Huntington Disease Health Related Quality of Life, Function and Well Being: The Patient’s Perspective by Jesús Pérez-Pérez, Sofía García-López, Tamara Fernández Valle, Cèlia Painous, Maria Rosa Querol-Pascual, Pedro J. García Ruiz, Elena Bellosta Diago, Esther Cubo Delgado, Barbara Vives Pastor, María Carmen Peiró Villaplana, Idaira Martín Santana, Marta Blázquez Estrada, Matilde Calopa Garride, Pablo Mir, Carmen Álvarez, Jorge Maurino, Anna de Prado, José Luis López-Sendón

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Ceftazidime-Avibactam Versus Colistin for the Treatment of Multidrug-Resistant <i>Pseudomonas aeruginosa</i> Infections: A Multicenter Cohort Study by Thamer A. Almangour, Zakiyah Alkherb, Leen Ghonem, Mohammed Al Musawa, Abdullah Almohaizeie, Sara Almuhisen, Aminah Alharbi, Nader Damfu, Doaa Aljefri, Jeelan Alghaith, Awaly Alfozan, Ahlam Alghamdi, Ahmad Aljabri, Abdullah A. Alhifany, Mohammed Alessa, Yazed Saleh Alsowaida

“…<b>Purpose:</b> To evaluate the real-world evidence of ceftazidime-avibactam (CAZ-AVI) compared to intravenous colistin for the treatment of multidrug-resistant (MDR) <i>P. aeruginosa</i> infections. …”
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Development and validation a methodology model for traditional Chinese medicine good practice recommendation: an exploratory sequential mixed methods study by Su Li, Su Li, Su Li, Luan Zhang, Yangyang Wang, Yangyang Wang, Runsheng Xie, Runsheng Xie, Wenjia Chen, Wenjia Chen, Myeong Soo Lee, Yasser Sami Amer, Yasser Sami Amer, Yasser Sami Amer, Amin Sharifan, Heba Hussein, Hui Li, Hui Li, Hui Li

“…BackgroundTo develop a rational and standardized traditional Chinese medicine (TCM) good practice recommendation (GPR) methodology model that guides the formulation of recommendations grounded in clinical experience.MethodsWe adopted an exploratory sequential mixed-method to develop a methodology model by coding systematically collected literature on methodology and TCM guidelines related to TCM GPR using a best-fit framework synthesis. Then based on real-world data (published TCM guidelines), saturation tests, structural rationality validation, and discriminability tests were conducted to validate methodology model.ResultsA total of 35 methodological literature and 190 TCM guidelines were included. …”
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Telehomecare Monitoring for Patients Receiving Anticancer Oral Therapy: Protocol for a Mixed Methods Evaluability Study by Dominique Tremblay, Thomas Joly-Mischlich, Annick Dufour, Marie-Claude Battista, Djamal Berbiche, José Côté, Marco Décelles, Catherine Forget, Brigitte Guérin, Manon Larivière, Frédéric Lemay, Manon Lemonde, Éric Maillet, Nathalie Moreau, Michel Pavic, Sara Soldera, Catherine Wilhelmy

“…The methodological choice aims to provide real-world data that are rigorous, rapidly usable in practice, and transferable to other settings. …”
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Temporal trends of the utilization patterns of sedative-hypnotic medications in children, adolescents and young adults: a 21-year population-based study with joinpoint regression a... by Carltin Chun Ting Kwok, Heidi Ka Ying Lo, Ching Yui Chan, Joe Kwun Nam Chan, Corine Sau Man Wong, Calvin Pak Wing Cheng, Chung Ho, Brian Man Ho Leung, Wilfred Shone Horn Wong, Zoe Hoi Shuen Yu, Edwin Ho Ming Lee, Wing Chung Chang

“…Abstract Background There is limited research on real-world utilization patterns of benzodiazepines and Z-drugs (collectively-termed benzodiazepine-receptor agonists [BZRAs]) in children and adolescents, particularly in non-western countries. …”
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Intelligent fault diagnosis method for rolling bearings based on flexible residual neural network by Chuang CHEN, Xianfeng LI, Jiantao SHI, Dongdong YUE

“…Rolling bearings play a crucial role in rotating machinery, and their efficient operation is vital for the machine’s longevity and performance. In numerous real-world situations, diagnosing faults in rolling bearings presents significant challenges. …”
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A deep learning model for carotid plaques detection based on CTA images: a two stepwise early-stage clinical validation study by Zhongping Guo, Ying Liu, Jingxu Xu, Chencui Huang, Fandong Zhang, Chongchang Miao, Yonggang Zhang, Mengshuang Li, Hangsheng Shan, Yan Gu

“…Additionally, the model’s diagnostic time for plaques (6 s) was found to be significantly shorter than that all of radiologists (p &lt; 0.001).ConclusionThis AI model demonstrated strong clinical potential for carotid plaque detection with improved clinician diagnostic performance, shortening time, and practical implementation in real-world clinical cases.…”
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Overground robotic exoskeleton vs conventional therapy in inpatient stroke rehabilitation: results from a pragmatic, multicentre implementation programme by Pui Kit Tam, Ning Tang, Nur Shafawati Binte Kamsani, Thian Yong Yap, Ita Coffey-Aladdin, Shi Min Goh, Jean Pei Pei Tan, Yook Cing Lui, Rui Ling Lee, Ramaswamy Suresh, Effie Chew

“…Abstract Background Despite the reported efficacy of overground robotic exoskeleton (ORE) for rehabilitation of mobility post-stroke, its effectiveness in real-world practice is still debated. We analysed prospectively collected data from Improving Mobility Via Exoskeleton (IMOVE), a multicentre clinical implementation programme of ORE enrolling participants with various neurological conditions and were given options to choose between 12 sessions of ORE or conventional therapy (control). …”
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Effectiveness of Virtual Reality Training in Improving Outcomes for Dialysis Patients: Systematic Review and Meta-Analysis by Xin Kang, Yiping Zhang, Chaonan Sun, Jiaxin Zhang, Zhe Che, Jinhui Zang, Rongzhi Zhang

“… BackgroundVirtual reality (VR) training uses computer-generated simulations that enable users to engage with immersive virtual environments, simulating real-world activities or therapeutic exercises. This technology is increasingly recognized as a promising intervention to address the physical and psychological challenges faced by dialysis patients, who frequently experience diminished physical function, social isolation, and emotional distress associated with prolonged treatment regimens. …”
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Development and Implementation of a Registry of Patients Attending Multidisciplinary Pain Treatment Clinics: The Quebec Pain Registry by M. Choinière, M. A. Ware, M. G. Pagé, A. Lacasse, H. Lanctôt, N. Beaudet, A. Boulanger, P. Bourgault, C. Cloutier, L. Coupal, Y. De Koninck, D. Dion, P. Dolbec, L. Germain, V. Martin, P. Sarret, Y. Shir, M.-C. Taillefer, B. Tousignant, A. Trépanier, R. Truchon

“…The QPR is also a powerful and comprehensive tool for conducting research in a “real-world” context with 27 observational studies and satellite research projects which have been completed or are underway. …”
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Advancing treatment choices: CDK4/6 inhibitor switching in HR+/HER2- metastatic breast cancer by Paola Zagami, Angela Esposito, Beatrice Taurelli Salimbeni, Pier Paolo Maria Berton Giachetti, Roberta Scafetta, Matteo Lambertini, Massimo Di Maio, Giuseppe Curigliano, Carmen Criscitiello, Saverio Cinieri

“…Yet, 49 % of respondents emphasized the need for more real world evidence on CDK4/6i switch safety and efficacy. 96 % of respondents reported discontinuation rates between 0% and 25 % of patients, with constipation and hematological toxicity being the most frequent treatment discontinuation reasons. …”
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Serum Lactate Dehydrogenase Is a Novel Predictor for the Severity in the Patients With MAFLD: A Cross-Sectional Study in Hefei, China by Yu L, Bao S, Zhu F, Xu Y, Zu F, Liu Y, Jiang R, Chen S, Chen W

“…Liang Yu,1,&ast; Shiming Bao,2,&ast; Feng Zhu,3,&ast; Yanyan Xu,1 Fuqiang Zu,1 Yanwei Liu,1 Runbeng Jiang,1 Wei Chen,4 Song Chen5 1Department of General Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Emergency Surgery, Tongling People’s Hospital, Tongling, People’s Republic of China; 3Department of General Surgery, Tongling People’s Hospital, Tongling, People’s Republic of China; 4Department of General Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 5Department of General Surgery, the Affiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chuzhou), Chuzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Song Chen, Department of General Surgery, the Affiliated Chuzhou Hospital of Anhui Medical University (The First People’s Hospital of Chuzhou), Chuzhou, People’s Republic of China, Email chensong101425@163.com Wei Chen, Department of General Surgery, the First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China, Email 13665560109@163.comBackground & Aims: The aim of this study was to assess the association between the level of lactate dehydrogenase (LDH) and the severity of metabolic syndrome (MetS) and Metabolic Associated Fatty Liver Disease (MAFLD) and the potential diagnostic value of LDH for identifying at-risk metabolic associated steatohepatitis (MASH).Methods: This cross-sectional, real-world retrospective study enrolled a total of 1118 obese patients in the department of bariatric surgery at the Second Affiliated Hospital of Anhui Medical University from January 1, 2018, to December 31, 2021. …”
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Effectiveness of case-area targeted interventions including vaccination on the control of epidemic cholera: protocol for a prospective observational study by Lauren D'Mello-Guyett, Ruwan Ratnayake, Andrew S Azman, Yap Boum, Francesco Checchi, W John Edmunds, Placide Okitayemba Welo, Nicolas Peyraud, Iza Ciglenecki, Etienne Gignoux, Maria Lightowler, Primitive Gakima, Jean Patrick Ouamba, Joseph Amadomon Sagara, Rollin Ndombe, Nana Mimbu, Alexandra Ascorra, Elisabeth Mukamba Musenga, Berthe Miwanda, Francisco Luquero, Klaudia Porten, Flavio Finger, Miriam Alia, Bachir Assao, Catherine Bachy, Rob D'hondt, Karl Njuwa Fai, Caroline Henry-Ostian, Abdoul-Moumouni Issa-Soumana, Danish Malik, Herbert Mutubuki, Rodrigue Ntone, Isabella Panunzi, Issaka Soumana, Oumar Touré, Mamady Traore

“…CATI will be triggered immediately on notification of a case in a new area. As with most real-world interventions, there will be delays to response as the strategy is rolled out. …”
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Evaluasi Faktor Manfaat Sistem Lingkungan Pembelajaran 3 Dimensi Berbasis Multi-User Virtual Reality (MuVR) by Adhi Rizal, Dadang Yusup, Apriade Voutama

“…The results showed that 3D-MuVLR can represent the learning environment as in a real world. However, there were several design aspect problems identified related to the lack of instructions of information in the system regarding procedures on how to enter or quit system and the absence of information on how to participate in learning activities. …”
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Multinational retrospective analysis of bridging therapy prior to chimeric antigen receptor t cells for relapsed/refractory acute lymphoblastic leukemia in children and young adult... by Maike Breidenbach, Peter Bader, Andishe Attarbaschi, Claudia Rossig, Roland Meisel, Markus Metzler, Marion Subklewe, Fabian Mueller, Paul-Gerhardt Schlegel, Irene Teichert von Lüttichau, Jean-Pierre Bourquin, Gabriele Escherich, Gunnar Cario, Peter Lang, Ramona Coffey, Arend von Stackelberg, Semjon Willier, Brigitte Strahm, Christina Peters, Tobias Feuchtinger

“…In this retrospective, multinational study, real-world data were collected from 14 different sites in Germany, Austria and Switzerland on 88 patients receiving 93 2nd-generation CAR therapies. …”
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Norepinephrine use in cardiogenic shock patients is associated with increased 30 day mortality by Xin Lu, Xue Wang, Yanxia Gao, Joseph Harold Walline, Shiyuan Yu, Zengzheng Ge, Mubing Qin, Huadong Zhu, Yi Li

“…This study aimed to explore the relationship between norepinephrine use and outcomes in cardiogenic shock patients in real‐world conditions. Methods and results We conducted a retrospective cohort study based on the Medical Information Mart for Intensive Care III (MIMIC‐III) database. …”
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Advanced Fractional Mathematics, Fractional Calculus, Algorithms and Artificial Intelligence with Applications in Complex Chaotic Systems by Dumitru Baleanu, Yeliz Karaca

“…Moreover, Fractional Calculus (FC), related to the dynamics of complicated real-world problems, ensures emerging processes adopting fractional dynamics rather than the ordinary integer-ordered ones, which means the related differential equations feature non integer valued derivatives. …”
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Anlotinib in combination with metronomic chemotherapy in HER2-negative metastatic breast cancer: an observational and retrospective study by Jiaxuan Liu, Jiayang Zhang, Huiping Li, Guohong Song, Lijun Di, Hanfang Jiang, Ying Yan, Huan Wang, Jing Wang, Xiaoran Liu, Bin Shao, Qiao Li

“…Within the context of real-world clinical practice, anlotinib in combination with metronomic chemotherapy provides a well-tolerated and effective treatment option for HER2-negative MBC, which warrants further investigation in the future.…”
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Orchard-Wide Visual Perception and Autonomous Operation of Fruit Picking Robots: A Review by CHEN Mingyou, LUO Lufeng, LIU Wei, WEI Huiling, WANG Jinhai, LU Qinghua, LUO Shaoming

“…To tackle this challenge, this review delves into the latest research methodologies and real-world applications in this field, critically assesses the strengths and limitations of existing methods and categorizes the essential components of continuous operation into three sub-modules: local target recognition, global mapping, and operation planning.…”
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Syphilis Point of Care Rapid Test and Immediate Treatment Evaluation (SPRITE) study: a mixed-methods implementation science research protocol of eight public health units in Ontari... by Patrick O'Byrne, Melissa Richard-Greenblatt, Michael Evans, Jennifer Adams, Brad Stoner, Patrick O’Byrne, Sahar Saeed, Vanessa Tran, Lucy Mackrell, Megan Carter, Maggie Hoover, Natasha Larkin, Felicia Maria G Magpantay, Sicheng Zhao, Bradley Stoner, Kira Mandryk, Kandace Belanger, Jennifer Burbidge, Gilles Charette, Gabrielle Deschenes, Duy A Dinh, Amanda Featherstone, Farhan Khandakar, Jorge Martinez-Cajas, Nicole Szumlanski, Stephanie Vance, Jessica Burnside, Clare Mak, Erin Stienstra, Patrick Sanderson, Eric Geen, Nancy McGeachy, Stephanie McFaul, Susan LaBrie, Brooke Rasinho, Christine Brannan, Michelle Street, Melanie St John, Casey Cassan, Sandra Dereski, Taylor Labadie, Mary France, Lynn Leggett Caron-Bruneau

“…This study assesses the real-world implementation and effectiveness of using a recently approved syphilis point-of-care test in conjunction with public health outreach to break barriers and bring services to the population at the highest risk.Methods and analysis The Syphilis Rapid Point-of-Care Testing and Immediate Treatment Evaluation (SPRITE) study includes eight public health units in Ontario, Canada. …”
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