Comparative effectiveness of urine drug screening strategies alongside opioid agonist treatment in British Columbia, Canada: a population-based observational study protocol by Malcolm Maclure, M Eugenia Socías, Evan Wood, Paul Gustafson, Robert W Platt, Bohdan Nosyk, Jeong Eun Min, Micah Piske, Julie Bruneau, U Siebert, P Todd Korthuis, Paxton Bach, B Carolina Guerra-Alejos, Megan Kurz, Laura M Dale, X Joan Hu, Kyle Kampman, Tom Loughin

“…However, there is limited evidence supporting the utility of mandatory UDTs—particularly the impact of UDT frequency on OAT retention. Real-world evidence can inform patient-centred approaches to OAT and improve current strategies to address the ongoing opioid public health emergency. …”
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Design of Intelligent Feature Selection Technique for Phishing Detection by Sharvari Sagar Patil, Narendra M. Shekokar, Sridhar Chandramohan Iyer

“…We have evaluated our technique using the real-world phishing dataset and compared its performance with the existing techniques. …”
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Analisis Kinerja Augmented Reality HyperText Markup Language (ARHTML) Melalui Pemanfaatan Web Graphics Library dan OpenGl Shading Language untuk Pengembangan 3D by Multohadi Hamzaturrazak, Abdul Jabbar, Rizal Setya Perdana, Aryo Pinandito

“…The fusion of virtual and real-world elements by augmented reality creates memorable and dynamic user interactions. …”
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ANN-based two hidden layers computational procedure for analysis of heat transport dynamics in polymer-based trihybrid Carreau nanofluid flow over needle geometry by Adil Darvesh, Fethi Mohamed Maiz, Basma Souayeh, Luis Jaime Collantes Santisteban, Hakim AL. Garalleh, Afnan Al Agha, Lucerito Katherine Ortiz García, Nicole Anarella Sánchez-Miranda

“…This geometry facilitates the heat transfer mechanism, which could be crucial in many real-world applications such as cooling of electronic devices, heat exchangers and advanced manufacturing techniques. …”
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DRAFTS: A Deep-learning-based Radio Fast Transient Search Pipeline by Yong-Kun Zhang, Di Li, Yi Feng, Chao-Wei Tsai, Pei Wang, Chen-Hui Niu, Hua-Xi Chen, Yu-Hao Zhu

“…We developed a large, real-world data set of FRBs for training deep-learning models. …”
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Intervening Non-Small-Cell Lung Cancer Progression by Cell Membrane Coated Platycodin D via Regulating Hsa-miR-1246/FUT9/GSK3β Pathway by Zheng S, Xie Z, Zhou Z, Wang S, Xin Y, Lin J, Cheng K, Lu T, Qi R, Guo Y

“…Prior studies showed Platycodin D (PD)-induced cell cycle arrest and apoptosis in NSCLC via RNA regulatory network, yet elucidating PD’s mechanisms in NSCLC progression is challenging in the real world.Methods: Biological effects of PD on NSCLC cell lines A549 and PC-9 were assessed through in vitro assays, encompassing apoptosis, proliferation, colony formation, migration and invasion. …”
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Methods to Adjust for Confounding in Test-Negative Design COVID-19 Effectiveness Studies: Simulation Study by Elizabeth AK Rowley, Patrick K Mitchell, Duck-Hye Yang, Ned Lewis, Brian E Dixon, Gabriela Vazquez-Benitez, William F Fadel, Inih J Essien, Allison L Naleway, Edward Stenehjem, Toan C Ong, Manjusha Gaglani, Karthik Natarajan, Peter Embi, Ryan E Wiegand, Ruth Link-Gelles, Mark W Tenforde, Bruce Fireman

“… BackgroundReal-world COVID-19 vaccine effectiveness (VE) studies are investigating exposures of increasing complexity accounting for time since vaccination. …”
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Proof of concept for multirotor systems with vortex-generating modes for regenerative wind energy: a study based on numerical simulations and experimental data by F. Avila Correia Martins, A. van Zuijlen, A. van Zuijlen, C. Simão Ferreira

“…It should be noted, however, that this study employs a simplified numerical setup to provide a proof of concept, and the current findings are not yet directly applicable to real-world scenarios.</p>…”
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Large-scale screening of HIV-1 T-cell epitopes restricted by 12 prevalent HLA-A allotypes in Northeast Asia and universal detection of HIV-1-specific CD8+ T cells by Yan Ding, Jialai Yan, Ling Huang, Jinhong Yu, Yandan Wu, Chuanlai Shen, Anning Fang

“…A total of 69 epitopes were validated as real-world HIV T-cell epitopes presented by 12 dominant HLA-A allotypes. …”
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Electrodermal activity and skin temperature characteristics related to stress and depression: A 4-week observational study of office workers by Yuki Ishikawa, Tatsuki Sugio, Kiko Shiga, Keisuke Izumi, Kazumichi Minato, Momoko Kitazawa, Sayaka Hanashiro, Ryo Takemura, Hiroyuki Uchida, Taishiro Kishimoto

“…However, there is a lack of long-term observational studies in real-world settings. Methods: This 4-week observational study analyzed data from 147 office workers across 11 Japanese companies. …”
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Addressing unfamiliar ship type recognition in real-scenario vessel monitoring: a multi-angle metric networks framework by Jiahua Sun, Jiawen Li, Jiawen Li, Jiawen Li, Jiawen Li, Ronghui Li, Ronghui Li, Ronghui Li, Langtao Wu, Liang Cao, Liang Cao, Liang Cao, Liang Cao, Molin Sun, Molin Sun, Molin Sun

“…These experimental results highlight the framework’s ability to effectively generalize its understanding beyond the training samples and adapt to real-world scenarios.…”
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Comparative effectiveness of buprenorphine-naloxone versus methadone for treatment of opioid use disorder: a population-based observational study protocol in British Columbia, Cana... by Lawrence C McCandless, Malcolm Maclure, M Eugenia Socías, Evan Wood, Paul Gustafson, Robert W Platt, Bohdan Nosyk, Sander Greenland, Micah Piske, Trevor Thomson, Emanuel Krebs, Natt Hongdilokkul, Julie Bruneau, M Ehsan Karim, Judith I Tsui

“…Introduction Despite a recent meta-analysis including 31 randomised controlled trials comparing methadone and buprenorphine for the treatment of opioid use disorder, important knowledge gaps remain regarding the long-term effectiveness of different treatment modalities across individuals, including rigorously collected data on retention rates and other treatment outcomes. Evidence from real-world data represents a valuable opportunity to improve personalised treatment and patient-centred guidelines for vulnerable populations and inform strategies to reduce opioid-related mortality. …”
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Cost-Consequence Analysis of Apixaban Versus Rivaroxaban for Managing Patients with Venous Thromboembolism in Saudi Arabia by Abdulaali R. Almutairi PhD, Yazed Alruthia PhD, Majed S. Alyami PharmD, Omar A. Alshaya PharmD, Taif Z. Alanazi PharmD, Sarah I. Al Daghreer PharmD, Ghazwa B. Korayem PharmD, Sarah A. Alrasheed PharmD, Reema A. Alorf PharmD, Omar A. Almohammed PhD

“…Nevertheless, there are no studies assessing the cost-effectiveness of DOACs for VTE treatment in Saudi Arabia using real-world data. Hence, this study seeks to examine the costs and medical consequences of apixaban compared to rivaroxaban in treating VTE patients in Saudi Arabia. …”
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Effect of Combination Therapy of Canagliflozin Added to Teneligliptin Monotherapy in Japanese Subjects with Type 2 Diabetes Mellitus: A Retrospective Study by Yoshiro Fushimi, Atsushi Obata, Junpei Sanada, Yuichiro Iwamoto, Akiko Mashiko, Megumi Horiya, Akiko Mizoguchi-Tomita, Momoyo Nishioka, Yuki Kan, Tomoe Kinoshita, Seizo Okauchi, Hidenori Hirukawa, Kenji Kohara, Fuminori Tatsumi, Masashi Shimoda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto

“…We retrospectively analyzed 56 Japanese subjects with T2DM in the real-world clinical practice. Three months after starting the combination therapy, the change of HbA1c (ΔHbA1c) was strongly related to HbA1c levels at baseline. …”
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Delirium Management Quality Improvement Project to Improve Awareness and Screening in a Medical ICU by Hirsh Makhija, Kyle Digrande, Omar Awan, Russell G. Buhr, Rajan Saggar, Victoria Ramirez, Rainbow Tarumoto, Janelle M. Fine, Atul Malhotra, Dale M. Needham, Jennifer L. Martin, Biren B. Kamdar

“…<b>Background/Objectives:</b> Although delirium is common during critical illness, standard-of-care detection and prevention practices in real-world intensive care unit (ICU) settings remain inconsistent, often due to a lack of provider education. …”
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Opportunities, challenges, and difficulties in NMR-based metabolomics applied to neovascular age-related macular degeneration (nAMD) patient follow-up by M. Schoumacher, M. Schoumacher, V. Lambert, M. Campas, P. Blaise, B. Locht, M. Thys, E. Duchateau, E. Cavalier, E. Cavalier, J.-M. Rakic, A. Noël, P. de Tullio, P. de Tullio

“…The dataset’s heterogeneity, reflecting real-world clinical practice, complicated the derivation of global conclusions. …”
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Hypercalcemia Following Adrenalectomy for Cushing Syndrome in a Patient with Post-Surgical Hypoparathyroidism by Pietro Locantore, Alessandro Oliva, Gianluca Cera, Rosa Maria Paragliola, Roberto Novizio, Caterina Policola, Andrea Corsello, Alfredo Pontecorvi

“…On the contrary, hypoparathyroidism is a relatively common cause of hypocalcemia, often arising as a complication of thyroid surgery. In real-world clinical practice, however, many challenges come into play, and a comprehensive approach may not be enough to establish a diagnosis. …”
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Perioperative outcomes in an age-adapted analysis of the German StuDoQ|Pancreas registry for PDAC by Tengis Tschaidse, Felix O. Hofmann, Bernhard Renz, Maximilian Hungbauer, Carsten Klinger, Heinz J. Buhr, Waldemar Uhl, Sören Torge Mees, Tobias Keck, Christoph Reissfelder, Michael Ghadimi, Jan G. D’Haese, Jens Werner, Matthias Ilmer

“…This study investigated the influence of age and tumor location on postoperative morbidity and mortality in a large, real-world dataset. Methods Patients with confirmed PDAC undergoing pancreatic surgery between 01/01/2014 and 31/12/2019 were identified from the German StuDoQ|Pancreas registry. …”
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A Novel Electrical Load Forecasting Model for Extreme Weather Events Based on Improved Gated Spiking Neural P Systems and Frequency Enhanced Channel Attention Mechanism by Yuanshuo Guo, Jun Wang, Yan Zhong, Tao Wang, Zeyuan Sui

“…We conducted extensive comparative experiments with ten baseline models on three real-world datasets, compared with GSNP model and TCN-GSNP model, the coefficient of determination (R2) of the FATCN-LF-FAGSNP model increases and mean absolute percentage error (MAPE), mean absolute error (MAE) and relative absolute error (RAE) reduce, the LF accuracy (measured by R2) of the proposed hybrid model gets 99.7% in seasonal LF task. …”
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Second-line treatment patterns and outcomes in advanced HCC after progression on atezolizumab/bevacizumab by Meng Wu, Claudia A.M. Fulgenzi, Antonio D’Alessio, Alessio Cortellini, Ciro Celsa, Giulia F. Manfredi, Bernardo Stefanini, Y. Linda Wu, Yi-Hsiang Huang, Anwaar Saeed, Angelo Pirozzi, Tiziana Pressiani, Lorenza Rimassa, Martin Schoenlein, Kornelius Schulze, Johann von Felden, Yehia Mohamed, Ahmed O. Kaseb, Arndt Vogel, Natascha Roehlen, Marianna Silletta, Naoshi Nishida, Masatoshi Kudo, Caterina Vivaldi, Lorenz Balcar, Bernhard Scheiner, Matthias Pinter, Amit G. Singal, Joshua Glover, Susanna Ulahannan, Fredrich Foerster, Arndt Weinmann, Peter R. Galle, Neehar D. Parikh, Wei-Fan Hsu, Alessandro Parisi, Hong Jae Chon, David J. Pinato, Celina Ang

“…Our study aims to fill in some of the knowledge gap by investigating real-world patient outcomes in the second-line treatment setting. …”
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