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2101
Yerba mate (Ilex paraguariensis) genome provides new insights into convergent evolution of caffeine biosynthesis
Published 2025-01-01“…In order to gain insight into the structural basis for the convergent enzyme activities, we obtained a crystal structure for the terminal enzyme in the pathway that forms caffeine. …”
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2102
Sophocarpine Attenuates LPS-Induced Liver Injury and Improves Survival of Mice through Suppressing Oxidative Stress, Inflammation, and Apoptosis
Published 2018-01-01“…Septic liver injury/failure that is mainly characterized by oxidative stress, inflammation, and apoptosis led to a great part of terminal liver pathology with limited effective intervention. …”
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2103
7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents
Published 2019-01-01“…TH immunostaining was performed to evaluate rotenone-induced neurotoxicity on substantia nigra (SN) dopaminergic neurons and the DA terminals in the striatum. Western blot analyses were used to examine the expressions of TH, BDNF/TrkB signaling cascades, phospho-α-synuclein (Ser129), α-synuclein, and phospho-tau (Ser396) in SN. …”
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2104
Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat
Published 2017-01-01“…A small number of animals developed ADAs, and the proportion of animals surviving until scheduled termination was >80%. N8-GP was well tolerated, and the immune-deficient rat proved suitable for testing long-term toxicity of human proteins that are immunogenic in animals.…”
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2105
HSP90 inhibitors promote cell death by degrading Met and BCR::ABL1 in both imatinib-resistant and -sensitive chronic myeloid leukemia cells
Published 2025-01-01“…KW-2478 inhibited the activation of Akt, extracellular regulated protein kinase 1/2, and c-Jun N-terminal kinase 1/2 in imatinib-resistant and -sensitive CML cells by promoting Met and BCR::ABL1 degradation. …”
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2106
Strategic Deconfliction of 4D Trajectory and Perturbation Analysis for Air Traffic Control and Automation System
Published 2016-01-01“…Finally, the proposed method was tested for the Shanghai air traffic control terminal area. The outcomes demonstrated that the planned strategic conflict-free 4D trajectories could avoid potential conflicts, and the slack time could be used to indicate their robustness. …”
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2107
Metal and Precursor Effect during 1-Heptyne Selective Hydrogenation Using an Activated Carbon as Support
Published 2013-01-01“…Palladium, platinum, and ruthenium supported on activated carbon were used as catalysts for the selective hydrogenation of 1-heptyne, a terminal alkyne. All catalysts were characterized by temperature programmed reduction, X-ray diffraction, transmission electron microscopy, and X-ray photoelectron spectroscopy. …”
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2108
Truncated SPAG9 as a novel candidate gene for a new syndrome: Coarse facial features, albinism, cataract and developmental delay (CACD syndrome)
Published 2025-01-01“…Abstract Sperm-associated antigen 9 (SPAG9) is a member of cancer-testis antigen, having characteristics of a scaffold protein, which is involved in the c-Jun N-terminal kinase JNK signaling pathway, suggesting its key involvement in different physiological processes, such as survival, apoptosis, tumorigenesis, and cell proliferation. …”
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2109
Modeling and Reduction of Nox Production in Submerged Combustion Vaporizer Using Fuzzy Inference System
Published 2024-04-01“…These equipments are actually heat exchangers that are used in liquefied natural gas (LNG) terminals to evaporate liquefied natural gas and convert it into gas. …”
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2110
Study of the mechanism of high-efficient in-situ SO2 fixation during oxidative roasting of high‑sulfur iron ores and DFT calculation
Published 2025-03-01“…This study will in-depth explore the mechanism of in-situ sulfur fixation with the aim of solving aforementioned issues and realizing the transition from terminal desulphurization to process control. Firstly, the effects of oxidation roasting temperature, oxygen concentration, gas flow rate and sulfur-fixation agent concentration on the sulfur-fixation efficiency were investigated to determine the regulation mechanism of sulfur fixation technology. …”
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2111
Efficacy and Safety of Ropivacaine Addition to Intrathecal Morphine for Pain Management in Intractable Cancer
Published 2015-01-01“…Although intrathecal drug infusion has been commonly adopted for terminal cancer pain relief, its adverse effects have made many clinicians reluctant to employ it for intractable cancer pain. …”
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2112
Macrocycle Unidirectional Transport Along a Linear Molecule by a Two‐Step Chemical Reaction Sequence
Published 2025-01-01“…On one side features a bulky ester group that can be exchanged by a smaller substituent; the other extreme contains an acid/base responsive moiety that plays a dual role, as part of the recognition motif and as a terminal group. In the acidic state, a dibenzo‐24‐crown‐8 ether slides into the linear component attracted by the positively charged recognition site. …”
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2113
Uterine histomorphological and immunohistochemical investigation during the follicular phase of estrous cycle in Saidi sheep
Published 2025-01-01“…Therefore, the purpose of this work was to provide further details on the histological, histochemical, and immunohistochemical analyses of superoxide dismutase 2 (SOD2), glutathione reductase (GR), and progesterone receptor alpha (PRA) as well as terminal deoxynucleotidyl transferase (TdT) dUTP nick-end labeling assay (TUNEL) of the uterus during the follicular phase of estrous cycle in Saidi sheep. …”
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2114
The effect of antenatal steroids on fetal lung maturation between 34 and 36 weeks of pregnancy
Published 2024-04-01“…There is no significant difference regarding weight of baby and time of termination. There is a significant difference between the studied groups regarding preterm labor and sex of the baby. …”
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2115
CAG Expansion in Androgen Receptor Gene of Infertile Men in Erbil Governorate
Published 2023-01-01“…This gene has a polymorphism site in Exon1 which encode androgen receptor and have various length of CAG trinucleotide repeat which causes the production of polyglutamine chain in different length of the N-terminal domain of AR protein which reduces producing sperm by disrupting spermatogenesis. …”
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2116
Theoretical and legal problems of the National Police of Ukraine employees` certification
Published 2021-12-01“…The key features of attestation have been highlighted, which, in turn, include the fact that it is: 1) a legal procedure that is regulated and carried out primarily on the basis of the legislation, in particular general labor; 2) the procedure for assessing not only the qualifications, but also the business, political, psychological, moral and other qualities of the employee, which one must have to perform the duties; 3) a procedure that entails certain legal consequences in the form of a change or termination of labor relations between the employee and the employer. …”
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2117
A Prospective Observational Comparative study Between qSOFA and SIRS Scores for Early Prediction of Sepsis Outcome in an Emergency Medicine Department , Kozhencherry, South Centr...
Published 2025-02-01“…Exclusion criteria included pregnancy, terminal illness, and severe comorbidities. Participants were followed up to determine final diagnosis and outcomes. …”
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2118
Chemotaxonomic studies on <i>Schwenckia americana</i> LINN
Published 2016-05-01“…The inflorescence is a panicle of 15 or more flowers occurring at stem terminal.The flowers are whitish tubular structures measuring up to 1.0±0.2cm in length and 0.1cm in diameter. …”
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2119
National, International and Legal Mechanisms of Control over the Activity of Non-Government Security Entities
Published 2019-06-01“…The author has stated that the purpose of control over the activity of non-government entities in the field of security and safety is to prevent deviations from the established order of state security and public order protection, prevention, detection and termination of actions that harm the protected state interests. …”
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2120
Cardiogenic Shock in a Hemodialyzed Patient on Flecainide: Treatment with Intravenous Fat Emulsion, Extracorporeal Cardiac Life Support, and CytoSorb® Hemoadsorption
Published 2019-01-01“…Serial determinations of serum flecainide concentration were obtained during the course of hemoadsorption, with a terminal half-life of 3.7 h during the first four hours and a global plasma clearance of 40.3 ml/min over the first 22 hours. …”
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