Editorial: Biologic drugs in immune-mediated inflammatory diseases, validation, drug-utilization, effectiveness, regulation, costs, and safety in the real-world by Irma Convertino, Luciane Cruz Lopes, Nicole Pratt, Ylenia Ingrasciotta, Marco Tuccori

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Real-world cost-effectiveness of nirmatrelvir-ritonavir as treatment for SARS-CoV-2 infection in the Belgian setting with omicron variant by Sophie Marbaix, Sophie Marbaix, Steven Simoens, Philippe Clevenbergh, Pascal Van Bleyenbergh, Keliane Liberman, Dimitri Dehenau

“…This paper aims to assess the cost-effectiveness of nirmatrelvir-ritonavir in Belgium using real-world evidence.MethodsA static decision tree model was developed to capture the health progression of patients infected with the SARS-CoV-2 virus. …”
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Real-world prognostic factors in autotransplanted multiple myeloma patients with severe renal impairment: study of the Polish Myeloma Study Group by Anna Waszczuk-Gajda, David H. Vesole, Jolanta Małyszko, Artur Jurczyszyn, Tomasz Wróbel, Joanna Drozd-Sokołowska, Piotr Boguradzki, Krzysztof Mądry, Agnieszka Tomaszewska, Jarosław Biliński, Maria Król, Longin Niemczyk, Magdalena Olszewska-Szopa, Wieslaw W. Jedrzejczak, Grzegorz W. Basak

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EdgeNet: An End-to-End Deep Neural Network Pretrained with Synthetic Data for a Real-World Autonomous Driving Application by Leanne Miller, Pedro J. Navarro, Francisca Rosique

“…The results show that including edge detection layers in the architecture improves performance for transfer learning when using synthetic and real-world data. In addition, pretraining with synthetic data reduces training time and enhances model performance when using real-world data.…”
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Burden of coeliac disease in Germany: real-world insights from a large retrospective health insurance claims database analysis by Bernd Bokemeyer, Leonarda Serdani-Neuhaus, Juliane Sünwoldt, Christina Dünweber, Svitlana Schnaidt, Detlef Schuppan

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Real-world studies of crizotinib in patients with ROS1-positive non-small-cell lung cancer: experience from China by Hua Zhong, Jun Lu, Mengzhao Wang, Baohui Han

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Drug-induced heart failure: a real-world pharmacovigilance study using the FDA adverse event reporting system database by Youqi Huang, Youqi Huang, Xiaowen Chen, Xiaowen Chen, Mingyu Chen, Mingyu Chen, Yuze Lin, Yuze Lin, Bingqi Chen, Hongjin Gao, Min Chen

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The real-world efficacy and toxicity of first-line paclitaxel and cisplatin with bevacizumab in platinum-naïve primary stage IVB cervical cancer by Junhwan Kim, Eun-Byul Park, Shin-Wha Lee, Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Ju-Hyun Kim

“…Objective: To investigate the real-world efficacy and toxicity of paclitaxel-cisplatin-bevacizumab and identify prognostic factors for paclitaxel-cisplatin-bevacizumab in platinum-naïve primary stage IVB cervical cancer. …”
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Long-Term Real-World Outcomes of Tenofovir Alafenamide in Chronic Hepatitis B: Detailed Analysis of Treatment-Naive and Experienced Patients by Yu-Xuan Song, Guang-Jun Song, Hui Ma, Bo Feng, Yan-Di Xie

“…Background/Aims: This study assessed the long-term efficacy and safety of tenofovir alafenamide (TAF) in real-world settings. Methods: Patients who were candidates for TAF treatment and were followed up at 12-week intervals over 192 weeks were enrolled in this study. …”
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Real-world clinical and economic impacts of delayed rotator cuff repair surgery in Japan: analysis of a large claims database by Hiroyuki Sugaya, MD, Yuki Otaka, BS, Yuichi Shiotsuki, MS, MPH, Akie Seno, BSc, MBA

Subjects: “…Real-world…”
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Risk prediction modeling for cardiorenal clinical outcomes in patients with non-diabetic CKD using US nationwide real-world data by Christoph Wanner, Johannes Schuchhardt, Chris Bauer, Meike Brinker, Frank Kleinjung, Tatsiana Vaitsiakhovich

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Relationship Among Macronutrients, Dietary Components, and Objective Sleep Variables Measured by Smartphone Apps: Real-World Cross-Sectional Study by Jaehoon Seol, Masao Iwagami, Megane Christiane Tawylum Kayamare, Masashi Yanagisawa

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Efficacy, safety, and biomarker analysis of TACE combined with lenvatinib plus sintilimab in unresectable hepatocellular carcinoma: a real-world study by Lingzhan Meng, Hu Li, Yingjie Ji, Peng Yu, Zizheng Wang, Li Cao, Bin Shi, Yanling Shao, Jin Yan, Yinjie Gao, Zhenyu Zhu

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Real-world cost-effectiveness analysis of thymoglobulin versus no induction therapy in kidney transplant recipients at low risk of graft loss by Adrieli Barros Bessa, Marina Pontello Cristelli, Claudia Rosso Felipe, Renato Demarchi Foresto, Marcelo Cunio Machado Fonseca, Jose Medina Pestana, Helio Tedesco-Silva

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Real-World Assessment of Weight Change in People with HIV-1 After Initiating Integrase Strand Transfer Inhibitors or Protease Inhibitors by Yen-Wen Chen, Helene Hardy, Christopher D. Pericone, Wing Chow

“…**Conclusion:** In a real-world setting, compared to PI-based regimens, INSTI-based regimens are associated with greater weight gain for treatment-naïve PLWH. …”
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Is Whole‐Brain Radiotherapy for Brain Metastases an Overestimated Therapy? A Retrospective Study of Real‐World Data Using Landmark Analyses by Florian Hoelzl, Oliver Koelbl, Isabella Gruber

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Clinical Features and Outcomes of Repeated Endoscopic Therapy for Esophagogastric Variceal Hemorrhage in Cirrhotic Patients: Ten-Year Real-World Analysis by Jia-li Ma, Ling-ling He, Ping Li, Yu Jiang, Ju-long Hu, Yu-ling Zhou, Xiu-xia Liang, Hong-shan Wei

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Drug-induced Parkinson-like events: a real-world study from 2004 to the first quarter of 2024 based on FAERS by Ke Wang, Ke Wang, Junyan Chen, Mingquan Huang, Xinhao Zeng, Xiaoqun Ren, Xiuqiong Liu, Chao Tao, Chao Tao, Liuxuan Yang, Liuxuan Yang, Jinlu Shang, Meiling Zhou

“…However, there is a significant lack of studies addressing these events in real-world settings.MethodsTo bridge this gap, we analyzed adverse event (AE) reports related to Parkinson-like events from the FDA Adverse Event Reporting System (FAERS) database from the first quarter of 2004 to the first quarter of 2024. …”
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Real-world efficacy and safety of dupilumab in children with atopic dermatitis under 6 years of age: a retrospective multicentric study by Filip Rob, Blanka Pinkova, Kristyna Sokolova, Jana Kopuleta, Zuzana Jiraskova Zakostelska, Jana Cadova

“…In this multicentric real-world observational retrospective study, we evaluated the efficacy and safety of dupilumab for atopic dermatitis in children <6 years of age who underwent a minimum of 16 weeks of therapy. …”
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Matched Unrelated Donor Hematopoietic Cell Transplantation: Increased Usage and Improvements in Clinical Outcomes in Canada by Matthew D. Seftel, Grace Musto, David Allan, Oliver Bucher, Kevin Hay, Ivan Pasic, Tony Truong, Kristjan Paulson

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