Identification of new ClpC1-NTD binders for Mycobacterium tuberculosis drug development by Katharina Weinhäupl, Louis Meuret, Sandy Desrat, Fanny Roussy, Nelly Morellet, Sandra Beaupierre, Catherine Guillou, Carine van Heijenoort, Olga Abian, Sonia Vega, Ian Wolf, Tatos Akopian, Olga Krandor, Eric Rubin, Adrian Velazquez-Campoy, Diego Gauto, Hugo Fraga

“…Recent studies have shown that several natural product antibiotics targeting the unfoldase N-terminal domain can impair MtbClpC1 function resulting in cell death. …”
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NT‐ProBNP and high‐sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population by Maria Averina, Michael Stylidis, Jan Brox, Henrik Schirmer

“…Abstract Aims The aim of this study was to establish age‐specific and sex‐specific cut‐off values for N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and high‐sensitivity troponin T (hs‐troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population. …”
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The effect of tumour necrosis factor-α (TNF-α) muteins on human neutrophils in vitro by H. Tchorzewski, K. Zeman, J. Kantorski, E. Paleolog, M. Kahan, M. Feldmann, M. Kwinkowski, P. Guga, B. Szymanska, P. Parniewski, A. Wilk, J. Jarosz

“…Blocking by muteins of anti-p75 antibody binding to PMN was as expected from their N-terminal amino acid composition and hydrophilic properties. …”
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Characterization of the bispecific VHH antibody tarperprumig (ALXN1820) specific for properdin and designed for low-volume administration by Paul Tamburini, Dennis Vestergaard Pedersen, Denise Devore, Josh Cone, Rekha Patel, Todd Hunter, Fang Sun, Gregers Rom Andersen, Jeffrey Hunter

“…Tarperprumig incorporates a C-terminal variable domain of a heavy chain only antibody (VHH) that binds properdin (FP) connected via a flexible linker to an N-terminal VHH that binds human serum albumin (HSA). …”
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Towards a Vaccine Against Rheumatic Fever by L. Guilherme, K. C. Faé, F. Higa, L. Chaves, S. E. Oshiro, S. Freschi de Barros, C. Puschel, M. A. Juliano, A. C. Tanaka, G. Spina, J. Kalil

“…Although these epitopes were from different regions of the C-terminal portion of the M protein, they showed an identical core of 16 amino acid residues. …”
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Competitive displacement of lipoprotein lipase from heparan sulfate is orchestrated by a disordered acidic cluster in GPIHBP1 by Anamika Biswas, Samina Arshid, Kristian Kølby Kristensen, Thomas J.D. Jørgensen, Michael Ploug

“…The trans-endothelial transport of LPL depends on ionic interactions with GPIHBP1’s intrinsically disordered N-terminal tail, which harbors two acidic clusters at positions 5–12 and 19–30. …”
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The effect of thioredoxin and prochymosin coexpression on the refolding of recombinant alpaca chymosin by S. V. Belenkaya, D. N. Shcherbakov, A. I. Chapoval, T. I. Esina, V. V. Elchaninov

“…To achieve this goal, on the basis of the pET32a plasmid, an expression vector was constructed containing the thioredoxin A gene fused to the N-terminal sequence of the marker enzyme zymogen, alpaca prochymosin. …”
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Thermodynamic Analysis of Supercritical CO2 Power Cycle with Fluidized Bed Coal Combustion by Chenchen Geng, Yingjuan Shao, Wenqi Zhong, Xuejiao Liu

“…In addition, thermodynamic analysis of critical operating parameters has been carried out, including terminal temperature difference, turbine inlet pressure/temperature, reheat stages, and parameters as well as compressor inlet pressure/temperature. …”
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New insights into the N-glycomes of Dictyostelium species by Alba Hykollari, Daniel Malzl, Chunsheng Jin, Carina Eschenbach, Kristína Kianičková, Iain B.H. Wilson, Katharina Paschinger

“…In contrast, neutral N-glycans with multiple fucose residues attached to terminal mannoses were found in D. giganteum. All three species have common modifications on their anionic N-glycans: while (methyl)phosphorylated residues are always associated with terminal mannose residues, the sulphation position differs. …”
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Ilececum: A Comprehensive Review by Shou-jiang Tang, Ruonan Wu

“…For gastrointestinal endoscopists, the ileocecum is the finishing line during colonoscopy and it is identified by three endoscopic landmarks: terminal ileum, ileocecal valve, and the appendiceal orifice. …”
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4-Chlorocurcumin by Phuong-Truc T. Pham, Mamoun M. Bader

“…The title compound [systematic name: 4-chloro-5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,4,6-trien-3-one], C21H19ClO6, is close to planar, with a dihedral angle of 2.61 (7)° between the terminal phenyl groups and three intramolecular O—H...O hydrogen bonds occur. …”
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Gallstone Ileus: a Surgical Emergency Presentation by Reinaldo Jiménez Prendes, Rasiel López Echemendia

“…Through this procedure, a large stone was found in the terminal ileum. Enterolithotomy was performed along with enterorraphy, thus solving the occlusion.…”
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Current Controlled Current Differencing Buffered Amplifier: Implementation and Applications by Sudhanshu Maheshwari, Iqbal A. Khan

“…A new four terminal current-controlled active element is introduced, where parasitic resistances at two current input ports are controlled leading to the definition of current-controlled current differencing buffered amplifier. …”
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Left Ventricular Assist Device Implantation with Concomitant Aortic Valve and Ascending Aortic Replacement by Katharina Huenges, Bernd Panholzer, Jochen Cremer, Assad Haneya

“…We present the case of a 74-year-old male patient who was admitted to our center with terminal heart failure in dilated cardiomyopathy and ascending aortic aneurysm with aortic valve regurgitation. …”
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Prevention and treatment of recurrent fractures after percutaneous vertebroplasty with denosumab in patients with osteoporotic vertebral compression fractures by Shouyu Xiang, Cheng Tang, Long Ling, Wei Liu, Bingwen Bai, Yanming Cao

“…[Methods] A total of 72 patients diagnosed with osteoporotic vertebral compression fracture and treated by percutaneous vertebroplasty in the orthopedic department of the Second Affiliated Hospital of Guangzhou Medical University from January 2022 to December 2022 were selected as the study subjects.Patients were randomly divided into two groups, each had 36 cases.The control group received conventional anti-osteoporosis treatment, and the observation group added denosumab on the basis of control group treatment.Both groups were followed for 1 year, while the fracture rate and the levels of bone mineral density(BMD), visual analogue scale(VAS) score, oswestry disability index(ODI), beck value, sagittal cobb angle and procollagen type ⅠN-terminal propeptid(PINP) and β-carboxy-terminal cross-linked telopeptide of type Ⅰ collagen(β-CTX) were compared between the two groups. …”
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A Structural Model of Truncated Gaussia princeps Luciferase Elucidating the Crucial Catalytic Function of No.76 Arginine towards Coelenterazine Oxidation. by Nan Wu, Zhi-Chao Xu, Kai-Dong Du, Shen Huang, Naohiro Kobayashi, Yutaka Kuroda, Yan-Hong Bai

“…However, deleting the C-terminal repeat only limited reduces the activity (over 30% residual luminescence intensity detectable), despite being a key part of the cavity. …”
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Regulation of NK cell development, maturation, and antitumor responses by the nuclear receptor NR2F6 by Johannes Woelk, Florian Hornsteiner, Stephanie Aschauer-Wallner, Patrizia Stoitzner, Gottfried Baier, Natascha Hermann-Kleiter

“…Administration of exogenous IL-15 in vitro and as IL-15 complex in vivo can compensate for these deficits, promoting terminal maturation of NK cells in Nr2f6-deficient mice. …”
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Utility of Endoscopic Examination in the Diagnosis of Acute Graft-versus-Host Disease in the Lower Gastrointestinal Tract by Kosuke Nomura, Toshiro Iizuka, Daisuke Kaji, Hisashi Yamamoto, Yasutaka Kuribayashi, Masami Tanaka, Tsukasa Furuhata, Satoshi Yamashita, Daisuke Kikuchi, Akira Matsui, Toshifumi Mitani, Yasunori Ota, Shuichi Taniguchi, Shu Hoteya

“…Useful endoscopic findings for the diagnosis of GVHD were atrophy of the ileocecal valve and villous atrophy in the terminal ileum and tortoise shell-like mucosae, edema, and low vascular permeability in the colon. …”
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A Cause of Diarrhea in a Patient with Selective Immunoglobulin A Deficiency by M. I. Gonik, V. S. Shcherbakha, E. Yu. Yuryeva, I. M. Kartavenko, A. S. Tertychny, P. V. Pavlov, A. E. Leonovich, T. L. Lapina, V. T. Ivashkin

“…An outpatient colonoscopy revealed signs of terminal ileitis. The patient’s medical history included selective IgA and vitamin B12 deficiency. …”
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INTUSUSCEPCIÓN CECOCÓLICA E INVAGINACIÓN DEL CIEGO EN UN CANINO: REPORTE DE CASO by J.F. Ortiz, A. Osorio, A.M. Tobón

“…Se decidió realizar una laparotomía exploratoria donde se encontró una intususcepción cecocólica y la invaginación del ciego, el procedimiento quirúrgico realizado consistió en hacer tiflectomia y enteroanastomosis término-terminal; luego de este procedimiento, el paciente se recuperó completamente del cuadro intestinal que presentaba.…”
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