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Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy
Published 2025-01-01“…Ying Gao,1 Lu Li,1 Fang Zhao,1 Yi Cheng,1 Mu Jin,2 Fu-Shan Xue1,3 1Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, People’s Republic of ChinaCorrespondence: Mu Jin, Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 An-Zhen Road, Chao-Yang District, Beijing, 100029, People’s Republic of China, Tel +86-13366600987, Email jinmu0119@hotmail.com Fu-Shan Xue, Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-An Road, Xi-Cheng District, Beijing, 100050, People’s Republic of China, Tel +86-13911177655, Fax +86-591-88217841, Email xuefushan@aliyun.com; xuefushan@mail.ccmu.edu.cnPurpose: This study aimed to assess the protective effect of a clinical dose esketamine on cerebral ischemia/reperfusion (I/R) injury and to reveal the potential mechanisms associated with microglial polarization and autophagy.Methods: Experimental cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in adult rats and simulated by oxygen-glucose deprivation (OGD) in BV-2 microglial cells. …”
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Quantitative Trait Loci Analysis of Folate Content in Dry Beans, Phaseolus vulgaris L.
Published 2013-01-01Get full text
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Genetic Associations Between Specific Sleep-Related Phenotypes and Idiopathic Sudden Sensorineural Hearing Loss: A Mendelian Randomization Analysis
Published 2025-02-01“…Man Li,1,* Jinbo He,2,* Yiting Liang,3 Fan Zou,1 Changlong Gou,4 Jing Lv,2 Xicheng Zhang,5 Dan Li,6 Zizhong Yu1 1Department of Otolaryngology, Head and Neck Surgery, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 2Department of Anesthesiology, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 3First Clinical College, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 4Department of Ultrasound Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 5Biomedical Engineering College, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China; 6Clinical Molecular Diagnostic Center, Taihe Hospital, Hubei University of Medicine, Shiyan, 442000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zizhong Yu, Department of Otolaryngology, Head and Neck Surgery, Taihe Hospital, Hubei University of Medicine, No. 32 Renmin South Road, Maojian District, Shiyan, Hubei, 442000, People’s Republic of China, Tel +86-719-8801459, Email yurick0994@163.com Dan Li, Clinical Molecular Diagnostic Center, Taihe Hospital, Hubei University of Medicine, No. 32 Renmin South Road, Maojian District, Shiyan, Hubei, 442000, China, Tel +86-719-8801881, Email lidan198016@163.comPurpose: The relationship between idiopathic sleep-related phenotypes (SRPs) and sudden sensorineural hearing loss (ISSNHL) remains unclear. …”
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Development and Evaluation of an ICU Nurse Training Program on Oral Mucosal Pressure Injury Prevention and Management Using the ADDIE Model
Published 2025-02-01“…Tiantian Jia,1 Yunxia Lan,2 Jing Pang,2 Mengdan Ma,1 Zhe Ding,3 Yongting Wang,1 Enshe Jiang4 1Cardiac Surgery Intensive Care Unit, The Affiliated Chest Hospital of Zhengzhou University, Zhengzhou, 450008, People’s Republic of China; 2Department of Nursing, The Affiliated Chest Hospital of Zhengzhou University, Zhengzhou, 450008, People’s Republic of China; 3Department of Rehabilitation, The Affiliated Chest Hospital of Zhengzhou University, Zhengzhou, 450008, People’s Republic of China; 4Institute of Nursing and Health, Henan University, Kaifeng, 475004, People’s Republic of ChinaCorrespondence: Enshe Jiang, Institute of Nursing and Health, Henan University, No. 1 Jinming Road, Kaifeng, Henan, 475004, People’s Republic of China, Email esjiang@gmail.com Yongting Wang, Cardiac Surgery Intensive Care Unit, the Affiliated Chest Hospital of Zhengzhou University, No. 1 Weiwu Road, Zhengzhou, Henan, 450008, People’s Republic of China, Email 2313992171@qq.comPurpose: To construct a training course program for ICU nurses to care for oral mucosal membrane pressure injury (MMPI) and evaluate its implementation effects based on the ADDIE model.Patients and Methods: A research team was established to construct the training course program in January 2024. …”
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Development of chimeric Nanobody-Granzyme B functionalized ferritin nanoparticles for precise tumor therapy
Published 2025-03-01Get full text
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Biodegradable Mg alloy modified with bioactive exosomes for cardiovascular stent application
Published 2024-12-01Get full text
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Détection automatique des parcelles sur les plans napoléoniens : comparaison de deux méthodes
Published 2021-05-01“…It contains a wealth of information (e.g. cadastre lot structure, lot numbering, rivers and road shapes, toponymy, buildings…) which underpin most historical studies of land usage and transformation. …”
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Key technology and application of intelligent connected patrol vehicles for security scenario
Published 2020-04-01“…Practical applications combined with industry scene is a common problem in the present artificial intelligence technology.Facing the security application scenario,the practice landing of unmanned technology -- intelligent connected patrol vehicle was studied.Integrating different sensors such as camera,LiDAR,inertial navigation system (INS),etc,the awareness system can accurately identify the platform itself,road conditions and target behavior using key technology such as artificial intelligence (AI),data fusion.Combining human intelligence (HI) in scene cognition of human experience and artificial intelligence (AI) in cognition of computing,a hybrid intelligent cognitive system using to security scene was built.Based on human in the loop system architecture and technology such as 5G ,vehicle to everything (V2X),edge computing,etc,different interactions between human ,machine and environment were designed,which ensured the safe and reliable operation of the system and increased the work efficiency by a wide margin.…”
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