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2881
Determinants of 5-year survival in patients with advanced NSCLC with PD-L1≥50% treated with first-line pembrolizumab outside of clinical trials: results from the Pembro-real 5Y glo...
Published 2025-02-01“…Background Pembrolizumab monotherapy is an established front-line treatment for advanced non-small cell lung cancer (NSCLC) with programmed cell death-ligand 1 (PD-L1) tumor proportion score (TPS)≥50%. However, real-world data on its long-term efficacy remains sparse.Methods This study assessed 5-year outcomes of first-line pembrolizumab monotherapy in a large, multicenter, real-world cohort of patients with advanced NSCLC and PD-L1 TPS≥50%, referred to as Pembro-real 5Y. …”
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2882
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2883
Impacts of genomic alterations on the efficacy of HER2-targeted antibody–drug conjugates in patients with metastatic breast cancer
Published 2025-01-01“…Methods This comprehensive real-world retrospective study collected clinical data from patients diagnosed with metastatic breast cancer and performed genomic profiling using targeted next-generation sequencing. …”
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2884
Contrastive learning with transformer for adverse endpoint prediction in patients on DAPT post-coronary stent implantation
Published 2025-01-01“…This study introduces a new contrastive learning-based approach to enhance prediction efficacy over multiple time intervals.MethodsWe utilized retrospective, real-world data from the OneFlorida + Clinical Research Consortium. …”
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2885
A General Framework for Closed Loop Negative Feedback Multivariable Physiological Control Systems: Existence, Uniqueness, and Stability of Homeostatic Equilibrium Points
Published 2025-01-01“…To this regard, in this paper, the existence, possible uniqueness and stability properties of the homeostatic equilibrium points of the general model are investigated; the theoretical framework is then illustrated through two real-world case-studies: (i) the PI3K/AKT/mTOR pathway nonlinear dynamics, a critical regulator of cellular growth, proliferation, and survival; (ii) the control mechanism of the neuromuscular stretch reflex, among the prime triggers implicated in postural control. …”
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2886
Design and Implementation of a Deep Learning-Based Hand Gesture Recognition System for Rehabilitation Internet-of-Things (RIoT) Environments Using MediaPipe
Published 2025-01-01“…Initial trials demonstrate promising results, though further testing is required under real-world conditions to validate the system's effectiveness fully. …”
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2887
Clinical validation of an artificial intelligence algorithm for classifying tuberculosis and pulmonary findings in chest radiographs
Published 2025-02-01“…Artificial Intelligence (AI) algorithms could be of great help, but using real-world data is crucial to ensure their effectiveness in diverse healthcare settings. …”
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2888
Swarm learning with weak supervision enables automatic breast cancer detection in magnetic resonance imaging
Published 2025-02-01“…Results Upon systematically benchmarking various weakly supervised two-dimensional (2D) and three-dimensional (3D) deep learning (DL) methods, we find that the 3D-ResNet-101 demonstrates superior performance. By implementing a real-world SL setup across three international centers, we observe that these collaboratively trained models outperform those trained locally. …”
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2889
Head and neck squamous cell carcinoma epidemiology at diagnosis: A description of public and private health care systems in Brazil regarding tumor location, staging and risk factor...
Published 2024-09-01“…Among patients with oropharyngeal cancer, only those in the private sector were tested for HPV, with the majority being positive. Conclusions: This real-world data study provides epidemiologic characteristics of patients with HNSCC in two different Brazilian healthcare settings, presenting relevant insights into possible opportunities for improvements in the patient's journey with HNSCC.…”
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2890
Detection Method of Apple Alternaria Leaf Spot Based on Deep-Semi-NMF
Published 2024-11-01“…These images reflect various real-world scenarios, capturing apple leaves at different stages of maturity, in diverse lighting conditions, angles, and noise environments. …”
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2891
Association of depression in multiple sclerosis with fatigue, sleep disturbances, disability, and health-related quality of life: Outcomes of a cross-sectional study
Published 2025-01-01“…Method: We investigated the prevalence of depressive symptoms in a cohort of 200 patients with MS (76% women) and their association with sleep patterns, fatigue, QoL, demographics, and other clinical characteristics in real-world settings. The study was conducted through clinical evaluations and questionnaires related to depression: Beck Depression Inventory (BDI) and Hamilton Depression Rating Scale (HDRS); fatigue: Modified Fatigue Impact Scale; sleep quality: Pittsburgh Sleep Quality Index and Epworth Sleepiness Scale; and QoL: Multiple Sclerosis Quality of Life-54 (MSQOL-54). …”
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2892
De la evidencia a la práctica: la Ciencia de la Diseminación e Implementación en atención primaria y comunitaria
Published 2025-01-01“…Abstract: Dissemination and Implementation Science focuses on bridging the gap between scientific research and its practical application in the real world. By identifying and promoting effective strategies, the Science of Dissemination and Implementation disseminates and implements evidence-based interventions in healthcare settings, taking into account the needs, barriers, context, resources, and end users. …”
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2893
Diagnosis, screening, and follow-up of patients with familial interstitial lung disease: Results from an international survey
Published 2025-02-01“…We aimed to examine current real-world strategies employed by pulmonologists working with familial ILD. …”
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2894
Protocol of the TransformUs SecondaryTeachers’ perceptions of the program reach, effectiveness,adoption, implementation and maintenance schools program: a type II hybrid implementa...
Published 2025-02-01“…The aim of this paper is to describe the protocol for TransformUs Secondary in relation to implementation and scale-up across Australia, and the real-world effectiveness of the intervention on adolescents’ physical activity and sedentary time, as well as sitting time, sleep, well-being and class and school engagement.Methods and analysis A type II hybrid implementation-effectiveness trial will be conducted using a mixed-methods design. …”
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2895
Service Models in the Public Sector
Published 2024-12-01“…Through inductive analyses of real-world cases, we gathered rich and detailed information that allowed us to uncover patterns, trends, and the unique characteristics of these service models. …”
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2896
Bioinformatic characterization of STING expression in hematological malignancies reveals association with prognosis and anti-tumor immunity
Published 2025-02-01“…Moreover, the value of STING in predicting the efficacy of immunotherapy was validated using tumor immune dysfunction and exclusion (TIDE) biomarkers and real-world immunotherapy datasets.Results and DiscussionSTING was found to be relatively highly expressed in acute myeloid leukemia (AML) and chronic myeloid leukemia, with higher STING expression correlated with poorer prognosis in AML. …”
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2897
Activity of CDK4/6 inhibitors and parameters affecting survival in elderly patients in age-subgroups: Turkish Oncology Group (TOG) retrospective study
Published 2024-12-01“…To contribute to the literature, we investigated the real-world efficacy, factors associated with survival and the rates of adverse events (AEs) of the treatment with palbociclib or ribociclib plus ET in the HR+/HER2- MBC patient cohort over the age of 65 for age subgroups. …”
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2898
An interpretable machine learning tool for in-home monitoring of agitation episodes in people living with dementia: a proof-of-concept studyResearch in context
Published 2025-02-01“…Current interventions for agitation are primarily medication-based, which may lead to severe side effects and lack personalisation. Understanding how real-world factors interact with agitation within home settings offers a promising avenue towards identifying potential personalised non-pharmacological interventions. …”
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2899
MSH-YOLOv8: Mushroom Small Object Detection Method with Scale Reconstruction and Fusion
Published 2024-09-01“…This demonstrates the practical applicability of the model in real-world agricultural settings, where such challenges are common.…”
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2900
Early warning systems for identifying severe maternal outcomes: findings from the WHO global maternal sepsis studyResearch in context
Published 2025-01-01“…There are limitations to applying EWS to real-world data, mainly due to the incompleteness of medical data that hinders EWS effectiveness. …”
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