Lipid trajectories improve risk models for Alzheimer’s disease and mild cognitive impairment by Bruce A. Chase, Roberta Frigerio, Chad J. Yucus, Smita Patel, Demetrius Maraganore, Alan R. Sanders, Jubao Duan, Katerina Markopoulou

“…Inclusion of lipid-trajectory and VIM groups improved risk-model predictive performance independent of APOE and AD or lipid-level PRSs, providing important real-world perspectives on how longitudinal levels and variation of blood-lipid concentrations contribute to risk of cognitive decline.…”
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Incidence of seroma and postoperative complications after breast surgery before and during the Covid-19 pandemic: results from a retrospective multicenter analysis by Maximilian Heinz Beck, Izabela A. Brachaczek, Pimrapat Gebert, Jens-Uwe Blohmer, Askin C. Kaya, Julia S. M. Zimmermann, Julia C. Radosa, Maria M. Karsten

“…Conclusion While our findings did not indicate an elevated incidence of seroma during the SARS-CoV-2 pandemic, we observed increased rates of erythema, wound healing disorders, and wound infection. Additional real-world evidence is needed for understanding both early and late complications following breast surgery in the context of the ongoing SARS-CoV-2 endemic.…”
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Drug utilization study of antiparkinsonian medication in Romania during 25 years by Camelia Bucsa, Denisa Bruhs, Anamaria Apan, Elena Francu, Cristina Mogosan, Irina Iaru

“…Observing the trend in antiparkinsonian medication utilization over time is essential for providing insights into their real-world use and uptake in a large population.…”
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Human Factors Studies to Assess the Usability of the Faricimab Prefilled Syringe by Barakat MR, Kwong Jr HM, Marcon G, O'Leary OE, Paris LP, Schneider P, Tang Y, Graff JM

“…One patient experienced one mild adverse event of eye irritation that resolved the same day and was deemed unrelated to the study drug.Conclusion: Participants were able to safely and correctly prepare and administer a faricimab 6 mg dose using the PFS in accordance with the instructions for use, under realistic conditions representing the real world. The faricimab 6 mg PFS may therefore offer a more convenient, safe-handling alternative to vial administration.Keywords: intravitreal injection, medical device, retina specialist, human factors validation study, anti-vascular endothelial growth factor therapy…”
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Evaluating the feasibility, sensitivity, and specificity of next-generation molecular methods for pleural infection diagnosis by Peter T. Bell, Timothy Baird, John Goddard, Olusola S. Olagoke, Andrew Burke, Shradha Subedi, Tiana R. Davey, James Anderson, Derek S. Sarovich, Erin P. Price

“…Here, we demonstrate the feasibility, utility, and challenges associated with the use of culture-independent molecular techniques for accurate pleural infection diagnosis in a real-world clinical setting. These data will help to inform the design of larger prospective clinical trials and identify potential obstacles to be overcome before next-generation sequencing technologies can be integrated into routine clinical practice.…”
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Safety of interleukin inhibitors in patients with plaque psoriasis and history of neoplasms: a multicenter retrospective study – IL PSO (Italian landscape psoriasis) by Mario Valenti, Luciano Ibba, Sara Di Giulio, Luigi Gargiulo, Piergiorgio Malagoli, Anna Balato, Carlo G. Carrera, Paolo Dapavo, Eugenia V. Di Brizzi, Valentina Dini, Francesca Gaiani, Francesco Loconsole, Angelo V. Marzano, Matteo Megna, Alessandra Michelucci, Luca Potestio, Simone Ribero, Antonio Costanzo, Alessandra Narcisi

“…However, their use in patients with a history of cancer is debated.Objective: We conducted a multicenter retrospective study across nine Italian Dermatology Units to assess the real-world effectiveness and safety of IL inhibitors (IL-23, IL-17, IL-12/23) in 136 oncological patients with moderate-to-severe plaque psoriasis. …”
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Effectiveness of an Impella Versus Intra‐Aortic Balloon Pump in Patients Who Received Extracorporeal Membrane Oxygenation by Yuji Nishimoto, Hiroyuki Ohbe, Jun Nakata, Toru Takiguchi, Mikio Nakajima, Yusuke Sasabuchi, Toshiaki Isogai, Hiroki Matsui, Yukihito Sato, Tetsuya Watanabe, Takahisa Yamada, Masatake Fukunami, Hideo Yasunaga

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Neuropsychiatric adverse events associated with Glucagon-like peptide-1 receptor agonists: a pharmacovigilance analysis of the FDA Adverse Event Reporting System database by Wenchao Lu, Shihan Wang, Huilin Tang, Tao Yuan, Wei Zuo, Yuling Liu

“…Abstract Background Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used due to their profound efficacy in glycemic control and weight management. Real-world observations have revealed potential neuropsychiatric adverse events (AEs) associated with GLP-1RAs. …”
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Computational Simulation of Virtual Patients Reduces Dataset Bias and Improves Machine Learning-Based Detection of ARDS from Noisy Heterogeneous ICU Datasets by Konstantin Sharafutdinov, Sebastian Johannes Fritsch, Mina Iravani, Pejman Farhadi Ghalati, Sina Saffaran, Declan G. Bates, Jonathan G. Hardman, Richard Polzin, Hannah Mayer, Gernot Marx, Johannes Bickenbach, Andreas Schuppert

“…However, the limited generalizability of ML models developed on single-center datasets, and their unproven performance in real-world settings, remain significant constraints to their widespread adoption in clinical practice. …”
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Design of a Cost-Effective Ultrasound Force Sensor and Force Control System for Robotic Extra-Body Ultrasound Imaging by Yixuan Zheng, Hongyuan Ning, Eason Rangarajan, Aban Merali, Adam Geale, Lukas Lindenroth, Zhouyang Xu, Weizhao Wang, Philipp Kruse, Steven Morris, Liang Ye, Xinyi Fu, Kawal Rhode, Richard James Housden

“…These results demonstrate the potential of the system to provide safe, precise, and autonomous robotic ultrasound imaging in real-world conditions.…”
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Towards Understanding the Security of Modern Image Captchas and Underground Captcha-Solving Services by Haiqin Weng, Binbin Zhao, Shouling Ji, Jianhai Chen, Ting Wang, Qinming He, Raheem Beyah

“…Third, we systematically evaluate our attack frameworks against 10 popular real-world image captchas, including captchas from tencent.com, google.com, and 12306.cn. …”
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Cost Savings in Chronic Pain Patients Initiating Peripheral Nerve Stimulation (PNS) with a 60-Day PNS Treatment by David M. Dickerson, Hemant Kalia, Kevin E. Vorenkamp, Konstantin V. Slavin, Jonathan M. Hagedorn, Candace Gunnarsson, Eric L. Keuffel, Andrew J. Epstein, Mark Stultz, Nathan D. Crosby

“…Clinical response to 60-Day PNS was estimated by retrospectively reviewing anonymized outcomes from a national real-world database, focusing on patients ≥ 65 years of age who were implanted with a 60-day percutaneous PNS system. …”
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PRECIS-2 used as an implementation science tool for global environmental health: A cross-sectional evaluation of the Ecolectivos study protocol to reduce burning of household plast... by Lisa M Thompson, Annalyse Ferguson, Hina Raheel, Amy E Lovvorn, Mayari Hengstermann-Artiga, Maria Renee Lopez, Melinda Higgins, Eri Saikawa, Margaret A Handley

“…RCTs that use a pragmatic design emphasize the effectiveness of interventions in complex, real world settings. Pragmatic trials may be especially relevant when community-based interventions address social and environmental determinants that threaten health equity. …”
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Chitosan-covered tamponade for the treatment of postpartum hemorrhage: a registry-based cohort study assessing outcomes and risk factors for treatment failure by Clara Leichtle, Annette Aigner, Carolin Biele, Paulina Hermann, Teresa Dangli, Charlotte Waldner, Thorsten Braun, Wolfgang Henrich, Anna Maria Dückelmann

“…The objective of this study was to assess the factors leading to unsuccessful intrauterine therapy with a chitosan-covered tamponade (CT) for the treatment of PPH and to evaluate clinical outcomes based on real-world data. Methods This registry-based cohort study included all women treated with CT for PPH between January 2017 and June 2022 at a university clinic’s perinatal department. …”
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Psychological, psychiatric, and behavioral sciences measurement scales: best practice guidelines for their development and validation by Alberto Stefana, Stefano Damiani, Umberto Granziol, Umberto Provenzani, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Marco Solmi, Eric A. Youngstrom, Eric A. Youngstrom, Eric A. Youngstrom, Paolo Fusar-Poli, Paolo Fusar-Poli, Paolo Fusar-Poli

“…This article presents a guide to scope, organize, and clarify the process of scale development and validation for psychological and psychiatric use by integrating current methodological literature with the authors’ real-world experience. The process is divided into five phases comprising 18 steps. …”
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Systematic Review with Network Meta-Analysis: Comparative Efficacy and Safety of Combination Therapy with Angiotensin II Receptor Blockers and Amlodipine in Asian Hypertensive Pati... by Dae Wook Lee, Mira Jung, Hye Won Wang, Zainah Khan, Philippe Pinton

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Pengembangan Permainan Edukasi Berbasis Augmented Reality untuk Pembelajaran Senyawa Hidrokarbon bagi Siswa Sekolah Menengan Atas (SMA) by Carlista Naba, Muhammad Aminul Akbar, Ahmad Afif Supianto

“…The game will be developed as a puzzle game, on which the player arrange and build a hydrocarbon compound that can be seen on the real world with AR. The game will also detects the compound’s name. …”
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Monitoring and evaluation in disaster management courses: a scoping review by George Teo Voicescu, Hamdi Lamine, Andra Elena Loșonți, Eugenia Maria Lupan-Mureșan, Sonia Luka, José García Ulerio, Luca Ragazzoni, Francesco Della Corte, Marta Caviglia

“…The mismatch between the learning objectives and the evaluation process led to deceptive evaluations, which may have resulted in graduates being deemed ready to deploy despite facing hardships in real-world settings, potentially leading to unprepared responders.…”
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Novel prehospital lactate cut-off estimation for mortality: a multicentre observational study by Ancor Sanz-García, Carlos del Pozo Vegas, Daniel Zalama-Sánchez, Raúl López-Izquierdo, Francisco Martín-Rodríguez, Pedro Ángel de Santos Castro, Eduardo Silva Alvarado, Santos Gracia Villar, Luis Alonso Dzul López, Silvia Aparicio Obregón, Rubén Calderon Iglesias

“…The mortality rate in patients who were less than 3.71 mmol/L was 0.004%, and that above that cut-off was 18%.Conclusions This study established a real-world lactate cut-off for 2-day in-hospital mortality of 3.71 mmol/L (95% CI 2.92 to 3.91) on the basis of data from the EMS. …”
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Effectiveness and safety of aripiprazole oral solution in the acute treatment of schizophrenia in Chinese patients by Zhen Mao, Fang Dong, Anning Li, Feng Li, Junhong Zhu, Xiangdong Du, Gang Wu, Huaili Deng, Xueqin Yu, Jintong Liu, Shiping Xie, Xiaowei Tang, Gang Wang

“…Name of trial registration: A real-world study of Aripiprazole Oral Solution in the treatment of schizophrenia (Registration date: 25/03/2021). …”
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