Small cell lung cancer with EML4-ALK fusion: report of a case responding to ALK TKI and literature review by Mingyue Wang, Hongzhi Liu, Ruixin Zhang, Runyu Li, Xiaoyu Qin, Fangling Ning, Lijun Tian

“…Abstract Purpose With the continuous development and progress of next-generation gene sequencing technology, many types of anaplastic lymphoma kinase (ALK) rearrangement have been discovered. …”
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Endocrine Aspects of 4H Leukodystrophy: A Case Report and Review of the Literature by Emma Billington, Geneviève Bernard, William Gibson, Bernard Corenblum

“…Making the diagnosis has important implications for prognosis and management. Progressive neurologic deterioration is expected, and progressive endocrine dysfunction may occur. …”
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Gut Microbiota at the Crossroad of Hepatic Oxidative Stress and MASLD by Fabrizio Termite, Sebastiano Archilei, Francesca D’Ambrosio, Lucrezia Petrucci, Nicholas Viceconti, Roberta Iaccarino, Antonio Liguori, Antonio Gasbarrini, Luca Miele

“…Despite extensive research, the molecular mechanisms driving MASLD initiation and progression remain incompletely understood. Oxidative stress and lipid peroxidation are pivotal in the “multiple parallel hit model”, contributing to hepatic cell death and tissue damage. …”
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Natural History of Metabolic Dysfunction-Associated Steatotic Liver Disease: From Metabolic Syndrome to Hepatocellular Carcinoma by Melchor Alpízar Salazar, Samantha Estefanía Olguín Reyes, Andrea Medina Estévez, Julieta Alejandra Saturno Lobos, Jesús Manuel De Aldecoa Castillo, Juan Carlos Carrera Aguas, Samary Alaniz Monreal, José Antonio Navarro Rodríguez, Dulce María Fernanda Alpízar Sánchez

“…<i>Conclusions</i>: MASLD as a metabolic disorder underscores its impact on public health, necessitating improved awareness and early management strategies to mitigate its progression to severe liver diseases.…”
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The First Autopsy Case of Fatal Acute Cardiac Failure after Administration of Carfilzomib in a Patient with Multiple Myeloma by Teruhito Takakuwa, Ippei Otomaru, Taku Araki, Akiko Miura, Yotaro Fujitani, Yasuhide Mochizuki, Yoshimi Miyagi, Hideto Senzaki, Ryosuke Yamamura

“…Her acute cardiac failure rapidly progressed, and she died on day 7 of the start of CFZ. …”
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Single-nucleus transcriptomes reveal the underlying mechanisms of dynamic whitening in thermogenic adipose tissue in goats by Manman Li, Nange Ma, Shujie Luo, Yuyi Lu, Xixi Yan, Yang Li, Xinmei Li, Zhuohui Li, Zhipei Wu, Zhenyu Wei, Wei Wang, Huimei Fan, Yu Jiang, Yan Xiong, Yu Wang

“…In this study, we employed single-nucleus RNA-seq to construct a cell atlas during whitening progression and identified the characteristics of thermogenic adipocytes. …”
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Alzheimer’s disease may develop from changes in the immune system, cell cycle, and protein processing following alterations in ribosome function by Akiko Yamakawa, Mutsumi Suganuma, Risa Mitsumori, Shumpei Niida, Kouichi Ozaki, Daichi Shigemizu

“…Pathway analyses using these DEGs, followed by protein–protein interaction network analysis, revealed key roles of ribosomal function in MCI progression, whereas immune responses, cell cycle, and protein processing in endoplasmic reticulum were involved in AD progression. …”
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Clinical Behavior of Bladder Urothelial Carcinoma in Young Patients: A Single Center Experience by Volkan Sen, Ozan Bozkurt, Omer Demir, Ahmet Adil Esen, Ugur Mungan, Guven Aslan, Aykut Kefi, Ilhan Celebi

“…Patients’ records were reviewed for recurrence and progression rates, demographic data, medical history, and treatment modalities. …”
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Metronomic Cyclophosphamide and Methotrexate Chemotherapy Combined with 1E10 Anti-Idiotype Vaccine in Metastatic Breast Cancer by Jorge L. Soriano, Noyde Batista, Eduardo Santiesteban, Mayté Lima, Joaquín González, Robin García, Yohanka Zarza, María V. López, Myriam Rodríguez, Jorge L. Loys, Narciso Montejo, Frank Aguirre, Amparo Macías, Ana M. Vázquez

“…Five patients achieved objective response, eight showed stable disease and eight had disease progression. Median time to progression was 9,8 months, while median overall survival time was 12,93 months. …”
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Acute Brainstem Dysfunction Caused by Cavernous Sinus Dural Arteriovenous Fistula by Yuwa Oka, Kenichi Komatsu, Soichiro Abe, Naoya Yoshimoto, Junya Taki, Sadayuki Matsumoto

“…Here, we describe a case with isolated and rapidly progressive brainstem dysfunction due to cavernous sinus dural arteriovenous fistula. …”
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The role of interleukin-17 in inflammation-related cancers by Xingru Zhang, Xingru Zhang, Bangjie Li, Tian Lan, Tian Lan, Conner Chiari, Xiaoyang Ye, Kepeng Wang, Ju Chen

“…Emerging evidence indicates a correlation between inflammation and the development and progression of cancer. Among the various inflammatory signals, interleukin-17 (IL-17) family cytokines serve as a critical link between inflammation and cancer. …”
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Overexpression of Delayed Rectifier K+ Channels Promotes In situ Proliferation of Leukocytes in Rat Kidneys with Advanced Chronic Renal Failure by Itsuro Kazama, Yoshio Maruyama, Yasuhiro Endo, Hiroaki Toyama, Yutaka Ejima, Mitsunobu Matsubara, Shin Kurosawa

“…Since lymphocytes are activated in patients with end-stage renal disease (ESRD), the channels expressed in those cells would contribute to the progression of renal fibrosis in advanced-stage chronic renal failure (CRF). …”
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Meeting Challenges in the Diagnosis and Treatment of Glaucoma by Karanjit S. Kooner, Dominic M. Choo, Priya Mekala

“…Glaucoma, a progressive and multifactorial optic neurodegenerative disease, still poses significant challenges in both diagnosis and management and remains a perpetual enigma [...]…”
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Differential expression of “A Disintegrin and Metalloproteinase 10” in hepatocellular carcinoma and the noncancerous hepatic tissues: Contribution to HCV-promoted hepatocarcinogene... by Amal Abd El Hafez, Basem H. Elesawy, Heba S. E. I. Hany

“…ADAM10 was particularly studied in hepatocellular carcinoma (HCC) for its potential role in hepatocarcinogenesis and HCC progression. Objective: To investigate the immunohistochemical (IHC) expression of ADAM10 in HCCs and the adjacent noncancerous tissues from 70 HCC patients, attempting to elucidate any association between ADAM10 and HCC development and/or progression. …”
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The Pathology of Orthopedic Implant Failure Is Mediated by Innate Immune System Cytokines by Stefan Landgraeber, Marcus Jäger, Joshua J. Jacobs, Nadim James Hallab

“…All of the over 1 million total joint replacements implanted in the US each year are expected to eventually fail after 15–25 years of use, due to slow progressive subtle inflammation at the bone implant interface. …”
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Cognitive analysis and path construction of Chinese students’ mathematics cognitive process based on CDA by Xiaopeng Wu, Nanxin Li, Rongxiu Wu, Hao Liu

“…Furthermore, analyses of the second and third learning progressions demonstrated diverse knowledge states among students. …”
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Mechanisms and new advances in the efficacy of plant active ingredients in tendon-bone healing by Yuan Li, Wei Wang, Wensheng Xu

“…Additionally, the mechanisms and progress of certain Chinese herbal compound components in tendon-bone healing are outlined. …”
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A narrative account of third space technology enhanced learning and teaching roles working in Australian higher education by Kate Mitchell, Kashmira Dave, Meredith Hinze, Alex Tsirgialos

“…., 2017), and limitations for career progression (Slade et al., 2019). We provide a selection of our accounts related specifically to key tensions for third space TEL roles in building collaborative relationships and what these contradictions in practice can mean for productivity, morale, wellbeing, career progression and identity formation.   …”
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Clinical and Radiological Outcomes of Extracorporeal Shock Wave Therapy in Early-Stage Femoral Head Osteonecrosis by Abdulrahman D. Algarni, Hassan M. Al Moallem

“…Femoral head osteonecrosis is a progressive clinical condition with significant morbidity and long-term disability. …”
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Construction and Analysis of Hepatocellular Carcinoma Prognostic Model Based on Random Forest by Yikai Wang, Le Ma, Pengjun Xue, Bianni Qin, Ting Wang, Bo Li, Lina Wu, Liyan Zhao, Xiongtao Liu

“…Twenty coexpressed genes were screened, and enrichment analysis indicated that glutathione metabolism was an important mechanism for these genes to regulate HCC progression. Conclusion. This study revealed the important DEGs affecting HCC progression and provided references for clinical assessment of patient prognosis and exploration of HCC progression mechanisms through the construction of predictive models and gene enrichment analysis.…”
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