Are Suggested Hiking Times Accurate? A Validation of Hiking Time Estimations for Preventive Measures in Mountains by Marco Vecchiato, Nicola Borasio, Emiliano Scettri, Vanessa Franzoi, Federica Duregon, Sandro Savino, Andrea Ermolao, Daniel Neunhaeuserer

“…<i>Materials and Methods</i>: A cross-sectional analysis was conducted using data from 25 Italian loop trails selected via the Wikiloc platform, considering user-uploaded GPS data from at least 20 users per trail. Real-world hiking times were compared with estimations from Komoot, Outdooractive, mountain signage, and the MOVE algorithm, which incorporates individualized biological and trail characteristics. …”
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SDG11-Based Sustainability Assessment of Urban Communities: A Case Study of Changsha by Qin Shuqian, Zhang Nan, Zhu Peijuan, Zhang Yong, Zhang Chen

“…Given the real-world challenges in implementing the United Nations Sustainable Development Goals (SDGs), it is important to study and formulate a localized assessment indicator system for each SDGs to monitor the current status of sustainable development at different scales, identify problems, and develop countermeasures. …”
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ILN-YOLOv8: A Lightweight Image Recognition Model for Crimped Wire Connectors by Xiaojian Zhou, Jicheng Kan, Nur Fatin Liyana Mohd Rosely, Xu Duan, Jiajing Cai, Zihan Zhou

“…Experimental results show that, compared to the original YOLOv8 model, the proposed method achieved 96.2% accuracy on a real-world crimped wire connectors dataset, with mAP@0.5 and mAP@.5:.95 improving by 6.1% and 7.4%, respectively, while Parameters and FLOPs decreased by 66.7% and 34.6%.…”
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Effectiveness of nicotine salt vapes, cytisine, and a combination of these products, for smoking cessation in New Zealand: protocol for a three-arm, pragmatic, community-based rand... by Natalie Walker, Amanda Calder, Joanne Barnes, George Laking, Varsha Parag, Chris Bullen

“…Discussion Pragmatic trials are of particular value as they reflect the ‘real world’ impact of interventions. The trial will provide some of the first evidence on the effectiveness of combining nicotine salt e-cigarettes with cytisine for smoking cessation, in a country with strong tobacco control policy. …”
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Direct-acting oral anticoagulant removal by intraoperative hemoadsorption in CABG and/or single valve surgery: interim analysis of the International Safe and Timely Antithrombotic... by Michael Schmoeckel, Matthias Thielmann, Keti Vitanova, Thomas Eberle, Nandor Marczin, Kambiz Hassan, Andreas Liebold, Sandra Lindstedt, Georg Mächler, Marijana Matejic-Spasic, Daniel Wendt, Efthymios N. Deliargyris, Robert F. Storey

“…The international STAR-registry reports real-world clinical outcomes associated with this application. …”
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Effect of Huaier granule on prognosis of breast cancer: A single-center propensity score matching retrospective study by Qianqian Guo, Yuting Peng, Ge Zhang, Huan Lin, Qianjun Chen, Sihan Zhou, Xiuyuan Hao

“…In this retrospective study, Huaier granules improved the DFS and OS of early invasive breast cancer patients, providing real-world evidence for further prospective studies on treating breast cancer with Huaier granules.…”
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Impact of same-day ART initiation on medical care and medication discontinuation among patients with incident HIV infection or AIDS in Taiwan: A population-based cohort study by Chen-Han Chueh, Hsiao-Jou Yu, Yu-Wen Wen, Ming-Neng Shiu, Yi-Ying Chen, Shao-Chin Chiang, Yi-Wen Tsai

“…Discrepancies exist between real-world evidence and randomized trials regarding early antiretroviral therapy (ART) initiation and care retention. …”
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mHealth-Augmented Care for Reducing Depression Symptom Severity Among Patients With Chronic Pain: Exploratory, Retrospective Cohort Study by Dan Holley, Amanda Brooks, Matthew Hartz, Sudhir Rao, Thomas Zaubler

“…MethodsOur team leveraged retrospective, real-world data from 3837 patients with comorbid depression and nonmalignant chronic pain who received integrated behavioral health care (IBH) at a subspecialty pain clinic. …”
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Use of Imaging Modalities in Real Life: Impact on Visual Acuity Outcomes of Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration in Germany by Joachim Wachtlin, Georg Spital, Steffen Schmitz-Valckenberg, Sandra Liakopoulos, Jessica Vögeler, Bettina Müller, Focke Ziemssen, Ocean study group

“…To date, there are limited prospective real-world data on the impact of optical coherence tomography (OCT) diagnostics on treatment outcomes in neovascular age-related macular degeneration (nAMD). …”
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Rationale and design of a prospective, observational, multicentre study on the safety and efficacy of apixaban for the prevention of thromboembolism in adults with congenital heart... by Despoina Ntiloudi, Sotiria Apostolopoulou, Alexandra Frogoudaki, Haralambos Karvounis, George Giannakoulas, Anastasios Kartas, Ioannis Doundoulakis, Athanasios Koutsakis, Diamantis Kosmidis, Georgios Rampidis, Afrodite Tzifa, Dimosthenis Avramidis, Olga Ntzoyvara, Sotiria Liori, Tereza Mousiama, Sophia Anastasia Mouratoglou

“…Data are limited regarding treatment with non-vitamin K oral anticoagulants in long-term studies involving patients with ACHD and AA.Methods and analysis PReventiOn of ThromboEmbolism in Adults with Congenital HearΤ disease and Atrial aRrhythmias is a prospective, multicenter, single-arm, non-interventional cohort study designed to investigate the safety and efficacy of apixaban for the prevention of thromboembolism in ACHD with AA in a ‘real-world’ setting. Eligible patients will be evaluated by the means of available registries and clinical counter. …”
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InHeritage—A Gamified Mobile Application with AR and VR for Cultural Heritage Preservation in the Metaverse by Paula Srdanović, Tibor Skala, Marko Maričević

“…These accolades underscore the project’s innovative approach and its potential for real-world application. By presenting a robust framework for integrating gamification and immersive technologies into cultural heritage preservation, this paper contributes to the growing discourse on utilizing advanced digital tools to ensure the sustainability and relevance of cultural heritage for future generations.…”
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Review and syntheses: Ocean alkalinity enhancement and carbon dioxide removal through marine enhanced rock weathering using olivine by L. J. J. Geerts, A. Hylén, F. J. R. Meysman, F. J. R. Meysman

“…In this review, we summarize recent research advancements to bridge the gap between existing laboratory results and the real-world environment in which mERW is intended to take place. …”
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Adverse events in different administration routes of amiodarone: a pharmacovigilance study based on the FDA adverse event reporting system by Jingrong Yang, Mengfan You, Jingxin Wang, Rongfei Sun, Lili Han, Xiaonan Liu, Kaibin Niu, Kaidi Xing, Juanping Sun, Wenge Su, Yifei Wang

“…While clinical trials have highlighted the safety and efficacy of amiodarone, there is limited real-world data on adverse events (AEs) associated with different administration routes. …”
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Mechanistic insights into chloride‐related heart failure progression according to the plasma volume status by Hajime Kataoka

“…The applicability of this concept to real‐world HF pathophysiology requires further investigation. …”
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Evaluating a targeted selective speech, language, and communication intervention at scale – Protocol for the Happy Talk cluster randomised controlled trial. [version 3; peer review... by Pauline Frizelle, Darren Dahly, Aoife O'Shea, Aileen Murphy, Cristina McKean

“…Discussion This robust study evaluates a public health approach to the delivery of speech language and communication intervention in the ‘real world’ in the community, which focuses on prevention and equity of access. …”
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Biosimilars in Focus: Evaluating Their Role Compared to Adalimumab in Clinical Practice by Dorota Waz, Michał Mazur, Jakub Szarłowicz, Zofia Goliszek, Karolina Łucja Sobek, Wiktoria Tabin-Barczak, Aldona Sokołowska, Klaudia Fikas, Kamil Chwaliszewski, Sebastian Samuła

“…Key studies on pharmacokinetics, efficacy, safety, therapeutic drug monitoring (TDM), and real-world outcomes were analyzed. Results: Adalimumab biosimilars demonstrate equivalent pharmacokinetic profiles and clinical efficacy across conditions, with comparable remission rates and safety profiles. …”
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Targeted detection of sequence variants in cell-free DNA from cerebrospinal fluid in pediatric central nervous system tumors by Katrina O’Halloran, Katrina O’Halloran, Erin E. Crotty, Eirini Christodoulou, Sarah E. Leary, Alexandra Miller, Alexandra Miller, Vera A. Paulson, Christina M. Lockwood, Ashley S. Margol, Ashley S. Margol, Jaclyn A. Biegel, Jaclyn A. Biegel

“…The goal of this paper is to facilitate an understanding of these targeted techniques and provide a context for clinical relevance within disease categories, as well as a discussion on optimizing real-world implementation for pediatric CNS tumors.…”
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Effect of Prehospital Epinephrine on Outcomes of Out-of-Hospital Cardiac Arrest: A Bayesian Network Approach by Joonghee Kim, Yu Jin Kim, Sangsoo Han, Han Joo Choi, Hyungjun Moon, Giwoon Kim

“…We sought to identify the real-world effect of epinephrine from a clinical registry using Bayesian network with time-sequence constraints. …”
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Effect of the gut microbiome in glaucoma risk from the causal perspective by He Chen, Meng Zhou, Zicheng Zhang, Siqi Bao, Jia Qu, Yaxuan Wu, Ronghua Shi

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Light People: Prof. Henry Snaith’s (FRS) perovskite optoelectronics journey by Ruidong Xia, Ying Hu

“…His career success is undoubtedly driven by his ambition for immediate real-world impact and his relentless pursuit of more efficient, low-cost, and sustainable energy solutions to address global environmental challenges. …”
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