Marburg virus VP35 can both fully coat the backbone and cap the ends of dsRNA for interferon antagonism. by Shridhar Bale, Jean-Philippe Julien, Zachary A Bornholdt, Christopher R Kimberlin, Peter Halfmann, Michelle A Zandonatti, John Kunert, Gerard J A Kroon, Yoshihiro Kawaoka, Ian J MacRae, Ian A Wilson, Erica Ollmann Saphire

“…All filoviruses encode a unique multi-functional protein termed VP35. The C-terminal double-stranded (ds)RNA-binding domain (RBD) of VP35 has been implicated in interferon antagonism and immune evasion. …”
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Utility of Lymphoblastoid Cell Lines for Induced Pluripotent Stem Cell Generation by Satish Kumar, Joanne E. Curran, David C. Glahn, John Blangero

“…Here, we report a new optimized LCL-to-iPSC reprogramming protocol using episomal plasmids encoding pluripotency transcription factors and mouse p53DD (p53 carboxy-terminal dominant-negative fragment) and commercially available reprogramming media. …”
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Delay in Diagnosis of Autoimmune Polyendocrine Syndrome Type 2 as a Consequence of Misinterpretation of Gastrointestinal Symptoms by Maciej Gonciarz, Michał Krogulecki, Dorota Brodowska-Kania, Szczepan Cierniak, Grzegorz Kamiński

“…Colonoscopy performed in this hospital identified irregular mucosal erosions in terminal ileum, and the microscopy of biopsy specimens demonstrated nonspecific inflammation. …”
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Detection of Hemoglobinopathies in Cuban Pregnant Women from the Program: Sickle Cell Anemias in Cuba by Yadira Valdés Fraser, Tatiana Acosta Sánchez, Jacqueline Pérez Rodríguez, Beatriz Suárez Besil, Sandra Bárbara Correa Jiménez

“…Hemoglobinopa-thies were detected in 47,465 women; 38,698 with heterozygous S variant, 8,706 hemoglobin C variants and 158 other variants. 44,283 husbands with hemoglobinopathies were detected, 3,099 high-risk couples were detected, and 2,689 molecular prenatal diagnoses were performed. 522 affected fetuses were confirmed and 382 couples requested termination of pregnancy. The program reached 99.24 % coverage in the country. …”
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Plant thionins: structure, biological functions and potential use in biotechnology by T. I. Odintsova, M. P. Slezina, E. A. Istomina

“…Thionins are synthesized as precursor proteins consisting of a signal peptide, the mature peptide region and the C-terminal prodomain. Thionins protect plants from pathogenic bacteria and fungi acting directly on the membranes of microorganisms at micromolar concentrations, although their precise mode of action remains unclear. …”
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Analysis of multidrug resistant group B streptococci with reduced penicillin susceptibility forming small, less hemolytic colonies. by Hirotsugu Banno, Kouji Kimura, Yosuke Tanaka, Tsuyoshi Sekizuka, Makoto Kuroda, Wanchun Jin, Jun-Ichi Wachino, Keiko Yamada, Keigo Shibayama, Yoshichika Arakawa

“…We identified a 276_277insG nucleic acid insertion in the thiamin pyrophosphokinase (tpk) gene, resulting in premature termination at amino acid 103 in TPK, as a candidate mutation responsible for small colony formation. …”
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Regimes of dispositivity in the legal regulation of contractual relations by Yu. I. Chalyі

“…In this regard, the legislator imperatively determines the terms of contracts on which the parties must reach an agreement; regulates sample (exemplary, typical) contracts; imposes pre-contractual obligations on entrepreneurs to fully inform consumers about the properties of products offered for sale; establishes general prohibitions on unfair contractual terms; provides consumers with certain guarantees regarding the conclusion, amendment and termination of contracts, etc. The regime of regulation of contractual relations involving individuals who are non-entrepreneurs occupies a middle position between the two above legal regimes and provides for: establishment of a relatively smaller number of legal forms of contracts that may be concluded by citizens; determination of conditions mandatory for the conclusion of contracts in the legislation; consolidation of a general prohibition on unfair contractual terms; establishment of a wider list of contracts subject to notarisation; introduction of judicial control over compliance by the parties with the requirements of the law regarding the validity of contracts, etc. …”
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Emergence of SARS-CoV-2 subgenomic RNAs that enhance viral fitness and immune evasion. by Harriet V Mears, George R Young, Theo Sanderson, Ruth Harvey, Jamie Barrett-Rodger, Rebecca Penn, Vanessa Cowton, Wilhelm Furnon, Giuditta De Lorenzo, Margaret Crawford, Daniel M Snell, Ashley S Fowler, Anob M Chakrabarti, Saira Hussain, Ciarán Gilbride, Edward Emmott, Katja Finsterbusch, Jakub Luptak, Thomas P Peacock, Jérôme Nicod, Arvind H Patel, Massimo Palmarini, Emma Wall, Bryan Williams, Sonia Gandhi, Charles Swanton, David L V Bauer

“…Here, we demonstrate that this TRS leads to the expression of a novel subgenomic mRNA encoding a truncated C-terminal portion of Nucleocapsid, which is an antagonist of type I interferon production and contributes to viral fitness during infection. …”
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Theory and pratice of translation and interpreting in minor degree programs at an engineering university by Yuliya N. Ziyatdinova

“…These programs used to be regulated by the state educational standards for minor degree program ‘Translator in the Sphere of Professional Communication’, which terminated in 2013 after the new ’Law on Education in the Russian Federation’ came into force. …”
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NT-Pro-B-Type Natriuretic Peptide Levels in Infants with Failure to Thrive due to Caloric Deprivation by L. B. Mänhardt, K. Norozi, C. Müller, C. Willaschek, B. Kostuch, R. Buchhorn

“…Brain natriuretic peptide and its inactive fragment N-terminal pro-BNP (N-BNP) are reliable markers of ventricular dysfunction in adults and children. …”
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Value of Biochemical Indexes of Bone Metabolism in Predicting Osteoporotic Lumbar Fractures by Fen Feng, CiLa Zhou, Ping Huang, QiaoLin Zhu, Gang Wang, Bin Zhou

“…To investigate the value of bone metabolism indexes such as type I procollagen N-terminal propeptide (P1NP), 25-hydroxyvitamin D (25(OH)D), osteocalcin (OSTEOC), and parathyroid hormone (PTH) in predicting osteoporotic lumbar fractures. …”
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Críticas construccionistas a la tesis de las Emociones Básicas by Rodrigo Sebastián Braicovich

“…Se argumentará que las críticas construccionistas conducen a una crisis terminal de la teoría de las Emociones Básicas (tanto desde un punto de vista metodológico como en cuanto al soporte empírico aducido) y que la alternativa construccionista se muestra ya en mejores condiciones de conformar el núcleo de un nuevo programa de investigación en el ámbito de la vida afectiva humana. …”
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Biomarkers as Diagnostic and Prognostic Tools in Cardiac Disorders: A Comprehensive Review by Rabinarayan Parhi, Goutam Kumar Jena, Chinam Niranjan Patra, Sruti Jammula

“…B-type natriuretic peptide and its precursor N-terminal pro-B-type natriuretic peptide play critical roles in the diagnosis and management of heart failure; elevated levels of these factors indicate poor prognosis and can guide therapeutic decision-making. …”
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Problem ubóstwa w biblijnej koncepcji człowieka by Tomasz Jelonek

“…Wszystkie przypadki braków, jakie są udziałem ludzi, określamy terminem „ubóstwa”, mówiąc bardziej szczegółowo o ubóstwie materialnym, fizycznym lub duchowym. Jednak termin „ubóstwo” ma także szersze zastosowanie i w sensie moralnym może oznaczać postawę wewnętrznej wolności względem posiadanych lub nieposiadanych dóbr materialnych, a w sensie religijnym oznacza wewnętrzne uzależnienie od Boga w odniesieniu do wszystkich potrzeb życiowych. …”
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Intracellular Membrane Contact Sites in Skeletal Muscle Cells by Matteo Serano, Stefano Perni, Enrico Pierantozzi, Annunziatina Laurino, Vincenzo Sorrentino, Daniela Rossi

“…These contact sites primarily involve the plasma membrane; among these, specialized membrane contact sites between the transverse tubules and the terminal cisternae of the sarcoplasmic reticulum form triads. …”
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Terminales, pasajeros y resignificación de los lugares en Maracaibo by Víctor Carreño

“… A través del análisis de los documentales El terminal de pasajeros (2006) y Shawantama’ana: Lugar de espera (2012), de la realizadora venezolana Yanilú Ojeda, se abordan las dinámicas de desplazamiento, interacción con el espacio urbano así como la resignificación de los no lugares que llevan a cabo los sujetos en dos Terminales de pasajeros de Maracaibo, Venezuela, caracterizada como ciudad-región o ciudad fronteriza, por su cercanía y vínculos con Colombia y su diversidad cultural, evidenciada tanto por la presencia indígena de la etnia Wayuu como por inmigrantes colombianos (Zacarías, Guillén y Chourio, 2007). …”
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Unraveling multimodality of digital health records by comparing mortality trajectories of diagnoses of diseases from over 12 million patients. by Hyojung Paik

“…In this study, I leveraged the diverse healthcare records of over 12 million patients to reconstitute mortality trajectories that navigate the sequence of disease processes shared among patients from initial presentation through interim conditions that ultimately terminate in fatal outcomes. I conducted a comprehensive analysis of longitudinal discharge records for 10.4 million patients from US hospitals, utilizing the US State Inpatient Data (USSID) including 290,253 records of deaths in clinics. …”
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Engineering of L-Plastin Peptide-Loaded Biodegradable Nanoparticles for Sustained Delivery and Suppression of Osteoclast Function In Vitro by Sunipa Majumdar, Aniket S. Wadajkar, Hanan Aljohani, Mark A. Reynolds, Anthony J. Kim, Meenakshi Chellaiah

“…We have recently demonstrated that a small molecular weight amino-terminal peptide of L-plastin (10 amino acids; “MARGSVSDEE”) suppressed the phosphorylation of endogenous L-plastin. …”
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Research progress on the antiviral immune regulation of ubiquitin ligase F-box family by MENG Xiangbo, LI Tianqi, ZHANG Tong

“…Based on the secondary structure of the C-terminal, FBPs can be classified as FBXW, FBXL, and FBXO. …”
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B3LYP Study on Reduction Mechanisms from O2 to H2O at the Catalytic Sites of Fully Reduced and Mixed-Valence Bovine Cytochrome 𝑐 Oxidases by Yasunori Yoshioka, Masaki Mitani

“…This water molecule constructs the network of hydrogen bonds of Tyr244, farnesyl ethyl, and Thr316 that is a terminal residue of the K-pathway. It plays crucial roles for the proton transfer to the dioxygen to produce the water molecules in both MV and FR C𝑐Os. …”
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