Identification of compounds against atherosclerosis induced by ox-LDL based on cell extraction/UPLC–MS/MS from mulberry twigs and their mechanistic analysis by Zhihui Jin, Wei Xiang, Xiaowen Shi, Fenglin Jiang, Yanan Jia, Yuansong Zhang, Lingshu Zeng, Xianzhi Huang, Li Xu

“…Conclusion In conclusion, Kuwanon H, Morusin, and Kuwanon G effectively protected HUVECs from ox-LDL-induced oxidative injury, with Kuwanon H showing the strongest protective effects via the Nrf-2/HO-1 signaling pathway. …”
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Interventional effects of different track and field sports on human cardiovascular function indicators and physiological energy metabolism by Ruibin Jing, Zhengwei Wang, Choi Mee-Seong

“…In a quantitative load state, long-distance runners have the strongest adaptability to load.…”
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Decoding the mannose receptor-mAb interaction: the importance of high-mannose N-glycans and glycan-pairing by Julia Baumeister, Maximilian Meudt, Sybille Ebert, Frank Rosenau, Boris Mizaikoff, Michaela Blech, Kristina M. J. Aertker, Fabian Higel

“…However, different glyco-pairs exhibited varying binding affinities to the MR, with the symmetrical high-mannose glyco-pair showing the strongest binding properties. These findings strengthen the hypothesis for the MR-mediated mAb interaction and contribute to a deeper understanding of the MR-mAb interaction, which could affect the criticality of high-mannose containing mAbs development strategies of IgG-based molecules and improve their PK profiles.…”
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Computational analysis of Allium sativum compounds to identify thermolabile hemolysin inhibitors against Vibrio alginolyticus in shrimp by Sayed Mashequl Bari, Nafees Bin Reza, Meamaching Marma, Sk. Foisal Ahmed, Md Arif Hussain, Md Naimuddin Jabed, Md Alomgir Hossain, Maria Manzoor, Md Saiful Alam

“…Out of thirty-five compounds from A. sativum, protopine (CID 4970), gibberellin A7 (CID 92782), and gibberellic acid (CID 6466) demonstrated the strongest binding affinities, with scores of -9.4, -8.0, and -7.4 kcal/mol, respectively. …”
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Simultaneous Determination of Night Effective Constituents and Correlation Analysis of Multiconstituents and Antiplatelet Aggregation Bioactivity In Vitro in Chuanxiong Rhizoma Sub... by Peihua Zhang, Linming Chen, Xiaoxiao Wang, Jinpei Chen, Shungui Xu, Ling Ye, Yixin Yao

“…The effective components and the strength of AAB at 10 and 20 minutes were the strongest, followed by 30–50 minutes, and 60 minutes were the weakest by analysis of SIMCA-PLS in CR decoction of different times. …”
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Future Extreme Climate Events Threaten Alpine and Subalpine Woody Plants in China by Yongru Wu, Jian Shen, David C. Deane, Haibin Yu, Fangyuan Yu, Xuerong Wang, Zheng Cao, Rong Yu, Fuan Xiao, Tiejun Wang, Zhifeng Wu

“…Abstract Increases in the frequency, intensity, and duration of extreme climate events (ECEs) are already impacting ecosystems, with many of the strongest effects associated with high‐elevation areas. …”
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Associations between a polygenic risk score and the risk of gestational diabetes mellitus in a Chinese population: a case-control study by Ying Li, Mengjiao Yang, Lu Yuan, Ting Li, Xinli Zhong, Yanying Guo

“…Among the genetic variants examined, TCF7L2 rs7903146 displayed the strongest association with GDM risk (logOR = 0.18, p = 2.37 × 10–19), followed by ADAMTSL1 rs10963767 (logOR = 0.14, p = 3.58 × 10–15). …”
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Multifield Coupling Mechanism of Unloading Deformation and Fracture of Composite Coal-Rock by Zhen Yang, Yan Li, Xin Li, Jiayu Zhuang, Hao Li, Xue Wang, Yuning Wang

“…Besides, the electromagnetic field is strongest on the surface of the coal body, and its propagation in the air decays exponentially. …”
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Value of Plasma NGAL and Creatinine on First Day of Admission in the Diagnosis of Cardiorenal Syndrome Type 1 by Hao Phan Thai, Bao Hoang Bui, Tien Hoang Anh, Minh Huynh Van

“…Multivariable logistic regression analysis eGFRCKDEPID1 remained the strongest independent predictor of CRS1. Building the optimal regression model (without eGFRCKDEPID1) by the BMA (Bayesian model average) method with two variables NGAL and Creatinine D1, we had the equation: odds ratio = ey while y = −2.39 + 0.0037 × NGAL + 0.17 × Creatinine D1. …”
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Synthesis and Pesticidal Activities of 5-(2-Cyclopropylaminopyrimidin-4-yl)-4-(thiophenyl)thiazole Derivatives by Won-Sik Choi, Seok-Woo Nam, Il-Doo Kim, Seung-Han Kim, Kun-Ho Park, In-Kyung Bae, Eun-Sil Park, Hwang-Ju Jeon, Sung-Eun Lee

“…Mosquito larvicidal activities of all the synthesized compounds against C. pipiens pallens were examined and Comp I among them showed the strongest larvicidal activity as 0.513 mM of LC50 value. …”
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Exploring the significance of medical humanities in shaping internship performance: insights from curriculum categories by Chao Ting Chen, Anna Y.Q. Huang, Po-Hsun Hou, Ji-Yang Lin, His-Han Chen, Shiau-Shian Huang, Stephen J. H. Yang

“…In the subgroup analysis of MH curricula, Medical Sociology and Cultural Studies, as well as Communication Skills and Interpersonal Relationships, stood out with AUC values of 0.710 and 0.705, respectively, under logistic regression.Conclusion MH had the strongest predictive association with clinical competence during formative internship training, beyond basic medical sciences. …”
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Ultrasonic-assisted extraction of luteolin from peanut shells using ionic liquid and its molecular mechanism by Liwei Niu, Siwen Zhang, Xiaoyu Si, Yuhan Fang, Shuang Wang, Lulu Li, Zunlai Sheng

“…Interaction energy analyses were conducted to elucidate the interactions between ILs and luteolin, confirming the experimental findings and highlighting the strongest interaction energy between 1-butyl-3-methylimidazolium tetrafluoroborate and luteolin. …”
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COVID-19 in the years 2020 to 2022 in Germany: effects of comorbidities and co-medications based on a large-scale database analysis by Roland Linder, Jonas Peltner, Anatoli Astvatsatourov, Willy Gomm, Britta Haenisch

“…Immunodeficiencies and use of immunosuppressives were strongest risk modifying factors for hospitalization in both study populations. …”
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Antagonism of Eucalyptus endophytic fungi against some important crop fungal diseases by Parmida Aleahmad, Leila Ebrahimi, Naser Safaie, Hassan Reza Etebarian

“…Among the isolates, Trichoderma sp. isolates KL1 and 8S1 consistently exhibited the strongest inhibition of disease severity for all four pathogens under greenhouse conditions. …”
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Immunostimulatory Effects of Guanine-Quadruplex Topologies as Scaffolds for CpG Oligodeoxynucleotides by Soumitra Pathak, Nguyen Bui Thao Le, Taiji Oyama, Yusuke Odahara, Atsuya Momotake, Kazunori Ikebukuro, Chiho Kataoka-Hamai, Chiaki Yoshikawa, Kohsaku Kawakami, Yoshihisa Kaizuka, Tomohiko Yamazaki

“…Among the three topology, the parallel G4 CpG ODN demonstrated the highest serum stability and cellular uptake, resulting in the strongest immune response from macrophage cells. Additionally, we investigated the binding affinities of the different G4 topologies to macrophage scavenger receptor-1 and TLR9, both of which are key to immune activation. …”
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Immunogenicity and Protective Efficacy of a Novel Recombinant BCG Strain Overexpressing Antigens Ag85A and Ag85B by Chun Wang, Ruiling Fu, Zhenhua Chen, Kun Tan, Lingxia Chen, Xindong Teng, Jia Lu, Chunwei Shi, Xionglin Fan

“…In this study, three rBCG strains overexpressing immunodominant antigens Ag85B (rBCG::85B), Ag85A (rBCG::85A), or both (rBCG::AB) of Mycobacterium tuberculosis were constructed, respectively. rBCG strains showed higher level of overexpression of Ag85A and/or Ag85B proteins than BCG containing empty vector pMV261(rBCG::261), which had low levels of endogenous expression of both proteins as expected. rBCG::AB strain could provide the strongest short-term and long-term protection in the lung against intravenous infection with virulent M. tuberculosis than rBCG::261 control and other two rBCG strains overexpressing single antigen. …”
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Validation of In-field Calibration for Low-Cost Sensors Measuring Ambient Particulate Matter in Kolkata, India by Siddharth Nobell, Arnab Majumdar, Shovon Mukherjee, Sukumar Chakraborty, Sanjoy Chatterjee, Soumitra Bose, Anindita Dutta, Sandhya Sethuraman, Daniel M. Westervelt, Shairik Sengupta, Rakhi Basu, V. Faye McNeill

“…Agreement between the LCS and RGM for 24-h averaged PM2.5 measurements was strongest at RBU, with an uncalibrated root mean squared error (RMSE) of 27.1 µg m−3, followed by PDM (32.6 µg m−3) and VICTORIA (50.7 µg m−3). …”
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Metabolic Syndrome May Not be a Good Predictor of Coronary Artery Disease in the Iranian Population: Population-Specific Definitions are Required by Mahmoud Ebrahimi, Seyyed Mohammad Reza Kazemi-Bajestani, Majid Ghayour-Mobarhan, Mohsen Moohebati, Roghaye Paydar, Mohsen Azimi-Nezhad, Habib Ollah Esmaily, Gordon A. A. Ferns

“…Of the parameters assessed, age, total cholesterol, and low serum HDL cholesterol were the strongest independent predictors of angiographically defined CAD (p < 0.01, p < 0.01, p < 0.05, respectively). …”
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Seasonal Variation in Vitamin D in Association with Age, Inflammatory Cytokines, Anthropometric Parameters, and Lifestyle Factors in Older Adults by Leticia Elizondo-Montemayor, Elena C. Castillo, Carlos Rodríguez-López, José R. Villarreal-Calderón, Merit Gómez-Carmona, Sofia Tenorio-Martínez, Bianca Nieblas, Gerardo García-Rivas

“…Vitamin D deficiency did not correlate to sun exposure or dietary intake. Gender was the strongest associated factor, explaining a variance of 20%. …”
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Extraction, Enrichment, and Quantification of Main Antioxidant Aglycones of Flavonoids and Tannins from Melastoma Dodecandrum Lour.: Guided by UPLC-ESI-MS/MS by Yingpeng Tong, Yu Jiang, Xubo Chen, Xiaonan Li, Ping Wang, Ye Jin, Kejun Cheng

“…Among the above five ethanol fractions, 50% ethanol fraction showed the strongest antioxidant activity and more than 95% antioxidants adsorbed in HPD500 could be eluted by 75% ethanol. …”
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