Fusion to Flaviviral Leader Peptide Targets HIV-1 Reverse Transcriptase for Secretion and Reduces Its Enzymatic Activity and Ability to Induce Oxidative Stress but Has No Major Eff... by Anastasia Latanova, Stefan Petkov, Yulia Kuzmenko, Athina Kilpeläinen, Alexander Ivanov, Olga Smirnova, Olga Krotova, Sergey Korolev, Jorma Hinkula, Vadim Karpov, Maria Isaguliants, Elizaveta Starodubova

“…Inactivated multidrug-resistant RT (RT1.14opt-in) was N-terminally fused to the signal providing secretion of NS1 protein of TBEV (Ld) generating optimized inactivated Ld-carrying enzyme RT1.14oil. …”
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Modern modes of chronic hepatitis B treatment in daily clinical practice by M. V. Mayevskaya, M. A. Morozova, S. A. Ondos, V. T. Ivashkin

“…This article reviews in brief up-to-date modes of CHB treatment, clinical case demonstrating the basic AVT stages is presented: decision-making on its onset, monitoring of the patient during treatment, rules of choice and substitution of antiviral agents, criteria of treatment response assessment and indications for its termination.Conclusion. The adequate choice of drug at definition of antiviral treatment approach allows to suppress virus replication effectively, reduces risk of resistance development and rate of side effects while violation of international standards can result in fatal outcome. …”
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Modeling of Measuring Transducers for Relay Protection Systems of Electrical Installations by Iliya Iliev, Andrey Kryukov, Konstantin Suslov, Nikolay Kodolov, Aleksandr Kryukov, Ivan Beloev, Yulia Valeeva

“…Based on the results of calculating the complexes of currents and voltages at the MT terminals, parametric identification of the power transmission line was performed. …”
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Effect of icatibant on sweating-induced dermal pain by Shunsuke Takahagi, Shunsuke Takahagi, Daiki Matsubara, Emi Murakami, Yumi Aoyama, Shinya Imamura, Atsushi Fukunaga, Atsushi Fukunaga, Yoshiko Oda, Hiroyuki Murota, Michihiro Hide, Michihiro Hide

“…Before and after drug administration, dermal pain induced by an artificial thermal loading was assessed using the visual analog scale (VAS).ResultsFour patients were enrolled, three of whom completed the full procedure with the termination in the other. Among the three patients, the pain-VAS score decreased more with icatibant than with saline in one patient, whereas it decreased more with saline than with icatibant in the other two patients. …”
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64Cu-chelated InP/ZnSe/ZnS QDs as PET/fluorescence dual-modal probe for tumor imaging by Ziyu Zhao, Ayaka Otsuka, Noriko Nakamura, Toshifumi Tatsumi, Kazuhiro Nakatsui, Taiki Tsuzukiishi, Tomo Sakanoue, Kenji Shimazoe, Seiichi Ohta

“…The surface of the InP/ZnSe/ZnS QDs was functionalized with polyethylene glycol terminated with either a methoxy group or a 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) chelator group. …”
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Epidural Analgesia for Severe Chest Trauma: An Analysis of Current Practice on the Efficacy and Safety by Jesse Peek, Reinier B. Beks, B. Feike Kingma, Marije Marsman, Jelle P. Ruurda, Roderick M. Houwert, Loek P. H. Leenen, Falco Hietbrink, Mirjam B. de Jong

“…In 14 patients (18%), epidural analgesia was terminated early without intervention due to insufficient sensory blockade (n=4), medication-related side effects (n=4), and catheter-related complications (n=6). …”
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Automated external defibrillator: Rhythm analysis and defibrillation on paediatric out-of-hospital cardiac arrest by Emma Menant, Delphine Lavignasse, Sarah Ménétré, Jean-Philippe Didon, Xavier Jouven

“…Conclusion: This study shows that AED detect shockable rhythm with a good sensitivity and specificity and that shocks are associated with a very high rates of termination of shockable rhythms in pOHCA.…”
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Which variables are associated with recruitment failure? A nationwide review on obstetrical and gynaecological multicentre RCTs (2003–2023) by Ben W Mol, Madelon van Wely, L Ramos, J J Duvekot, J B Derks, Fulco van der Veen, Ruben Duijnhoven, H J van Beekhuizen, M J E Mourits, J A M van der Post, E Pajkrt, M A Oudijk, H C J Scheepers, Mariette Goddijn, J Huirne, Marijke C van der Weide, A Kwee, C Willekes, M Y Bongers, Judith Rikken, Romee Casteleijn, S Middeldorp, I M Custers, M P Lambregtse – van den Berg, V Mijatovic, F J M Broekmans, A Hoek, J P de Bruin, M H Mochtar, S Mastenbroek, J P W R Roovers, F Mol, A Vollebregt, C H van der Vaart, K B Kluivers, M E Vierhout, R C Painter, P M A J Geomini

“…Secondary outcomes were recruitment target not achieved within an extension period of at least 12 months and premature termination of the trial. In all RCTs, we collected information on variables with a potential effect on recruitment failure, recorded at five levels; patient, doctor, participating centre, study organisation and study design.Results In total, 46 of 83 RCTs (55%) did not achieve their targeted recruitment within the preplanned study period with a maximal extension period of 6 months. …”
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Anomaly Detection in High Mobility MDT Traces Through Self-Supervised Learning by J. M. Sanchez-Martin, C. Gijon, M. Toril, S. Luna-Ramirez, V. Wille

“…Results show that considering predictors regarding positioning error increases model accuracy, whereas omitting this information allows to cover a wider range of terminals. Likewise, Shapley Additive exPlanations (SHAP) analysis proves that the use of high-level predictors significantly improves model explainability.…”
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Evaluation of various RNA-seq approaches for identification of gene outrons in the flatworm Opisthorchis felineus by N. I. Ershov, D. E. Maslov, N. P. Bondar

“…One is based on the enzymatic elimination of overrepresented cDNAs, the other utilizes exonucleolytic degradation of uncapped RNA by Terminator enzyme. By using the outron-targeting methods, we were not able to obtain the enrichment of RNA preparations by processed outrons, which is most likely indicative of a rapid turnover of these trans-splicing intermediate products. …”
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Kinematic characteristics in patients with subcortical vascular cognitive impairment: a quantitative analysis of digitized spiral drawing metrics by Hyo Jeong Kim, Hyemin Jang, Hee Jin Kim, Duk L. Na, Ji Hye Yoon

“…These results may be due to complex cognitive-motor deficits, motor patterns, or impaired motor termination and conversion following damage to the frontal-subcortical circuit. …”
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Development of an ISOBUS-compliant communication node for multiple machine vision systems on wide boom sprayers for nozzle control in spot application schemes by Mozammel Bin Motalab, Ahmad Al-Mallahi, Alex Martynenko, Karama Al-Tamimi, Dimitrios S. Paraforos

“…ISOBUS compatibility tests across three different virtual terminals confirmed interoperability and standardized control within 51.5 to 70 s. …”
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Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study by Evgeny N. Mikhaylov, Tamara A. Lyubimtseva, Aleksandr D. Vakhrushev, Dmitry Stepanov, Dmitry S. Lebedev, Elena Yu. Vasilieva, Alexandra O. Konradi, Evgeny V. Shlyakhto

“…The study was prematurely terminated after the enrollment of 50 participants without a history of SARS-CoV-2 infection: 25 were assigned to bromhexine hydrochloride treatment (8 mg 3 times per day), and 25 were controls. …”
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Results of the ORION open comparative randomized trial: evaluation of efficacy of the Russian drugs Altevir and Phosphogliv in combined treatment of chronic hepatitis C by V. T. Ivashkin, M. V. Mayevskaya, P. O. Bogomolov, I. G. Nikitin, A. O. Buyeverov, A. V. Lapshin

“…Altevir was injected subcutaneously in a dose of 3 million IU 3 times per week in combination to ribavirin dosed according to body weight. After the termination of phosphogliv infusions oral intake of phosphogliv forte of 1 capsule tid along with ongoing AVT was prescribed to patients. …”
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An open-label study to determine the maximum tolerated dose of oral ESK-440 administered as a single agent in patients with advanced or metastatic solid tumors by Russell J. Schilder, Drew Rasco, Manish R. Sharma

“…Conclusions: ESK-440 was safe and tolerable with a maximum tolerated dose of 500 mg daily; however, the study was terminated early based on sponsor decision.…”
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REFERENCE POINTS OF THE PATHOGENESIS OF THE PHENOMENON OF MODEL FORMATION RISKY REPRODUCTIVE BEHAVIOR TEENAGE GIRLS by Ирина Вячеславовна Бабенко-Сорокопуд

“…As the severity of menstrual disorders increased, the share of teenage girls who had risky sexual practices increased, which leads to an increase in the number of sexually transmitted diseases, including HPV/HIV, unplanned pregnancy, its termination. The importance of the gynecologist's work with minors is increasing: during preventive examinations and lectures-trainings, counseling sessions, there should be a dialogue with the transmission of the values and meanings of sexuality determined by society, giving the opportunity to the younger generation to form reasonable models of sexual behavior.…”
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Examining the etiology and pregnancy outcomes of 152 critically ill pregnant patients in the Intensive Care Unit by Weiman Liu, Junyou Su, Sumei Wang

“…Furthermore, the incidence of pregnancy termination and induced abortion before 28 weeks in the group affected by non-obstetric factors was significantly higher than that in the group affected by obstetric factors (all p < 0.05). …”
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Wen fand Ghillebert de Lannoy in Trakai oder was bedeutet "Jude von Trakai" by Jurgita Šiaučiūnaitė-Verbickienė

“…Nach der Entdeckung der Zweideutigkeit der Termine „Jude von Trakai" und „Jude von Luzk" wird Trakai zu der ersten Stadt des ethnischen Litauen, die die Gemeinden von Juden und Karäern aufgenommen hat.   …”
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Anatomical simulation analysis of pancreaticobiliary junction in occult pancreaticobiliary reflux: based on Fluent study by LÜ Beining, HOU Nianzong, XIANG Yukai, DA Xuanbo, YANG Yulong, TIAN Fuzhou

“…Pancreaticobiliary reflux can be terminated by shortening the common channel length of pancreaticobiliary junction and expanding the opening of outflow tract.…”
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Timosin alpha-1 immunomodulating properties by M. V. Mayevskaya

“…It is shown, that Timosin alpha-1 efficacy is increased eventually and is more pronounced at the end of monitoring period after termination of therapy. According to original studies The Asian-Pacific association for the study of the liver (APASL) included Timosin alpha-1 in the list of immunomodulating agents for CHB treatment besides standard and pegilated interferon-a (PEG-IFN-a). …”
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