Enzymatic Hydrolysis Systems Enhance the Efficiency and Biological Properties of Hydrolysates from Frozen Fish Processing Co-Products by Maria Sapatinha, Carolina Camacho, Antónia Juliana Pais-Costa, Ana Luísa Fernando, António Marques, Carla Pires

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Plasma and Milk Pharmacokinetics and Estimated Milk Withdrawal Time of Tolfenamic Acid in Lactating Sheep by Orhan Corum, Kamil Uney, Devran Coskun, Duygu Durna Corum, Gul Cetin, Muammer Elmas

“…Results Compared to the 2 mg/kg dose, plasma volume of distribution at steady state (from 0.43 to 0.50 L/kg), terminal elimination half‐life (from 2.41 to 4.14 h) and dose‐normalized area under the plasma concentration–time curve (AUC0−∞, from 9.46 to 30.11 h µg/mL) increased, whereas total body clearance (from 0.21 to 0.13 L/h/kg) decreased at the 4 mg/kg dose. …”
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Hemşirelerin Palyatif Bakım ve Ölüme İlişkin Görüşleri: Nitel Bir Çalışma by Gamze Alıncak, Gamze Acavut, Bilge Dilek Soyaslan, Hilal Zengin

“…Ayrıca hemşirelerin terminal dönemdeki hastaya bakım verme konusunda zorluk yaşadıkları belirlenmiştir. …”
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Colonic cytokines for severe ulcerative colitis by Ye. A. Konovich, K. Ye. Shirokikh, I. L. Khalif, M. V. Shapina

“…The cytokine content in biopsy specimens of the large intestine has been increased in comparison to terminal portion of the small intestine, and the cytokine level in the left and transverse part of the colon was higher, than in cecum and ascending colon. …”
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Serum NT-Pro-BNP versus Noninvasive Bedside Inotropic Index in Paediatric Shock: A Contest of Myocardial Performance in Response to Fluid Loading by Antonius Hocky Pudjiadi, Tuty Rahayu, Stephanie Wijaya, Fatima Safira Alatas

“…Mild elevation of serum amino-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is associated with myocardial dysfunction. …”
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(-)-Epigallocatechin Gallate Reduces Platelet-Derived Growth Factor-BB-Stimulated Interleukin-6 Synthesis in Osteoblasts: Suppression of SAPK/JNK by Shinji Takai, Rie Matsushima-Nishiwaki, Seiji Adachi, Hideo Natsume, Chiho Minamitani, Jun Mizutani, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa

“…We previously showed that the mitogen-activated protein (MAP) kinase superfamily, p44/p42 MAP kinase, p38 MAP kinase, and stress-activated protein kinase (SAPK)/c-Jun N-terminal (JNK), positively plays a part in the platelet-derived growth factor-BB- (PDGF-BB-) stimulated synthesis of interleukin-6 (IL-6), a potent bone resorptive agent, in osteoblast-like MC3T3-E1 cells while Akt and p70 S6 kinase negatively regulates the synthesis. …”
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Anti-SARS-Cov-2 S-RBD IgG Formed after BNT162b2 Vaccination Can Bind C1q and Activate Complement by Anas H. A. Abu-Humaidan, Fatima M. Ahmad, Dima Awajan, Raba’a F. Jarrar, Nader Alaridah

“…Anti-RBD IgG formed following vaccination can bind C1q with subsequent complement activation, and the degree of terminal complement pathway activation differed between vaccines, which could play a role in the protection offered by COVID-19 vaccines. …”
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655Val and 1170Pro ERBB2 SNPs in Familial Breast Cancer Risk and BRCA1 Alterations by Stefania Tommasi, Vita Fedele, Rosanna Lacalamita, Michele Bruno, Francesco Schittulli, David Ginzinger, Gery Scott, Serenella Eppenberger-Castori, Daniele Calistri, Silvia Casadei, Ian Seymour, Salvatore Longo, Gianluigi Giannelli, Brunella Pilato, Giovanni Simone, Christopher C. Benz, Angelo Paradiso

“…Another SNP, Ala1170Pro, introduces a structural change in the carboxyl-terminal regulatory domain of the protein, but its clinical and biological importance remains undefined. …”
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Uncoupling Protein 2 Increases Susceptibility to Lipopolysaccharide-Induced Acute Lung Injury in Mice by Qin Wang, Jianchun Wang, Mingdong Hu, Yu Yang, Liang Guo, Jing Xu, Chuanjiang Lei, Yan Jiao, JianCheng Xu

“…LPS-induced apoptosis and release of inflammatory factors were alleviated by pretreatment of the Jun N-terminal kinase (JNK) inhibitor SP600125 or the p38 MAPK inhibitor SB203580, but not by the extracellular signal-regulated kinase (ERK) inhibitor PD98059 in UCP2-overexpressing mice. …”
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Banxia Xiexin Decoction Ameliorates t-BHP-Induced Apoptosis in Pancreatic Beta Cells by Activating the PI3K/AKT/FOXO1 Signaling Pathway by Li-juan Du, Bing Pang, Yu-meng Tan, Ya-nan Yang, Mei-zhen Zhang, Qing Pang, Min Sun, Qing Ni

“…The antiapoptotic effects were evaluated by Hoechst 33342 staining and terminal deoxynucleotidyl transferase dUTP nick end labeling assay (TUNEL). …”
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Identification of heat tolerant lentil genotypes through stress tolerance indices by Rohit Sarkar, Gyan Prakash Mishra, Premakumar, Ankita Singh, Jenia Roy, Kumbarahally Murthigowda Shivaprasad, Shashidhar B. Reddappa, Sudhir Kumar, Ruchi Bansal, Uttarayan Dasgupta, Soma Gupta, Susheel Kumar Sarkar, Sanjeev Gupta, Shiv Kumar, Harsh K. Dikshit, Prachi Sripathrao Yadav, Muraleedhar S. Aski

“…Abstract With climate change projections indicating an increase in the frequency of extreme heat events and irregular rainfall patterns globally, the threat to global food security looms large. Terminal heat stress, which occurs during the critical reproductive stage, significantly limits lentil productivity. …”
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Profundización del tope de permafrost y tendencias en la dinámica criogénica, a partir de 1989, en el glaciar de escombros compuesto del valle de Morenas Coloradas, Mendoza, Argent... by Darío Trombotto Liaudat

“…El engrosamiento de la capa activa en la lengua terminal, o límite inferior del creeping permafrost en este valle, de 4,9 m a 7,5 / 7,8 m en los últimos años, así como la tendencia de la dinámica criogénica desde 1992, y la geomorfología (termokarst inactivos en los frentes), expresan el fenómeno de calentamiento que se está detectando también en otros lugares del mundo. …”
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Single-cell sequencing elucidates the mechanism of NUSAP1 in glioma and its diagnostic and prognostic significance by Meng-Yu Zhao, Zhao-Lei Shen, Hongzhen Dai, Wan-Yan Xu, Li-Na Wang, Yu- Gu, Jie-Hui Zhao, Tian-Hang Yu, Cun-Zhi Wang, Jia-feng Xu, Guan-Jun Chen, Dong-Hui Chen, Wen-Ming Hong, Wen-Ming Hong, Fang Zhang

“…Notably, differentiation trajectory analysis identified NUSAP1 as a key marker for the terminal subpopulation. We found that elevated NUSAP1 expression correlated with poor prognosis, prompting further investigation of its functional role through both cellular and animal studies.ConclusionsNUSAP1-based risk models hold potential as predictive and therapeutic tools for personalized glioma treatment. …”
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Peroxiredoxin 6 Attenuates Alloxan-Induced Type 1 Diabetes Mellitus in Mice and Cytokine-Induced Cytotoxicity in RIN-m5F Beta Cells by Elena G. Novoselova, Olga V. Glushkova, Sergey M. Lunin, Maxim O. Khrenov, Svetlana B. Parfenyuk, Tatyana V. Novoselova, Mars G. Sharapov, Vladimir I. Novoselov, Evgeny E. Fesenko

“…Signal transduction studies showed that PRDX6 prevented the activation of NF-κB and c-Jun N-terminal kinase signaling cascades in RIN-m5F β cells cultured with cytokines. …”
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Angiopoietin-2 and D-dimer add prognostic information to clinical risk in pulmonary arterial hypertension by Heather L. Clark, Daniel Lachant, Allison N. Light, Deborah Haight, Samia Lopia, Nigel Mackman, R. James White

“…We assessed treatment response with Reveal Lite 2 scores (all patients had N-terminal-pro-brain natriuretic peptide, 6-minute walk, and functional class assessment at both visits) and followed clinical outcomes for 3 years. …”
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How do serum cytokine levels change in myocarditis and inflammatory dilated cardiomyopathy relative to healthy individuals? A protocol for a systematic review and meta-analysis by Romuald Wojnicz, Piotr Lewandowski, Maciej Baron, Marcin A Rojek, Marcin Goławski, Karol Krystek, Magdalena Żegleń, Pascal Zytkiewicz, Jakub Kancerek, Klaudia Gabriela Lis, Jakub Warecki, Jakub Kufel, Kamila Kuśpiel

“…Subgroup analysis will be stratified by age, sex, sample size, New York Heart Association scale, cardiac Troponin T, N-terminal prohormone of brain natriuretic peptide, C reactive protein, number of lymphocytes per mm2 in the endomyocardial biopsy.Ethics approval and dissemination This study does not require ethics approval. …”
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Safety and Efficacy in Mitral Regurgitation Management with the MitraClip^® G4 System: Insights from a Single-Center Study by Georgios E. Papadopoulos, Ilias Ninios, Sotirios Evangelou, Andreas Ioannidis, Vlasis Ninios

“…The Kansas City Cardiomyopathy Questionnaire (KCCQ) score improved from 51 ± 20 at baseline to 69 ± 15 at 30 days (<i>p</i> < 0.001) and 70.5 ± 15 at 1 year (<i>p</i> < 0.001). Lower baseline N-terminal pro-brain natriuretic peptide (NT-proBNP) predicted achieving NYHA class I at 30 days (HR: 0.63, 95% CI: 0.41–0.95, <i>p</i> = 0.030), while lower European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) and NT-proBNP predicted it at 1 year [(HR: 0.50, 95% CI: 0.28–0.89, <i>p</i> = 0.019), (HR: 0.67, 95% CI: 0.44–0.99, <i>p</i> = 0.049), respectively]. …”
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Vasoreactive testing prevalence and characteristics in patients with idiopathic pulmonary arterial hypertension by Goncharova Natalia, Kirill Lapshin, Aelita Berezina, Irina Zlobina, Anton Ryzhkov, Zhaneta Matakaeva, Elizaveta Andreeva, Olga Moiseeva

“…Patients with negative VRT demonstrated worse hemodynamics and exercise tolerance, higher N-terminal pro-brain-type natriuretic peptide (NT-proBNP) level, and right heart dilatation compared with VRT+. …”
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Targeting of retrovirus-derived Rtl8a/8b causes late-onset obesity, reduced social response and increased apathy-like behaviour by Yoshifumi Fujioka, Hirosuke Shiura, Masayuki Ishii, Ryuichi Ono, Tsutomu Endo, Hiroshi Kiyonari, Yoshikazu Hirate, Hikaru Ito, Masami Kanai-Azuma, Takashi Kohda, Tomoko Kaneko-Ishino, Fumitoshi Ishino

“…Mouse RTL8A/8B proteins are expressed in the prefrontal cortex and hypothalamus and localize to both the nucleus and cytoplasm of neurons, presumably due to the N-terminal nuclear localization signal-like sequence at the N-terminus. …”
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Caspase 3-specific cleavage of ubiquitin-specific peptidase 48 enhances drug-induced apoptosis in AML by Zhanglin Zhang, Xiang Lin, Yaling Yang, Xuemei Wang, Yi Wang, Xianbao Huang, Miao Hong, Wei Gao, Hua He, M. James You, Yi Yang, Guangyao Kong

“…Subsequent analysis showed that the cleavage USP48 N-terminal fragment which contains catalytic active domain is easily degraded by ubiquitination. …”
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