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2041
Peroxiredoxin 6 Attenuates Alloxan-Induced Type 1 Diabetes Mellitus in Mice and Cytokine-Induced Cytotoxicity in RIN-m5F Beta Cells
Published 2020-01-01“…Signal transduction studies showed that PRDX6 prevented the activation of NF-κB and c-Jun N-terminal kinase signaling cascades in RIN-m5F β cells cultured with cytokines. …”
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2042
Leptin Antagonizes Peroxisome Proliferator-Activated Receptor-γ Signaling in Growth Plate Chondrocytes
Published 2012-01-01“…Locally, PPARγ negatively regulates chondrogenic differentiation and terminal differentiation in the growth plate. The aim of this study was to test the hypothesis that leptin may suppress the inhibitory effects of PPARγ on growth plate chondrocytes. …”
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2043
Pegilated interferon α2а in treatment of chronic hepatitis C
Published 2012-09-01“…Sustained virologic response (SVR) after the termination of antiviral therapy was achieved in 70,1% of patients. …”
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2044
Novel Scalable Topologies of High Power Density Quadratic Converters With Low Voltage Stress on Power Diode
Published 2024-01-01“…The current at the input and output terminals are continuous, which facilitates the converter for various applications such as distributed generation (DG)s integration to microgrid and uninterruptible power supplies for integrated battery storage systems. …”
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2045
Muramyl Dipeptide Enhances Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption through Increased RANKL Expression in Stromal Cells
Published 2015-01-01“…The number of osteoclasts, the level of mRNA for cathepsin K and tartrate-resistant acid phosphatase (TRAP), the ratio of the bone destruction area, the level of tartrate-resistant acid phosphatase form 5b (TRACP 5b), and C-terminal telopeptides fragments of type I collagen as a marker of bone resorption in mice administrated both LPS and MDP were higher than those in mice administrated LPS or MDP alone. …”
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2046
Results of multicenter observation study on application of international questionnaire GerdQ for diagnostics of gastroesophageal reflux disease
Published 2013-10-01“…During the subsequent 2 wks patients underwent EGDS, 24-hour pH-metry and diagnosis was specified. Upon termination of the study the data received after filling of questionnaire and data of physical investigation by gastroenterologist have been compared to results of instrumental methods of GERD diagnostics. …”
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2047
Self-Assembling Multifunctional Peptide Dimers for Gene Delivery Systems
Published 2015-01-01“…MP was oxidized to form multifunctional peptide dimer (MPD) by DMSO oxidation of thiols in terminal cysteine residues. MPD could condense pDNA successfully at a weight ratio of 5. …”
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2048
All‐Inorganic Perovskite Quantum‐Dot Optical Neuromorphic Synapses for Near‐Sensor Colored Image Recognition
Published 2025-02-01“…Abstract As the demand for the neuromorphic vision system in image recognition experiences rapid growth, it is imperative to develop advanced architectures capable of processing perceived data proximal to sensory terminals. This approach aims to reduce data movement between sensory and computing units, minimizing the need for data transfer and conversion at the sensor‐processor interface. …”
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2049
Case Report: Respiratory outcome in a preterm infant following previable rupture of membranes and persistent oligohydramnios
Published 2025-01-01“…The favorable respiratory outcome of this case is a rarity for cases with similar clinical circumstances, in which the managing team counsels parents about poor fetal outcomes and many proceed to terminate the pregnancies. In this reported case, we highlight the importance of multidisciplinary and interprofessional team management from antepartum monitoring and planning delivery time to subsequent short- and long-term postnatal care involving maternal-fetal medicine specialists, neonatologists, pediatric cardiology and respiratory specialists, and home care teams.…”
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2050
Pregnancy after Cancer Treatment and Pregnancy Associated Cancer: A Single Center Experience with 96 Cases
Published 2015-08-01“…Pregnancies resulted in 77 healthy newborns, 7 abortions and 12 medical terminations. The most common type of cancer was the breast cancer in 25 patients, followed by thyroid, leukemia, osteosarcoma, lymphoma and ovarian cancer. …”
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2051
Reduced UPF1 levels in senescence impair nonsense-mediated mRNA decay
Published 2025-01-01“…Nonsense-mediated mRNA decay (NMD), a well-characterized RNA surveillance mechanism, degrades aberrant mRNAs with premature termination codons (PTCs) to prevent the synthesis of truncated proteins. …”
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2052
Monosomy 21 Seen in Live Born Is Unlikely to Represent True Monosomy 21: A Case Report and Review of the Literature
Published 2014-01-01“…The CMA also showed complete monosomy for an 8.8 Mb terminal segment (21q22.13q22.3). Whilst this patient had a provisional clinical diagnosis of trisomy 21, the patient also had phenotypic features consistent with monosomy 21, such as prominent epicanthic folds, broad nasal bridge, anteverted nares, simple ears, and bilateral overlapping fifth fingers, features which can also be present in individuals with Down syndrome. …”
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2053
Phylogenomic and mitogenomic data can accelerate inventorying of tropical beetles during the current biodiversity crisis
Published 2021-12-01“…The species-rich dataset included ~6500 terminals, ~ 1850 putative species delimited at 5% uncorrected pairwise threshold, possibly ~1000 of them unknown to science. …”
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2054
Ginkgetin Alleviates Inflammation and Senescence by Targeting STING
Published 2025-01-01“…Subsequent cell biological and biophysical data confirmed that Ginkgetin directly binds to the carboxy‐terminal domain of STING protein, thereby inhibiting STING activation and signal transduction. …”
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2055
Reverse mutational scanning of SARS-CoV-2 spike BA.2.86 identifies epitopes contributing to immune escape from polyclonal sera
Published 2025-01-01“…Interestingly, 16insMPLF within the spike N-terminal domain and P621S within S1/S2 also significantly contribute to antibody escape of BA.2.86. …”
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2056
ICESat-2 Reveals Accelerated Global Glacier Mass Loss Except Alaska From 2019 to 2023
Published 2025-01-01“…In the maritime regions, land-terminating glaciers have experienced more extensive mass loss except Svalbard and the Russian Arctic. …”
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2057
Targeting of retrovirus-derived Rtl8a/8b causes late-onset obesity, reduced social response and increased apathy-like behaviour
Published 2025-01-01“…Mouse RTL8A/8B proteins are expressed in the prefrontal cortex and hypothalamus and localize to both the nucleus and cytoplasm of neurons, presumably due to the N-terminal nuclear localization signal-like sequence at the N-terminus. …”
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2058
Gypsum heterogenous nucleation pathways regulated by surface functional groups and hydrophobicity
Published 2025-01-01“…Herein, we use in situ microscopy to investigate the real-time gypsum nucleation on self-assembled monolayers (SAMs) terminated with −CH3, −hybrid (a combination of NH2 and COOH), −COOH, −SO3, −NH3, and −OH functional groups. …”
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2059
Rectal cancer with severe distal spreading
Published 2012-09-01“…In the case of prolonged radiological (chemoradiation) therapy careful investigation is required in 6–8 wks after the termination of radiation therapy, before surgical intervention. …”
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2060
Ethical Issues in Uncontrolled Donation After Circulatory Determination of Death: A Scoping Review to Reveal Areas of Broad Consensus, and Those for Future Research
Published 2025-02-01“…Broad consensus was identified on several issues including: decisions about termination of resuscitation and entry into a uDCD protocol should be made by different teams; at least 20–30 min of cardio-pulmonary resuscitation is required; a hands-off period of 5–7 min is required alongside continuous monitoring; organ preserving techniques should be as minimally invasive as possible; families should be approached early to discuss organ donation by trained staff; public knowledge and engagement about uDCD is poor and must be improved; transparency and informed consent are essential for potential uDCD organ recipients. …”
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