-Ho Lee, Yeon-Soo Kim, Sang J. Chung, Young Il Yeom, Dong Chul Lee

“…Mechanistically, KRAS protein binds to the C-terminal serine/threonine-rich region of NDRG3, subsequently going through deubiquitination by USP9X recruited to the complex. …”
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Prenatal Diagnosis of 4p and 4q Subtelomeric Microdeletion in De Novo Ring Chromosome 4 by Halit Akbas, Naci Cine, Mahmut Erdemoglu, Ahmet Engin Atay, Selda Simsek, Aysegul Turkyilmaz, Mehmet Fidanboy

“…These results were confirmed by means of array-CGH showing terminal deletions on 4p16.3 (130 kb) and 4q35.2 (2.449 Mb). …”
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Pervasive glacier retreats across Svalbard from 1985 to 2023 by Tian Li, Stefan Hofer, Geir Moholdt, Adam Igneczi, Konrad Heidler, Xiao Xiang Zhu, Jonathan Bamber

“…Abstract A major uncertainty in predicting the behaviour of marine-terminating glaciers is ice dynamics driven by non-linear calving front retreat, which is poorly understood and modelled. …”
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Exploring the Gating Mechanism of the Human Copper Transporter, hCtr1, Using EPR Spectroscopy by Shahaf Peleg, Shelly Meron, Yulia Shenberger, Lukas Hofmann, Lada Gevorkyan-Airapetov, Sharon Ruthstein

“…In this study, we employed distance electron paramagnetic resonance to investigate the conformational changes of the extracellular N-terminal domain of full-length hCtr1, both in vitro and in cells, as a function of Cu(I) binding. …”
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An Unusual Presentation of Metastatic Squamous Cell Cervical Carcinoma Involving the Distal Ileum Mimicking Crohn’s Disease by Eric M Yoshida, Hugh Chaun, Kenneth D Swenerton, Kenneth W Berean, Gregor I McGregor

“…Biopsies and subsequent laparotomy revealed that the lesions were metastatic cervical carcinoma involving the terminal ileum.…”
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Sodium‐Glucose Cotransporter 2 Inhibitors for Mesenchymal–Epithelial Transition Inhibitor‐Induced Edema by Takuya Oyakawa, Keita Miura, Nao Muraoka, Kei Iida, Ayano Fujita, Tateaki Naito, Toshiaki Takahashi

“…In a patient with tepotinib‐induced edema and an N‐terminal pro‐brain natriuretic peptide (NTproBNP) level ≥ 300 pg/mL, the addition of empagliflozin to loop diuretics reduced the edema. …”
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FORMATION OF COSTS AND CALCULATION OF THE COST OF MAINTENANCE OF IMPLEMENTED LABORATORY MEDICAL EQUIPMENT by E. Shapoval, I. Nesterovа

“…In article questions of sectoral planning of costs of warranty repair of medical equipment and the equipment and also the repair made upon termination of warranty periods, their similarity and distinctions are investigated. …”
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The role of Pnut and its functional domains in Drosophila spermatogenesis by K. A. Akhmetova, N. D. Dorogova, E. U. Bolobolova, I. N. Chesnokov, S. A. Fedorova

“…Both GTPase domain and C-terminal domain mutant males were sterile and produced immotile sperm. …”
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