Lipopolysaccharide Inhibits the Channel Activity of the P2X7 Receptor by Elias Leiva-Salcedo, Claudio Coddou, Felipe E. Rodríguez, Antonello Penna, Ximena Lopez, Tanya Neira, Ricardo Fernández, Mónica Imarai, Miguel Rios, Jorge Escobar, Margarita Montoya, J. Pablo Huidobro-Toro, Alejandro Escobar, Claudio Acuña-Castillo

“…The bacterial endotoxin lipopolysaccharide (LPS) is one of the strongest stimuli of the immune response, and it has been shown that P2X7R activation can modulate LPS-induced responses. Moreover, a C-terminal binding site for LPS has been proposed. In order to evaluate if LPS can directly modulate the activity of the P2X7R, we tested several signaling pathways associated with P2X7R activation in HEK293 cells that do not express the TLR-4 receptor. …”
Get full text

Correction of Excessive Tibial Plateau Angle and Limb Shortening in a Juvenile Dog Using a Hinged Circular Fixator Construct and Distraction Osteogenesis by Daniel D. Lewis, Stanley E. Kim, Justin Shmalberg, Sandra L. MacArthur

“…Distraction was initiated the day following surgery at a rate of 1 mm per day as measured along the caudal cortex of the tibia with a rhythm of three distractions daily. Distraction was terminated 19 days postoperatively. Sequential distraction of the osteotomy resulted in 17 mm of tibial lengthening and a final TPA of 3°. …”
Get full text

Pore-scale investigation of forced imbibition in porous rocks through interface curvature and pore topology analysis by Jianchao Cai, Xiangjie Qin, Han Wang, Yuxuan Xia, Shuangmei Zou

“…During forced imbibition, the interface curvature gradually increases, with the pore-filling mechanisms involving the cooperation of main terminal meniscus movement and arc menisci filling. …”
Get full text

Fucosylated haptoglobin promotes inflammation via Mincle in sepsis: an observational study by Taylor Roh, Sungeun Ju, So Young Park, Yeonghwan Ahn, Jiyun Chung, Miyako Nakano, Gyoungah Ryu, Young Jae Kim, Geumseo Kim, Hyewon Choi, Sung-Gwon Lee, In Soo Kim, Song-I Lee, Chaeuk Chung, Takashi Shimizu, Eiji Miyoshi, Sung-Soo Jung, Chungoo Park, Sho Yamasaki, Seung-Yeol Park, Eun-Kyeong Jo

“…Our study reveals elevated levels of terminal fucosylation at Asn207 and Asn211 of Hp in SP plasma, along with heightened inflammatory responses, compared to healthy controls (trial registration NCT05911711). …”
Get full text

SP600125 Attenuates Nicotine-Related Aortic Aneurysm Formation by Inhibiting Matrix Metalloproteinase Production and CC Chemokine-Mediated Macrophage Migration by Zhen-Zhen Guo, Qun-An Cao, Zong-Zhuang Li, Li-Ping Liu, Zhi Zhang, Ya-Juan Zhu, Guang Chu, Qiu-Yan Dai

“…Nicotine, a major chemical component of cigarettes, plays a pivotal role in the development of abdominal aortic aneurysm (AAA). c-Jun N-terminal kinase (JNK) has been demonstrated to participate in elastase-induced AAA. …”
Get full text

Krill oil ameliorates benign prostatic hyperplasia by regulating G1-phase cell cycle arrest and altering signaling pathways and benign prostatic hyperplasia-associated markers by Hoon Kim, Jongyeob Kim, Byungdoo Hwang, SangYong Park, Ji-Yeon Shin, EunByeol Go, Jae Sil Kim, Youngjin Roh, SoonChul Myung, Seok-Joong Yun, YungHyun Choi, Wun-Jae Kim, Sung-Kwon Moon

“…KO treatment stimulated phosphorylation of c-Jun N-terminal kinase (JNK) and p38 signaling. In addition, KO changed the expression of BPH-related markers (5α-reductase, androgen receptor, FGF, Bcl-2, and Bax) and the activity of the proliferation-mediated NF-κB binding motif. …”
Get full text

PSCA-targeted BPX-601 CAR T cells with pharmacological activation by rimiducid in metastatic pancreatic and prostate cancer: a phase 1 dose escalation trial by Mark N. Stein, Ecaterina E. Dumbrava, Benjamin A. Teply, Usama S. Gergis, Martin E. Guiterrez, Ran Reshef, Sumit K. Subudhi, Céline F. Jacquemont, Joseph H. Senesac, J. Henri Bayle, Charity D. Scripture, Monica S. Chatwal, Mehmet A. Bilen, Walter M. Stadler, Carlos R. Becerra

“…Two dose-limiting toxicities and two treatment-related deaths occurred in the highest-dose mCRPC cohort, after which the study was terminated, without determination of the RP2D. Two mCRPC patients experienced partial responses (one unconfirmed), and 56% of mCRPC patients achieved ≥50% reduction in prostate-specific antigen. …”
Get full text

Placental Oxidative Status throughout Normal Gestation in Women with Uncomplicated Pregnancies by Jayasri Basu, Bolek Bendek, Enyonam Agamasu, Carolyn M. Salafia, Aruna Mishra, Nerys Benfield, Ronak Patel, Magdy Mikhail

“…Placental tissues were obtained from normal pregnant women who delivered at term or underwent elective pregnancy termination at 6 to 23 + 6 weeks of pregnancy. Placental tissues were analyzed for total antioxidant capacity (TAC) and lipid peroxide (malondialdehyde, MDA) levels using commercially available kits. …”
Get full text

Norcantharidin induces G2/M arrest and apoptosis via activation of ERK and JNK, but not p38 signaling in human renal cell carcinoma ACHN cells by Huang Shuaishuai, Tuergong Gulimire, Zhu Hangjie, Wang Xue, Weng Guobin, Ren Yu

“…Interestingly, NCTD treatment provoked the phosphorylation of extracellular-regulated protein kinase (ERK) and c-Jun-N-terminal kinase (JNK), but not of p38 MAPK. Moreover, SCH772984 and SP600125, ERK and JNK inhibitors, respectively, could partially abolish NCTD-induced apoptosis and G2/M phase cell cycle arrest. …”
Get full text

RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining by Mansoor Hussain, Prabhat Khadka, Komal Pekhale, Tomasz Kulikowicz, Samuel Gray, Alfred May, Deborah L. Croteau, Vilhelm A. Bohr

“…PARP1 specifically promoted RECQL4 PARylation at both its N- and C-terminal regions, promoting RECQL4 recruitment to DNA double-strand breaks (DSBs). …”
Get full text

Radical Scavenging Activity-Based and AP-1-Targeted Anti-Inflammatory Effects of Lutein in Macrophage-Like and Skin Keratinocytic Cells by Jueun Oh, Ji Hye Kim, Jae Gwang Park, Young-Su Yi, Kye Won Park, Ho Sik Rho, Min-Seuk Lee, Jae Won Yoo, Seung-Hyun Kang, Yong Deog Hong, Song Seok Shin, Jae Youl Cho

“…By evaluating the intracellular signaling pathway and the nuclear transcription factor levels, we determined that lutein inhibited the activation of redox-sensitive AP-1 pathway by suppressing the activation of p38 and c-Jun-N-terminal kinase (JNK). Evaluation of the radical and ROS scavenging activities further revealed that lutein was able to act as a strong anti-oxidant. …”
Get full text

Peste Des Petits Ruminants (PPR) in Dromedary Camels and Small Ruminants in Mandera and Wajir Counties of Kenya by R. N. Omani, G. C. Gitao, J. Gachohi, P. K. Gathumbi, B. A. Bwihangane, K. Abbey, V. J. Chemweno

“…This study establishes that camels in the study area suffer with PPR manifest clinical signs that are mainly characterized by inappetence, loss of body condition, and general weakness terminally leading to diarrhea, conjunctivitis, and ocular nasal discharges preceding death. …”
Get full text

A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration by Minkoo Seo, Jin-Chul Kim, Hyung-Ki Kim, Eun wook Choi, Suyeong Jeong, Ki Chang Nam, Mihue Jang

“…Multipotent stem cells have the capacity to generate terminally differentiated cell types of each lineage; thus, they have great therapeutic potential for a wide variety of diseases. …”
Get full text

Induction of Apoptosis Coupled to Endoplasmic Reticulum Stress through Regulation of CHOP and JNK in Bone Marrow Mesenchymal Stem Cells from Patients with Systemic Lupus Erythemato... by Genkai Guo, Yan Meng, Wei Tan, Yunfei Xia, Chun Cheng, Xiaolan Chen, Zhifeng Gu

“…Interestingly, we discovered that 4-phenylbutyric acid (4-PBA), a selective inhibitor of ERS, blocked the apoptosis of BM-MSCs from SLE patients and alleviated the level of Jun N-terminal kinase1/2 (JNK1/2) and CHOP. Furthermore, blockage of PERK signaling expression by siRNA not only significantly reduced the expression of CHOP, but also activated the anti-apoptotic regulator B-cell lymphoma-2 (Bcl-2). …”
Get full text

Finite Element Analysis for Estimating Strength and Fatigue of the APM Structure by Klabklay Teerawat, Sumpavakup Chaiyut, Khumkrong Asawadech, Thasanavirud Natthikan, Pensuk Pannachai

“…APM stands for autonomous people mover, which is a mass transit system widely used in many airports to transport passengers between terminals. This article focuses on APM structure newly designed comprising five components namely, chassis, floor, body, roof, and support. …”
Get full text

A Bioclinical Pattern for the Early Diagnosis of Cardioembolic Stroke by Bruno Zecca, Clara Mandelli, Alberto Maino, Chiara Casiraghi, Giovanbattista Bolla, Dario Consonni, Paola Santalucia, Giuseppe Torgano

“…We aim to evaluate if plasma biomarkers can predict stroke subtypes in the early phase from stroke onset. Methods. Plasma N-terminal prohormone of brain natriuretic peptide (NT-proBNP), D-dimer, C-reactive protein, serum albumin, and globulin levels have been investigated in 114 consecutive patients presenting at the emergency room within 6 hours of the ischemic stroke onset. …”
Get full text

Hypoxia Associated Proteolytic Processing of OS-9 by the Metalloproteinase Meprin β by Barry Lee Martin, Sabena Michelle Conley, Regine Simone Harris, Corshe Devon Stanley, Jean-Marie Vianney Niyitegeka, Elimelda Moige Ongeri

“…The endoplasmic reticulum-associated protein, osteosarcoma-9 (OS-9), has been shown to interact with the carboxyl-terminal tail of meprin β. More importantly, OS-9 interacts with the hypoxia inducible factor-1α (HIF-1α) and the prolyl-hydroxylase, proteins which mediate the cell’s response to hypoxia. …”
Get full text

Prenatal Diagnosis of Complete Atrioventricular Septal Defect: Perinatal and Neonatal Outcomes by Gokhan Yıldırım, Kemal Gungorduk, Fehmi Yazıcıoğlu, Ahmet Gul, Fatma Çakar, Özgü Çelikkol, Yavuz Ceylan

“…As for pregnancy outcomes, there were 36 (58%) terminations of pregnancy and 4 (6.4%) intrauterine fetal deaths. …”
Get full text

Metformin Delays Satellite Cell Activation and Maintains Quiescence by Theodora Pavlidou, Milica Marinkovic, Marco Rosina, Claudia Fuoco, Simone Vumbaca, Cesare Gargioli, Luisa Castagnoli, Gianni Cesareni

“…We report that satellite cells, when treated with metformin in vitro, ex vivo, or in vivo, delay activation, Pax7 downregulation, and terminal myogenic differentiation. We correlate the metformin-induced delay in satellite cell activation with the inhibition of the ribosome protein RPS6, one of the downstream effectors of the mTOR pathway. …”
Get full text

Phenomenological understanding of the contribution of bulk and grain boundary precipitates on strengthening in prolonged-aged Al-Zn-Mg-Cu aluminium alloys by Cheng-Ling Tai, Yu-Ning Chiu, Chu-Jen Chen, Shih-Kang Lin, Hsin-Chih Lin, R. Devesh Kumar Misra, Yo-Lun Yang, Chien-Nan Hsiao, Cheng-Si Tsao, Tsai-Fu Chung

“…Combining aberration-corrected scanning transmission electron microscopy and first-principles calculations, the transition of bulk η-phase precipitates, which originated at Zn-terminated interfaces under tensile lattice strain field, was fundamentally explored. …”
Get full text